We don’t just apply research. We conduct it.

Our clinic regularly publishes peer-reviewed studies to evaluate, refine, and improve how we treat complex chronic conditions. Every protocol we use is informed by clinical experience. Many are also tested, analyzed, and documented in the medical literature.

View Our Published Research See How Our Research Improves Care

Why We Do Research

Our research arm exists for one reason: to continually improve how we help patients.

Publishing allows us to:

Evaluate what works in real-world clinical populations
Measure outcomes objectively
Refine protocols based on data
Share practical, reproducible approaches with other clinicians
Maintain accountability to scientific standards

By studying our own clinical methods, we close the loop between research and practice.

What we learn in the clinic informs our research.
What we publish informs how we care for patients.

Publication Summaries

Biofilm Disruption Enhances Antimicrobial Therapy for Small Intestinal Bacterial Overgrowth and Intestinal Methanogen Overgrowth

PMID: 41394228

Small Intestinal Bacterial Overgrowth (SIBO) and Intestinal Methanogen Overgrowth (IMO) often persist or recur despite antimicrobial therapy. We hypothesized that biofilms, protective microbial structures, may contribute to treatment resistance.

We evaluated whether adding a biofilm-disrupting agent to antimicrobial therapy was associated with improved outcomes in patients with SIBO or IMO.

Key Findings:

Study type: Clinical analysis of SIBO/IMO patients
Adding a biofilm disruptor was associated with improved treatment response
Higher rates of breath test normalization were observed when biofilm strategies were included

Clinical Implication

These findings support the role of biofilms in persistent SIBO and IMO and inform our use of targeted biofilm-disruption strategies in selected patients.

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The Relationship between Gastrointestinal Health, Micronutrient Concentrations, and Autoimmunity: A Focus on the Thyroid

PMID: 36079838

Many patients with thyroid dysfunction remain symptomatic despite achieving normal lab values. We explored whether gastrointestinal health may be a missing driver of persistent thyroid-related symptoms.

In this narrative review, we introduced the concept of the nutrient–GI–thyroid axis, examining how gastrointestinal dysfunction can impair absorption of thyroid-specific nutrients, influence thyroid physiology, and affect thyroid autoimmunity.

Key Findings:

Study type: Comprehensive narrative review
Gastrointestinal conditions can reduce absorption of key thyroid-supporting nutrients
Targeted GI interventions may improve nutrient status
GI health influences thyroid autoimmunity and symptom presentation
GI disorders are substantially more common than primary hypothyroidism

Clinical Implication

This work supports evaluating gastrointestinal health as a central factor in persistent symptoms and autoimmunity. In selected patients, addressing GI dysfunction may improve nutrient status, thyroid markers, and clinical outcomes.

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Symptoms Originally Attributed to Thyroid Dysfunction Were Instead Caused by Suboptimal Gastrointestinal Health: A Case Series and Literature Review

PMID: 35999903

Fatigue, weight changes, and brain fog are often managed as primary thyroid dysfunction. In many patients, clinicians adjust medication or optimize hormone levels, yet symptoms persist.

In this paper, we examined whether treating underlying gastrointestinal dysfunction could improve symptoms originally attributed to the thyroid. We reviewed the literature on the gut–thyroid axis and presented six clinical cases demonstrating outcomes following gut-focused interventions.

Key Findings:

Study type: Case series and literature review
All six patients experienced improvement in thyroid-related symptoms after gastrointestinal treatment
Some patients were able to reduce their thyroid medication dosag

Clinical Implication

These findings inform our clinical approach of evaluating gastrointestinal drivers in patients with persistent thyroid-related symptoms. In selected cases, addressing gut dysfunction may improve outcomes and reduce medication reliance.

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Is SIBO A Real Condition?

PMID: 31550680

As awareness of Small Intestinal Bacterial Overgrowth (SIBO) has grown, so has confusion around how to test and treat it appropriately. Expanding access to laboratory testing and new therapies has increased interest in SIBO, but has also led to over-testing and overly aggressive treatment in some settings.

In this review, we evaluated the evidence surrounding SIBO diagnosis and management with the goal of establishing balanced, evidence-informed best practices.

Key Findings:

Over-restriction of foods and non-validated therapies may lead to unnecessary burden
Best outcomes occur when breath test results are interpreted alongside symptoms and history
A logical, stepwise treatment approach improves care quality

Clinical Implication

This work reinforces a measured, evidence-based framework for SIBO care. Testing and treatment can provide meaningful relief, but must be applied thoughtfully to avoid over-treatment and unnecessary dietary restriction.

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Do You Really Want a Hunter-Gatherer Microbiota? Perils and Pitfalls for Your Gut

As interest in ancestral health and microbiome diversity has grown, many have proposed that modern disease stems from insufficient microbial exposure and inadequate fiber intake. Popular recommendations often emphasize increasing prebiotics, maximizing fiber, and replicating hunter-gatherer environments.

In this review, we evaluated whether aggressively pursuing microbiota diversity improves clinical outcomes and examined the potential risks of applying these strategies indiscriminately.

Key Findings:

Study type: Narrative review
High-fiber and high-prebiotic strategies may worsen symptoms in patients with IBS or IBD
Microbiome testing lacks clear clinical utility in routine practice
Hunter-gatherer diets vary widely and are not universally high in fiber
Clinical improvement does not consistently correlate with microbiome shifts

Clinical Implication

This work supports a patient-centered model in which symptom response and clinical outcomes guide care rather than microbiome ideology. Broad dietary flexibility and gastrointestinal stability take precedence over pursuing microbial diversity for its own sake.

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How Our Research Shapes Patient Treatment

TEST We evaluate protocols in real clinical settings.

MEASURE We analyze outcomes across patient populations.

REFINE We adjust dosing, sequencing, and duration based on data.

SYSTEMATIZE We update our clinical frameworks and decision pathways.

IMPROVE Patients benefit from methods that have been tested, evaluated, and refined.

Medicine should evolve. Our care model does.

Ongoing Research Areas

We continue to investigate emerging and complex areas of chronic illness, including:

Key Findings:

Mold protocols that address sinus colonization
The association between mold exposure and fungal overgrowth
Membrane Lipid Replacement Therapy and mitochondrial function
Stepwise probiotic sequencing strategies
Biofilm disruption in SIBO
Gut-immune interactions in chronic inflammatory conditions

These studies reflect the real questions we encounter in practice, and our commitment to answering them rigorously.

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