The Best Research-Backed Supplements to Balance Hormones

The Best Research-Backed Supplements to Balance Hormones

How Supplements Can Restore Balance to Your Hormones and Resolve Your Symptoms

Key Takeaways:

  • Probiotics, B vitamins, lecithin, and botanicals — like black cohosh and vitex — are useful in regulating hormone levels.
  • These supplements can reduce symptoms of a hormonal imbalance, including (but not limited to) PMS, irregular or heavy menses, low sex drive, infertility, and weight gain.
  • When using supplements to balance hormones, it’s likely most beneficial to use them in combination formulas.
  • In order to see the most benefits from hormone-balancing supplements, it’s best to adopt a healthy lifestyle that incorporates a balanced diet and exercise regimen.

Hormonal imbalances are behind some of the most problematic conditions and symptoms for women today. Fortunately, you can use natural supplements to balance your hormone levels, reduce your symptoms, and improve your overall quality of life. The benefits of probiotics, B vitamins, lecithin, and herbal formulas are supported by research and can help you get your hormones back on track. 

Conventional therapy for resolving hormonal imbalances often involves placing menstruating women on synthetic hormones — in the form of birth control — to help regulate estrogen, progesterone, and testosterone levels. However, this is often a band-aid solution and doesn’t fully resolve the underlying imbalance or symptoms. 

Whether your symptoms are due to poor gut health, stress, or the natural decline of your body’s hormone production, supplements can be used in both menstruating and menopausal women to help fix the root cause. Not to mention, they can help you avoid any unwanted side effects of synthetic hormones. 

When used alongside a healthy lifestyle, these promising supplements can help reduce symptoms of PMS, PCOS, and menopause, both naturally and effectively. If you’re looking for a way to regulate your menstrual cycle, lessen your mood swings, or reduce your hot flashes and night sweats, these research-backed supplements may be the boost you need. 

Top 5 Supplements to Balance Hormones

Regardless of your specific condition, research shows that the following supplements may help reduce symptoms associated with an endocrine (hormonal) imbalance. In the clinic, we see that these supplements seem to work best when combined with lifestyle changes. 

A healthy diet, stress reduction, and getting enough exercise and sleep all help set the proper foundations so that your body can naturally restore your hormone levels. We’ll get into some of those details later, but, for now, let’s dive into the best supplements to balance hormones. 

1. Probiotics

Our gut health and the endocrine system are highly interconnected, and research shows that women with certain hormonal disorders may have:

Having healthy gut bacteria is essential to endocrine health, as they play an important role in the detoxification of certain female hormones. A dysbiosis (imbalance) in the microbiome can disrupt estrogen levels and lead to changes in hormone levels [5 Trusted SourcePubMedGo to source, 6 Trusted SourcePubMedGo to source].

Furthermore, dysbiosis and gut inflammation can damage the lining of the GI tract and decrease the absorption of important nutrients [7 Trusted SourcePubMedGo to source]. This is problematic, as your body cannot create hormones without the proper amount of vitamins, minerals, and fats, potentially leading to a hormonal imbalance [8 Trusted SourcePubMedGo to source, 9 Trusted SourcePubMedGo to source].

Fortunately, probiotics can restore normal gut bacteria, regulate the immune system to reduce inflammation, and improve the intestinal lining (reversing leaky gut) [10 Trusted SourcePubMedGo to source, 11 Trusted SourcePubMedGo to source, 12 Trusted SourcePubMedGo to source, 13 Trusted SourcePubMedGo to source]. Because of their positive effects on the digestive tract and endocrine system, probiotic supplements can reduce symptoms of various hormonal disorders, including premenstrual syndrome (PMS).

One study showed that women who took probiotics saw an improvement in menstrual cramps, gas and bloating, abdominal pain, and diarrhea [5 Trusted SourcePubMedGo to source, 14 Trusted SourcePubMedGo to source, 15 Trusted SourcePubMedGo to source, 16 Trusted SourcePubMedGo to source]. Adding probiotics into your daily regimen can likely improve your overall gut health and restore balance to your hormones. 

2. Black Cohosh 

This popular herb may reduce hot flashes, night sweats, and other symptoms in menopausal women [17 Trusted SourcePubMedGo to source, 18 Trusted SourcePubMedGo to source]. Research supports that its effects are particularly evident when menopausal symptoms present alongside mood changes and sleep disturbances [17 Trusted SourcePubMedGo to source].

Black cohosh’s ability to balance hormone levels and reduce menopausal symptoms is likely magnified when used in combination with other herbal supplements, such as [19 Trusted SourcePubMedGo to source]:

  • Dong quai
  • Milk thistle
  • Red clover
  • Vitex 
  • American ginseng

One study showed that when these botanicals were used together, menopausal women experienced nearly a 70% decrease in hot flashes and night sweats, along with an overall improvement in sleep quality [19 Trusted SourcePubMedGo to source]. More importantly, in all of the research studies that we reviewed, the use of these herbs was shown to be safe.

