Does your gut need a reset?

Yes, I'm Ready

Do you want to start feeling better?

Yes, Where Do I Start?

Do you want to start feeling better?

Yes, Where Do I Start?

What Is Candida? 5 Facts You May Not Know

Improve Your Overall Microbiome Balance to Tackle Gut Candida

So, what is Candida? Candida is a yeast, a type of fungus, that can populate our skin, digestive tract, and reproductive system, and it may sometimes cause infections. Symptoms like bloating, gas, diarrhea, skin issues, genital and vaginal yeast infections, and depression may all point to Candida overgrowth. 

However, we now know there are several myths and misconceptions around what Candida is and the role it plays in the body. In the light of more recent research and new knowledge about the microbiome, it’s likely that Candida overgrowth of the gut has been over-diagnosed.



That’s not to say that intestinal Candida overgrowths can’t happen (they can, and do, in both the small intestine and bowel). But over-focusing on this specific microorganism makes it easy to miss the bigger picture: the health of your gut and its diverse ecosystem of microbes.

In this article, I’ll correct some of the inaccuracies around Candida. Then I’ll share a simple research-based plan for getting rid of excess Candida in the intestines while bringing your gut microbiome back to balance.

Before we begin, though, it’s helpful to realize that Candida is often the scapegoat that takes the blame for poor gut health and poor diet in general. It’s good to keep this in mind as we dig into five lesser-known facts about Candida, starting with the misconception that this yeast is always a bad guy.

Fact 1: Candida is a Common—Even Friendly—Gut Resident

Candida is a yeast (a type of fungus) that resides in most people’s guts, usually without causing problems. In a recent study of stool samples, researchers found Candida albicans (the most common Candida species in humans), in the stool of about 577 (83%) of 695 healthy people [1].

This suggests that Candida is a normal part of the ecosystem of microbes in our gut, and it may even be beneficial when it coexists peacefully with other microbes.

So, how did Candida get such a bad rap? One reason could be that when Candida infections do occur, they can cause some pretty well-known and miserable symptoms. For example, both vaginal thrush (vaginal candidiasis) and oral thrush (oral candidiasis) are caused by a Candida infection (usually Candida albicans). Candida can also cause invasive candidiasis, a severe infection (sometimes life-threatening) that occurs in very sick patients and those with a weakened immune system, affecting the blood, heart, brain, eyes, and bones.

Given that Candida can cause these unpleasant conditions, it’s easy to assume that if this type of yeast is in your intestine, it must be producing your gut symptoms, too.

On the more cynical side of things, I’ll also point out that there’s a big market on the internet for Candida testing kits and Candida-killing supplements. Those who are pushing these kits have a vested interest in making you believe Candida is the main factor behind your symptoms.

In reality, what’s important to your gut health is the overall balance of microbes in your gut, not just whether Candida is present. In particular, having a robust and diverse population of bacteria in your gut is what keeps Candida numbers in check [2].

In other words, if you can focus on keeping your microbiome as a whole, healthy ecosystem, you don’t need specialized actions to get rid of intestinal Candida.

Key Takeaway: Although Candida can cause gut and wider symptoms, it’s actually a normal part of the microbiome.

Fact 2: Tests for Intestinal Candida Aren’t Helpful

I pretty much never use stool tests to quantify intestinal Candida for three reasons. 

First, Candida is commonly found in the stool of healthy people, as we have already seen, and is no cause for alarm [1]. 

Second, there are no established standards for what a “normal” or “high” level of Candida is in the gut. So, two labs might measure the same level of Candida in your stool, but one may define your level as normal, while the other might label it as high.

For example, scientific researchers studying Candida populations in the gut have suggested that between 10,000 and 100,000 colony-forming units (CFU) indicate a high amount of Candida [3, 4, 5, 6]. In contrast, functional medicine labs may not provide a normal value, or they may suggest that anything over 5,000 CFU is too much [7]. 

In other words, there is no standard agreement on what is high and what isn’t, so it’s better to use your symptoms as your guide [8]. 

The third reason I don’t use stool tests to measure Candida is that there’s a lot of inconsistency in test results from lab to lab. For example, at the clinic, we did a test in which we split one person’s stool sample in two and sent each half to a different testing center. The results were telling. In the same stool sample, one lab found an overgrowth of Candida, while the other lab did not. There were also huge differences reported in the amount of other species in the stool, including Akkermansia, Klebsiella, and Pseudomonas.

Just as a footnote here, urine and blood test tests that check for d-arabinitol (a Candida-made sugar that we excrete in the urine) have partial validity for diagnosing  invasive candidiasis, a serious infection [9, 10, 11]. However, these tests are not validated for assessing intestinal Candida.

To recap, with gut Candida tests being so inaccurate and unreliable, I no longer use them. Instead, I recommend that my patients use their symptoms as a barometer to help us guide their treatment. In fact, research shows that intestinal Candida overgrowth and symptoms may correlate closely [8]. 

But that’s almost beside the point: that gut symptoms indicate a problem with the whole intestinal ecosystem, of which, as you’ll find out in the next section, Candida is simply an interdependent part.

