What Are Healthy Levels for Thyroid Antibodies

Understanding Thyroid Antibodies: Why Is My Thyroglobulin Antibody High?

Thyroid Autoimmunity and the Importance and Limitations of Elevated Thyroid Antibodies 

Key Points

  • Thyroglobulin antibodies do not appear to correlate with thyroid health, except in select cases.
  • Thyroid peroxidase antibodies (TPO) show greater correlation with thyroid disease and can help monitor disease progression.
  • You should use caution when interpreting the usefulness of thyroid peroxidase antibodies.
  • There are many holistic ways to address elevated thyroid antibody levels and improve thyroid health.

If a recent lab test showed that you have elevated thyroglobulin antibodies, your next question might be “why is my thyroglobulin antibody high?” and, “How can I bring it down to a normal level?” However, when it comes to thyroid antibodies, striving for perfection may be overrated. Elevated levels of thyroid antibodies do not necessarily correlate with your thyroid health or symptoms. 

Thyroglobulin antibodies are notoriously difficult for health care providers to interpret and for patients to understand. Often the level of antibody that is produced does not correlate with clinical hypothyroidism or symptom control.

In this article, we will break down the importance of thyroid antibodies including thyroglobulin and thyroid peroxidase antibodies (TPO), when elevated levels actually matter, and what you can do about it.

I Found Out My Thyroglobulin Antibody Is High. Now What?

Thyroglobulin antibody high: woman with sore throat

Despite thyroglobulin (TG) antibody levels showing a correlation with thyroid health, research supports that they are not a strong predictor of thyroid disease. There are much more reliable tests for diagnosing Hashimoto’s thyroiditis, such as TPO-antibodies, TSH levels, and thyroxine levels. 

Hashimoto’s thyroiditis is a common autoimmune condition that causes the immune system to attack the thyroid gland. In some cases, this leads to hypothyroidism, however this is much less common than many people assume (only about 9-19% of Hashimoto’s patients ever develop hypothyroidism). 

Hashimoto’s is diagnosed by several thyroid function tests, such as [1 Trusted SourcePubMedGo to source]:

  • Elevated thyroid stimulating hormone (TSH) levels.
  • Low thyroid hormone levels, reported as free or total T3 and T4
  • Elevated thyroid peroxidase (TPO) antibodies
  • Elevated thyroglobulin (TG) antibodies 
  • Elevated TSH antibodies 

While TPO-antibodies are more indicative of Hashimoto’s thyroiditis, elevated anti-TG antibodies are often reported on lab results, creating concern for patients. 

A 2019 study found that anti-TG antibodies are elevated in 60-80% of patients with Hashimoto’s thyroiditis and in 40-60% of those with Grave’s disease. However, the presence of thyroglobulin antibodies showed only a low-to-moderate sensitivity in diagnosing autoimmune thyroiditis. Additionally, they were not useful in identifying when a patient has transitioned from subclinical to overt hypothyroidism (when hypothyroidism is visible on lab results) [2 Trusted SourcePubMedGo to source].

Thyroglobulin antibodies can even be incidental findings in patients with normal thyroid function [2 Trusted SourcePubMedGo to source]. This means that patients with no other laboratory signs or physical symptoms of thyroid disease can have elevated thyroglobulin antibodies.

It is no wonder that these elusive antibodies cause so much confusion to health care providers and patients. 

What Are Thyroid Antibodies?

Antibodies are not inherently bad and are actually a very important part of our immune system. When the body detects foreign pathogens, such as bacterial or viral infections, it produces proteins called antibodies. These proteins help recruit other immune cells and fight off intruders. 

However, in some people, the immune system goes awry and starts to produce antibodies against normal body tissue. In the case of thyroid autoimmune disorders, like Hashimoto’s hypothyroidism and Grave’s disease, the immune system mistakenly produces antibodies that attack the thyroid cells.

When they go unchecked, these antibodies can lead to inflammation in the thyroid — known as “thyroiditis.” This destruction to the gland may eventually cause the person to enter a hypothyroid or hyperthyroid state. 

Not everyone who has antithyroid antibodies is hypothyroid, but some people with elevated TPO, TSH, or TG antibodies will eventually become hypothyroid. Furthermore, some patients with thyroid disease may never show elevated levels of any thyroid antibodies [1 Trusted SourcePubMedGo to source]. 