3. Vitex

Also known as chaste tree or chaste berry, vitex may be especially useful for balancing hormones in cycling women. Its influence on progesterone levels can help regulate irregular and painful menstrual cycles, improve fertility, and lessen PMS symptoms [20 Trusted SourcePubMedGo to source, 21 Trusted SourcePubMedGo to source, 22 Trusted SourcePubMedGo to source, 23 Trusted SourcePubMedGo to source, 24 Trusted SourcePubMedGo to source].

Common PMS symptoms include [25 Trusted SourcePubMedGo to source]:

  • Cramping
  • Breast pain and/or swelling
  • Headaches
  • Low energy levels
  • Nausea
  • Constipation or diarrhea
  • Mood swings and irritability

Research shows that vitex may lessen some of these symptoms, particularly mood disturbances, like anxiety, low mood, and irritability [20 Trusted SourcePubMedGo to source]. This makes it a promising herbal supplement for minimizing the severe mood swings that present with premenstrual dysphoric disorder (PMDD).

Furthermore, vitex may reduce mood changes and pain associated with post-menstrual syndrome — a condition similar to PMS, but which presents after the menstrual cycle and prior to ovulation [26 Trusted SourcePubMedGo to source].

When used in combination with other herbs, like licorice, vitex may relieve symptoms in menopausal women, making it a good and safe choice for women of all ages [27 Trusted SourcePubMedGo to source].

4. Lecithin

Lecithin is a health-promoting supplement that is derived from soy. It contains two important compounds, known as phosphatidylserine and phosphatidic acid complex (PAC). Phosphatidylserine can help regulate mood by altering neurotransmitter levels and calming the nervous system [28 Trusted SourcePubMedGo to source]. However, it’s PAC that shines when it comes to balancing hormones.

In women with PMS, phosphatidic acid complex [28 Trusted SourcePubMedGo to source]:

  • Reduces PMS symptom severity
  • Improves physical and depressive symptoms
  • Increases productivity
  • Alleviates relationship tension

Because of PAC’s success in treating PMS, it’s currently being considered for further research and use in PMDD [28 Trusted SourcePubMedGo to source]. While this supplement clearly has many beneficial effects on overall health, it’s probably best to avoid this supplement if you have an allergy or sensitivity to soy. 


5. B Vitamins and Micronutrients

Vitamin B1, also known as thiamine, is likely helpful in treating PMS symptoms and painful menstruation. Several studies show that thiamine can effectively manage period pain and reduce symptoms of PMS [29 Trusted SourcePubMedGo to source, 30 Trusted SourcePubMedGo to source, 31 Trusted SourcePubMedGo to source].

Pyridoxine, or vitamin B6, also shows promise in reducing PMS symptoms, but is likely less effective when used alone instead of with other B vitamins [30 Trusted SourcePubMedGo to source]. We recommend that you use a high-quality, B-complex formula that contains the active form of B vitamins for maximum benefit.

Research shows that several other micronutrients are also effective in improving hormonal health and reducing symptoms of an imbalance. 

  • Zinc: Supplemental zinc can help reduce excess hair growth in women with polycystic ovary syndrome (PCOS), and may decrease triglycerides, blood sugar, and insulin resistance [32 Trusted SourcePubMedGo to source, 33 Trusted SourcePubMedGo to source].
  • Vitamin D3: This important vitamin, or a daily dose of sunlight, may alleviate PMS symptoms when balanced with vitamin K2 [34 Trusted SourcePubMedGo to source]. As vitamin D can be toxic at high doses, it’s important to get your levels checked prior to supplementation.
  • Magnesium: Taking magnesium may benefit women who experience anxiety with PMS, making it a viable treatment option for mood changes associated with the menstrual cycle [35 Trusted SourcePubMedGo to source]. Additionally, when used together with zinc, it reduces markers of oxidative stress and inflammation in women with PCOS [36 Trusted SourcePubMedGo to source].
  • Selenium: This trace mineral may improve hormone levels, inflammation, excess hair growth, and cholesterol levels in women with PCOS [37 Trusted SourcePubMedGo to source, 38 Trusted SourcePubMedGo to source, 39 Trusted SourcePubMedGo to source]. However, not all research supports the use of selenium in this condition, and it may increase insulin resistance associated with PCOS [40 Trusted SourcePubMedGo to source]. It’s important to speak with your healthcare provider before determining if this supplement is right for you.
  • Calcium: Research shows that women who experience PMS have lower calcium levels than women who do not [41 Trusted SourcePubMedGo to source]. When used in combination with vitamin D, calcium can help lessen cramping and painful periods (dysmenorrhea) by preventing muscle contractions in the uterus [42 Trusted SourcePubMedGo to source]. Furthermore, this combination reduced the need for painkillers, which often have undesirable side effects on the gut [43 Trusted SourcePubMedGo to source].

Other Useful Supplements to Balance Hormones

The sky might actually be the limit when it comes to using supplements to balance hormones, as there are many other options that show beneficial effects on hormone levels. Below are just a few that are supported by current research. 