Key Takeaway: Testing is widely available for Candida, but it’s not useful for accurately diagnosing an intestinal Candida overgrowth. It’s more reliable to follow and treat your symptoms instead.

Fact 3: Candida Overgrowths Don’t Usually Happen in Isolation

When we help patients at the clinic, we often find that Candida overgrowth is a symptom of a more generalized problem with their microbiome health. 

Although this observation is anecdotal, we also have data supporting the idea that microbiome imbalances occur together, not singly. 

For example, one study involving 150 participants with chronic gastrointestinal (GI) symptoms linked with overgrowths found that 34% of the group had a mixture of small intestinal fungal overgrowth (SIFO) and small intestinal bacterial overgrowth (SIBO) [12]. In other words, Candida yeast and unhealthy bacteria were commonly overgrowing together in the small intestine.

A helpful way to think about this is that it doesn’t really matter if you have SIFO, SIBO, or some other type of gut imbalance. If you’re having a host of gut symptoms, it’s likely your microbial ecosystem as a whole has shifted toward a more unhealthy composition. The way to resolve this is to improve your gut health and general health without getting lost in trying to treat one specific gut microbe. Usually, if one is out of balance, it means the others are, too.

Working on your underlying gut health will help bring your whole gut microbiome back into balance, which prevents symptom-causing overgrowths and negates the need to find a specific culprit.

Key Takeaway: Candida overgrowth in the gut often seems to coexist with other microbiome imbalances, such as SIBO, leaky gut, and bacterial imbalances

Fact 4: You Don’t Have to Eat a Low-Carb Diet if You Have Intestinal Candida 

The idea that you have to eat a low-carb diet if you have intestinal Candida—even if you find low-carb doesn’t suit you—is quite entrenched within the field of functional medicine. I’ve met patients who doggedly stuck to a low-carb diet that clearly didn’t work well for them, based on a Candida overgrowth stool test from 1–3 years prior! 

I find this disturbing because we know that gut Candida tests are inaccurate and unhelpful and, as I’m about to explain, low-carb diets are unnecessary.

Case in point: In a study of Candida treatments, a whole-foods diet (with grains, cooked potatoes, and brown rice) plus antifungal medication (nystatin) were twice as effective as nystatin plus a regular diet including more added sugar and processed foods [5]. That suggests the whole-foods diet played a significant role in correcting the Candida overgrowth, even though it included unprocessed carbohydrates. In other words, not all carbohydrates are bad if you have intestinal Candida!

Sure, the helpful diet did restrict certain carbs (sugars and refined grains and starches), as well as alcohol and meats, other than fresh fish and lean chicken. That this diet helped treat Candida makes sense because we have evidence that a Westernized, processed diet can encourage this fungus to grow [13]. 

The main point here is that you don’t need to be on a super-restrictive “anti-Candida” diet that excludes all carbs. For most people, simply shifting to a healthy diet that’s low in processed foods and added sugars is enough. 

Key takeaway: Avoiding sugary foods is sensible for good health overall, but you don’t have to avoid all carbs to resolve a Candida overgrowth or Infection. 

I’ll touch more on the types of diet that can help to rebalance your microbiome and keep Candida in check, with the 4-point plan below.

Fact 5: Antacid Use Could Be Making a Candida Condition Worse

Stomach acid-reducing medications for heartburn and gastroesophageal reflux disease (GERD) are also implicated in intestinal Candida overgrowths and infections. These medications include antacids (e.g. Tums) and proton pump inhibitor medications (e.g. omeprazole).

You need a certain concentration of stomach acid to kill excess bacteria and fungi and prevent them from populating your intestines. But acid-lowering medications raise the pH of your stomach contents, which can allow too many bad bacteria and yeasts to survive the stomach, seeding overgrowths further down the GI tract [12]. 

If you absolutely have to take acid-lowering medications (something to discuss with your healthcare provider), you may have to be extra scrupulous with the 4-step anti-Candida plan below. You may need to head to step 4 (antimicrobials) quicker than would normally be the case.

Key takeaway: Acid-lowering medications can play a big part in setting up Candida overgrowths in the intestines. 

Other Potential Causes of Candida Overgrowth

Though sometimes unavoidable, antibiotic medications are a well-understood factor in the overgrowth of Candida in the gut. Basically, when you lose beneficial bacteria during antibiotic treatment, Candida levels can start to rise [6]. 

In addition to a sedentary lifestyle and highly processed diets, preventable factors that can contribute to the growth of Candida in the gut include smoking and excess alcohol intake [14, 15, 16]. 

Chronic stress is a less preventable, but manageable risk factor for microbial overgrowth and other microbiome imbalances (dysbiosis) [13, 17, 18].

I’ll also note here that oral contraceptives for birth control can increase your risk of vaginal candidiasis [19], which may increase your risk for intestinal Candida infections [20].

Let’s now look at how to fight Candida overgrowths in the gut by making your gut microbiome healthier. 

A 4-Step Plan to Beat Candida by Bringing Your Microbiome Back Into Balance

From my 10 years of experience with patients who have gut symptoms suggestive of Candida overgrowth or other microbial imbalances, I find this 4-step plan is the most effective. It works so well because it tackles fungal overgrowths by strengthening the health of the microbiome overall. 

Each person will respond slightly differently to these four steps, and not everybody will need all of them.

The important thing is for you to let your symptoms guide you. An improvement in symptoms usually correlates closely with healthy changes in the gut microbiome, including a reduction in excess Candida [8]. 

Your progress may not be linear, but if you keep a diary of your symptoms, look for small improvements that add up over a couple months or so.

Step 1: Make Healthy Diet and Lifestyle Changes

When it comes to Candida, diet and lifestyle changes are the treatment options that make the biggest impact. In particular, moving away from processed foods with lots of added sugar is very helpful.

However, I’m not prescriptive about which diet you should follow, since different diets work for different people. And as we’ve already discussed, you don’t necessarily have to eat a low-carb diet. 

But if you want to know where to start, two whole-food options that are generally good choices are a Mediterranean-style diet and a Paleo-style diet.

The Mediterranean diet (fresh vegetables, lean meats, oily fish, nuts, olive oil, and whole grains) is low in processed foods and sugar and has been shown to be a microbiome-friendly diet [21]. It also has benefits for the cardiovascular system [22], is protective against colon and breast cancer [22, 23], and may have benefits for mental health [24].

Many of my patients with suspected Candida overgrowth also do well on a Paleo diet, particularly if their gut symptoms are more pronounced.

Like a Mediterranean diet, a Paleo diet meal plan reduces or eliminates processed ingredients and added sugars. However, it also cuts out potential trigger foods like dairy, gluten, and soy that might promote inflammation, gut dysbiosis, and Candida overgrowth [25, 25, 26, 27, 28, 29, 30]. 

In tandem with diet changes, incorporating physical activity into your life is important. Exercise increases gut microbial diversity [31], and more healthy gut bacteria means better control of Candida.

A combination of resistance exercise (weights) and aerobic exercise will increase your chances of living longer and more healthily in general [32]. The optimum level of aerobic exercise to help you live longer may be higher than the official guidelines of 150–300 minutes per week of moderate physical exercise (e.g. walking or jogging) or 75–150 minutes a week of vigorous physical activity (e.g. running) [33]. 

If that sounds daunting, just remember that any movement is better than none, and you can always increase your intensity or duration over time.

Another important lifestyle hack for helping your gut microbiome is to reduce stress, especially if you suspect you have a Candida [34]. Of course, exercise is a great way to reduce stress while also benefiting the microbiome. Other stress-busters that can improve gut symptoms include meditation [23], yoga [35], and especially time in nature [36, 37, 38]. 

Once you’ve made strides to improve your diet and lifestyle, you can double down on any remaining symptoms suggestive of Candida overgrowth by taking probiotics.

Step 2: Probiotics

Probiotics are a perfect fit for tackling Candida overgrowth symptoms because they have antifungal and anti-inflammatory properties, and they can increase the number of beneficial bacteria that keep fungus in check. Probiotics may also help to heal a leaky gut and promote a healthy immune response [39, 40, 41]. In some cases, probiotics can be as effective as common antifungal medications for treating fungal overgrowths [42, 43]. 

There’s no need to seek out a specific strain of probiotic that’s best for dealing with anti-fungal infections—the evidence doesn’t yet suggest one is better than another. However, research does suggest that a multi-strain approach is best [44, 45, 46], and we see this borne out in our patients with suspected Candida.

In the clinic, we use a triple-therapy protocol that comprises a blend of Lactobacillus and Bifidobacterium strains, Saccharomyces boulardii (a beneficial yeast), and a soil-based probiotic, typically for 2–3 months. 

If you still have gut symptoms after making changes to your diet and lifestyle and using probiotics, the next step is to give your digestive system a short break with an elemental diet.

Step 3: Elemental Diet

An elemental diet is a tool to help you to starve any remaining Candida and allow residual sensitivity and inflammation to subside. This hypoallergenic, anti-inflammatory meal replacement provides you with fully or partially broken-down nutrients to give your small intestine a rest. Having to work less hard to get nutrients helps to fast-track gut repair and quickly restore a healthy immune system response. An elemental diet is one of the most effective ways to reset your gut.

While we don’t have research on using an elemental diet for Candida overgrowths specifically, we do have good data showing it can benefit digestive health conditions related to microbiome imbalances, like inflammatory bowel disease [47, 48] and small intestinal bacterial overgrowth [49]. Knowing that, it’s fair to assume that an elemental diet may be useful for fungal overgrowths, too.

At the clinic, we’ve found that many people do well with a “half-elemental diet,” in which you replace one or two meals a day with an elemental shake and eat a healthy diet the rest of the time. You can give this a try if you feel like a shake for every meal is a bit too much. You can also do a 24-hour full elemental diet, followed by a half-elemental diet. Essentially, the elemental diet is a highly flexible and effective tool for gut issues. 

Typically, for my patients with overgrowths, I coach them on using an elemental diet for 1–3 weeks. If you’re doing an elemental diet on your own, 4 days is the maximum term I would suggest. If you need to go longer, please only do so with the supervision of a practitioner. If you still have symptoms suggestive of Candida after your elemental diet term, then I would move on to the next step.

Step 4: Antimicrobials

Lingering gut symptoms after you’ve incorporated the first three steps suggest a stubborn case of microbial imbalance that needs an antimicrobial nudge. Antimicrobials include a variety of plant extracts and over-the-counter or prescription medications that can knock out bad bacteria, infectious microbes, and fungal overgrowths [50, 51]. 

Natural, plant-based antimicrobials with potential antifungal effects include: 

  • Caprylic acid (a fatty acid that occurs naturally in coconut oil and breast milk) [52].
  • Artemisinin (from sweet wormwood) [53, 54, 55, 56]
  • Thymol and carvacrol (in oregano oil) [57, 58

Conventional antifungal medicines include fluconazole, miconazole, clotrimazole, and nystatin. Oral tablet or capsule versions are available for intestinal or systemic infections. They can also come as ointments or creams for fungal infections on the skin, or in suppositories for vulvovaginal candidiasis. 

In general, I prefer to use herbal antimicrobials, which tend to have a broad-acting pharmacology, and therefore contribute less to the rise of antifungal- and antimicrobial-resistant organisms [59, 60, 61]. They are also less likely to have unpleasant side effects [62] or negatively disrupt the gut microbiome [63].

Antimicrobials with antifungal actions can be useful to get rid of intestinal Candida overgrowths. However, I recommend them as a final resort because it is so important to prime the whole gut ecosystem with foundational support first, via steps 1–3. 

The way to look at it is that diet, lifestyle, and probiotics by themselves can often be enough to foster the beneficial bacteria that keep Candida in check. Herbal antimicrobials are certainly something to consider with your healthcare provider as an extra help, but only when the first supportive elements are in place.

Key Takeaway: Our 4-step Candida treatment plan: 
1. Improve your diet and lifestyle.
2. Try probiotics if needed.
3. Use an elemental diet gut reset if your treatment needs a boost.
4. For stubborn symptoms, and with a clinician’s support, try antimicrobials.

Candida Knowledge Makes For More Effective Treatment

Candida is a natural resident of the gut microbiome that can live peacefully alongside other gut microbes but will sometimes overgrow because of an imbalanced diet and lifestyle.

If you suspect you have an intestinal Candida overgrowth, fixating on special anti-Candida diets or getting your Candida levels down to a particular level as measured by a stool test isn’t the way forward. The only reliable way to tackle it is to bolster your overall gut health. 

If you go through this process but still haven’t completely nailed your Candida symptoms, we are here to help. Check out my book Healthy Gut, Healthy You for my complete Great-in-8 gut healing protocol, or contact us at the Ruscio Institute for Functional Health to schedule an appointment. 

The Ruscio Institute has developed a range of high-quality formulations to help our patients and audience. If you’re interested in learning more about these products, please click here. Note that there are many other options available, and we encourage you to research which products may be right for you.

Paste end of the article here. Either “Wrap Up” or “Conclusion” or last “Bottom Line.” Add an “Anchor” block above each heading.