Certain Conditions Can Make Your Thyroglobulin Antibody High

Even though antithyroglobulin antibodies are not the best predictor of thyroid disorders, they should not necessarily be ignored. Unlike TPO antibodies, thyroglobulin antibodies are not able to stimulate an immune response in the thyroid, but they may be useful in diagnosing certain thyroid conditions [2 Trusted SourcePubMedGo to source, 3 Trusted SourcePubMedGo to source].

Anti-TG antibody levels may show importance in the following:

  • Patients diagnosed with thyroid carcinoma who have elevated TG antibodies may be at a higher risk of the cancer spreading to lymph nodes or surrounding organs. Elevated levels may also indicate a high risk of thyroid cancer recurrence after treatment [4 Trusted SourcePubMedGo to source].
  • Breast cancer patients may also have thyroglobulin antibody high test results [4 Trusted SourcePubMedGo to source].
  • Elevated TG-antibodies may have a higher prevalence in those with autoimmune connective tissue disease. This suggests that screening for thyroid disease in these populations may be beneficial [5 Trusted SourcePubMedGo to source]. 

One study found that after successfully treating thyroid disease, thyroglobulin levels dropped back down into normal reference ranges [6 Trusted SourcePubMedGo to source]. It is important to point out that this study tested the actual levels of thyroglobulin protein, not the TG-antibody levels. 

However, this finding is consistent with another study that found elevated anti-TG antibodies to correlate with the severity of hypothyroid symptoms, including fragile hair, swelling of the face and eyes, and vocal hoarseness [3 Trusted SourcePubMedGo to source].

Thyroglobulin autoantibodies may not be the best indicator of thyroid disease, but likely will continue to be useful in the screening and monitoring of select conditions. 

Thyroglobulin antibody high: person getting a pill from a spoonful of pills

Thyroglobulin and Iodine Levels

Thyroglobulin is a protein secreted by the thyroid gland that aids in the production and storage of thyroid hormones. TG fluctuates with iodine levels, and high thyroglobulin levels may be an indicator of iodine deficiency or excess [7 Trusted SourcePubMedGo to source, 8 Trusted SourcePubMedGo to source].

Iodine is a nutrient that is essential for the proper functioning of our thyroid gland. Iodine deficiency is an independent risk factor for underactive thyroid and can even lead to the development of a goiter (enlarged thyroid gland) and thyroid nodules [7 Trusted SourcePubMedGo to source].

Excess iodine blood levels can create toxicity symptoms, such as stomach pain, nausea and vomiting, and neurological dysfunction. Therefore, screening thyroglobulin levels may be useful in detecting abnormal iodine levels, as iodine is not routinely run on blood tests.

Other Thyroid Antibodies Like TPO May Be More Useful

Thyroid peroxidase antibody (TPO) levels are a much stronger indicator of an increased risk for thyroid disease. TPO antibodies are 90% sensitive in detecting thyroiditis, and are effective in monitoring the progression and severity of thyroid conditions [2 Trusted SourcePubMedGo to source].

Unlike thyroglobulin antibodies, TPO antibodies can stimulate the immune system and cause inflammation in thyroid tissue, leading to the development of thyroid disease [2 Trusted SourcePubMedGo to source]. However, monitoring anti-TPO antibodies come with their own limitations.

The “normal” reference range for TPO antibodies is less than 35 IU/mL. But a 2016 study published in the Journal of Hormone and Metabolic Research [9 Trusted SourcePubMedGo to source] found:

  • Those who had TPO antibodies below 500 IU/mL had a low risk of future progression to hypothyroidism. 
  • Those who were above 500 IU/mL still only had a moderate risk. 

The Tehran Thyroid Study, which followed the course of thyroid disease in a large cohort of people over nine years, showed similar results: those with elevated TPO antibodies only had a 9-19% chance of becoming hypothyroid after 6 years of follow up [10 Trusted SourcePubMedGo to source, 11 Trusted SourcePubMedGo to source].

If we consider this, elevated thyroid antibodies are not as consequential as many thyroid experts would suggest. 

I’ve commonly seen people with Hashimoto’s disease or elevated thyroid antibodies become hyper-focused on reducing their antibody test results to the “normal” reference range, and becoming unnecessarily stressed. The research suggests this isn’t necessary. 