Building the Proper Foundation for Healthy Hormone Levels

While natural supplements can certainly lessen your symptoms, a healthy lifestyle is the cornerstone of fixing a hormonal imbalance. If the proper building blocks of good health aren’t in place while taking supplements, you may not see the desired benefits.

The following recommendations can assist in improving your overall health, while balancing out your hormone levels.

Get Some Sleep

Sleep disorders often go hand-in-hand with hormone imbalances. Restless legs syndrome, insomnia, sleep apnea, and sleep movement disorders often plague menopausal women [52 Trusted SourcePubMedGo to source], creating a sleepless cycle that can further disrupt hormone levels. Add in symptoms of hot flashes and night sweats, and good-quality sleep may seem far out of reach for women who are transitioning through menopause. 

Fortunately, research shows that cognitive behavioral therapy (CBT), hormone replacement therapy (HRT), yoga, and acupuncture improve sleep in menopausal women [52 Trusted SourcePubMedGo to source, 53 Trusted SourcePubMedGo to source, 54 Trusted SourcePubMedGo to source, 55 Trusted SourcePubMedGo to source]. It may also be helpful to get screened for sleep disorders, such as sleep apnea, which may interfere with your ability to get a restful sleep.

For women who have exhausted other options, research shows that antidepressant therapy, particularly with SSRIs, may improve sleep quality during menopause [52 Trusted SourcePubMedGo to source].

Eat a Balanced Diet

As previously mentioned, it’s essential to eat a healthy, balanced diet that provides you with all of the nutrients and fats you need in order to make hormones. As long as you don’t have a sensitivity to these foods, some good dietary fats include:

  • Extra-virgin olive oil
  • Avocados
  • Flaxseed
  • Fatty fish
  • Nuts and seeds

Unfortunately, not all diets are created equal and diets that involve fasting, or those that focus on extreme weight loss, can stress the body by wreaking havoc on your blood sugar levels. In fact, skipping meals, eating processed foods, and engaging in weight-loss diets can all worsen period pain [56 Trusted SourcePubMedGo to source].

We recommend using a framework like the Paleo diet, which focuses on consuming healthy fats and plenty of nutrients. It has added benefits of reducing gut inflammation and restoring the gut microbiome, which can help balance hormone levels and improve hormone detoxification. 

Work on Your Stress Levels

In women, sex hormones, like progesterone, testosterone, and estrogen, are made in the adrenal glands. These hormones often become depleted during periods of chronic stress, in order for the body to increase cortisol levels (our stress hormone) [57 Trusted SourcePubMedGo to source].

Additionally, stress affects our hormones further upstream by disrupting the pituitary gland or “master gland” of the endocrine system. The pituitary gland controls the creation and release of many hormones, and a dysregulation of this system can offset normal hormone production [57 Trusted SourcePubMedGo to source].

Over time, chronic stress can create symptoms of a hormonal imbalance and potentially lead to an endocrine disorder. Common stressors include:

  • Work, relationship, and personal life issues
  • Blood sugar fluctuations
  • Infections (including gut pathogens)
  • Chronic inflammation

Fortunately, there are several things you can do to reduce your stress levels. Cognitive behavioral therapy (CBT) and coping-skills training can both reduce stress and symptoms of hormonal disorders [58 Trusted SourcePubMedGo to source, 59 Trusted SourcePubMedGo to source]. Meditation, yoga, deep-breathing exercises, and other forms of mindfulness are all effective at reducing overall stress levels. 

Eating a balanced diet to control blood sugar levels, healing the gut, and lessening your inflammatory burden on the body are all ways in which you can reduce your overall stress load.

Get Some Exercise

Regular exercise is essential for improving your hormonal health — plus, it has numerous overall health benefits. Research shows that consistent exercise can:

We already know that stress, blood sugar swings, and lack of sleep can all disrupt your hormone levels, and exercise appears to be an effective way to bring your hormones back into balance. 

Even better, you may not have to exercise daily in order to reap the benefits. One study looked at women with PMS who swam for 30 minutes three times a week. Compared to controls, the participants experienced an overall decrease in [64 Trusted SourcePubMedGo to source]:

  • Anxiety, depression, and other mood changes
  • Tension and feeling out of control
  • Fatigue and sleep disturbances
  • Menstrual pain and cramping
  • Breast tenderness 

This goes to show that exercising just a few days per week may help lessen PMS symptoms, and likely provides significant benefits to other hormonal conditions and symptoms. 

Final Thoughts on Using Supplements to Balance Hormones

Supplements are a viable option when treating hormonal conditions and non-specific symptoms of an endocrine disorder. While research shows that they may be particularly beneficial for PMS, menopause, and PCOS, their benefits likely extend beyond these to other types of hormonal imbalances. 

We see that many of the above supplements provide the best results when used in combination, such as in our hormone balancing formulas, Estro-Harmony and Progest-Harmony. These formulas can help improve hormone levels and non-specific symptoms in a variety of conditions, and are approved for use in both cycling and menopausal women. 

