Why Colonics Aren’t Helpful and What Works Better Than a Colon Cleanse

What is Colonic Hydrotherapy, and What are the Downsides?

Key Takeaways:

  • While anecdotally, colonics may ease constipation and other chronic symptoms, there are several downsides to consider.
  • Colon hydrotherapy doesn’t get to the root of gut health issues. There’s very little scientific evidence to support this and other types of colon cleanse.
  • You can support your gut health much better with the right diet and probiotics, which have been proven to help keep the microbiome (gut bacteria) balanced and healthy.

Colon hydrotherapy or having a “colonic” has become a wellness trend in recent years.

During this fairly extreme type of colon cleanse, a large amount of water is flushed through the colon via a tube inserted into the rectum. Colon hydrotherapy is billed as an ultimate detoxification regimen — you may have considered this therapy if you’re struggling with chronic constipation, dysbiosis, or related symptoms such as stomach pain, bloating, fatigue, or brain fog.

However, you might want to take a pause before having a colonic.

In this article, we’ll look at what colon hydrotherapy is, whether it works, and the scientifically-tested alternatives that can improve your gut and overall health instead.

Colonic: Medical practitioner massaging a patient's abdomen

What is a Colonic?

A colonic (also known as colon hydrotherapy, colonic hydrotherapy, colonic irrigation or a colon cleanse) is offered by some alternative practitioners to remove waste material, toxins and bacteria from your system.

During a colonic, large amounts of filtered water — up to 16 gallons, or about 60 liters — are flushed through the bowel (colon/large intestine). The whole process can take about 1-1.25 hours [1 Trusted SourcePubMedGo to source].

To administer a colonic, a colon hydrotherapist has the person lie on their side in much the same position as might be adopted for a colonoscopy. A hose then delivers a pressurized stream of water into the rectum. The water and waste material drain back out of the hose and into a plumbing unit.

Proponents of colonic hydrotherapy say that the process offers these health benefits [2]:

  • Improves the immune system and general well-being
  • Relieves constipation and helps digestive health
  • Eases allergies
  • Helps weight loss
  • Improves headaches
  • Helps with acne 

Unfortunately, after digging into the research on colonics, we found the scientific backing for these assertions to be weak to non-existent. One systematic review of 17 studies concluded that “the practice of colonic cleansing to improve or promote general health is not supported in the published literature and cannot be recommended at this time” [1 Trusted SourcePubMedGo to source, 3 Trusted SourcePubMedGo to source].

This can be hard to handle if you’ve been struggling with symptoms and hear glowing anecdotal reports. You may have met someone who swears by colonics and of course it is always great that someone feels better. However, it’s highly likely that the effect is a placebo one.

It’s always worth remembering that the placebo effect can be a really powerful one. In IBS, for example, research has shown that a placebo medication produces positive results on average 40-72% of the time [4 Trusted SourcePubMedGo to source].

If you feel better, that’s a good thing, but with colon hydrotherapy you risk becoming dependent on a placebo that can be expensive, invasive, and potentially harmful. The bottom line is that you’re better off exploring treatment options that have more thorough evidence and fewer risks behind them.

What About Enemas?

An enema also involves introducing a liquid into the bowel via the rectum, but a smaller quantity that generally only reaches the bottom half of the bowel. Enemas can be [5 Trusted SourcePubMedGo to source]:

  • Evacuative: Typically for constipation, in place of laxatives.
  • Retentive: When the enema is held in. Often used as a way to deliver medication to the bowel.

Enemas may be administered by a doctor or self-administered with kits bought from the pharmacy. They are scientifically more accepted than colon hydrotherapy, but they can still have risks [6 Trusted SourcePubMedGo to source]. 

This is especially the case with enemas used without good medical reason, such as coffee enemas that involve injecting brewed coffee and water into the rectum. These have been claimed (incorrectly) to detoxify the body and even help cure cancer [7 Trusted SourcePubMedGo to source]. 

Transanal Irrigation

Another form of irrigating the colon — called transanal irrigation — has specific, medically advised uses, for people who cannot have normal bowel movements due to nerve damage, (ex., as a result of multiple sclerosis, spina bifida or stroke) [8, 9, 10].

In this method, a device pumps warm water into the bowel which is temporarily held in with an inflated balloon until the water stimulates bowel contractions. The balloon is then deflated and the contents of the bowel comes out into the toilet.