Instead, it implies that only a minority of patients with elevated TPO antibodies will progress to full hypothyroidism. What this means for you is that you don’t have to continuously pursue lower and lower levels of antibodies with strict diets or supplements, especially if your thyroid symptoms are under control.

If you’re a patient, or a doctor working with patients, it’s important to understand that reducing TPO antibodies to under 500 IU/mL—or getting your thyroid symptoms under control through other means—is a clinical win.

Very High Thyroid Antibodies

All that said, if your TPO antibodies are very high, reducing your antibody count is definitely a worthwhile goal. The higher the antibodies, the more likely you are to develop hypothyroidism.

The farther you reduce your antibodies, even if you can’t get them down to 500 IU/mL, the less damage to your thyroid gland. Just don’t feel discouraged by failing to get them down to the “normal” reference range.

4 Ways to Reduce Thyroid Antibodies

There are several ways you can reduce your thyroid antibodies and improve your thyroid function, using diet and lifestyle.

1. Improve Your Gut Health

Preliminary evidence suggests that gut health is closely linked to thyroid health and that improving gut health can decrease thyroid antibodies and balance your thyroid hormones. Here are several ways you can work on improving your gut health.

2. Supplements

Woman getting an infrared facial

3. Light Therapy

There are some encouraging data showing that low-level laser therapy can improve thyroid function and decrease TPO antibodies. The therapy also reduced the amount of levothyroxine medication the patients needed, even after nine months of follow-up [36 Trusted SourcePubMedGo to source, 37 Trusted SourcePubMedGo to source].

4. Optimize Iodine Levels

Iodine is an important nutrient for the thyroid gland, but must be used cautiously. Supplemental dietary iodine has been shown in several population-based studies to increase the incidence of autoimmune thyroid diseases [38 Trusted SourcePubMedGo to source, 39 Trusted SourcePubMedGo to source]. On the other hand, too little iodine can also cause thyroid symptoms. Optimizing your iodine levels may reduce thyroid antibodies.

For more on how to optimize your iodine, including how to test, see How Should I Use Thyroid Supplements?

Final Thoughts on Thyroid Antibodies

In summary, thyroglobulin antibody high levels likely hold little clinical relevance to the presence and severity of thyroid disease. TPO antibodies are a greater indicator of thyroid health and can be used to monitor the progression of thyroid dysfunction. 

However, even TPO antibodies come with their own limitations. Unless your TPO antibodies are very high, it’s not necessary to be hyper-focused on reducing your thyroid antibodies to the lab reference range. Reducing elevated TPO thyroid antibodies to below 500 IU/mL, and improving your thyroid function with diet and lifestyle changes significantly reduces your risk of developing hypothyroidism.

If you want help with reducing thyroglobulin antibody high levels or reducing thyroid symptoms, schedule an appointment at our center for functional medicine.

The Ruscio Institute has developed a range of high quality formulations to help our patients and audience. If you’re interested in learning more about these products, please click here. Note that there are many other options available, and we encourage you to research which products may be right for you.

➕ References
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Discussion

I care about answering your questions and sharing my knowledge with you. Leave a comment or connect with me on social media asking any health question you may have and I just might incorporate it into our next listener questions podcast episode just for you!

561 thoughts on “Understanding Thyroid Antibodies: Why Is My Thyroglobulin Antibody High?

    1. Hey Susan,
      One study showed increased risk occurred when TG were 10 times the reference range, and below that the risk was minimal… but we know less about TG, in my opinion.

    2. I also have the TG antibodies, not the TPO. @susan are you taking any hormone replacement for this, whats your TSH (if you dont mind me asking) Thank you so much!
      Becky

  1. Hi Dr Ruscio:

    My TSH fluctuates between .1 to 4.5….causing me to constantly be jockying my meds between one dose and the next higher. Meanwhile, my TPO has gone between 297 and 335, which would sound pretty good, according to what you say in your video. So, could that mean that I don’t really have Hashimoto’s but rather just hypothyroidism?

    Thanks for all you do!
    Sheri

    1. Hi Sheri,
      Those levels for TPO are favorable. The reason why your dose fluctuates may be due to impaired absorption. Improving your gut health may enable you to have a more steady dose. Also, Tirosint which is a liquid Rx may help also. I would mention this to a good clinician.

