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16 Oil of Oregano Benefits & Uses—How This Herb Helps Health

Written by Dr. Michael Ruscio, DC on April 10, 2025

Written by Dr. Michael Ruscio, DC on April 10, 2025 — Reviewed by Kellie Blake

• What is Oil of Oregano?|
• 16 Benefits|
• Oil of Oregano and Gut Health|
• Choosing an Oregano Oil Product|
• When to Start Antimicrobials|
• Introduce Antimicrobials Slowly|
• A Note About Antibiotic Resistance|

When you think of oregano, the first thing that might come to mind is pizza or pasta sauce. 

But the uses of this Mediterranean herb (Latin name Origanum vulgare) go far beyond its role in the kitchen. 

What is Oil of Oregano?

Oil of oregano is extracted from the Italian oregano plant, specifically from the oregano leaves. It has anti-inflammatory and antioxidant properties and strong antibacterial activity that can help cleanse the gut of pathogens and improve chronic gut symptoms 1 2.

The active ingredients in oil of oregano belong to the phenol family and include: 

• Thymol
• Carvacrol
• Rosmarinic acid

Oregano oil and other natural antimicrobials are step number three in the Great-in-8 protocol for gut healing that I outline in Healthy Gut, Healthy You. They certainly aren’t necessary for everyone with gut imbalances, and the more fundamental steps of diet changes and probiotics should always come first.

However, a number of my clients, especially those with trickier gut problems, have used antimicrobials, including oil of oregano, with great results. For my client Mona, for example, they proved a game-changer for chronic reflux and irritable bowel syndrome (IBS) in conjunction with a low FODMAP diet and probiotics.

Let’s dive into the benefits of oil of oregano and how you can incorporate oregano into a gut-healing plan. 

16 Oil of Oregano Benefits 

Oil of oregano extract has a long history of use as an herbal medicine. 

Science is only just starting to validate the traditional uses of oregano. More research is needed from human clinical trials to fully understand the health benefits of oregano oil. However, we already have enough studies to give a good insight into the probable benefits of oregano oil in people. 

Benefits Found in Human Studies

The following studies have noted these oil of oregano benefits in studies on humans. Studies like these are considered high-quality evidence because they help us understand how an intervention, such as oil of oregano, can provide real-world benefits. 

1. Improves symptoms of gastrointestinal infections

A randomized controlled trial (RCT) found that oregano oil was associated with significant improvements in Staphylococcus, Streptococcus, and E. coli infections in people with metabolic syndrome 3. 

• Notably, oregano oil improved gastrointestinal symptoms such as diarrhea, abdominal pain, and flatulence. Additionally, oregano did not lead to significant disruption of the gut microbiome of the patients, indicating a more gentle effect than antibiotics. 

2. Boosts lung function

Two separate RCTs found that carvacrol from oregano oil helped improve lung function, inflammation, and respiratory symptoms in asthma patients and people with lung damage 4 5.

3. Helps to eliminate intestinal parasites

A small human study examined patients with fatigue and chronic GI symptoms who tested positive for fecal parasites 2. 

• With oregano oil taken daily over a period of six weeks, 93% (13 out of 14 patients) were able to eliminate their parasites.

4. Expedites wound healing

An RCT found that oregano oil ointment helped enhance wound healing and reduce pathogenic skin microorganisms (Staphylococcus aureus) in patients who had undergone surgery 6. 

Other Research

The following are findings about oregano oil that come largely from animal or in vitro studies (performed on cells or tissues in the lab). They cannot be given as much credence as human clinical trials, but they are interesting, nevertheless. These studies suggest oregano oil, or its active ingredients, may have the following benefits: 

5. Aids with skin aging and acne 7

6. Improves respiratory tract symptoms, including cough, bronchitis, and sore throat 8 9

7. Stops the growth of mold by inhibiting the growth of certain mold species and mycotoxins 10

8. Fights vaginal infections, such as Candida 11 12

9. Alleviates indigestion and diarrhea 8 

10. Soothes athlete’s foot symptoms 13

11. Helps with symptoms of depression 14 

12. Improves sperm motility 1

How Oil of Oregano Helps Gut Health

As I touched on earlier, oil of oregano contains the powerful phenols, carvacrol, thymol, and rosemarinic acid that have antimicrobial and anti-inflammatory properties. Let’s take a look at a few of the specific ways that these properties may help at the cellular level.