 Fluid UsedClaimed BenefitsEvidence Level
Colon HydrotherapyUp to 60 liters (16 gallons)Detox, flush out bad bacteria, boost immune system, reduce colon cancer riskPoor – benefits are anecdotal and there are reports of potential harm.
Enema150ml–1 liter (5 – 33 ounces)Ease constipation, act as a colon cleanser, deliver medicationModerate — some enemas may be medically useful, but they can harm if used inappropriately
Transanal Irrigation500ml–1 liter (17–34 ounces)Relieve constipation and anal leakage in people with nerve-related bowel dysfunctionGood (for the specific intended use)

Why a Colon Cleanse Misses the Mark

The whole concept of colon cleansing has a long and chequered history, including many misconceptions around what the process may achieve. One of these misconceptions is a colon cleanse could fight “intestinal autointoxication”, or being poisoned by the contents of the gut, a theory which was discredited in the 1930s [3 Trusted SourcePubMedGo to source]. 

Today, the colon cleansing industry still promotes everything from purgative herbs and colon hydrotherapy to coffee and apple cider vinegar enemas as a way to improve health, despite no good evidence for benefit [3 Trusted SourcePubMedGo to source]. 

A colon cleanse might seem an attractive idea and might temporarily help digestive system symptoms. But when you compare science-backed methods to improve gut health with colon cleansing, you’ll find two main problems with the latter:

  • Colon cleansing only targets your bowel — not the whole gastrointestinal tract, including the small intestine where nutrients are absorbed and gut imbalances, such as SIBO (small intestinal overgrowth), can also occur.
  • A colon cleanse can be harsh — it can cause issues such as cramping. It also flushes good as well as bad bacteria from the bowel [11 Trusted SourcePubMedGo to source].
Colonic: Colon hydrotherapy infographic by Dr. Ruscio

Without being alarmist, it’s important to mention some of the dangers associated with colon hydrotherapy and self-administered cleansing enemas in particular. 

These include colorectal perforation, inflammation of the lining of the rectum, lower abdominal pain, and bloody stools [12 Trusted SourcePubMedGo to source, 13 Trusted SourcePubMedGo to source, 14 Trusted SourcePubMedGo to source].

What’s Going on in Your Gut?

If you’ve been investigating colon cleanses or colonic hydrotherapy you’ve likely pinpointed some gut-related health issues.

But rather than settle for an unproven colon cleansing regimen, an approach that targets the underlying causes more thoroughly and holistically is a better choice.

Let’s consider what may be going wrong with your gut and the distressing symptoms this can cause. 

Common underlying gut issues include: 

  • Dysbiosis, or imbalances in the gut bacteria (microbiome) 
  • Inflammation
  • Abnormal immune function
  • Increased gut permeability (leaky gut)

These four issues tend to cluster together causing chronic health symptoms.

Colonic: Four underlying gut issues infographic

The many health issues that can occur as a result include:

Using Diet to Reset Gut Health

When addressing any of these chronic symptoms, changing your diet should be your first approach. With the groundwork established, you can add other therapies, should they be needed. 

Because many common foods can inflame the gut, a gut healing diet should focus on:

  • Reducing or removing foods that may irritate your gut lining or feed imbalanced gut bacteria
  • Healing and sealing any intestinal permeability 
  • Feeding your good gut bacteria
  • Reducing inflammation
  • Helping you understand which foods are triggering your symptoms

For many people, a Paleo-style diet ticks most of these boxes. I generally recommend you try this healthy eating plan before other more restrictive diets. On a Paleo diet, you eat a lot of fruit and vegetables and lean protein, while avoiding gluten-containing grains, dairy, and processed foods. This helps to calm inflammation by minimizing your exposure to foods that provoke an immune response [31 Trusted SourcePubMedGo to source, 32 Trusted SourcePubMedGo to source]. 

Colonic: Paleo diet infographic by Dr. Ruscio

If a Paleo diet doesn’t alleviate symptoms after a week or two, you can try progressively more restrictive diets such as the low FODMAP diet. The low FODMAP diet helps to reduce bacterial overgrowth by restricting foods that feed bacteria, and has many scientifically validated benefits, such as:

It can take a few weeks to find a diet that makes you feel healthier. When you’ve arrived at this point, it’s a good idea to also support your diet with probiotics.

Supporting Your Gut With Probiotics

White capsules and white powder on top of a light green surface

Probiotics — or friendly bacteria supplements— are the second essential step in a gut health protocol.

Whatever the reason you sought out colon hydrotherapy, probiotics can probably help relieve your symptoms more effectively. There’s some great research backing to support this. 

For example, probiotics help to: 

Many people don’t seem to achieve balance in their microbiota with just one probiotic formula. I have seen the best results with my patients when they include one probiotic from each of these three categories:

  1. Lactobacillus and Bifidobacteria blends, including species of probiotics such as Lactobacillus acidophilus and Bifidobacterium infantis
  2. Saccharomyces boulardii (a beneficial yeast)
  3. Soil-based probiotics, usually Bacillus species

For many patients who have tried just one type of probiotic, this approach makes all the difference. 

Research also supports combining different probiotic strains — for example, two systematic reviews and meta-analyses indicated that multi-strain probiotics were more effective than single-strain probiotics for treating IBS [48 Trusted SourcePubMedGo to source].

3 probiotics for gut balance infographic

Additional Approaches

If you’re still not on top of your symptoms after making changes to your diet and taking probiotics, there are plenty more strategies to try. It still isn’t a good idea to resort to therapies science doesn’t support, such as colonic hydrotherapy.

For example, herbal antimicrobial agents such as oil of oregano can be a useful strategy that can help further reduce gut inflammation and damage [55 Trusted SourcePubMedGo to source] and help get rid of lingering bad microbes and parasites [56 Trusted SourcePubMedGo to source].

If you have indications that your stomach acid is low, you could also consider supporting your digestion with enzymes and hydrochloric acid supplements [57 Trusted SourcePubMedGo to source, 58 Trusted SourcePubMedGo to source].

Everybody’s recovery progress tends to be different, and healing is not linear  — it’s a process that can go in stops and starts. But sticking with these tried and tested protocols can help support better health, helping you to enjoy life.

The Bottom Line

Colon hydrotherapy comes with some extravagant claims but no real evidence to support them. It therefore makes sense to try the trusted route of diet and probiotics instead.

Finding your way through troublesome ailments may not be easy on your own though. If you require more personalized help with gut-related or other symptoms, you can schedule a virtual or in-person consultation at our functional medicine center.


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➕ References
  1. Mishori R, Otubu A, Jones AA. The dangers of colon cleansing. J Fam Pract. 2011 Aug;60(8):454–7. Trusted SourcePubMedGo to source
  2. Colon Hydrotherapy Toronto — Best Price On Colonic Hydrotherapy In Toronto [Internet]. [cited 2021 Jul 11]. Available from: https://europeancolonic.com/colon-therapy/
  3. Acosta RD, Cash BD. Clinical effects of colonic cleansing for general health promotion: a systematic review. Am J Gastroenterol. 2009 Nov;104(11):2830–6; quiz 2837. Trusted SourcePubMedGo to source
  4. Ballou S, Beath A, Kaptchuk TJ, Hirsch W, Sommers T, Nee J, et al. Factors associated with response to placebo in patients with irritable bowel syndrome and constipation. Clin Gastroenterol Hepatol. 2018 Nov;16(11):1738-1744.e1. Trusted SourcePubMedGo to source
  5. Lowry M. Rectal drug administration in adults: how, when, why. Nurs Times. 2016;112(8):12–4. Trusted SourcePubMedGo to source
  6. Niv G, Grinberg T, Dickman R, Wasserberg N, Niv Y. Perforation and mortality after cleansing enema for acute constipation are not rare but are preventable. Int J Gen Med. 2013 Apr 26;6:323–8. Trusted SourcePubMedGo to source
  7. Cassileth B. Gerson regimen. Oncology (Williston Park, NY). 2010 Feb;24(2):201. Trusted SourcePubMedGo to source
  8. 1 Recommendations | Peristeen transanal irrigation system for managing bowel dysfunction | Guidance | NICE [Internet]. [cited 2021 Jul 11]. Available from: https://www.nice.org.uk/guidance/MTG36/chapter/1-Recommendations
  9. Choi EK, Shin SH, Im YJ, Kim MJ, Han SW. The effects of transanal irrigation as a stepwise bowel management program on the quality of life of children with spina bifida and their caregivers. Spinal Cord. 2013 May;51(5):384–8.
  10. Emmanuel AV, Krogh K, Bazzocchi G, Leroi AM, Bremers A, Leder D, et al. Consensus review of best practice of transanal irrigation in adults. Spinal Cord. 2013 Oct;51(10):732–8.
  11. Jalanka J, Salonen A, Salojärvi J, Ritari J, Immonen O, Marciani L, et al. Effects of bowel cleansing on the intestinal microbiota. Gut. 2015 Oct;64(10):1562–8. Trusted SourcePubMedGo to source
  12. Cirocchi R, Randolph J, Panata L, Verdelli AM, Mascagni D, Mingoli A, et al. The tip of the iceberg of colorectal perforation from enema: a systematic review and meta-analysis. Tech Coloproctol. 2020 Jul 14;24(11):1109–19. Trusted SourcePubMedGo to source
  13. Lee AH, Kabashneh S, Tsouvalas CP, Rahim U, Khan MY, Anees M, et al. Proctocolitis from coffee enema. ACG Case Rep J. 2020 Jan 2;7(1):e00292. Trusted SourcePubMedGo to source
  14. Son H, Song HJ, Seo H-J, Lee H, Choi SM, Lee S. The safety and effectiveness of self-administered coffee enema: A systematic review of case reports. Medicine (Baltimore). 2020 Sep 4;99(36):e21998. Trusted SourcePubMedGo to source
  15. Frändemark Å, Jakobsson Ung E, Törnblom H, Simrén M, Jakobsson S. Fatigue: a distressing symptom for patients with irritable bowel syndrome. Neurogastroenterol Motil. 2017 Jan;29(1). Trusted SourcePubMedGo to source
  16. Han CJ, Yang GS. Fatigue in Irritable Bowel Syndrome: A Systematic Review and Meta-analysis of Pooled Frequency and Severity of Fatigue. Asian Nurs Res (Korean Soc Nurs Sci). 2016 Mar;10(1):1–10. Trusted SourcePubMedGo to source
  17. Volta U, Bardella MT, Calabrò A, Troncone R, Corazza GR, Study Group for Non-Celiac Gluten Sensitivity. An Italian prospective multicenter survey on patients suspected of having non-celiac gluten sensitivity. BMC Med. 2014 May 23;12(1):85. Trusted SourcePubMedGo to source
  18. Maes M, Leunis J-C. Normalization of leaky gut in chronic fatigue syndrome (CFS) is accompanied by a clinical improvement: effects of age, duration of illness and the translocation of LPS from gram-negative bacteria. Neuro Endocrinol Lett. 2008 Dec;29(6):902–10. Trusted SourcePubMedGo to source
  19. Vara EJ, Valeur J, Hausken T, Lied GA. Extra-intestinal symptoms in patients with irritable bowel syndrome: related to high total IgE levels and atopic sensitization? Scand J Gastroenterol. 2016 Aug;51(8):908–13.
  20. Geng Q, Zhang Q-E, Wang F, Zheng W, Ng CH, Ungvari GS, et al. Comparison of comorbid depression between irritable bowel syndrome and inflammatory bowel disease: A meta-analysis of comparative studies. J Affect Disord. 2018 Sep;237:37–46. Trusted SourcePubMedGo to source
  21. Simpson CA, Mu A, Haslam N, Schwartz OS, Simmons JG. Feeling down? A systematic review of the gut microbiota in anxiety/depression and irritable bowel syndrome. J Affect Disord. 2020 Apr 1;266:429–46. Trusted SourcePubMedGo to source
  22. Koloski NA, Jones M, Talley NJ. Evidence that independent gut-to-brain and brain-to-gut pathways operate in the irritable bowel syndrome and functional dyspepsia: a 1-year population-based prospective study. Aliment Pharmacol Ther. 2016 Sep;44(6):592–600. Trusted SourcePubMedGo to source
  23. Ocon AJ. Caught in the thickness of brain fog: exploring the cognitive symptoms of Chronic Fatigue Syndrome. Front Physiol. 2013 Apr 5;4:63.
  24. Lee YB, Byun EJ, Kim HS. Potential role of the microbiome in acne: A comprehensive review. J Clin Med. 2019 Jul 7;8(7). Trusted SourcePubMedGo to source
  25. Lee SY, Lee E, Park YM, Hong SJ. Microbiome in the Gut-Skin Axis in Atopic Dermatitis. Allergy Asthma Immunol Res. 2018 Jul;10(4):354–62.
  26. Varjonen E, Vainio E, Kalimo K. Antigliadin IgE–indicator of wheat allergy in atopic dermatitis. Allergy. 2000 Apr;55(4):386–91. Trusted SourcePubMedGo to source
  27. Nosrati A, Afifi L, Danesh MJ, Lee K, Yan D, Beroukhim K, et al. Dietary modifications in atopic dermatitis: patient-reported outcomes. J Dermatolog Treat. 2017 Sep;28(6):523–38. Trusted SourcePubMedGo to source
  28. Bhatia BK, Millsop JW, Debbaneh M, Koo J, Linos E, Liao W. Diet and psoriasis, part II: celiac disease and role of a gluten-free diet. J Am Acad Dermatol. 2014 Aug;71(2):350–8.
  29. Fu Y, Lee C-H, Chi C-C. Association of Psoriasis With Inflammatory Bowel Disease: A Systematic Review and Meta-analysis. JAMA Dermatol. 2018 Dec 1;154(12):1417–23. Trusted SourcePubMedGo to source
  30. Mancini A, Di Segni C, Raimondo S, Olivieri G, Silvestrini A, Meucci E, et al. Thyroid hormones, oxidative stress, and inflammation. Mediators Inflamm. 2016 Mar 8;2016:6757154. Trusted SourcePubMedGo to source
  31. Whalen KA, McCullough ML, Flanders WD, Hartman TJ, Judd S, Bostick RM. Paleolithic and Mediterranean Diet Pattern Scores Are Inversely Associated with Biomarkers of Inflammation and Oxidative Balance in Adults. J Nutr. 2016 Jun;146(6):1217–26. Trusted SourcePubMedGo to source
  32. Olendzki BC, Silverstein TD, Persuitte GM, Ma Y, Baldwin KR, Cave D. An anti-inflammatory diet as treatment for inflammatory bowel disease: a case series report. Nutr J. 2014 Jan 16;13:5. Trusted SourcePubMedGo to source
  33. Zahedi MJ, Behrouz V, Azimi M. Low fermentable oligo-di-mono-saccharides and polyols diet versus general dietary advice in patients with diarrhea-predominant irritable bowel syndrome: A randomized controlled trial. J Gastroenterol Hepatol. 2018 Jun;33(6):1192–9. Trusted SourcePubMedGo to source
  34. Gibson PR, Shepherd SJ. Evidence-based dietary management of functional gastrointestinal symptoms: The FODMAP approach. J Gastroenterol Hepatol. 2010 Feb;25(2):252–8. Trusted SourcePubMedGo to source
  35. Gibson PR, Shepherd SJ. Food choice as a key management strategy for functional gastrointestinal symptoms. Am J Gastroenterol. 2012 May;107(5):657–66; quiz 667. Trusted SourcePubMedGo to source
  36. Gibson PR. Use of the low-FODMAP diet in inflammatory bowel disease. J Gastroenterol Hepatol. 2017 Mar;32 Suppl 1:40–2. Trusted SourcePubMedGo to source
  37. Pedersen N, Ankersen DV, Felding M, Wachmann H, Végh Z, Molzen L, et al. Low-FODMAP diet reduces irritable bowel symptoms in patients with inflammatory bowel disease. World J Gastroenterol. 2017 May 14;23(18):3356–66. Trusted SourcePubMedGo to source
  38. Zhan Y, Zhan Y-A, Dai S-X. Is a low FODMAP diet beneficial for patients with inflammatory bowel disease? A meta-analysis and systematic review. Clin Nutr. 2018 Feb;37(1):123–9. Trusted SourcePubMedGo to source
  39. Cox SR, Lindsay JO, Fromentin S, Stagg AJ, McCarthy NE, Galleron N, et al. Effects of low FODMAP diet on symptoms, fecal microbiome, and markers of inflammation in patients with quiescent inflammatory bowel disease in a randomized trial. Gastroenterology. 2020 Jan;158(1):176-188.e7. Trusted SourcePubMedGo to source
  40. Marum AP, Moreira C, Saraiva F, Tomas-Carus P, Sousa-Guerreiro C. A low fermentable oligo-di-mono saccharides and polyols (FODMAP) diet reduced pain and improved daily life in fibromyalgia patients. Scand J Pain. 2016 Aug 22;13:166–72. Trusted SourcePubMedGo to source
  41. Wen Y, Li J, Long Q, Yue C-C, He B, Tang X-G. The efficacy and safety of probiotics for patients with constipation-predominant irritable bowel syndrome: A systematic review and meta-analysis based on seventeen randomized controlled trials. Int J Surg. 2020 Jul;79:111–9. Trusted SourcePubMedGo to source
  42. Zhang C, Jiang J, Tian F, Zhao J, Zhang H, Zhai Q, et al. Meta-analysis of randomized controlled trials of the effects of probiotics on functional constipation in adults. Clin Nutr. 2020 Oct;39(10):2960–9. Trusted SourcePubMedGo to source
  43. Miller LE, Ouwehand AC, Ibarra A. Effects of probiotic-containing products on stool frequency and intestinal transit in constipated adults: systematic review and meta-analysis of randomized controlled trials. Ann Gastroenterol. 2017 Sep 21;30(6):629–39. Trusted SourcePubMedGo to source
  44. Yuan F, Ni H, Asche CV, Kim M, Walayat S, Ren J. Efficacy of Bifidobacterium infantis 35624 in patients with irritable bowel syndrome: a meta-analysis. Curr Med Res Opin. 2017 Jul;33(7):1191–7. Trusted SourcePubMedGo to source
  45. Tiequn B, Guanqun C, Shuo Z. Therapeutic effects of Lactobacillus in treating irritable bowel syndrome: a meta-analysis. Intern Med. 2015;54(3):243–9. Trusted SourcePubMedGo to source
  46. McFarland LV, Dublin S. Meta-analysis of probiotics for the treatment of irritable bowel syndrome. World J Gastroenterol. 2008 May 7;14(17):2650–61. Trusted SourcePubMedGo to source
  47. Whelan K. Probiotics and prebiotics in the management of irritable bowel syndrome:  a review of recent clinical trials and systematic reviews. Curr Opin Clin Nutr Metab Care. 2011 Nov;14(6):581–7. Trusted SourcePubMedGo to source
  48. Ford AC, Quigley EMM, Lacy BE, Lembo AJ, Saito YA, Schiller LR, et al. Efficacy of prebiotics, probiotics, and synbiotics in irritable bowel syndrome and chronic idiopathic constipation: systematic review and meta-analysis. Am J Gastroenterol. 2014 Oct;109(10):1547–61; quiz 1546, 1562. Trusted SourcePubMedGo to source
  49. Leblhuber F, Steiner K, Schuetz B, Fuchs D, Gostner JM. Probiotic Supplementation in Patients with Alzheimer’s Dementia – An Explorative Intervention Study. Curr Alzheimer Res. 2018;15(12):1106–13. Trusted SourcePubMedGo to source
  50. Toribio-Mateas M. Harnessing the power of microbiome assessment tools as part of neuroprotective nutrition and lifestyle medicine interventions. Microorganisms. 2018 Apr 25;6(2). Trusted SourcePubMedGo to source
  51. Stenman LK, Lehtinen MJ, Meland N, Christensen JE, Yeung N, Saarinen MT, et al. Probiotic With or Without Fiber Controls Body Fat Mass, Associated With Serum Zonulin, in Overweight and Obese Adults-Randomized Controlled Trial. EBioMedicine. 2016 Nov;13:190–200. Trusted SourcePubMedGo to source
  52. Mujagic Z, de Vos P, Boekschoten MV, Govers C, Pieters H-JHM, de Wit NJW, et al. The effects of Lactobacillus plantarum on small intestinal barrier function and mucosal gene transcription; a randomized double-blind placebo controlled trial. Sci Rep. 2017 Jan 3;7:40128. Trusted SourcePubMedGo to source
  53. Sindhu KNC, Sowmyanarayanan TV, Paul A, Babji S, Ajjampur SSR, Priyadarshini S, et al. Immune response and intestinal permeability in children with acute gastroenteritis treated with Lactobacillus rhamnosus GG: a randomized, double-blind, placebo-controlled trial. Clin Infect Dis. 2014 Apr;58(8):1107–15. Trusted SourcePubMedGo to source
  54. Lamprecht M, Bogner S, Schippinger G, Steinbauer K, Fankhauser F, Hallstroem S, et al. Probiotic supplementation affects markers of intestinal barrier, oxidation, and inflammation in trained men; a randomized, double-blinded, placebo-controlled trial. J Int Soc Sports Nutr. 2012 Sep 20;9(1):45. Trusted SourcePubMedGo to source
  55. Nagoor Meeran MF, Javed H, Al Taee H, Azimullah S, Ojha SK. Pharmacological properties and molecular mechanisms of thymol: prospects for its therapeutic potential and pharmaceutical development. Front Pharmacol. 2017 Jun 26;8:380. Trusted SourcePubMedGo to source
  56. Force M, Sparks WS, Ronzio RA. Inhibition of enteric parasites by emulsified oil of oregano in vivo. Phytother Res. 2000 May;14(3):213–4. Trusted SourcePubMedGo to source
  57. Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, et al. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Mol Pharm. 2013 Nov 4;10(11):4032–7. Trusted SourcePubMedGo to source
  58. Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, et al. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. AAPS J. 2014 Nov;16(6):1358–65. Trusted SourcePubMedGo to source

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