      1. Thanks, Dr, Ruscio. Appreciate that! I’ll focus more on my gut. I am taking Tirosint and alternate every-other day with .88 and .100 mcg. I’ve just taken my blood labs and am waiting for results to see if that is working. Many thanks for your brilliant insights. You’re the best!

        1. all my blood work cam back he says its all normal…….
          here r the others
          my thyrotropin binding inhibitory immunoglobulin was >1.00iu/l
          cbc was normal
          lft hepatic panel all normal
          t3 total 116
          free t4 1.7
          tsh 2.31

  2. I have a TPO of 370 and TSH 7.96 with no symptoms other than weight gain. I am not taking any meds but have been advised to by my PCP. Is it Hashimotos and therefore hypothroidism and is it okay not to treat with meds since I feel fine?

      1. Thank you doctor for giving me hope. I have been on Hashimoto protocol for 6 months and my TPO antibodies are below 40. Feeling I have lots of energy and going to do some blood work to see if the dose can be lowered 🙂 I also lost 30 pounds 😉

          1. Hello Dr ,

            What do anti tpo bodies represent?

            I see No co Relation between anti tpo Count and TSH value?

            I have No symptoms.

            TSH 6.7
            Ft5 and ft3 are normal
            Tpo Count ist 15000

            What does this implying.

            Some people habe Symptoms at TSH 5 …and antibodies value Just in a few hundreds.

            Why does this Happen?

    1. Hello
      how are your tpo Count now .?
      Mine is 15000 with normal ft4 and ft3. TSH ist 6.7.

      I was Wondering If There is a Direct co Relation between TSH value and tpo Antibody Count.

  3. My Thyroid Peroxidase antibodies are 8131.3. And my Thyroglobulin are 470.1. My report states both should be under 60. I just stared tirosint 100 I still feel awful

  4. Hi there,

    My thyroid antibodies were 29, so slightly below the normal range. My doctor said they really shouldn’t be above zero. I am having them retested but I’m worried about what could be going on.
    Is there a reason why you would have antibodies present? Is it normal?
    Thanks in advance.
    M

    1. Hi Megan,
      In short, I would not be concerned about this. Antibodies perform some normal and necessary housekeeping functions. I will elaborate in a future listener questions podcast.

      1. Thanks for your reply! All of my other thyroid levels were completely normal but I did have very low levels of vitamin d- I think it was 20- so I am on a high dose to help bring it up plus a multivitamin and other supplements. Some research I’ve looked at says low levels of vitamin d can increase antibodies. Not sure if google got that correct or not but thought it was interesting 🙂
        Thanks again!

  5. Hi there,

    My thyroid antibodies were 29, so slightly below the normal range. My doctor said they really shouldn’t be above zero. I am having them retested but I’m worried about what could be going on.
    Is there a reason why you would have antibodies present? Is it normal?
    Thanks in advance.
    M

    1. Hi Megan,
      In short, I would not be concerned about this. Antibodies perform some normal and necessary housekeeping functions. I will elaborate in a future listener questions podcast.

      1. Thanks for your reply! All of my other thyroid levels were completely normal but I did have very low levels of vitamin d- I think it was 20- so I am on a high dose to help bring it up plus a multivitamin and other supplements. Some research I’ve looked at says low levels of vitamin d can increase antibodies. Not sure if google got that correct or not but thought it was interesting 🙂
        Thanks again!

  6. You mention that “…normal is usually defined as at or below 30 or 35 for…TPO or thyroid peroxidase.”

    Mine is 18, which my lab says is high, and I find numerous sources indicating that 0-15 is optimal.

    Any thoughts or comments?

    1. Hi Joel,
      Any of those ranges I consider a ‘clinical win’ meaning indicate very minimal risk of progression of thyroid disease. But, check in with your doctor on this.

      1. I got result for tyroid perox autoAb and it’s <10IU/ML but Standard range is 35IU/ML so is it normal? I am trying to understand. Help!!!!

        1. Hi Sylvia,

          It seems as though it’s indicating your levels are less than 10, which would be below the standard range of 35 (aka the result is normal), but definitely have your practitioner confirm for you.

          Good luck!