13. Fights harmful bacteria

Carvacrol in oregano oil inhibits food-borne pathogens like E. coli, B. cereus, and Salmonella 15.

14. Combats fungi and biofilms

Carvacrol also inhibits fungi like Candida, as well as inhibits biofilms, a kind of sticky layer that bacteria produce to protect themselves 15.

15. Reduces gut inflammation

Thymol in oregano oil is an effective reducer of inflammation in the gut, helping to protect the gastric mucosa (lining), improve digestive enzyme production, and heal ulcers 16. 

16. Provides antioxidant support

Rosmarinic acid in oregano oil has powerful antioxidant and anti-inflammatory properties, reducing harmful free radicals’ ability to cause cellular damage 17. 

You may have noticed that many of the effects of oregano relate to gut health. The important benefits oregano can bring to gut health are its strong antimicrobial, antiviral, and antifungal properties. Together, these may help cleanse the intestines and clear out any lingering bacterial infections, overgrowths, or fungal infections, which in turn can have wider benefits for health. 

For background, many symptoms and conditions, such as colitis, thyroid issues, and general brain fog and fatigue, are connected to gut health. They can be the result of imbalances (gut dysbiosis) and lack of diversity in gut bacteria, small intestine bacterial overgrowth (SIBO), or fungal or parasitic infections 18 19 20.

Oregano oil is a valuable tool because of its broad-spectrum antimicrobial capabilities. You don’t necessarily need to know exactly what pathogen you’re dealing with to use oil of oregano—rather, you can use it as a tool to correct an overall imbalance or pathogenic load in your gut environment. 

Choosing an Oregano Oil Product

When looking for a quality oregano oil product, note that there is a difference between therapeutic-grade oil of oregano and oregano essential oil used for aromatherapy.

Oil of oregano is safe to ingest and use internally, while oregano essential oil for aromatherapy should only be applied topically. For topical use, a few drops of oregano oil can be added to a carrier oil such as coconut oil or olive oil for skin use (or it can be aerosolized in a diffuser).

Each has its own uses, but you should stick to a therapeutic quality oil of oregano for internally treating gut infections or helping to lower inflammation.

When to Start Antimicrobials

Before you jump right in with oil of oregano, let’s look at where it should come in a balanced approach to healing your gut.

Check the flowchart below, and you’ll see that antimicrobials, including oil of oregano, feature as the third step (“remove”) in my eight-step protocol for pursuing troublesome symptoms being driven by a problem in your gut.

In a gut healing program, it generally makes the most sense to tackle your diet first, followed by a regimen of probiotics to help balance your gut. There’s good scientific evidence and treatment guidelines from around the world to support this approach 21 22.

If these two steps aren’t effective, herbal antimicrobials like oregano oil can be added as the next part of your gut-healing journey.

Step 1:Diet

As the foundation of your gut health, we recommend following a nutrient-rich diet that: 

• Greatly reduces or eliminates foods that can irritate the delicate lining of the gut and contribute to microbial imbalances
• Incorporates foods that feed commensal bacteria (the good guys)
• Heals and seals a “leaky gut” (aka increased intestinal permeability)
• Lowers inflammation
• Allows you to identify trigger foods as you eliminate and then reintroduce them

For most people, the Paleo diet is the place to start. Research has shown this diet can reduce inflammation and calm the immune system by removing trigger foods, including processed grains and sugar, chemical additives, unhealthy fats, and common problem foods like dairy, soy, and gluten 23.

