Important SIBO Updates that You’ll Want to Know

In a recent interview with Dr. Allison Siebecker, we discussed some great information regarding SIBO treatment. The two main topics of our conversation were the use of anti-biofilm agents and the issue of yeast overgrowth in conjunction with SIBO.

If you need help resolving SIBO or dysbiosis, click here

 SIBO

Important SIBO Updates that You’ll Want to Know

In a recent interview with Dr. Allison Siebecker, we discussed some great information regarding small intestinal bacterial overgrowth (SIBO) treatment. The two main topics in our conversation were the use of anti-biofilm agents and the issue of yeast overgrowth in conjunction with SIBO.

Anti-biofilm agents for treating SIBO

We recently completed an in-house study with anti-biofilm agents in conjunction with herbal antimicrobials for treating SIBO. This information was presented at the SIBO Symposium last June.

The agents used were either InterFase Plus or N-acetylcysteine (NAC). Our results showed a significant reduction in hydrogen gas levels, but not methane. This was surprising, due to the fact that we’ve never believed anti-biofilm agents to provide much benefit in SIBO treatment.

Dr. Siebecker has over 6 years of experience treating thousands of SIBO patients and has never been able to perceive a benefit in using anti-biofilm agents for SIBO. She has never noticed that anti-biofilms reduce gas levels more, provide shorter treatment duration, or prevent relapse. Nothing has stood out as being significantly helpful when using anti-biofilm agents.

Why might the study results and the clinical results be so different? There’s a difference between statistical and clinical results. Statistically significant means that, numerically, the results are valid. It’s not just by chance that the end results happened. However, just because it’s mathematically significant doesn’t mean it’s impactful enough to mean anything in the real world.

This might be the case with anti-biofilm agents. They may provide enough of an effect to be statistically significant, but not enough to drastically impact patients and their symptoms.

The recommendation in this case is not to make anti-biofilm agents part of standard SIBO protocol, but to consider them when someone has not seen much improvement with antimicrobials.

Dr. Paul Anderson suggests that the standard anti-biofilm agents aren’t effective enough to really impact the treatment of SIBO, so he has created a stronger anti-biofilm called Biosolve-PA. Dr. Siebecker is experimenting with this agent to see how it works in some tougher cases. She doesn’t have final results yet, but she is seeing results in her SIBO patients who also have yeast overgrowth. These patients seem to be experiencing more die-off reactions.

What about yeast overgrowth (SIFO)?

Dr. Siebecker tests for yeast overgrowth with organic acids, blood antibodies, and/or stool. She also uses patient symptoms quite often, as many of her patients are remote. The symptoms tend to be the same for both SIBO and small intestinal fungal overgrowth (SIFO).

If symptoms still reside after treating SIBO, then you must consider another cause. So often, the culprit is yeast overgrowth. That’s why it can be a great option to treat with herbal antimicrobials because they are both antibacterial and anti-fungal. A good sign that yeast overgrowth might be present is when the patient experiences bad die-off symptoms. Die-off is usually worse with yeast than with bacteria.

While herbal antimicrobials have antibacterial, antifungal, and antiparasitic properties, some are better at treating specific microbes. In Dr. Siebecker’s experience, when she treats SIBO with antimicrobials, she usually has to put the patient on more targeted antifungals if they also have a yeast overgrowth. Typically the herbs used for SIBO aren’t enough for the yeast.

Dr. Siebecker’s favorite antifungal herbs:

  • Caprylic acid
  • Undecenoic/undecylenic acid
  • Uva ursi
  • Pau d’Arco
  • Oregano
  • Berberine
  • Grapefruit seed extract

For those who are really sensitive, it’s best to use single agents rather than broad-spectrum antimicrobial formulas.

What about worms?

It seems that many patients believe they have a parasite or worm that is causing their issues. There are lots of times when we may get hung up on preconceived beliefs. We see this a lot with diet. We’re convinced that a certain food is causing our issues, but we just can’t correlate it to symptoms. The same may be true with the idea of worms or parasites. What may look like a worm in your stool could possibly be mucus. The best thing to do in this case is to get it tested at a reliable, integrative lab.

Over the years we’ve heard the term parasites used a lot in relation to gut issues. However, it’s more of a catch-all term referring to a dysbiosis or overgrowth in the intestines. Now, as we have more testing capabilities and more clarity, we can distinguish the issues. More commonly, we find that the issue is related to yeast or bacteria rather than parasites.


If you need help resolving SIBO or dysbiosis, click here

What do you think? I would like to hear your thoughts or experience with this.

Discussion

I care about answering your questions and sharing my knowledge with you. Leave a comment or connect with me on social media asking any health question you may have and I just might incorporate it into our next listener questions podcast episode just for you!