        2. My wife is suggested for the anti thyroid peroxidase (Tpo) result is 380.77 and also Thyroid stimulating Immunoglobulin which resulted 0.11, what does that mean I am away from home and want to know the interpretation

          1. Hi there,

            I would suggest watching the video, as Dr Ruscio addresses what the different TPO levels mean. Also, be sure to get an interpretation from your doctor. Good luck!

  7. You mention that “…normal is usually defined as at or below 30 or 35 for…TPO or thyroid peroxidase.”

    Mine is 18, which my lab says is high, and I find numerous sources indicating that 0-15 is optimal.

    Any thoughts or comments?

    1. Hi Joel,
      Any of those ranges I consider a ‘clinical win’ meaning indicate very minimal risk of progression of thyroid disease. But, check in with your doctor on this.

      1. I got result for tyroid perox autoAb and it’s <10IU/ML but Standard range is 35IU/ML so is it normal? I am trying to understand. Help!!!!

        1. Hi Sylvia,

          It seems as though it’s indicating your levels are less than 10, which would be below the standard range of 35 (aka the result is normal), but definitely have your practitioner confirm for you.

          Good luck!

        2. My wife is suggested for the anti thyroid peroxidase (Tpo) result is 380.77 and also Thyroid stimulating Immunoglobulin which resulted 0.11, what does that mean I am away from home and want to know the interpretation

          1. Hi there,

            I would suggest watching the video, as Dr Ruscio addresses what the different TPO levels mean. Also, be sure to get an interpretation from your doctor. Good luck!

  8. Hi there ,
    Just recently got some thyroid bloods done privately and was hoping you could interpret them for me as to what the best treatment course of action would be
    TSH: 1.9 uIU/ml
    Free T4: 0.8934 ng/ml
    Free T3: 1.8 pg/ml
    Total T3: 73.563 ng/dl
    Anti Thyroglobulin anti-bodies: 1.51 IU/ml
    Anti Thyroperoxidase anti-bodies: 0.24 kIU/L

    Hormonal profile
    Total Testosterone: 810.46 ng/dl
    Estradiol: 18.8 pg/ml
    FSH: 3.23 IU/ml
    LH: 1.6 IU/ml
    SHBG: 65 nmol/L
    DHEA: 25.7 nmol/L
    Prolactin: 140 IU/ml
    Cortisol (9.30am)- 261 nmol/L

    Would appreciate any advice to help tackle the hypothyroid type symptoms I’m experiencing, young male aged 21 competing in endurance sport
    Thanks

  9. Hi there ,
    Just recently got some thyroid bloods done privately and was hoping you could interpret them for me as to what the best treatment course of action would be
    TSH: 1.9 uIU/ml
    Free T4: 0.8934 ng/ml
    Free T3: 1.8 pg/ml
    Total T3: 73.563 ng/dl
    Anti Thyroglobulin anti-bodies: 1.51 IU/ml
    Anti Thyroperoxidase anti-bodies: 0.24 kIU/L

    Hormonal profile
    Total Testosterone: 810.46 ng/dl
    Estradiol: 18.8 pg/ml
    FSH: 3.23 IU/ml
    LH: 1.6 IU/ml
    SHBG: 65 nmol/L
    DHEA: 25.7 nmol/L
    Prolactin: 140 IU/ml
    Cortisol (9.30am)- 261 nmol/L

    Would appreciate any advice to help tackle the hypothyroid type symptoms I’m experiencing, young male aged 21 competing in endurance sport
    Thanks

  10. Sir I have no symptoms nor any history of thyroid disorders. Coincidentally I went for blood tests tsh was 5.7 and t4 normal. But my tpo ab were 326 IU/ml. Thus denotes subclinical hypothyroidism do u think it LL later progress to overt. I also don’t take any meds I have a healthy lifestyle too

    1. Hi Hammad,
      The older you are the less important the 5.7 TSH is. Also, that antibody level has been shown to be associated with minimal risk of progression to overt hypothyroidism. Many cases of SCH remit. I would discuss this with your doctor. Hope this helps!

  11. Sir I have no symptoms nor any history of thyroid disorders. Coincidentally I went for blood tests tsh was 5.7 and t4 normal. But my tpo ab were 326 IU/ml. Thus denotes subclinical hypothyroidism do u think it LL later progress to overt. I also don’t take any meds I have a healthy lifestyle too

    1. Hi Hammad,
      The older you are the less important the 5.7 TSH is. Also, that antibody level has been shown to be associated with minimal risk of progression to overt hypothyroidism. Many cases of SCH remit. I would discuss this with your doctor. Hope this helps!

  12. My TPO ab was 590.6 and my doctor said that since I have a family history of thyroid problems, it’s normal.

    The lab results standard range was <=5.5

    The whole reason my TPO was tested was because I had a high TSH of 6.9, which she said was sluggish. I had an ultrasound and a small growth was found, she recommends checking it in 6 months.

    I have an appt with her and I want to know what I should be tested for. I am always tired, sluggish and I am super emotional. I used to go to the gym 5 days a week, I haven&#039t had the energy to go in almost 5 months. My lower limbs are sore every day, like I worked out very hard or hiked 1o miles the day before….as I mentioned, I am not exercising.
    This just all happened recently, I am/was an avid hiker and I eat mostly paleo.

    Any suggestions on whether or not I should have any additional tests run?

    Thank you,

    Kimberly

    1. Hi Kim,
      It really depends on what is suspect based upon your presentation. Sounds like you might have sub-clinical hypothyroid, which often does not require thyroid Rx. If you have not had a thorough gut screening, I would start there. Or you can go through the protocol in my book. See here for more resources, http://www.drruscio.com/gutbook

  13. My TPO ab was 590.6 and my doctor said that since I have a family history of thyroid problems, it’s normal.

    The lab results standard range was <=5.5

    The whole reason my TPO was tested was because I had a high TSH of 6.9, which she said was sluggish. I had an ultrasound and a small growth was found, she recommends checking it in 6 months.

    I have an appt with her and I want to know what I should be tested for. I am always tired, sluggish and I am super emotional. I used to go to the gym 5 days a week, I haven't had the energy to go in almost 5 months. My lower limbs are sore every day, like I worked out very hard or hiked 1o miles the day before….as I mentioned, I am not exercising.
    This just all happened recently, I am/was an avid hiker and I eat mostly paleo.

    Any suggestions on whether or not I should have any additional tests run?

    Thank you,

    Kimberly

    1. Hi Kim,
      It really depends on what is suspect based upon your presentation. Sounds like you might have sub-clinical hypothyroid, which often does not require thyroid Rx. If you have not had a thorough gut screening, I would start there. Or you can go through the protocol in my book. See here for more resources, http://www.drruscio.com/gutbook

  14. Hello,

    Let me start out by saying Thank You, and if this is the wrong forum, my apologies. I had a partial thyroidectomy 1 year ago (half was removed) and just returned home from my 1 year follow-up. I am concerned somewhat by my lab results and wanted to seek your opinion on my results. In April my Thyroglobulin Tumor Marker was 3.3 and my Thyroglobulin Antibody was <0.9. Now in October, my results were Thyroglobulin Tumor Marker 6.2 and Thyroglobulin Antibody was again, <0.9. My lab results also showed my Thyroid Stimulating Hormone at 1.59. My Doctor, who is a very well regarded Surgeon isn&#039t very strong in discussing with me what all of this means. He did however increase my prescription strength from 60 to 90 but was very nonchalant with my questions. I am taking Armor Pig Thyroid. Should I seek a second opionion based on these results? Thank You.

  15. Hello,

    Let me start out by saying Thank You, and if this is the wrong forum, my apologies. I had a partial thyroidectomy 1 year ago (half was removed) and just returned home from my 1 year follow-up. I am concerned somewhat by my lab results and wanted to seek your opinion on my results. In April my Thyroglobulin Tumor Marker was 3.3 and my Thyroglobulin Antibody was <0.9. Now in October, my results were Thyroglobulin Tumor Marker 6.2 and Thyroglobulin Antibody was again, <0.9. My lab results also showed my Thyroid Stimulating Hormone at 1.59. My Doctor, who is a very well regarded Surgeon isn't very strong in discussing with me what all of this means. He did however increase my prescription strength from 60 to 90 but was very nonchalant with my questions. I am taking Armor Pig Thyroid. Should I seek a second opionion based on these results? Thank You.