My Paleo Diet guide contains a simple list of foods to include or avoid while following a Paleo Diet. 

If there isn’t a significant change in your symptoms with the Paleo diet, you can move on to other diets like the low-FODMAP diet or a low-histamine diet, depending on your symptoms. It may take a few weeks to find a compatible diet that works for your body and makes you feel good. When you reach this point, you can move on to step two.

Step 2: Add Probiotics

After your diet has been addressed, the next step is to add in probiotic supplements, which can help: 

• Increase the healthy bacteria levels in your gut, which can also begin to naturally reduce the harmful microbes even without antimicrobials like oregano oil 24 25
• Further lower inflammation in the gut 26
• Encourage a healthy and balanced immune system response in the gut 27 28
• Heal and fortify the gut lining 29

Most probiotics contain a spectrum of Lactobacillus and Bifidobacteria probiotic strains, but I also recommend adding Saccharomyces boulardii (a beneficial yeast) and a soil-based probiotic for a well-rounded protocol that addresses the whole microbial community in your gut.

Each type of probiotic has different benefits and targets, and meta-analyses have shown that multi-strain probiotics tend to improve gut symptoms more than single-strain probiotics 30 31.

Introduce Antimicrobials Slowly

If you’ve completed the above two steps and you’ve seen some improvements but some of your symptoms still persist, this is the time to introduce antimicrobial agents like oregano oil into your treatment regimen.

Natural antimicrobials can resolve the trickier symptoms of gut imbalances—such as brain fog, fatigue, and any stubborn GI issues like bloating and constipation—for many people.

However, that doesn’t mean you should jump in with a high dose right away. In my clinical experience, people, especially those who have had pathogen overgrowth in the gut for a long time, may experience a temporary worsening of symptoms that occurs when pathogens die and release certain chemicals into their bloodstream.

Symptoms of a die-off might include: 

• Headache
• Increased fatigue
• Digestive problems
• Flu-like symptoms, including nausea and sweating

On the one hand, this would indicate that the antimicrobial is doing its job and killing the pathogens. On the other hand, the additional symptoms may set you back in your healing journey, and you may need a short period of recovery before you can continue with your protocol.

Some people also do better with certain antimicrobials over others. If oil of oregano is too strong for you, or not strong enough, you could give other compounds like berberine or artemisinin a try. 

It’s best to experiment and find one or two antimicrobials that work really well for you. I suggest you then rotate them as long as you need to for health improvement.

A Note About Antimicrobial Resistance

Antimicrobial resistance occurs when a bacteria, virus, or fungus adapts over time to resist a certain antimicrobial agent. It will either take a higher dose of the antimicrobial to have antibacterial properties, or it will no longer be effective at all.

To decrease the prevalence of antibiotic resistance in the overall population, we should always take care when using any kind of antimicrobial, including natural types like oil of oregano. 

Fortunately, due to more broad-spectrum pharmacology, herbal antibiotics are not as likely to cause antibiotic resistance as conventional drugs 32.

Rotating antimicrobials every month or so, as recommended above, will also keep the pathogens you’re trying to eliminate from recognizing the antimicrobial and developing resistance to it. 

Taking the Next Step

If you are considering oil of oregano or other antimicrobial agents for your gut issues, this article will hopefully have helped you. But it may also be beneficial to get some expert guidance on your next steps. To do this, you can reach out and schedule a consultation with the Ruscio Institute for Functional Health.

Our integrative doctors and health coaches have helped dozens of clients identify and heal their gut imbalances using a combination of diet, lifestyle, and supplementation when needed. Our goal is to get you back to living your healthiest life as quickly as possible.

The Ruscio Institute has developed a range of high-quality formulations to help our clients and audience. If you’re interested in learning more about these products, please click here. Note that there are many other options available, and we encourage you to research which products may be right for you. The information on DrRuscio.com is for educational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment.