Does Thyroid Autoimmunity Cause Anxiety and Depression

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Does Thyroid Autoimmunity Cause Anxiety and Depression – The Scientific Consensus

The best evidence to date shows a significant association between thyroid autoimmunity and depression & anxiety.  But what does this mean and what should you do about it? Let’s discuss the bottom line regarding the best diets and natural treatment options for improving thyroid autoimmunity and mood.

Dr. Michael Ruscio, DC: Hi, this is Dr Ruscio, and let’s discuss the association between thyroid autoimmunity, and anxiety and depression. Now what is thyroid autoimmunity? Thyroid autoimmunity is an immune condition in which your immune cells attack your thyroid gland, which they shouldn’t, and this can cause progressive damage to the gland which can then lead to hypothyroid. It is the most common cause of hypothyroidism.

In this study, I’ll put the abstract here on the screen entitled Association of Depression and Anxiety Disorders with Autoimmune Thyroiditis, a Systematic Review and Meta Analysis. They were looking for and tracking, and trying to answer from a high level if there is a consistent association between thyroid autoimmunity and depression or anxiety. To quote this study, “19 studies comparing 21 independent samples, looking at over 36,000 patients were examined.” What they found, and I’ll quote again here, “Patients with AIT,” that’s autoimmune thyroid, “Hashimoto’s thyroiditis, or subclinical or overt hypothyroidism had significantly higher scores for anxiety and depression.”

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Dr. R’s Fast Facts Summary

Association of Depression and Anxiety Disorders With Autoimmune Thyroiditis: A Systematic Review and Meta-analysis. 

Study Results

  • 19 studies comprising 21 independent samples were included, with a total of 36, 174 participants
  • Patients with Autoimmune Thyroiditis (AIT), Hashimoto thyroiditis, or subclinical or overt hypothyroidism had significantly higher scores for anxiety and depression

Study Conclusions and Relevance

  • Patients with AIT exhibit an increased chance of developing symptoms of depression and anxiety or of receiving a diagnosis of depression and anxiety disorders.

What can you do?

  • Be very cautious with the functional (or natural) medicine advice you take.

Diet and Gut Health

  • Gluten-free or gluten-reduced diet
  • Potentially a Paleo low FODMAP diet
  • Improve your gut health, this is often overlooked

Supplements & Medication

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DrMR: I’ll quote here their conclusion. “This meta-analysis establishes the association between AIT, autoimmune thyroid, and depression and anxiety disorders. Patients with AIT exhibit an increased chance of developing symptoms of depression and anxiety, or receiving a diagnosis of depression and anxiety disorders.” Okay, so clearly there is an association between thyroid autoimmunity, being overtly hypothyroid, or subclinical hypothyroid and anxiety and depression.

So the question is what can you do? Well, the first thing I would do is be very cautious with, unfortunately, with the advice that you take from alternative natural and functional medicine. The reason for this is because this community, which I include myself in, but I practice this, is very quick to give people very grim diagnoses or prognoses when they’re diagnosed with hypothyroidism, and this is incredibly damaging. When you take someone who has a predilection toward anxiety and depression and you paint their prognosis to be worse than it actually is, you are in effect going to exacerbate their anxiety and depression, and I see this all the time.

It’s very upsetting. It’s very disheartening to see people come into the office who think that their condition is far worse than it actually is, and they have this baseline level of anxiety and depression now exacerbated. Because their practitioner, who’s probably operating with virtuous intent but is trying to scare them into motivation, is actually making the situation much, much worse. So you have to be really careful. Unfortunately, and there’s another aspect to this, if I’m being fully candid, which is thyroid disorders are highly marketable disorders.

Thyroid symptoms are highly marketable symptoms, and so, unfortunately, there’s a flooding of the space on the Internet with claims about thyroid, about how all your problems are caused by thyroid. This further exacerbates this problem of fear, and overzealousness and overly grim prognoses being painted for those looking to get an answer about, “Okay, I have a thyroid condition, and I’m depressed or anxious or have some mood disorders. What does this mean? What can I do?”

I would first offer you take a big breath in and step back and relax a bit because much of what you are told makes a situation look far worse than it actually is. Yes, they’re an association, but there are plenty of things that you can do to improve your thyroid, and I would argue to also improve your mood. You don’t need to be fear factored into thinking that you can never eat out, have a bite of gluten, or not take handfuls of supplements in order to feel well. Let me run through some of what you can do, outside of being very cautious and circumspect with the advice that you take.

Diet and Gut Health

A gluten-free or gluten-reduced diet. There’s been one study to date showing a benefit in those without celiac disease. Now the problem here is there’s a number of studies in those with Celiac and thyroid conditions showing improvement when going gluten-free. Yeah, that shouldn’t be surprising. The bigger question is if you don’t have celiac, or you have what’s known as non-celiac, gluten sensitivity, or maybe no celiac-like diagnosis at all, but you have a thyroid condition, and you’re gluten-free, can that improve your condition? One study has assessed that’s shown benefit (subscription required). I think it’s worthwhile to try.

I do not think you need to be strictly gluten-free if you have a thyroid problem unless you’ve done an elimination of gluten, you feel better, you reintroduce gluten and you clearly notice you feel worse. If you do, then you have my full support and you should be fairly strict with your application of a gluten-free diet. But if you don’t, this is one of the main pain points where people I think are misled. If you’ve eliminated and then reintroduced and you notice a little to nothing, then eating the gluten-reduced diet is okay. Meaning you can have some gluten from time and time, and I wouldn’t really sweat it. So, that recommendation, gluten avoidance needs to be personalized based upon your response to a gluten reintroduction.

Low Fodmap

You could also potentially try a low FODMAP diet. Another study has looked at essentially a paleo diet, and I’m painting a bit of an inference into this recommendation. But essentially using a paleo diet, they showed improvements in multiple measures in addition to the thyroid status, and this population seemed to potentially have a FODMAP sensitivity. A few other, well-performed analyses, have shown that those with thyroid autoimmunity and hypothyroidism have a higher tendency to have small intestinal bacterial overgrowth, which may benefit from a low FODMAP diet also. So, two dietary approaches you can try in addition to the basic advice of getting off of processed foods, trans fats, and sugars, and sodas and things like that.

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Supplements & Medication

Now there are a few supplements that can be helpful. Vitamin D, there’s been a number of studies showing vitamin D can improve thyroid autoimmunity. Selenium, there’s been a number of studies showing selenium can improve thyroid autoimmunity, but not all studies have shown benefit. Some data has shown that selenium may also improve quality of life, and we can infer from that, that if it’s improving quality of life, people probably have a better mood. So the whole point of the video here is the association between thyroid disorders and mood disorders. So, there’s some evidence that suggests that the use of selenium may help with not only thyroid autoimmunity but with mood.

Now, the key point about selenium is you don’t need to use it forever, three to six months if you’re not on thyroid medication. If you’re on thyroid medication, you could make a case for using it for up to a year, and simply track your antibodies, and you’re looking for a significant drop in your antibody levels. Antibodies typically used, known as TPO and you’re looking for a significant drop, but you know, I’d say at least 300 would be what I typically would consider a significant movement, and also your mood to improve. But remember, you don’t have to be on selenium forever. The benefit seems to drop off after three to six months if you’re not on thyroid medication, or about a year if you’re on thyroid medication.

Funtional Medicine Formulations

Also, CoQ10 and magnesium have also been shown to help, namely with thyroid autoimmunity. I don’t know that there’s been a tie to mood, certainly, I have no opposition to trying these and seeing how you feel. The other thing that I think alludes a lot of people is improving your gut health, and admittedly I have a gut leaning biased. However, there has now been a number of studies documenting the gut-brain connection, and we reviewed recently a landmark study showing that those with IBS, irritable bowel syndromes: gas, bloating, abdominal pain, altered bowel function, have a higher predilection or a higher prevalence of anxiety and depression. Other data has shown that a treatment for the gut, probiotics can actually help to improve mood.


So the gut can be one of these, unfortunately, overlooked pieces of the picture that needs to be addressed. I hope people are not overlooking their gut health, but I see this more often than I’d like to admit where someone gets pulled into a thyroid treatment program because of, let’s say anxiety, fatigue, and depression; all the while the gut has been overlooked. So it’s not to say that the gut is always going to be at the root of the problem, but it’s definitely something to consider because there is this gut-brain connection. Inflammation in the gut, dysfunction in the gut can cause inflammation and dysfunction in the brain, essentially.

Then lastly, I would consider, and this is something you need to take on a case by case basis and talk with your doctor, but if you’re on a medication, consider trying a different medication. If you’ve done any research on thyroid, you’ve likely seen something about needing to be on T4 plus T3. I think that recommendation is overstated, but there is evidence to support that. Now, I wouldn’t recommend starting there. Why? Because if you do these other things, and especially improve your gut health, you will improve both the absorption of the medication and the conversion of that medication from T4, the inactive form, to the active form T3.

We’ve documented a few case studies now out of our office where patients have felt vastly better, and at the same time, because they’re improving their gut health, been able to decrease their dose of thyroid medication. So, it is possible to take less medication and feel better if you improve what absorbs and helps metabolize that medication, which is your gut. So, switching from a T4 only formulation, like levothyroxine or Synthroid, to a T4/T3 combination like Armor, or Nature-Thyroid or WP Thyroid is something to consider. There’s a little bit more nuance there for people who have chronic non-responsive digestive issues, they may want to consider a trial on a liquid gel tab known as Tirosint, that may also help them.

But if you run through some of these steps, you have a very high probability of improving, in my opinion, any thyroid associated anxiety and depression. I think one of the most important things to emphasize is that you don’t need to be scared into a corner where you have to live a highly restrictive dietary lifestyle. A small percentage of people may need to do that, right? Just quickly here, one Italian study that looked at over 12,000 patients found that there was only about a nine percent incidence of thyroid autoimmunity in those who had non-celiac gluten sensitivity.

So they took this large group of people who had non-celiac gluten sensitivity … or there’s large of people and they assessed who had non-celiac gluten sensitivity. Of those who had non-celiac gluten sensitivity, only nine percent of them had a thyroid problem. So yes, there’s an association. Yes, it’s documentable. Yes, it’s significant. Does it mean that every person with a thyroid problem needs to be strict, 100 percent gluten-free? No. Why do I say that? Because the fear and anguish that can be associated with living in this stressed out state all the time, because you’re trying to avoid every trace of gluten, can be problematic if you don’t need to do that.

What can you do?

Remember to eliminate, and then reintroduce and then consume to your tolerance. Some people need to be very strict, other people have some leeway and it’s important to understand that. Also, to understand that a thyroid condition is not a death sentence, it’s actually a very manageable condition that should respond well to these therapies, plus or minus medication if you need it. You can live a very healthy, happy, productive life, which is important for people with thyroid problems to hear, because you may have a tendency to be more anxious and depressed. So we don’t want to fuel that fire.

The truth actually is that you can be very happy, very healthy and very functional. So hopefully this is a lifeline that will pull you out of any despair you can fall into if you’re reading the wrong information on the Internet. So, this is Dr Ruscio with some thoughts on this study; Looking at the connection between thyroid autoimmunity, anxiety, depression.

I hope this information helps you get healthy and get back to your life. Thanks.

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