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Flu Vaccine Is More Effective with Probiotics

Can a flu vaccine damage your gut health?  Let’s discuss this question and the role probiotics have in relation to vaccinations.

Dr. R’s Fast Facts

Question: Does the Flu Vaccine Have a Negative Impact on the Gut?

  • For immunocompetent adults – the flu vaccine seems to have minimal benefit as well as minimal risk (however I have not performed a comprehensive review on this)

Using a Probiotic May Help Protect Your Gut and Improve Effectiveness of the Flu Vaccine

The Influence of Probiotics on Vaccine Responses – A Systematic Review.

  • “We found 26 studies, involving 3812 participants, investigating the effect of 40 different probiotic strains on the response to 17 different vaccines.”
  • “A beneficial effect of probiotics was reported in about half of the studies.”

Strongest Evidence was for Influenza Vaccination and for other Vaccinations that were Administered Orally

  • “The studies in our review suggest that probiotics offer a relatively cheap intervention to improve vaccine efficacy and duration of protection.”

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Dr. Michael Ruscio: Hi, this is Dr. Ruscio. And let’s discuss if probiotics can actually help make vaccines, specifically the flu vaccine, work more effectively. And I’d like to answer an audience question. I’m going to use my super high-tech method here of playing her question.

“Hi, Dr. Ruscio. My name is Kelly. I listen to your podcast all the time. Thank you so much for making sure that they’re understandable by the layperson, such as myself. I am in the process of healing my leaky gut, and I am curious to know your thoughts on the flu shot and how that impacts gut health and your thoughts on if it’s worth getting the flu shot or not. I have read a lot of research, both positive and negative, in terms of getting the flu shot. And I was just curious about your opinion. Thank you so much.”

Ok. So great question by Kelly, and certainly at this time of year an understandable question. Now, in adults, in immunocompetent adults, I’m not highly concerned about the flu vaccine in either direction. The benefit seems to be minimal, but the risk also seems to be minimal. So what I tell my patients is I’m not highly concerned about this one way or the other.

Now, in higher risk populations like children and those who are elderly, it’s a different conversation. But in immunocompetent or adults with normal immune systems, there does seem to be some benefit. But that benefit seems to be minimal. It does not mean that benefit is necessarily nonexistent, but it does appear to be minimal at least to the best of my knowledge. But the risk also seems to be minimal because in an immunocompetent and well-formed adult, there’s not the same potential risks that there may be in other populations.

Now, I should also mention that I have not performed a comprehensive review of the literature here. So that recommendation I’m making or that comment I’m making may be shown to be not the most accurate or the most reflective of what the evidence shows. But I think it’s a pretty reasonable recommendation that it doesn’t seem to make a huge difference detrimental or beneficial, one way or the other, in immunocompetent adults. So I wouldn’t be too worried about it.

However, there is some interesting information that may be able to help you mitigate any potential damage to your gut that you’re describing, your leaky gut. And that may be with probiotics. And the probiotics may actually be able to help not only with helping to keep your gut healthy but also to enhance the effectiveness of the vaccination.

And I’d like to share with you a study. The study is entitled “The Influence of Probiotics on Vaccine Response: A Systematic Review.” Now, remember, a systematic review reviews all the literature. So in a sense, this is a semi-comprehensive review of the literature on the relationship between probiotics and vaccines as a general class.

So to quote, “We found 26 studies involving 3812 patients, investigating the effects of 40 different probiotics and response to 17 different vaccines.” So a pretty good review. A beneficial effect of probiotics was reported in about half of these studies. So again, not bad. And the strongest evidence was actually found for the influenza vaccination and also for other vaccinations that were administered orally.

And they conclude, “The studies in our review suggest that probiotics offer a relatively cheap intervention to improve vaccine efficacy and duration of protection.” So that’s pretty interesting information. We see that probiotics may help vaccines to work more effectively, and the duration of the response may be prolonged from using probiotics. And they may also help any negative gut consequences that may be secondary to the flu vaccine.

There was another paper—I couldn’t find it—that I recently read that also showed that probiotics, when co-administered along with vaccines, may help to reduce any negative side effects. And I’ve searched for. I couldn’t pick that one out. But essentially, if you’re going to use a vaccine as an adult that doesn’t have any other frank immune issues, then I don’t think you’re going to garner a huge benefit. But I also don’t think there’s going to be much in the way of detriment. So you can really go either way.

And if you have your general practitioner or someone who’s leaning on you to get one, again, it’s not a huge deal in my opinion either way. Using a probiotic may help protect the gut, not that I think there’s a lot negative that’s going to occur in the gut anyway from a vaccine. But it may help protect from any potential negative gut side effects. And may actually help the vaccine work more effectively.

So just a few of the thoughts for you there, Kelly, and a few thoughts on the relationship between vaccines and probiotics at large and gut health. And hopefully, this information helps you get healthy and get back to your life.

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