For more help on how to balance your hormones and improve your lifestyle, reach out to our clinic at the Ruscio Institute for Functional Medicine for an appointment. You can also learn how to regulate your hormones by healing your gut in my book, Healthy Gut, Healthy You

The Ruscio Institute has developed a range of high-quality formulations, including Progest-Harmony and Estro-Harmony, to help our patients and audience. If you’re interested in learning more about these products, please click here. Note that there are many other options available, and we encourage you to research which products may be right for you.

➕ References
  1. Torres PJ, Siakowska M, Banaszewska B, Pawelczyk L, Duleba AJ, Kelley ST, et al. Gut microbial diversity in women with polycystic ovary syndrome correlates with hyperandrogenism. J Clin Endocrinol Metab. 2018 Apr 1;103(4):1502–11. DOI: 10.1210/jc.2017-02153. PMID: 29370410. PMCID: PMC6276580. Trusted SourcePubMedGo to source
  2. Lindheim L, Bashir M, Münzker J, Trummer C, Zachhuber V, Leber B, et al. Alterations in Gut Microbiome Composition and Barrier Function Are Associated with Reproductive and Metabolic Defects in Women with Polycystic Ovary Syndrome (PCOS): A Pilot Study. PLoS ONE. 2017 Jan 3;12(1):e0168390. DOI: 10.1371/journal.pone.0168390. PMID: 28045919. PMCID: PMC5207627. Trusted SourcePubMedGo to source
  3. Qi X, Yun C, Sun L, Xia J, Wu Q, Wang Y, et al. Gut microbiota-bile acid-interleukin-22 axis orchestrates polycystic ovary syndrome. Nat Med. 2019 Aug;25(8):1225–33. DOI: 10.1038/s41591-019-0509-0. PMID: 31332392. PMCID: PMC7376369. Trusted SourcePubMedGo to source
  4. Tremellen K, Pearce K. Dysbiosis of Gut Microbiota (DOGMA)–a novel theory for the development of Polycystic Ovarian Syndrome. Med Hypotheses. 2012 Jul;79(1):104–12. DOI: 10.1016/j.mehy.2012.04.016. PMID: 22543078. Trusted SourcePubMedGo to source
  5. Baker JM, Al-Nakkash L, Herbst-Kralovetz MM. Estrogen-gut microbiome axis: Physiological and clinical implications. Maturitas. 2017 Sep;103:45–53. DOI: 10.1016/j.maturitas.2017.06.025. PMID: 28778332. Trusted SourcePubMedGo to source
  6. Plottel CS, Blaser MJ. Microbiome and malignancy. Cell Host Microbe. 2011 Oct 20;10(4):324–35. DOI: 10.1016/j.chom.2011.10.003. PMID: 22018233. PMCID: PMC3264051. Trusted SourcePubMedGo to source
  7. Arrieta MC, Bistritz L, Meddings JB. Alterations in intestinal permeability. Gut. 2006 Oct;55(10):1512–20. DOI: 10.1136/gut.2005.085373. PMID: 16966705. PMCID: PMC1856434. Trusted SourcePubMedGo to source
  8. Delgado BJ, Lopez-Ojeda W. Estrogen. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2021. PMID: 30855848. Trusted SourcePubMedGo to source
  9. Nassar GN, Leslie SW. Physiology, Testosterone. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2021. PMID: 30252384. Trusted SourcePubMedGo to source
  10. Leblhuber F, Steiner K, Schuetz B, Fuchs D, Gostner JM. Probiotic Supplementation in Patients with Alzheimer’s Dementia – An Explorative Intervention Study. Curr Alzheimer Res. 2018;15(12):1106–13. DOI: 10.2174/1389200219666180813144834. PMID: 30101706. PMCID: PMC6340155. Trusted SourcePubMedGo to source
  11. Mujagic Z, de Vos P, Boekschoten MV, Govers C, Pieters H-JHM, de Wit NJW, et al. The effects of Lactobacillus plantarum on small intestinal barrier function and mucosal gene transcription; a randomized double-blind placebo controlled trial. Sci Rep. 2017 Jan 3;7:40128. DOI: 10.1038/srep40128. PMID: 28045137. PMCID: PMC5206730. Trusted SourcePubMedGo to source
  12. Sindhu KNC, Sowmyanarayanan TV, Paul A, Babji S, Ajjampur SSR, Priyadarshini S, et al. Immune response and intestinal permeability in children with acute gastroenteritis treated with Lactobacillus rhamnosus GG: a randomized, double-blind, placebo-controlled trial. Clin Infect Dis. 2014 Apr;58(8):1107–15. DOI: 10.1093/cid/ciu065. PMID: 24501384. PMCID: PMC3967829. Trusted SourcePubMedGo to source
  13. Lamprecht M, Bogner S, Schippinger G, Steinbauer K, Fankhauser F, Hallstroem S, et al. Probiotic supplementation affects markers of intestinal barrier, oxidation, and inflammation in trained men; a randomized, double-blinded, placebo-controlled trial. J Int Soc Sports Nutr. 2012 Sep 20;9(1):45. DOI: 10.1186/1550-2783-9-45. PMID: 22992437. PMCID: PMC3465223. Trusted SourcePubMedGo to source
  14. Rogha M, Esfahani MZ, Zargarzadeh AH. The efficacy of a synbiotic containing Bacillus Coagulans in treatment of irritable bowel syndrome: a randomized placebo-controlled trial. Gastroenterol Hepatol Bed Bench. 2014;7(3):156–63. PMID: 25120896. PMCID: PMC4129566. Trusted SourcePubMedGo to source
  15. McFarland LV, Dublin S. Meta-analysis of probiotics for the treatment of irritable bowel syndrome. World J Gastroenterol. 2008 May 7;14(17):2650–61. DOI: 10.3748/wjg.14.2650. PMID: 18461650. PMCID: PMC2709042. Trusted SourcePubMedGo to source
  16. Ibarra A, Latreille-Barbier M, Donazzolo Y, Pelletier X, Ouwehand AC. Effects of 28-day Bifidobacterium animalis subsp. lactis HN019 supplementation on colonic transit time and gastrointestinal symptoms in adults with functional constipation: A double-blind, randomized, placebo-controlled, and dose-ranging trial. Gut Microbes. 2018 Feb 8;9(3):236–51. DOI: 10.1080/19490976.2017.1412908. PMID: 29227175. PMCID: PMC6219592. Trusted SourcePubMedGo to source
  17. Wong VCK, Lim CED, Luo X, Wong WSF. Current alternative and complementary therapies used in menopause. Gynecol Endocrinol. 2009 Mar;25(3):166–74. DOI: 10.1080/09513590802549866. PMID: 19347706. Trusted SourcePubMedGo to source
  18. Frei-Kleiner S, Schaffner W, Rahlfs VW, Bodmer C, Birkhäuser M. Cimicifuga racemosa dried ethanolic extract in menopausal disorders: a double-blind placebo-controlled clinical trial. Maturitas. 2005 Aug 16;51(4):397–404. DOI: 10.1016/j.maturitas.2004.10.003. PMID: 16039414. Trusted SourcePubMedGo to source
  19. Rotem C, Kaplan B. Phyto-Female Complex for the relief of hot flushes, night sweats and quality of sleep: randomized, controlled, double-blind pilot study. Gynecol Endocrinol. 2007 Feb;23(2):117–22. DOI: 10.1080/09513590701200900. PMID: 17454163. Trusted SourcePubMedGo to source
  20. Cerqueira RO, Frey BN, Leclerc E, Brietzke E. Vitex agnus castus for premenstrual syndrome and premenstrual dysphoric disorder: a systematic review. Arch Womens Ment Health. 2017 Dec;20(6):713–9. DOI: 10.1007/s00737-017-0791-0. PMID: 29063202. Trusted SourcePubMedGo to source
  21. Moini Jazani A, Hamdi K, Tansaz M, Nazemiyeh H, Sadeghi Bazargani H, Fazljou SMB, et al. Herbal medicine for oligomenorrhea and amenorrhea: A systematic review of ancient and conventional medicine. Biomed Res Int. 2018 Mar 18;2018:3052768. DOI: 10.1155/2018/3052768. PMID: 29744355. PMCID: PMC5878906. Trusted SourcePubMedGo to source
  22. Maleki-Saghooni N, Karimi FZ, Behboodi Moghadam Z, Mirzaii Najmabadi K. The effectiveness and safety of Iranian herbal medicines for treatment of premenstrual syndrome: A systematic review. Avicenna J Phytomed. 2018 Apr;8(2):96–113. PMID: 29632841. PMCID: PMC5885324. Trusted SourcePubMedGo to source
  23. Verkaik S, Kamperman AM, van Westrhenen R, Schulte PFJ. The treatment of premenstrual syndrome with preparations of Vitex agnus castus: a systematic review and meta-analysis. Am J Obstet Gynecol. 2017 Aug;217(2):150–66. DOI: 10.1016/j.ajog.2017.02.028. PMID: 28237870. Trusted SourcePubMedGo to source
  24. Rafieian-Kopaei M, Movahedi M. Systematic review of premenstrual, postmenstrual and infertility disorders of vitex agnus castus. Electron Physician. 2017 Jan 25;9(1):3685–9. DOI: 10.19082/3685. PMID: 28243425. PMCID: PMC5308513. Trusted SourcePubMedGo to source
  25. Gudipally PR, Sharma GK. Premenstrual Syndrome. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2022. PMID: 32809533. Trusted SourcePubMedGo to source
  26. Freeman EW, Rickels K, Sondheimer SJ, Polansky M, Xiao S. Continuous or intermittent dosing with sertraline for patients with severe premenstrual syndrome or premenstrual dysphoric disorder. Am J Psychiatry. 2004 Feb;161(2):343–51. DOI: 10.1176/appi.ajp.161.2.343. PMID: 14754784. Trusted SourcePubMedGo to source
  27. Dietz BM, Hajirahimkhan A, Dunlap TL, Bolton JL. Botanicals and their bioactive phytochemicals for women’s health. Pharmacol Rev. 2016 Oct;68(4):1026–73. DOI: 10.1124/pr.115.010843. PMID: 27677719. PMCID: PMC5050441. Trusted SourcePubMedGo to source
  28. Schmidt K, Weber N, Steiner M, Meyer N, Dubberke A, Rutenberg D, et al. A lecithin phosphatidylserine and phosphatidic acid complex (PAS) reduces symptoms of the premenstrual syndrome (PMS): Results of a randomized, placebo-controlled, double-blind clinical trial. Clin Nutr ESPEN. 2018 Apr;24:22–30. DOI: 10.1016/j.clnesp.2018.01.067. PMID: 29576358. Trusted SourcePubMedGo to source
  29. Saei Ghare Naz M, Kiani Z, Rashidi Fakari F, Ghasemi V, Abed M, Ozgoli G. The Effect of Micronutrients on Pain Management of Primary Dysmenorrhea: a Systematic Review and Meta-Analysis. J Caring Sci. 2020 Mar 1;9(1):47–56. DOI: 10.34172/jcs.2020.008. PMID: 32296659. PMCID: PMC7146731. Trusted SourcePubMedGo to source
  30. Wyatt KM, Dimmock PW, Jones PW, Shaughn O’Brien PM. Efficacy of vitamin B-6 in the treatment of premenstrual syndrome: systematic review. BMJ. 1999 May 22;318(7195):1375–81. DOI: 10.1136/bmj.318.7195.1375. PMID: 10334745. PMCID: PMC27878. Trusted SourcePubMedGo to source
  31. Retallick-Brown H, Blampied N, Rucklidge JJ. A Pilot Randomized Treatment-Controlled Trial Comparing Vitamin B6 with Broad-Spectrum Micronutrients for Premenstrual Syndrome. J Altern Complement Med. 2020 Feb;26(2):88–97. DOI: 10.1089/acm.2019.0305. PMID: 31928364. Trusted SourcePubMedGo to source
  32. Jamilian M, Foroozanfard F, Bahmani F, Talaee R, Monavari M, Asemi Z. Effects of Zinc Supplementation on Endocrine Outcomes in Women with Polycystic Ovary Syndrome: a Randomized, Double-Blind, Placebo-Controlled Trial. Biol Trace Elem Res. 2016 Apr;170(2):271–8. DOI: 10.1007/s12011-015-0480-7. PMID: 26315303. Trusted SourcePubMedGo to source
  33. Foroozanfard F, Jamilian M, Jafari Z, Khassaf A, Hosseini A, Khorammian H, et al. Effects of zinc supplementation on markers of insulin resistance and lipid profiles in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. Exp Clin Endocrinol Diabetes. 2015 Apr 13;123(4):215–20. DOI: 10.1055/s-0035-1548790. PMID: 25868059. Trusted SourcePubMedGo to source
  34. Arab A, Golpour-Hamedani S, Rafie N. The Association Between Vitamin D and Premenstrual Syndrome: A Systematic Review and Meta-Analysis of Current Literature. J Am Coll Nutr. 2019 Oct;38(7):648–56. DOI: 10.1080/07315724.2019.1566036. PMID: 31074708. Trusted SourcePubMedGo to source
  35. Boyle NB, Lawton C, Dye L. The Effects of Magnesium Supplementation on Subjective Anxiety and Stress-A Systematic Review. Nutrients. 2017 Apr 26;9(5). DOI: 10.3390/nu9050429. PMID: 28445426. PMCID: PMC5452159. Trusted SourcePubMedGo to source
  36. Afshar Ebrahimi F, Foroozanfard F, Aghadavod E, Bahmani F, Asemi Z. The Effects of Magnesium and Zinc Co-Supplementation on Biomarkers of Inflammation and Oxidative Stress, and Gene Expression Related to Inflammation in Polycystic Ovary Syndrome: a Randomized Controlled Clinical Trial. Biol Trace Elem Res. 2018 Aug;184(2):300–7. DOI: 10.1007/s12011-017-1198-5. PMID: 29127547. Trusted SourcePubMedGo to source
  37. Jamilian M, Razavi M, Fakhrie Kashan Z, Ghandi Y, Bagherian T, Asemi Z. Metabolic response to selenium supplementation in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. Clin Endocrinol (Oxf). 2015 Jun;82(6):885–91. DOI: 10.1111/cen.12699. PMID: 25510442. Trusted SourcePubMedGo to source
  38. Razavi M, Jamilian M, Kashan ZF, Heidar Z, Mohseni M, Ghandi Y, et al. Selenium Supplementation and the Effects on Reproductive Outcomes, Biomarkers of Inflammation, and Oxidative Stress in Women with Polycystic Ovary Syndrome. Horm Metab Res. 2016 Mar;48(3):185–90. DOI: 10.1055/s-0035-1559604. PMID: 26267328. Trusted SourcePubMedGo to source
  39. Jamilian M, Mansury S, Bahmani F, Heidar Z, Amirani E, Asemi Z. The effects of probiotic and selenium co-supplementation on parameters of mental health, hormonal profiles, and biomarkers of inflammation and oxidative stress in women with polycystic ovary syndrome. J Ovarian Res. 2018 Sep 14;11(1):80. DOI: 10.1186/s13048-018-0457-1. PMID: 30217229. PMCID: PMC6137747. Trusted SourcePubMedGo to source
  40. Hajizadeh-Sharafabad F, Moludi J, Tutunchi H, Taheri E, Izadi A, Maleki V. Selenium and polycystic ovary syndrome; current knowledge and future directions: A systematic review. Horm Metab Res. 2019 May 9;51(5):279–87. DOI: 10.1055/a-0890-6823. PMID: 31071732. Trusted SourcePubMedGo to source
  41. Arab A, Rafie N, Askari G, Taghiabadi M. Beneficial role of calcium in premenstrual syndrome: A systematic review of current literature. Int J Prev Med. 2020 Sep 22;11:156. DOI: 10.4103/ijpvm.IJPVM_243_19. PMID: 33312465. PMCID: PMC7716601. Trusted SourcePubMedGo to source
  42. Abdul-Razzak KK, Ayoub NM, Abu-Taleb AA, Obeidat BA. Influence of dietary intake of dairy products on dysmenorrhea. J Obstet Gynaecol Res. 2010 Apr;36(2):377–83. DOI: 10.1111/j.1447-0756.2009.01159.x. PMID: 20492391. Trusted SourcePubMedGo to source
  43. Abdi F, Amjadi MA, Zaheri F, Rahnemaei FA. Role of vitamin D and calcium in the relief of primary dysmenorrhea: a systematic review. Obstet Gynecol Sci. 2021 Jan 7;64(1):13–26. DOI: 10.5468/ogs.20205. PMID: 33406811. PMCID: PMC7834752. Trusted SourcePubMedGo to source
  44. Ishihara M, Ito Y, Nakakita T, Maehama T, Hieda S, Yamamoto K, et al. [Clinical effect of gamma-oryzanol on climacteric disturbance -on serum lipid peroxides (author’s transl)]. Nippon Sanka Fujinka Gakkai Zasshi. 1982 Feb;34(2):243–51. PMID: 7061906. Trusted SourcePubMedGo to source
  45. Ishihara M. Effect of gamma-oryzanol on serum lipid peroxide level and clinical symptoms of patients with climacteric disturbances. Asia Oceania J Obstet Gynaecol. 1984 Sep;10(3):317–23. DOI: 10.1111/j.1447-0756.1984.tb00693.x. PMID: 6525087. Trusted SourcePubMedGo to source
  46. Wong RHX, Evans HM, Howe PRC. Resveratrol supplementation reduces pain experience by postmenopausal women. Menopause. 2017 Aug;24(8):916–22. DOI: 10.1097/GME.0000000000000861. PMID: 28350759. Trusted SourcePubMedGo to source
  47. Evans HM, Howe PRC, Wong RHX. Effects of Resveratrol on Cognitive Performance, Mood and Cerebrovascular Function in Post-Menopausal Women; A 14-Week Randomised Placebo-Controlled Intervention Trial. Nutrients. 2017 Jan 3;9(1). DOI: 10.3390/nu9010027. PMID: 28054939. PMCID: PMC5295071. Trusted SourcePubMedGo to source
  48. Behboudi-Gandevani S, Hariri F-Z, Moghaddam-Banaem L. The effect of omega 3 fatty acid supplementation on premenstrual syndrome and health-related quality of life: a randomized clinical trial. J Psychosom Obstet Gynaecol. 2018 Dec;39(4):266–72. DOI: 10.1080/0167482X.2017.1348496. PMID: 28707491. Trusted SourcePubMedGo to source
  49. Prego-Dominguez J, Hadrya F, Takkouche B. Polyunsaturated Fatty Acids and Chronic Pain: A Systematic Review and Meta-analysis. Pain Physician. 2016 Dec;19(8):521–35. PMID: 27906932. Trusted SourcePubMedGo to source
  50. Hosseinlou A, Alinejad V, Alinejad M, Aghakhani N. The effects of fish oil capsules and vitamin B1 tablets on duration and severity of dysmenorrhea in students of high school in Urmia-Iran. Glob J Health Sci. 2014 Sep 18;6(7 Spec No):124–9. DOI: 10.5539/gjhs.v6n7p124. PMID: 25363189. PMCID: PMC4796395. Trusted SourcePubMedGo to source
  51. Rao A, Steels E, Beccaria G, Inder WJ, Vitetta L. Influence of a Specialized Trigonella foenum-graecum Seed Extract (Libifem), on Testosterone, Estradiol and Sexual Function in Healthy Menstruating Women, a Randomised Placebo Controlled Study. Phytother Res. 2015 Aug;29(8):1123–30. DOI: 10.1002/ptr.5355. PMID: 25914334. Trusted SourcePubMedGo to source
  52. Silvestri R, Aricò I, Bonanni E, Bonsignore M, Caretto M, Caruso D, et al. Italian Association of Sleep Medicine (AIMS) position statement and guideline on the treatment of menopausal sleep disorders. Maturitas. 2019 Nov;129:30–9. DOI: 10.1016/j.maturitas.2019.08.006. PMID: 31547910. Trusted SourcePubMedGo to source
  53. Chiu H-Y, Hsieh Y-J, Tsai P-S. Acupuncture to Reduce Sleep Disturbances in Perimenopausal and Postmenopausal Women: A Systematic Review and Meta-analysis. Obstet Gynecol. 2016 Mar;127(3):507–15. DOI: 10.1097/AOG.0000000000001268. PMID: 26855097. Trusted SourcePubMedGo to source
  54. Cintron D, Lipford M, Larrea-Mantilla L, Spencer-Bonilla G, Lloyd R, Gionfriddo MR, et al. Efficacy of menopausal hormone therapy on sleep quality: systematic review and meta-analysis. Endocrine. 2017 Mar;55(3):702–11. DOI: 10.1007/s12020-016-1072-9. PMID: 27515805. PMCID: PMC5509066. Trusted SourcePubMedGo to source
  55. Ghaffarilaleh G, Ghaffarilaleh V, Sanamno Z, Kamalifard M, Alibaf L. Effects of yoga on quality of sleep of women with premenstrual syndrome. Altern Ther Health Med. 2019 Sep;25(5):40–7. PMID: 31221931. Trusted SourcePubMedGo to source
  56. Bajalan Z, Alimoradi Z, Moafi F. Nutrition as a potential factor of primary dysmenorrhea: A systematic review of observational studies. Gynecol Obstet Invest. 2019 Jan 10;84(3):209–24. DOI: 10.1159/000495408. PMID: 30630172. Trusted SourcePubMedGo to source
  57. Yaribeygi H, Panahi Y, Sahraei H, Johnston TP, Sahebkar A. The impact of stress on body function: A review. EXCLI J. 2017 Jul 21;16:1057–72. DOI: 10.17179/excli2017-480. PMID: 28900385. PMCID: PMC5579396. Trusted SourcePubMedGo to source
  58. Kancheva Landolt N, Ivanov K. Short report: cognitive behavioral therapy – a primary mode for premenstrual syndrome management: systematic literature review. Psychol Health Med. 2021 Dec;26(10):1282–93. DOI: 10.1080/13548506.2020.1810718. PMID: 32845159. Trusted SourcePubMedGo to source
  59. Han J, Cha Y, Kim S. Effect of psychosocial interventions on the severity of premenstrual syndrome: a meta-analysis. J Psychosom Obstet Gynaecol. 2019 Sep;40(3):176–84. DOI: 10.1080/0167482X.2018.1480606. PMID: 29962276. Trusted SourcePubMedGo to source
  60. Kirwan JP, Sacks J, Nieuwoudt S. The essential role of exercise in the management of type 2 diabetes. Cleve Clin J Med. 2017 Jul;84(7 Suppl 1):S15–21. DOI: 10.3949/ccjm.84.s1.03. PMID: 28708479. PMCID: PMC5846677. Trusted SourcePubMedGo to source
  61. Yesildere Saglam H, Orsal O. Effect of exercise on premenstrual symptoms: A systematic review. Complement Ther Med. 2020 Jan;48:102272. DOI: 10.1016/j.ctim.2019.102272. PMID: 31987230. Trusted SourcePubMedGo to source
  62. Matthewman G, Lee A, Kaur JG, Daley AJ. Physical activity for primary dysmenorrhea: a systematic review and meta-analysis of randomized controlled trials. Am J Obstet Gynecol. 2018 Sep;219(3):255.e1-255.e20. DOI: 10.1016/j.ajog.2018.04.001. PMID: 29630882. Trusted SourcePubMedGo to source
  63. Kelley GA, Kelley KS. Exercise and sleep: a systematic review of previous meta-analyses. J Evid Based Med. 2017 Feb;10(1):26–36. DOI: 10.1111/jebm.12236. PMID: 28276627. PMCID: PMC5527334. Trusted SourcePubMedGo to source
  64. Maged AM, Abbassy AH, Sakr HRS, Elsawah H, Wagih H, Ogila AI, et al. Effect of swimming exercise on premenstrual syndrome. Arch Gynecol Obstet. 2018 Apr;297(4):951–9. DOI: 10.1007/s00404-018-4664-1. PMID: 29350276. Trusted SourcePubMedGo to source

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