14 thoughts on “Important SIBO Updates that You’ll Want to Know

  1. I’m glad to see you addressing this issue, as all of these topics currently apply to me as well. After chronic diarrhea over the past year I finally did stool testing. Both a 1 day and 3 day test came back negative for parasites. I couldn’t overlook the other symptoms though( diarrhea every third day, mouth lesions on my inside lower lip and teeth grinding). I decided on my own to do a course of Humaworm and within the first 24 hours had positive results for what appear to be round worms.At the end of this protocol I was tested for SIBO as well and came back hydrogen +. I am using an elemental diet for two weeks in conjunction with an herbal SIBO protocol which includes Interfase. This has been a miserable year so I’m hoping all of these things in combination will do the trick. Thanks for providing such excellent info!

    1. Hi Stacy,
      Thanks for sharing, sounds like this may have been a case of SIBO instead of parasites as we discussed. Glad you are starting to improve. If you aren’t able to get there on your own my book should be able to help.
      My pleasure!

  2. I’m glad to see you addressing this issue, as all of these topics currently apply to me as well. After chronic diarrhea over the past year I finally did stool testing. Both a 1 day and 3 day test came back negative for parasites. I couldn’t overlook the other symptoms though( diarrhea every third day, mouth lesions on my inside lower lip and teeth grinding). I decided on my own to do a course of Humaworm and within the first 24 hours had positive results for what appear to be round worms.At the end of this protocol I was tested for SIBO as well and came back hydrogen +. I am using an elemental diet for two weeks in conjunction with an herbal SIBO protocol which includes Interfase. This has been a miserable year so I’m hoping all of these things in combination will do the trick. Thanks for providing such excellent info!

    1. Hi Stacy,
      Thanks for sharing, sounds like this may have been a case of SIBO instead of parasites as we discussed. Glad you are starting to improve. If you aren’t able to get there on your own my book should be able to help.
      My pleasure!

  3. Any thoughts on Antrantil? I just caught a podcast over at Chriss Kesser’s website about it and was surprised I haven’t heard about it from you as well.

    Happy Holidays!

    -Mike in NYC

    1. Hi Mike,
      I think we have briefly mentioned this in a previous episode. I presented on this at the 2016 SIBO Symposium and we are currently studying this compound. It’s too early to tell if its any better than the current treatments that we have but our research is attempting to answer this question. We will release more info once we have collected enough data. More to come!

  4. Any thoughts on Antrantil? I just caught a podcast over at Chriss Kesser’s website about it and was surprised I haven’t heard about it from you as well.

    Happy Holidays!

    -Mike in NYC

    1. Hi Mike,
      I think we have briefly mentioned this in a previous episode. I presented on this at the 2016 SIBO Symposium and we are currently studying this compound. It’s too early to tell if its any better than the current treatments that we have but our research is attempting to answer this question. We will release more info once we have collected enough data. More to come!

  5. Hi. Thanks for the article. I was diagnosed with sibo+methane 3 months ago. I finished 2 weeks of elwmental and also took caprylic acid scd compliant probiotics and collodial silver . during treatment i felt bad but after i felt great! For about 2 weeks…then the bloat creeped back up. All along i followed a low fod map diet. I retested and my levels dropped alot but the dr says im borderline having sibo or not. So i was put on dr mullin protocol of 2 tab fc cidal 2 tab oregano 2 tab dysbiocide and 8 drop allimed in the am and in the pm on empty stomach. I felt relief for 2 weeks then bloat started back. Im currenly waiting for berberine to come in and only taking allimed and fccidal while i wait bc my other herbs ran out. Dr is suspecting sifo now as i am dealing with a moldy environment issue as well. My question is…..can i take caprylic acid probiotics and collodial silver with the allimed berberine and fc cidal? Treat sibo and possible sifo at the same time ?also i notice when i take essential oil oregano internally the bloat is relieved some….is this attacking sibo or sifo?

  6. Hi. Thanks for the article. I was diagnosed with sibo+methane 3 months ago. I finished 2 weeks of elwmental and also took caprylic acid scd compliant probiotics and collodial silver . during treatment i felt bad but after i felt great! For about 2 weeks…then the bloat creeped back up. All along i followed a low fod map diet. I retested and my levels dropped alot but the dr says im borderline having sibo or not. So i was put on dr mullin protocol of 2 tab fc cidal 2 tab oregano 2 tab dysbiocide and 8 drop allimed in the am and in the pm on empty stomach. I felt relief for 2 weeks then bloat started back. Im currenly waiting for berberine to come in and only taking allimed and fccidal while i wait bc my other herbs ran out. Dr is suspecting sifo now as i am dealing with a moldy environment issue as well. My question is…..can i take caprylic acid probiotics and collodial silver with the allimed berberine and fc cidal? Treat sibo and possible sifo at the same time ?also i notice when i take essential oil oregano internally the bloat is relieved some….is this attacking sibo or sifo?

Leave a Reply

Your email address will not be published. Required fields are marked *