➕ References
  1. Delavy M, Sertour N, Patin E, Le Chatelier E, Cole N, Dubois F, et al. Unveiling Candida albicans intestinal carriage in healthy volunteers: the role of micro- and mycobiota, diet, host genetics and immune response. Gut Microbes. 2023 Dec;15(2):2287618. DOI: 10.1080/19490976.2023.2287618. PMID: 38017705. PMCID: PMC10732203.
  2. Talapko J, Juzbašić M, Matijević T, Pustijanac E, Bekić S, Kotris I, et al. Candida albicans-The Virulence Factors and Clinical Manifestations of Infection. J Fungi (Basel). 2021 Jan 22;7(2). DOI: 10.3390/jof7020079. PMID: 33499276. PMCID: PMC7912069.
  3. Nkuo-Akenji TK, Ndip RN, Ntoko FA. The prevalence of Candida albicans-associated diarrhoea in Buea, South West Cameroon. Afr J Health Sci. 2002;9(3–4):153–7. DOI: 10.4314/ajhs.v9i2.30769. PMID: 17298159.
  4. Brunetti G, Giuliani A, Navazio AS, Paradisi C, Raponi F, Conti LA, et al. Candida gut colonization, yeast species distribution, and biofilm production in Clostridioides difficile infected patients: a comparison between three populations in two different time periods. Braz J Microbiol. 2021 Dec;52(4):1845–52. DOI: 10.1007/s42770-021-00512-4. PMID: 34264501. PMCID: PMC8578342.
  5. Otašević S, Momčilović S, Petrović M, Radulović O, Stojanović NM, Arsić-Arsenijević V. The dietary modification and treatment of intestinal Candida overgrowth – a pilot study. J Mycol Med. 2018 Dec;28(4):623–7. DOI: 10.1016/j.mycmed.2018.08.002. PMID: 30166063.
  6. Ezeonu IM, Ntun NW, Ugwu KO. Intestinal candidiasis and antibiotic usage in children: case study of Nsukka, South Eastern Nigeria. Afr Health Sci. 2017 Dec;17(4):1178–84. DOI: 10.4314/ahs.v17i4.27. PMID: 29937890. PMCID: PMC5870271.
  7. GI-MAP Sample Report.pdf – Google Drive [Internet]. [cited 2024 Mar 21]. Available from: https://drive.google.com/file/d/1pOGKXWd8Opv4kfpWuJUax6GvOOg-TbLg/view
  8. van Thiel I, de Jonge W, van den Wijngaard R. Fungal feelings in the irritable bowel syndrome: the intestinal mycobiome and abdominal pain. Gut Microbes. 2023;15(1):2168992. DOI: 10.1080/19490976.2023.2168992. PMID: 36723172. PMCID: PMC9897793.
  9. Yeo SF, Wong B. Current status of nonculture methods for diagnosis of invasive fungal infections. Clin Microbiol Rev. 2002 Jul;15(3):465–84. DOI: 10.1128/CMR.15.3.465-484.2002. PMID: 12097252. PMCID: PMC118074.
  10. Yeo SF, Huie S, Sofair AN, Campbell S, Durante A, Wong B. Measurement of serum D-arabinitol/creatinine ratios for initial diagnosis and for predicting outcome in an unselected, population-based sample of patients with Candida fungemia. J Clin Microbiol. 2006 Nov;44(11):3894–9. DOI: 10.1128/JCM.01045-06. PMID: 16957030. PMCID: PMC1698297.
  11. Barantsevich N, Barantsevich E. Diagnosis and treatment of invasive candidiasis. Antibiotics (Basel). 2022 May 26;11(6). DOI: 10.3390/antibiotics11060718. PMID: 35740125. PMCID: PMC9219674.
  12. Jacobs C, Coss Adame E, Attaluri A, Valestin J, Rao SSC. Dysmotility and proton pump inhibitor use are independent risk factors for small intestinal bacterial and/or fungal overgrowth. Aliment Pharmacol Ther. 2013 Jun;37(11):1103–11. DOI: 10.1111/apt.12304. PMID: 23574267. PMCID: PMC3764612.
  13. Jawhara S. Healthy diet and lifestyle improve the gut microbiota and help combat fungal infection. Microorganisms. 2023 Jun 11;11(6). DOI: 10.3390/microorganisms11061556. PMID: 37375058. PMCID: PMC10302699.
  14. Bishehsari F, Magno E, Swanson G, Desai V, Voigt RM, Forsyth CB, et al. Alcohol and Gut-Derived Inflammation. Alcohol Res. 2017;38(2):163–71. PMID: 28988571. PMCID: PMC5513683.
  15. Engen PA, Green SJ, Voigt RM, Forsyth CB, Keshavarzian A. The gastrointestinal microbiome: alcohol effects on the composition of intestinal microbiota. Alcohol Res. 2015;37(2):223–36. PMID: 26695747. PMCID: PMC4590619.
  16. Antinozzi M, Giffi M, Sini N, Gallè F, Valeriani F, De Vito C, et al. Cigarette smoking and human gut microbiota in healthy adults: A systematic review. Biomedicines. 2022 Feb 21;10(2). DOI: 10.3390/biomedicines10020510. PMID: 35203720. PMCID: PMC8962244.
  17. Vanuytsel T, van Wanrooy S, Vanheel H, Vanormelingen C, Verschueren S, Houben E, et al. Psychological stress and corticotropin-releasing hormone increase intestinal permeability in humans by a mast cell-dependent mechanism. Gut. 2014 Aug;63(8):1293–9. DOI: 10.1136/gutjnl-2013-305690. PMID: 24153250.