  16. I have always felt my thyroid was off … terribly brittle and dry hair, dry skin, eyebrows shrinking, NO energy, brain fog and loss of memory. Every time I have thyroid levels drawn, my doctor says they are low normal. Had my TPO checked and it’s 1150. He wants me to have another TSH level. In the meantime I asked for ADD med and he put me on Adderall. It allows me to focus somewhat, but now I’m thinking it is hypothyroidism. Now I’m afraid the Aderall and HRT I’m on will affect my THS level. When do I need to see an endocrinologist/expert, since diagnosing hypothyroidism (after years of asking my MD) about it has not changed the outcome? Thank you

  17. Hello Dr. Ruscio! Is it weird for a doctor to refuse to check antibodies?!

    I am pretty outraged about it. I requested my antibodies to be checked (after not having any thyroid labs for more than a year) and she outright refused – with this rationalization that knowing that number in no way helps us.

    I was first diagnosed with Hashi when TSH and T4 were both extremely low. They decided to check again in six months and both had risen, putting them in normal range. A year later, with this new doctor, both have continued to rise (but still in the normal range). I don’t know what’s going on.

    1. Hi Zerina,
      It’s not weird for a conventional doctor because conventional medicine doesn’t recognize thyroid autoimmunity treatments for Hashimoto’s despite what the science says. I would continue to see this doctor but also find yourself a good functional medicine doc who is versed in thyroid. Feel free to reach out to my office if you need help.

  18. Hello Dr. Ruscio! Is it weird for a doctor to refuse to check antibodies?!

    I am pretty outraged about it. I requested my antibodies to be checked (after not having any thyroid labs for more than a year) and she outright refused – with this rationalization that knowing that number in no way helps us.

    I was first diagnosed with Hashi when TSH and T4 were both extremely low. They decided to check again in six months and both had risen, putting them in normal range. A year later, with this new doctor, both have continued to rise (but still in the normal range). I don’t know what’s going on.

    1. Hi Zerina,
      It’s not weird for a conventional doctor because conventional medicine doesn’t recognize thyroid autoimmunity treatments for Hashimoto’s despite what the science says. I would continue to see this doctor but also find yourself a good functional medicine doc who is versed in thyroid. Feel free to reach out to my office if you need help.

  19. My test results came at 458.8 which is high? I was also diagnosed with mthfr mutation which lead to folate deficiency. Does my thyroglobulin antibody blood test results could be related to this?

    1. Maritza,
      If you’re referring to a TPO of 458, then that is a positive test but I would consider that only a mild level of elevation. The MTHFR mutation means almost nothing in my opinion.

      1. The test was actually for thyroid anthyroglobulin antibody? Is that high? Does it means I might have Hashimoto’s

  20. My test results came at 458.8 which is high? I was also diagnosed with mthfr mutation which lead to folate deficiency. Does my thyroglobulin antibody blood test results could be related to this?

    1. Maritza,
      If you’re referring to a TPO of 458, then that is a positive test but I would consider that only a mild level of elevation. The MTHFR mutation means almost nothing in my opinion.

      1. The test was actually for thyroid anthyroglobulin antibody? Is that high? Does it means I might have Hashimoto’s

  21. Hi,
    My anti TPO came back 36.2 with TSH, T3,T4 perfectly normal. Do I have Hashimoto’s?
    How high is the risk of developing the disease in the future.
    Thank you in adcance.

    1. Hi Claudia,
      If your TPO was considered positive according to the lab range, than this can indicate Hashimotos. It sound like you might just be over the cusp, which often has a very good prognosis. But, I would check in with your doctor on this.

      1. Thanks for your response Dr Ruscio.
        What do you suggest that I should do next? Should I do a re-testing? Since is just slightly above could it be a false positive? How to prevent the progression to hypothyroidism? Sorry for all the questions, but I don’t know much about this.
        Thank you very much!

        1. Hi Claudia,
          I have spoken at length on the site in terms of therapies for hashimoto’s. If you need personalized guidance feel free to contact my office. The very low levels of antibodies you listed are associated with minimal risk so I wouldn’t be worried.
          Hope this helps.

  22. Hi,
    My anti TPO came back 36.2 with TSH, T3,T4 perfectly normal. Do I have Hashimoto’s?
    How high is the risk of developing the disease in the future.
    Thank you in adcance.

    1. Hi Claudia,
      If your TPO was considered positive according to the lab range, than this can indicate Hashimotos. It sound like you might just be over the cusp, which often has a very good prognosis. But, I would check in with your doctor on this.

      1. Thanks for your response Dr Ruscio.
        What do you suggest that I should do next? