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This article is based on scientific evidence, written by experts and fact checked by experts.

Our team of licensed nutritionists and dietitians strive to be objective, unbiased, honest and to present both sides of the argument.

This article contains scientific references. The numbers in the parentheses (1, 2, 3) are clickable links to peer-reviewed scientific papers.

Does “Nature’s Ozempic” Live Up to the Hype?

Written by Michael Ruscio on November 8, 2024

Hannah Wright

Written by Michael Ruscio on November 8, 2024 — Reviewed by Hannah Wright Hannah Wright

Ozempic has been making news headlines for its blood sugar benefits and potential to induce weight loss. But without insurance coverage, it’s expensive and the supply hasn’t kept up with the demand making it difficult to get. Enter berberine—a common dietary supplement that’s now being advertised on social media as “nature’s Ozempic.” 

In this article, I will explain what Ozempic is and how it works. I’ll also share important details about berberine, why it’s gotten the “nature’s Ozempic” title, and whether science supports this distinction.

Ozempic has been making news headlines for its blood sugar benefits and potential to induce weight loss. But without insurance coverage, it’s expensive and the supply hasn’t kept up with the demand making it difficult to get. Enter berberine—a common dietary supplement that’s now being advertised on social media as “nature’s Ozempic.” 

In this article, I will explain what Ozempic is and how it works. I’ll also share important details about berberine, why it’s gotten the “nature’s Ozempic” title, and whether science supports this distinction.

What is Ozempic?

Ozempic is the brand name of a Food and Drug Administration (FDA) approved injectable drug called semaglutide (a glucagon-like peptide-1 receptor agonist or GLP-1RA). It’s most often prescribed (along with diet and exercise) to help adults with type 2 diabetes control their blood sugar. When blood sugar levels are well-controlled, the risk of serious complications like heart disease, blindness, neuropathy, and kidney disease can be significantly reduced 1. 

How Does Ozempic Work?

To better appreciate the usefulness of Ozempic for people with type 2 diabetes, let me share a brief review of how the body manages blood sugar. 

When you eat a meal, especially one that contains carbohydrates, your pancreas produces a hormone called insulin. Insulin acts as a shuttle to get the glucose (sugar) from the meal out of your bloodstream and into the cells of your body so it can be used for energy. 

People with type 2 diabetes either don’t produce enough insulin or they can’t use their insulin properly (insulin resistance), so blood sugar levels remain elevated. If this continues day after day, the risk of type 2 diabetes complications increases significantly. This is where semaglutide drugs (like Ozempic) come in handy—they reduce blood sugar levels, which tends to mean better health and less risk of serious health complications. 

Specifically, semaglutide activates GLP-1 receptors in the pancreas and brain to make insulin production more efficient—appropriate amounts of insulin equate to better blood sugar control 1. In addition to more efficient insulin production, semaglutide drugs 2:

  • Stop the release of glucagon (a pancreatic hormone that increases blood sugar)
  • Reduce the liver’s production of sugar, both when fasting and after meals
  • Improve insulin sensitivity

I want to point out here that Ozempic is not a cure for type 2 diabetes and it’s not used to treat type 1 diabetes or diabetic ketoacidosis 1. 

Though it’s not specifically designed for weight loss, Ozempic is being used off-label as a weight loss drug for people with or without type 2 diabetes 1. Let’s shift from blood sugar management to how Ozempic may exert its weight loss benefits.  

Ozempic for Weight Loss

You’ve likely heard of people who have lost an enormous amount of weight on Ozempic. But research suggests it may not be all that effective when it comes to healthy weight loss.

A 2024 meta-analysis of 76 randomized controlled trials studying semaglutide drugs in patients with type 2 diabetes found that 6–12 months on the drugs led to an average loss of 7.2 pounds of body weight. Weight loss went down to 6 pounds when the drugs were used for over a year 3.

Nevertheless, some people lose a significant amount of weight on Ozempic, so what gives? It’s not entirely clear, but the drug may slow the movement of food through the stomach reducing appetite and thus substantially lowering calorie intake 1. Fewer calories taken in over time tends to lead to weight loss. 

Outside of calorie reduction, weight loss on Ozempic may be the result of gastrointestinal side effects like nausea, vomiting, diarrhea, and constipation 4. If you experience GI upset every time you eat, you’re probably going to skip many a meal. One 2021 literature review concluded that GI side effects may be partly responsible for weight loss in some people on semaglutide drugs 5. 

With that background out of the way, let me get into what berberine is and why it’s being called “nature’s Ozempic.”

What is Berberine?

Berberine is an alkaloid compound found in many different plants like Oregon grape, barberry, and goldenseal. It may seem like the new kid on the block but berberine has been used for more than 3,000 years—first in traditional Chinese medicine (TCM) and more recently in the integrative and functional medicine space 6. 

Medicinally, berberine acts to lower inflammation and fight oxidation, and it has antimicrobial properties 6 7. Traditionally, it’s been used for fever, wound healing, toothaches, inflammation, and digestive symptoms 6 7. Animal studies suggest berberine may exert gut health benefits by improving leaky gut and dysbiosis 8 9 and targeting motility 10. One 2015 randomized controlled trial in IBS patients showed 800 milligrams of berberine HCl for 2 months improved diarrhea frequency, abdominal pain, urgency, anxiety, and depression 11.

More recently, berberine herbal supplements have become a popular option for improving blood sugar—thus its new designation as “nature’s Ozempic.”  Let’s take a closer look at how berberine improves blood sugar, and then see how it compares to Ozempic when it comes to weight management. 

Berberine for Blood Sugar Regulation

The blood sugar-lowering benefits of berberine have been known for quite some time 12. They seem to be a result of improved insulin sensitivity and glucose uptake into the cells through the activation of enzymes that regulate energy use (SIRT1 and AMPK) 13 14. But berberine also helps to reduce inflammatory markers like IL-6, TNF-α, and CRP. This reduction in inflammation may partly explain why berberine helps to reduce hemoglobin A1c (a marker of average blood sugar control over 2–3 months) 15.

While we don’t yet have data comparing berberine to Ozempic, a 2021 meta-analysis of 46 randomized controlled trials showed berberine lowered blood sugar levels to a similar degree as metformin (the most established type 2 diabetes drug). When metformin and berberine were combined, these benefits were amplified 14. 

The data for using berberine to lower blood sugar is strong. As I mentioned in the intro, Ozempic may be expensive (about $900 a month without insurance coverage) and difficult to come by due to drug shortages. Berberine is far less expensive (about $20–$50 a month) and is pretty easy to get over the counter. For those with elevated blood sugar, it may be worth it to discuss berberine with a healthcare provider as a natural option for keeping blood sugar in check (along with diet and lifestyle).

Here’s a table comparing important details about berberine and Ozempic:

OutcomeBerberineOzempic
Controls blood sugar Yes 14Yes 1
Induces weight lossNo 16Yes 1
Reduces inflammationYes 14 15 17Yes 18
Improves gut healthYes 11 19No 5
Side effectsFewer 14 20 21 More 1 3 4 22
Cost without insurance$20–50/month$900+/month

It’s important to know that as with all dietary supplements, not all of the berberine options out there are created equally. A recent report from ConsumerLab.com showed that many of the 33 berberine supplements they tested from Walmart and Amazon contained less than half of the berberine stated on the label. It’s best to look for supplements with GMP certification, third-party testing, and allergen information.

Here’s how we typically dose berberine in the clinic: 

  • Dose: 770–2,400 mg/day in divided doses with food to reduce the risk of GI symptoms like constipation, diarrhea, flatulence, and abdominal pain 20 21
  • Duration: Proven safe for 6–12 months 
  • Form: Berberine HCl 

Remember, it’s always best to discuss any dietary supplement with your healthcare provider first.

When it comes to blood sugar control, berberine may live up to the “nature’s Ozempic” title. But you likely saw in the above table that berberine isn’t a great weight loss supplement—let me share the research.

Berberine for Weight Loss

If you’re thinking of trying berberine to support you in your weight loss journey, you may be disappointed.

Despite being touted on social media platforms (like TikTok and Instagram) as an alternative to Ozempic for weight loss effects, berberine doesn’t appear to be a great option. A recent umbrella review of meta-analyses showed an average weight loss of just 1.9 pounds in 17,256 participants 21.

Hypothetically, any weight loss benefits of berberine may be due to increased fat burning and improved metabolism 13 23.

If you’ve been planning on trying berberine, I don’t want you to feel disheartened. We have many natural options for helping you lose weight if that’s your goal. 

Creating a Foundation for a Weight Loss

It can be really frustrating to feel like you’re doing all the right things with your diet and exercise but still aren’t reaching your weight loss goals. I like to use a recipe analogy here—in order to make a great dish, you not only need all the right ingredients, but you also have to layer them in the correct order. In my experience in the clinic, many of my clients have the ingredients for weight loss, they just need some guidance on how to apply them.  

The recipe for weight loss success will be different for everyone. But building a healthy foundation with research-backed natural strategies (that are applied consistently) can help create an environment in your body that makes it easier to reach your weight loss goals. So let’s get into what it looks like to create a healthy foundation for weight loss.  

Diet for Weight Loss

Without question, diet has a huge impact on health and weight. In the clinic, we harness the power of nutrition to improve gut health, mood, energy levels, blood sugar, weight, and much more.

I would love to tell you there’s one specific diet for weight loss but that’s just not the case. We’re all different and require a personalized approach. But generally, research suggests a whole-foods meal pattern high in protein (about 15–25% of calories) and low in processed foods may be effective for weight loss 24 25 26 27 28 29 30. 

But what types of diets fit this description? Here are three science-backed dietary patterns that when combined with regular exercise can induce significant weight loss:

Along with what you’re eating, the size and timing of your meals may impact your ability to lose weight. Years ago, I remember being told to eat small, frequent meals throughout the aday. But research has suggested this type of eating pattern may actually contribute to weight gain (especially fat around the belly and in the liver) 29. 

It may be best to eat fewer, larger meals, which tends to increase the calories you burn during digestion 24. And if it feels good to you, intermittent fasting may give you a weight loss edge—as well as improve metabolic parameters like insulin sensitivity and triglycerides 37 38 39 40 41 42 43 44 45.

Exercise for Weight Loss 

As with diet, there isn’t a one-size-fits-all approach to exercise. For my clients in the clinic who are new to exercise, I recommend building a solid base by walking as much and as often as possible, preferably outside in nature. 

Once a foundation of walking is established, I encourage at least two days of full-body resistance training each week and here’s why—as we age, it’s important to maintain muscle mass for both metabolic health and to maintain our functional ability. My podcast guest, Dr. Gabrielle Lyon (a muscle-centric practitioner) refers to muscle as the organ of longevity and she’s spot on. 

During our discussion, Dr. Lyon discussed the two factors that contribute to muscle protein synthesis—dietary protein (thus the recommendation for a higher protein diet) and resistance training 46.

Recent evidence suggests that resistance training, typically 3 days per week, can raise the metabolic rate and thus the number of calories burned each day 47.

In addition to walking and resistance training, sprinkling in other forms of exercise like swimming, hiking, jogging, and cycling can help improve overall health and cardiorespiratory fitness.

Lifestyle for Weight Loss

Getting diet and exercise habits established can go a long way when it comes to losing weight. But you can easily sabotage your results if you neglect other lifestyle factors like sleep, stress, and community. The following table highlights tips for success in each of these important categories: 

Lifestyle Strategy Tips for Success
Restful Sleep
  • Set a bedtime routine and a consistent bedtime and waking time 48
  • Avoid all-nighters and shift work if possible 49
  • Try to eat dinner at least two hours before bedtime
  • Avoid bright lights and screen use for at least two hours before bed 50
  • Modify the bedroom environment (temperature, lights, sounds) to support good sleep 51
  • Address breathing problems, like mouth breathing, snoring, sleep apnea, or allergies, by consulting with a medical professional 52 53 54
  • Exercise regularly, but avoid vigorous exercise close to bedtime 55
  • Try taking melatonin to help you fall asleep quickly, and try probiotics for general sleep support 56 57 58 59 60 61 62
Stress Management
Community
  • Create and nurture healthy relationships 67 68 69 70
  • Get involved with people who have common interests
  • Learn a new activity with family or friends 71 72
  • Volunteer at a local food bank or pet shelter 73 74 75
  • Join a hiking or walking group 76 77

As you can see, there are a lot of options here but don’t feel overwhelmed. In the clinic, we suggest our clients take one or two suggestions from each category and start applying them consistently. As they get their healthy lifestyle established, we encourage them to add new challenges and goals over time. 

Other Supportive Therapies for Weight Loss

Creating a healthy foundation with diet, exercise, healthy sleep, stress management, and community is a top priority for improving health and weight loss if that’s your goal. There are a couple of other supportive therapies to consider once the foundation is in place:

  • Red light therapy doesn’t necessarily help with weight loss but it may help reduce body fat and improve body composition (less fat and more muscle) 78 79 80.
  • Cold exposure may increase metabolism both at rest and after exercise 81 82 83.

A Healthy Foundation Outperforms “Nature’s Ozempic” for Weight Loss

Berberine is being touted as a “nature’s Ozempic” for blood sugar control and weight loss. Research has established the benefits of both Ozempic and berberine for improving blood sugar. But the data for using berberine as a weight loss tool isn’t there. 

If you feel like you’re doing all the right things to lose weight but are coming up empty-handed, medications and supplements can be really enticing. I’m not anti-medication or anti-supplement by any means but there are many research-backed natural strategies to help with weight loss if that’s your goal. 

My clients in the clinic tend to do well when they establish a healthy foundation with a higher protein diet, resistance training, healthy sleep habits, daily stress management techniques, and developing a supportive community. If you lay this foundation but still aren’t reaching your goals, we’d love to support you on your journey. Contact us at the Ruscio Institute for Functional Health for an appointment.

The Ruscio Institute has developed a range of high-quality formulations to help our clients and audience. If you’re interested in learning more about these products, please click here. Note that there are many other options available, and we encourage you to research which products may be right for you. The information on DrRuscio.com is for educational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment.

Dr. Michael Ruscio is a DC, natural health provider, researcher, and clinician. He serves as an Adjunct Professor at the University of Bridgeport and has published numerous papers in scientific journals as well as the book Healthy Gut, Healthy You. He also founded the Ruscio Institute of Functional Health, where he helps patients with a wide range of GI conditions and serves as the Head of Research.

➕ References

  1. Semaglutide Injection: MedlinePlus Drug Information [Internet]. [cited 2024 Mar 19]. Available from: https://medlineplus.gov/druginfo/meds/a618008.html
  2. Mahapatra MK, Karuppasamy M, Sahoo BM. Semaglutide, a glucagon like peptide-1 receptor agonist with cardiovascular benefits for management of type 2 diabetes. Rev Endocr Metab Disord. 2022 Jun;23(3):521–39. DOI: 10.1007/s11154-021-09699-1. PMID: 34993760. PMCID: PMC8736331.
  3. Yao H, Zhang A, Li D, Wu Y, Wang C-Z, Wan J-Y, et al. Comparative effectiveness of GLP-1 receptor agonists on glycaemic control, body weight, and lipid profile for type 2 diabetes: systematic review and network meta-analysis. BMJ. 2024 Jan 29;384:e076410. DOI: 10.1136/bmj-2023-076410. PMID: 38286487. PMCID: PMC10823535.
  4. https://rsc.niaid.nih.gov/sites/default/files/1.14.2.2-package-insert-ozempic.pdf [Internet]. [cited 2024 Mar 19]. Available from: https://rsc.niaid.nih.gov/sites/default/files/1.14.2.2-package-insert-ozempic.pdf
  5. Smits MM, Van Raalte DH. Safety of Semaglutide. Front Endocrinol (Lausanne). 2021 Jul 7;12:645563. DOI: 10.3389/fendo.2021.645563. PMID: 34305810. PMCID: PMC8294388.
  6. Song D, Hao J, Fan D. Biological properties and clinical applications of berberine. Front Med. 2020 Oct;14(5):564–82. DOI: 10.1007/s11684-019-0724-6. PMID: 32335802.
  7. Neag MA, Mocan A, Echeverría J, Pop RM, Bocsan CI, Crişan G, et al. Berberine: botanical occurrence, traditional uses, extraction methods, and relevance in cardiovascular, metabolic, hepatic, and renal disorders. Front Pharmacol. 2018 Aug 21;9:557. DOI: 10.3389/fphar.2018.00557. PMID: 30186157. PMCID: PMC6111450.
  8. Hou Q, Zhu S, Zhang C, Huang Y, Guo Y, Li P, et al. Berberine improves intestinal epithelial tight junctions by upregulating A20 expression in IBS-D mice. Biomed Pharmacother. 2019 Oct;118:109206. DOI: 10.1016/j.biopha.2019.109206. PMID: 31306972.
  9. Huang Y-Q, Liu J-L, Chen G-X, Shen D-T, Zhu W, Chen X-L, et al. Berberine enhances intestinal mucosal barrier function by promoting vitamin D receptor activity. Chin J Integr Med. 2024 Feb;30(2):143–51. DOI: 10.1007/s11655-023-3547-x. PMID: 37046128.
  10. Chen C, Lu M, Pan Q, Fichna J, Zheng L, Wang K, et al. Berberine Improves Intestinal Motility and Visceral Pain in the Mouse Models Mimicking Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) Symptoms in an Opioid-Receptor Dependent Manner. PLoS ONE. 2015 Dec 23;10(12):e0145556. DOI: 10.1371/journal.pone.0145556. PMID: 26700862. PMCID: PMC4689480.
  11. Chen C, Tao C, Liu Z, Lu M, Pan Q, Zheng L, et al. A Randomized Clinical Trial of Berberine Hydrochloride in Patients with Diarrhea-Predominant Irritable Bowel Syndrome. Phytother Res. 2015 Nov;29(11):1822–7. DOI: 10.1002/ptr.5475. PMID: 26400188.
  12. Zhao JV, Huang X, Zhang J, Chan Y-H, Tse H-F, Blais JE. Overall and Sex-Specific Effect of Berberine on Glycemic and Insulin-Related Traits: a Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Nutr. 2023 Oct;153(10):2939–50. DOI: 10.1016/j.tjnut.2023.08.016. PMID: 37598753.
  13. Xie L, Zhang D, Ma H, He H, Xia Q, Shen W, et al. The Effect of Berberine on Reproduction and Metabolism in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomized Control Trials. Evid Based Complement Alternat Med. 2019 Dec 13;2019:7918631. DOI: 10.1155/2019/7918631. PMID: 31915452. PMCID: PMC6930782.
  14. Guo J, Chen H, Zhang X, Lou W, Zhang P, Qiu Y, et al. The Effect of Berberine on Metabolic Profiles in Type 2 Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Oxid Med Cell Longev. 2021 Dec 15;2021:2074610. DOI: 10.1155/2021/2074610. PMID: 34956436. PMCID: PMC8696197.
  15. Vahedi-Mazdabadi Y, Shahinfar H, Toushih M, Shidfar F. Effects of berberine and barberry on selected inflammatory biomarkers in adults: A systematic review and dose-response meta-analysis of randomized clinical trials. Phytother Res. 2023 Dec;37(12):5541–57. DOI: 10.1002/ptr.7998. PMID: 37675930.
  16. Amini MR, Sheikhhossein F, Naghshi S, Djafari F, Askari M, Shahinfar H, et al. Effects of berberine and barberry on anthropometric measures: A systematic review and meta-analysis of randomized controlled trials. Complement Ther Med. 2020 Mar;49:102337. DOI: 10.1016/j.ctim.2020.102337. PMID: 32147051.
  17. Haftcheshmeh SM, Abedi M, Mashayekhi K, Mousavi MJ, Navashenaq JG, Mohammadi A, et al. Berberine as a natural modulator of inflammatory signaling pathways in the immune system: Focus on NF-κB, JAK/STAT, and MAPK signaling pathways. Phytother Res. 2022 Mar;36(3):1216–30. DOI: 10.1002/ptr.7407. PMID: 35142403.
  18. Maskery MP, Holscher C, Jones SP, Price CI, Strain WD, Watkins CL, et al. Glucagon-like peptide-1 receptor agonists as neuroprotective agents for ischemic stroke: a systematic scoping review. J Cereb Blood Flow Metab. 2021 Jan;41(1):14–30. DOI: 10.1177/0271678X20952011. PMID: 32954901. PMCID: PMC7747170.
  19. Fang S, Guo S, Du S, Cao Z, Yang Y, Su X, et al. Efficacy and safety of berberine in preventing recurrence of colorectal adenomas: A systematic review and meta-analysis. J Ethnopharmacol. 2022 Jan 10;282:114617. DOI: 10.1016/j.jep.2021.114617. PMID: 34509605.
  20. Li Z, Wang Y, Xu Q, Ma J, Li X, Yan J, et al. Berberine and health outcomes: An umbrella review. Phytother Res. 2023 May;37(5):2051–66. DOI: 10.1002/ptr.7806. PMID: 36999891.
  21. Kavyani Z, shahhosseini E, Moridpour AH, Falahatzadeh M, Vajdi M, Musazadeh V, et al. The effect of berberine supplementation on lipid profile and obesity indices: An umbrella review of meta-analysis. PharmaNutrition. 2023 Dec;26:100364. DOI: 10.1016/j.phanu.2023.100364.
  22. Shu Y, He X, Wu P, Liu Y, Ding Y, Zhang Q. Gastrointestinal adverse events associated with semaglutide: A pharmacovigilance study based on FDA adverse event reporting system. Front Public Health. 2022 Oct 20;10:996179. DOI: 10.3389/fpubh.2022.996179. PMID: 36339230. PMCID: PMC9631444.
  23. Asbaghi O, Ghanbari N, Shekari M, Reiner Ž, Amirani E, Hallajzadeh J, et al. The effect of berberine supplementation on obesity parameters, inflammation and liver function enzymes: A systematic review and meta-analysis of randomized controlled trials. Clin Nutr ESPEN. 2020 Aug;38:43–9. DOI: 10.1016/j.clnesp.2020.04.010. PMID: 32690176.
  24. Quatela A, Callister R, Patterson A, MacDonald-Wicks L. The Energy Content and Composition of Meals Consumed after an Overnight Fast and Their Effects on Diet Induced Thermogenesis: A Systematic Review, Meta-Analyses and Meta-Regressions. Nutrients. 2016 Oct 25;8(11). DOI: 10.3390/nu8110670. PMID: 27792142. PMCID: PMC5133058.
  25. Vogtschmidt YD, Raben A, Faber I, de Wilde C, Lovegrove JA, Givens DI, et al. Is protein the forgotten ingredient: Effects of higher compared to lower protein diets on cardiometabolic risk factors. A systematic review and meta-analysis of randomised controlled trials. Atherosclerosis. 2021 Jul;328:124–35. DOI: 10.1016/j.atherosclerosis.2021.05.011. PMID: 34120735.
  26. Hansen TT, Astrup A, Sjödin A. Are Dietary Proteins the Key to Successful Body Weight Management? A Systematic Review and Meta-Analysis of Studies Assessing Body Weight Outcomes after Interventions with Increased Dietary Protein. Nutrients. 2021 Sep 14;13(9). DOI: 10.3390/nu13093193. PMID: 34579069. PMCID: PMC8468854.
  27. Clifton PM, Condo D, Keogh JB. Long term weight maintenance after advice to consume low carbohydrate, higher protein diets–a systematic review and meta analysis. Nutr Metab Cardiovasc Dis. 2014 Mar;24(3):224–35. DOI: 10.1016/j.numecd.2013.11.006. PMID: 24472635.
  28. Zhang Y, Chen X, Allison DB, Xun P. Efficacy and safety of a specific commercial high-protein meal-replacement product line in weight management: meta-analysis of randomized controlled trials. Crit Rev Food Sci Nutr. 2022;62(3):798–809. DOI: 10.1080/10408398.2020.1829539. PMID: 33938779.
  29. Bray GA, Bouchard C. The biology of human overfeeding: A systematic review. Obes Rev. 2020 Sep;21(9):e13040. DOI: 10.1111/obr.13040. PMID: 32515127.
  30. Bray GA, Smith SR, de Jonge L, Xie H, Rood J, Martin CK, et al. Effect of dietary protein content on weight gain, energy expenditure, and body composition during overeating: a randomized controlled trial. JAMA. 2012 Jan 4;307(1):47–55. DOI: 10.1001/jama.2011.1918. PMID: 22215165. PMCID: PMC3777747.
  31. Frączek B, Pięta A, Burda A, Mazur-Kurach P, Tyrała F. Paleolithic Diet-Effect on the Health Status and Performance of Athletes? Nutrients. 2021 Mar 21;13(3). DOI: 10.3390/nu13031019. PMID: 33801152. PMCID: PMC8004139.
  32. Muscogiuri G, El Ghoch M, Colao A, Hassapidou M, Yumuk V, Busetto L, et al. European Guidelines for Obesity Management in Adults with a Very Low-Calorie Ketogenic Diet: A Systematic Review and Meta-Analysis. Obes Facts. 2021 Apr 21;14(2):222–45. DOI: 10.1159/000515381. PMID: 33882506. PMCID: PMC8138199.
  33. Amini MR, Aminianfar A, Naghshi S, Larijani B, Esmaillzadeh A. The effect of ketogenic diet on body composition and anthropometric measures: A systematic review and meta-analysis of randomized controlled trials. Crit Rev Food Sci Nutr. 2022;62(13):3644–57. DOI: 10.1080/10408398.2020.1867957. PMID: 33443451.
  34. Esposito K, Kastorini C-M, Panagiotakos DB, Giugliano D. Mediterranean diet and weight loss: meta-analysis of randomized controlled trials. Metab Syndr Relat Disord. 2011 Feb;9(1):1–12. DOI: 10.1089/met.2010.0031. PMID: 20973675.
  35. Huo R, Du T, Xu Y, Xu W, Chen X, Sun K, et al. Effects of Mediterranean-style diet on glycemic control, weight loss and cardiovascular risk factors among type 2 diabetes individuals: a meta-analysis. Eur J Clin Nutr. 2015 Nov;69(11):1200–8. DOI: 10.1038/ejcn.2014.243. PMID: 25369829.
  36. Ajala O, English P, Pinkney J. Systematic review and meta-analysis of different dietary approaches to the management of type 2 diabetes. Am J Clin Nutr. 2013 Mar;97(3):505–16. DOI: 10.3945/ajcn.112.042457. PMID: 23364002.
  37. Patikorn C, Roubal K, Veettil SK, Chandran V, Pham T, Lee YY, et al. Intermittent Fasting and Obesity-Related Health Outcomes: An Umbrella Review of Meta-analyses of Randomized Clinical Trials. JAMA Netw Open. 2021 Dec 1;4(12):e2139558. DOI: 10.1001/jamanetworkopen.2021.39558. PMID: 34919135. PMCID: PMC8683964.
  38. Gu L, Fu R, Hong J, Ni H, Yu K, Lou H. Effects of Intermittent Fasting in Human Compared to a Non-intervention Diet and Caloric Restriction: A Meta-Analysis of Randomized Controlled Trials. Front Nutr. 2022 May 2;9:871682. DOI: 10.3389/fnut.2022.871682. PMID: 35586738. PMCID: PMC9108547.
  39. Allaf M, Elghazaly H, Mohamed OG, Fareen MFK, Zaman S, Salmasi A-M, et al. Intermittent fasting for the prevention of cardiovascular disease. Cochrane Database Syst Rev. 2021 Jan 29;1(1):CD013496. DOI: 10.1002/14651858.CD013496.pub2. PMID: 33512717. PMCID: PMC8092432.
  40. Yang F, Liu C, Liu X, Pan X, Li X, Tian L, et al. Effect of Epidemic Intermittent Fasting on Cardiometabolic Risk Factors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Front Nutr. 2021 Oct 18;8:669325. DOI: 10.3389/fnut.2021.669325. PMID: 34733872. PMCID: PMC8558421.
  41. Zhang Q, Zhang C, Wang H, Ma Z, Liu D, Guan X, et al. Intermittent Fasting versus Continuous Calorie Restriction: Which Is Better for Weight Loss? Nutrients. 2022 Apr 24;14(9). DOI: 10.3390/nu14091781. PMID: 35565749. PMCID: PMC9099935.
  42. Yuan X, Wang J, Yang S, Gao M, Cao L, Li X, et al. Effect of Intermittent Fasting Diet on Glucose and Lipid Metabolism and Insulin Resistance in Patients with Impaired Glucose and Lipid Metabolism: A Systematic Review and Meta-Analysis. Int J Endocrinol. 2022 Mar 24;2022:6999907. DOI: 10.1155/2022/6999907. PMID: 35371260. PMCID: PMC8970877.
  43. Wang X, Li Q, Liu Y, Jiang H, Chen W. Intermittent fasting versus continuous energy-restricted diet for patients with type 2 diabetes mellitus and metabolic syndrome for glycemic control: A systematic review and meta-analysis of randomized controlled trials. Diabetes Res Clin Pract. 2021 Sep;179:109003. DOI: 10.1016/j.diabres.2021.109003. PMID: 34391831.
  44. Schoenfeld BJ, Aragon AA, Krieger JW. Effects of meal frequency on weight loss and body composition: a meta-analysis. Nutr Rev. 2015 Feb;73(2):69–82. DOI: 10.1093/nutrit/nuu017. PMID: 26024494.
  45. Stockman M-C, Thomas D, Burke J, Apovian CM. Intermittent fasting: is the wait worth the weight? Curr Obes Rep. 2018 Jun;7(2):172–85. DOI: 10.1007/s13679-018-0308-9. PMID: 29700718. PMCID: PMC5959807.
  46. Pontzer H, Yamada Y, Sagayama H, Ainslie PN, Andersen LF, Anderson LJ, et al. Daily energy expenditure through the human life course. Science. 2021 Aug 13;373(6556):808–12. DOI: 10.1126/science.abe5017. PMID: 34385400. PMCID: PMC8370708.
  47. MacKenzie-Shalders K, Kelly JT, So D, Coffey VG, Byrne NM. The effect of exercise interventions on resting metabolic rate: A systematic review and meta-analysis. J Sports Sci. 2020 Jul;38(14):1635–49. DOI: 10.1080/02640414.2020.1754716. PMID: 32397898.
  48. Makarem N, German CA, Zhang Z, Diaz KM, Palta P, Duncan DT, et al. Rest-Activity Rhythms Are Associated With Prevalent Cardiovascular Disease, Hypertension, Obesity, and Central Adiposity in a Nationally Representative Sample of US Adults. J Am Heart Assoc. 2024 Jan 2;13(1):e032073. DOI: 10.1161/JAHA.122.032073. PMID: 38156474. PMCID: PMC10863829.
  49. Liu Q, Shi J, Duan P, Liu B, Li T, Wang C, et al. Is shift work associated with a higher risk of overweight or obesity? A systematic review of observational studies with meta-analysis. Int J Epidemiol. 2018 Dec 1;47(6):1956–71. DOI: 10.1093/ije/dyy079. PMID: 29850840.
  50. Tähkämö L, Partonen T, Pesonen A-K. Systematic review of light exposure impact on human circadian rhythm. Chronobiol Int. 2019 Feb;36(2):151–70. DOI: 10.1080/07420528.2018.1527773. PMID: 30311830.
  51. Valham F, Sahlin C, Stenlund H, Franklin KA. Ambient temperature and obstructive sleep apnea: effects on sleep, sleep apnea, and morning alertness. Sleep. 2012 Apr 1;35(4):513–7. DOI: 10.5665/sleep.1736. PMID: 22467989. PMCID: PMC3296793.
  52. Ilea A, Timuș D, Höpken J, Andrei V, Băbțan A-M, Petrescu NB, et al. Oral appliance therapy in obstructive sleep apnea and snoring – systematic review and new directions of development. Cranio. 2021 Nov;39(6):472–83. DOI: 10.1080/08869634.2019.1673285. PMID: 31588866.
  53. Cavalcante-Leão BL, de Araujo CM, Ravazzi GC, Basso IB, Guariza-Filho O, Taveira KVM, et al. Effects of respiratory training on obstructive sleep apnea: systematic review and meta-analysis. Sleep Breath. 2022 Dec;26(4):1527–37. DOI: 10.1007/s11325-021-02536-4. PMID: 34850331.
  54. Zhang F, Tian Z, Shu Y, Zou B, Yao H, Li S, et al. Efficiency of oro-facial myofunctional therapy in treating obstructive sleep apnoea: A meta-analysis of observational studies. J Oral Rehabil. 2022 Jul;49(7):734–45. DOI: 10.1111/joor.13325. PMID: 35342989.
  55. Kelley GA, Kelley KS. Exercise and sleep: a systematic review of previous meta-analyses. J Evid Based Med. 2017 Feb;10(1):26–36. DOI: 10.1111/jebm.12236. PMID: 28276627. PMCID: PMC5527334.
  56. Ferracioli-Oda E, Qawasmi A, Bloch MH. Meta-analysis: melatonin for the treatment of primary sleep disorders. PLoS ONE. 2013 May 17;8(5):e63773. DOI: 10.1371/journal.pone.0063773. PMID: 23691095. PMCID: PMC3656905.
  57. Auld F, Maschauer EL, Morrison I, Skene DJ, Riha RL. Evidence for the efficacy of melatonin in the treatment of primary adult sleep disorders. Sleep Med Rev. 2017 Aug;34:10–22. DOI: 10.1016/j.smrv.2016.06.005. PMID: 28648359.
  58. McDonagh MS, Holmes R, Hsu F. Pharmacologic treatments for sleep disorders in children: A systematic review. J Child Neurol. 2019 Apr;34(5):237–47. DOI: 10.1177/0883073818821030. PMID: 30674203.
  59. Takada M, Nishida K, Gondo Y, Kikuchi-Hayakawa H, Ishikawa H, Suda K, et al. Beneficial effects of Lactobacillus casei strain Shirota on academic stress-induced sleep disturbance in healthy adults: a double-blind, randomised, placebo-controlled trial. Benef Microbes. 2017 Apr 26;8(2):153–62. DOI: 10.3920/BM2016.0150. PMID: 28443383.
  60. Marotta A, Sarno E, Del Casale A, Pane M, Mogna L, Amoruso A, et al. Effects of probiotics on cognitive reactivity, mood, and sleep quality. Front Psychiatry. 2019 Mar 27;10:164. DOI: 10.3389/fpsyt.2019.00164. PMID: 30971965. PMCID: PMC6445894.
  61. Romijn AR, Rucklidge JJ, Kuijer RG, Frampton C. A double-blind, randomized, placebo-controlled trial of Lactobacillus helveticus and Bifidobacterium longum for the symptoms of depression. Aust N Z J Psychiatry. 2017 Aug;51(8):810–21. DOI: 10.1177/0004867416686694. PMID: 28068788. PMCID: PMC5518919.
  62. Nakakita Y, Tsuchimoto N, Takata Y, Nakamura T. Effect of dietary heat-killed Lactobacillus brevis SBC8803 (SBL88TM) on sleep: a non-randomised, double blind, placebo-controlled, and crossover pilot study. Benef Microbes. 2016 Sep;7(4):501–9. DOI: 10.3920/BM2015.0118. PMID: 27013460.
  63. Shah K, Ramos-Garcia M, Bhavsar J, Lehrer P. Mind-body treatments of irritable bowel syndrome symptoms: An updated meta-analysis. Behav Res Ther. 2020 May;128:103462. DOI: 10.1016/j.brat.2019.103462. PMID: 32229334.
  64. Kavuri V, Raghuram N, Malamud A, Selvan SR. Irritable bowel syndrome: yoga as remedial therapy. Evid Based Complement Alternat Med. 2015 May 6;2015:398156. DOI: 10.1155/2015/398156. PMID: 26064164. PMCID: PMC4438173.
  65. Balban MY, Neri E, Kogon MM, Weed L, Nouriani B, Jo B, et al. Brief structured respiration practices enhance mood and reduce physiological arousal. Cell Rep Med. 2023 Jan 17;4(1):100895. DOI: 10.1016/j.xcrm.2022.100895. PMID: 36630953. PMCID: PMC9873947.
  66. Househam AM, Peterson CT, Mills PJ, Chopra D. The effects of stress and meditation on the immune system, human microbiota, and epigenetics. Adv Mind Body Med. 2017;31(4):10–25. PMID: 29306937.
  67. Wang ML, Pbert L, Lemon SC. Influence of family, friend and coworker social support and social undermining on weight gain prevention among adults. Obesity (Silver Spring). 2014 Sep;22(9):1973–80. DOI: 10.1002/oby.20814. PMID: 24942930. PMCID: PMC4435839.
  68. Holt-Lunstad J. Why social relationships are important for physical health: A systems approach to understanding and modifying risk and protection. Annu Rev Psychol. 2018 Jan 4;69:437–58. DOI: 10.1146/annurev-psych-122216-011902. PMID: 29035688.
  69. Fernandez-Portero C, Amian JG, Alarcón D, Arenilla Villalba MJ, Sánchez-Medina JA. The Effect of Social Relationships on the Well-Being and Happiness of Older Adults Living Alone or with Relatives. Healthcare (Basel). 2023 Jan 11;11(2). DOI: 10.3390/healthcare11020222. PMID: 36673590. PMCID: PMC9858722.
  70. Holt-Lunstad J, Smith TB, Layton JB. Social relationships and mortality risk: a meta-analytic review. PLoS Med. 2010 Jul 27;7(7):e1000316. DOI: 10.1371/journal.pmed.1000316. PMID: 20668659. PMCID: PMC2910600.
  71. Leanos S, Kürüm E, Strickland-Hughes CM, Ditta AS, Nguyen G, Felix M, et al. The Impact of Learning Multiple Real-World Skills on Cognitive Abilities and Functional Independence in Healthy Older Adults. J Gerontol B Psychol Sci Soc Sci. 2023 Aug 2;78(8):1305–17. DOI: 10.1093/geronb/gbad053. PMID: 37171401. PMCID: PMC10394988.
  72. Soldevila-Domenech N, Forcano L, Vintró-Alcaraz C, Cuenca-Royo A, Pintó X, Jiménez-Murcia S, et al. Interplay between cognition and weight reduction in individuals following a Mediterranean Diet: Three-year follow-up of the PREDIMED-Plus trial. Clin Nutr. 2021 Sep;40(9):5221–37. DOI: 10.1016/j.clnu.2021.07.020. PMID: 34474192.
  73. Burr JA, Han SH, Tavares JL. Volunteering and cardiovascular disease risk: does helping others get “under the skin?”. Gerontologist. 2016 Oct;56(5):937–47. DOI: 10.1093/geront/gnv032. PMID: 26035902.
  74. Michalski CA, Diemert LM, Helliwell JF, Goel V, Rosella LC. Relationship between sense of community belonging and self-rated health across life stages. SSM Popul Health. 2020 Dec;12:100676. DOI: 10.1016/j.ssmph.2020.100676. PMID: 33134474. PMCID: PMC7585135.
  75. Yeung JWK, Zhang Z, Kim TY. Volunteering and health benefits in general adults: cumulative effects and forms. BMC Public Health. 2017 Jul 11;18(1):8. DOI: 10.1186/s12889-017-4561-8. PMID: 28693551. PMCID: PMC5504679.
  76. Hanson S, Jones A. Is there evidence that walking groups have health benefits? A systematic review and meta-analysis. Br J Sports Med. 2015 Jun;49(11):710–5. DOI: 10.1136/bjsports-2014-094157. PMID: 25601182. PMCID: PMC4453623.
  77. Schnall S, Harber KD, Stefanucci JK, Proffitt DR. Social support and the perception of geographical slant. J Exp Soc Psychol. 2008 Sep 1;44(5):1246–55. DOI: 10.1016/j.jesp.2008.04.011. PMID: 22389520. PMCID: PMC3291107.
  78. Sene-Fiorese M, Duarte FO, de Aquino Junior AE, Campos RM da S, Masquio DCL, Tock L, et al. The potential of phototherapy to reduce body fat, insulin resistance and “metabolic inflexibility” related to obesity in women undergoing weight loss treatment. Lasers Surg Med. 2015 Oct;47(8):634–42. DOI: 10.1002/lsm.22395. PMID: 26220050.
  79. Roche GC, Shanks S, Jackson RF, Holsey LJ. Low-Level Laser Therapy for Reducing the Hip, Waist, and Upper Abdomen Circumference of Individuals with Obesity. Photomed Laser Surg. 2017 Mar;35(3):142–9. DOI: 10.1089/pho.2016.4172. PMID: 27935737.
  80. McRae E, Boris J. Independent evaluation of low-level laser therapy at 635 nm for non-invasive body contouring of the waist, hips, and thighs. Lasers Surg Med. 2013 Jan;45(1):1–7. DOI: 10.1002/lsm.22113. PMID: 23355338.
  81. Millet J, Siracusa J, Tardo-Dino P-E, Thivel D, Koulmann N, Malgoyre A, et al. Effects of Acute Heat and Cold Exposures at Rest or during Exercise on Subsequent Energy Intake: A Systematic Review and Meta-Analysis. Nutrients. 2021 Sep 28;13(10). DOI: 10.3390/nu13103424. PMID: 34684424. PMCID: PMC8538265.
  82. How brown fat improves metabolism | National Institutes of Health (NIH) [Internet]. [cited 2023 May 4]. Available from: https://www.nih.gov/news-events/nih-research-matters/how-brown-fat-improves-metabolism
  83. Herz CT, Kulterer OC, Prager M, Marculescu R, Langer FB, Prager G, et al. Sex differences in brown adipose tissue activity and cold-induced thermogenesis. Mol Cell Endocrinol. 2021 Aug 20;534:111365. DOI: 10.1016/j.mce.2021.111365. PMID: 34126190.

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