  18. Karl JP, Margolis LM, Madslien EH, Murphy NE, Castellani JW, Gundersen Y, et al. Changes in intestinal microbiota composition and metabolism coincide with increased intestinal permeability in young adults under prolonged physiological stress. Am J Physiol Gastrointest Liver Physiol. 2017 Jun 1;312(6):G559–71. DOI: 10.1152/ajpgi.00066.2017. PMID: 28336545.
  19. Aminzadeh A, Sabeti Sanat A, Nik Akhtar S. Frequency of Candidiasis and Colonization of Candida albicans in Relation to Oral Contraceptive Pills. Iran Red Crescent Med J. 2016 Oct;18(10):e38909. DOI: 10.5812/ircmj.38909. PMID: 28184328. PMCID: PMC5291939.
  20. Lin X, Li Z, Zuo X. [Study on the relationship between vaginal and intestinal candida in patients with vulvovaginal candidiasis]. Zhonghua Fu Chan Ke Za Zhi. 2011 Jul;46(7):496–500. PMID: 22041440.
  21. Gundogdu A, Nalbantoglu OU. The role of the Mediterranean diet in modulating the gut microbiome: A review of current evidence. Nutrition. 2023 Oct;114:112118. DOI: 10.1016/j.nut.2023.112118. PMID: 37437419.
  22. Sofi F, Cesari F, Abbate R, Gensini GF, Casini A. Adherence to Mediterranean diet and health status: meta-analysis. BMJ. 2008 Sep 11;337:a1344. DOI: 10.1136/bmj.a1344. PMID: 18786971. PMCID: PMC2533524.
  23. Rosato V, Guercio V, Bosetti C, Negri E, Serraino D, Giacosa A, et al. Mediterranean diet and colorectal cancer risk: a pooled analysis of three Italian case-control studies. Br J Cancer. 2016 Sep 27;115(7):862–5. DOI: 10.1038/bjc.2016.245. PMID: 27537381. PMCID: PMC5046203.
  24. Loke GMI, Low J, Danaher J. The influence of the Mediterranean diet on mood states, anxiety, and depression. Proc Nutr Soc. 2023;82(OCE2). DOI: 10.1017/S0029665123000733.
  25. Whalen KA, McCullough ML, Flanders WD, Hartman TJ, Judd S, Bostick RM. Paleolithic and Mediterranean Diet Pattern Scores Are Inversely Associated with Biomarkers of Inflammation and Oxidative Balance in Adults. J Nutr. 2016 Jun;146(6):1217–26. DOI: 10.3945/jn.115.224048. PMID: 27099230. PMCID: PMC4877627.
  26. Olendzki BC, Silverstein TD, Persuitte GM, Ma Y, Baldwin KR, Cave D. An anti-inflammatory diet as treatment for inflammatory bowel disease: a case series report. Nutr J. 2014 Jan 16;13:5. DOI: 10.1186/1475-2891-13-5. PMID: 24428901. PMCID: PMC3896778.
  27. Lupp C, Robertson ML, Wickham ME, Sekirov I, Champion OL, Gaynor EC, et al. Host-mediated inflammation disrupts the intestinal microbiota and promotes the overgrowth of Enterobacteriaceae. Cell Host Microbe. 2007 Aug 16;2(2):119–29. DOI: 10.1016/j.chom.2007.06.010. PMID: 18005726.
  28. Nistal E, Caminero A, Herrán AR, Arias L, Vivas S, de Morales JMR, et al. Differences of small intestinal bacteria populations in adults and children with/without celiac disease: effect of age, gluten diet, and disease. Inflamm Bowel Dis. 2012 Apr;18(4):649–56. DOI: 10.1002/ibd.21830. PMID: 21826768.
  29. Hakansson A, Molin G. Gut microbiota and inflammation. Nutrients. 2011 Jun 3;3(6):637–82. DOI: 10.3390/nu3060637. PMID: 22254115. PMCID: PMC3257638.
  30. Lobionda S, Sittipo P, Kwon HY, Lee YK. The Role of Gut Microbiota in Intestinal Inflammation with Respect to Diet and Extrinsic Stressors. Microorganisms. 2019 Aug 19;7(8). DOI: 10.3390/microorganisms7080271. PMID: 31430948. PMCID: PMC6722800.
  31. Monda V, Villano I, Messina A, Valenzano A, Esposito T, Moscatelli F, et al. Exercise Modifies the Gut Microbiota with Positive Health Effects. Oxid Med Cell Longev. 2017 Mar 5;2017:3831972. DOI: 10.1155/2017/3831972. PMID: 28357027. PMCID: PMC5357536.
  32. Momma H, Kawakami R, Honda T, Sawada SS. Muscle-strengthening activities are associated with lower risk and mortality in major non-communicable diseases: a systematic review and meta-analysis of cohort studies. Br J Sports Med. 2022 Jul;56(13):755–63. DOI: 10.1136/bjsports-2021-105061. PMID: 35228201. PMCID: PMC9209691.
  33. Lee DH, Rezende LFM, Joh H-K, Keum N, Ferrari G, Rey-Lopez JP, et al. Long-Term Leisure-Time Physical Activity Intensity and All-Cause and Cause-Specific Mortality: A Prospective Cohort of US Adults. Circulation. 2022 Aug 16;146(7):523–34. DOI: 10.1161/CIRCULATIONAHA.121.058162. PMID: 35876019. PMCID: PMC9378548.
  34. Meyer H, Goettlicher S, Mendling W. Stress as a cause of chronic recurrent vulvovaginal candidosis and the effectiveness of the conventional antimycotic therapy. Mycoses. 2006 May;49(3):202–9. DOI: 10.1111/j.1439-0507.2006.01235.x. PMID: 16681811.
  35. Schumann D, Anheyer D, Lauche R, Dobos G, Langhorst J, Cramer H. Effect of yoga in the therapy of irritable bowel syndrome: a systematic review. Clin Gastroenterol Hepatol. 2016 Dec;14(12):1720–31. DOI: 10.1016/j.cgh.2016.04.026. PMID: 27112106.
  36. Shuda Q, Bougoulias ME, Kass R. Effect of nature exposure on perceived and physiologic stress: A systematic review. Complement Ther Med. 2020 Sep;53:102514. DOI: 10.1016/j.ctim.2020.102514. PMID: 33066853.
  37. Corazon SS, Sidenius U, Poulsen DV, Gramkow MC, Stigsdotter UK. Psycho-Physiological Stress Recovery in Outdoor Nature-Based Interventions: A Systematic Review of the Past Eight Years of Research. Int J Environ Res Public Health. 2019 May 16;16(10). DOI: 10.3390/ijerph16101711. PMID: 31100773. PMCID: PMC6572302.
  38. Sudimac S, Sale V, Kühn S. How nature nurtures: Amygdala activity decreases as the result of a one-hour walk in nature. Mol Psychiatry. 2022 Nov;27(11):4446–52. DOI: 10.1038/s41380-022-01720-6. PMID: 36059042. PMCID: PMC9734043.
  39. Rosenfeldt V, Benfeldt E, Valerius NH, Paerregaard A, Michaelsen KF. Effect of probiotics on gastrointestinal symptoms and small intestinal permeability in children with atopic dermatitis. J Pediatr. 2004 Nov;145(5):612–6. DOI: 10.1016/j.jpeds.2004.06.068. PMID: 15520759.
  40. Mujagic Z, de Vos P, Boekschoten MV, Govers C, Pieters H-JHM, de Wit NJW, et al. The effects of Lactobacillus plantarum on small intestinal barrier function and mucosal gene transcription; a randomized double-blind placebo controlled trial. Sci Rep. 2017 Jan 3;7:40128. DOI: 10.1038/srep40128. PMID: 28045137. PMCID: PMC5206730.
  41. Yan F, Polk DB. Probiotics and immune health. Curr Opin Gastroenterol. 2011 Oct;27(6):496–501. DOI: 10.1097/MOG.0b013e32834baa4d. PMID: 21897224. PMCID: PMC4006993.
  42. Demirel G, Celik IH, Erdeve O, Saygan S, Dilmen U, Canpolat FE. Prophylactic Saccharomyces boulardii versus nystatin for the prevention of fungal colonization and invasive fungal infection in premature infants. Eur J Pediatr. 2013 Oct;172(10):1321–6. DOI: 10.1007/s00431-013-2041-4. PMID: 23703468.
  43. Mollazadeh-Narestan Z, Yavarikia P, Homayouni-Rad A, Samadi Kafil H, Mohammad-Alizadeh-Charandabi S, Gholizadeh P, et al. Comparing the Effect of Probiotic and Fluconazole on Treatment and Recurrence of Vulvovaginal Candidiasis: a Triple-Blinded Randomized Controlled Trial. Probiotics Antimicrob Proteins. 2023 Oct;15(5):1436–46. DOI: 10.1007/s12602-022-09997-3. PMID: 36198994. PMCID: PMC9534588.
  44. American College of Gastroenterology Task Force on Irritable Bowel Syndrome, Brandt LJ, Chey WD, Foxx-Orenstein AE, Schiller LR, Schoenfeld PS, et al. An evidence-based position statement on the management of irritable bowel syndrome. Am J Gastroenterol. 2009 Jan;104 Suppl 1:S1-35. DOI: 10.1038/ajg.2008.122. PMID: 19521341.
  45. Ford AC, Quigley EMM, Lacy BE, Lembo AJ, Saito YA, Schiller LR, et al. Efficacy of prebiotics, probiotics, and synbiotics in irritable bowel syndrome and chronic idiopathic constipation: systematic review and meta-analysis. Am J Gastroenterol. 2014 Oct;109(10):1547–61; quiz 1546, 1562. DOI: 10.1038/ajg.2014.202. PMID: 25070051.
  46. Zhang C, Jiang J, Tian F, Zhao J, Zhang H, Zhai Q, et al. Meta-analysis of randomized controlled trials of the effects of probiotics on functional constipation in adults. Clin Nutr. 2020 Oct;39(10):2960–9. DOI: 10.1016/j.clnu.2020.01.005. PMID: 32005532.
  47. Heuschkel RB, Menache CC, Megerian JT, Baird AE. Enteral nutrition and corticosteroids in the treatment of acute Crohn’s disease in children. J Pediatr Gastroenterol Nutr. 2000 Jul;31(1):8–15. DOI: 10.1097/00005176-200007000-00005. PMID: 10896064.
  48. Takagi S, Utsunomiya K, Kuriyama S, Yokoyama H, Takahashi S, Iwabuchi M, et al. Effectiveness of an “half elemental diet” as maintenance therapy for Crohn’s disease: A randomized-controlled trial. Aliment Pharmacol Ther. 2006 Nov 1;24(9):1333–40. DOI: 10.1111/j.1365-2036.2006.03120.x. PMID: 17059514.
  49. Pimentel M, Constantino T, Kong Y, Bajwa M, Rezaei A, Park S. A 14-day elemental diet is highly effective in normalizing the lactulose breath test. Dig Dis Sci. 2004 Jan;49(1):73–7. DOI: 10.1023/b:ddas.0000011605.43979.e1. PMID: 14992438.
  50. Purssell E. Antimicrobials. In: Hood P, Khan E, editors. Understanding pharmacology in nursing practice. Cham: Springer International Publishing; 2020. p. 147–65. DOI: 10.1007/978-3-030-32004-1_6.
  51. Ionescu MI. Are herbal products an alternative to antibiotics? In: Kırmusaoğlu S, editor. Bacterial pathogenesis and antibacterial control. InTech; 2018. DOI: 10.5772/intechopen.72110.
  52. Omura Y, O’Young B, Jones M, Pallos A, Duvvi H, Shimotsuura Y. Caprylic acid in the effective treatment of intractable medical problems of frequent urination, incontinence, chronic upper respiratory infection, root canalled tooth infection, ALS, etc., caused by asbestos & mixed infections of Candida albicans, Helicobacter pylori & cytomegalovirus with or without other microorganisms & mercury. Acupunct Electrother Res. 2011;36(1–2):19–64. PMID: 21830350.
  53. Chen Y-X, Lai L-N, Zhang H-Y, Bi Y-H, Meng L, Li X-J, et al. Effect of artesunate supplementation on bacterial translocation and dysbiosis of gut microbiota in rats with liver cirrhosis. World J Gastroenterol. 2016 Mar 14;22(10):2949–59. DOI: 10.3748/wjg.v22.i10.2949. PMID: 26973391. PMCID: PMC4779918.
  54. Liu Y, Yang Y, Lei Y, Yang L, Zhang X, Yuan J, et al. Effects of dihydroartemisinin on the gut microbiome of mice. Mol Med Report. 2020 Aug;22(2):707–14. DOI: 10.3892/mmr.2020.11165. PMID: 32468008. PMCID: PMC7339414.
  55. Lei Z, Yang Y, Liu S, Lei Y, Yang L, Zhang X, et al. Dihydroartemisinin ameliorates dextran sulfate sodium induced inflammatory bowel diseases in mice. Bioorg Chem. 2020 May 12;100:103915. DOI: 10.1016/j.bioorg.2020.103915. PMID: 32450383.
  56. Priotto G, Kabakyenga J, Pinoges L, Ruiz A, Eriksson T, Coussement F, et al. Artesunate and sulfadoxine-pyrimethamine combinations for the treatment of uncomplicated Plasmodium falciparum malaria in Uganda: a randomized, double-blind, placebo-controlled trial. Trans R Soc Trop Med Hyg. 2003 Jun;97(3):325–30. PMID: 15228253.
  57. Mechan AO, Fowler A, Seifert N, Rieger H, Wöhrle T, Etheve S, et al. Monoamine reuptake inhibition and mood-enhancing potential of a specified oregano extract. Br J Nutr. 2011 Apr;105(8):1150–63. DOI: 10.1017/S0007114510004940. PMID: 21205415.
  58. Sharifi-Rad M, Varoni EM, Iriti M, Martorell M, Setzer WN, Del Mar Contreras M, et al. Carvacrol and human health: A comprehensive review. Phytother Res. 2018 Sep;32(9):1675–87. DOI: 10.1002/ptr.6103. PMID: 29744941.
  59. Shaheen G, Akram M, Jabeen F, Ali Shah SM, Munir N, Daniyal M, et al. Therapeutic potential of medicinal plants for the management of urinary tract infection: A systematic review. Clin Exp Pharmacol Physiol. 2019 Jul;46(7):613–24. DOI: 10.1111/1440-1681.13092. PMID: 30932202.
  60. Lee J-Y, Abundo MEC, Lee C-W. Herbal Medicines with Antiviral Activity Against the Influenza Virus, a Systematic Review. Am J Chin Med. 2018;46(8):1663–700. DOI: 10.1142/S0192415X18500854. PMID: 30612461.
  61. Hsu H, Sheth CC, Veses V. Herbal Extracts with Antifungal Activity against Candida albicans: A Systematic Review. Mini Rev Med Chem. 2021;21(1):90–117. DOI: 10.2174/1389557520666200628032116. PMID: 32600229.
  62. Chen C, Tao C, Liu Z, Lu M, Pan Q, Zheng L, et al. A Randomized Clinical Trial of Berberine Hydrochloride in Patients with Diarrhea-Predominant Irritable Bowel Syndrome. Phytother Res. 2015 Nov;29(11):1822–7. DOI: 10.1002/ptr.5475. PMID: 26400188.
  63. Yang K, Zhang L, Liao P, Xiao Z, Zhang F, Sindaye D, et al. Impact of gallic acid on gut health: focus on the gut microbiome, immune response, and mechanisms of action. Front Immunol. 2020 Sep 16;11:580208. DOI: 10.3389/fimmu.2020.580208. PMID: 33042163. PMCID: PMC7525003.

Need help or would like to learn more?
View Dr. Ruscio’s, DC additional resources

Get Help

Discussion

I care about answering your questions and sharing my knowledge with you. Leave a comment or connect with me on social media asking any health question you may have and I just might incorporate it into our next listener questions podcast episode just for you!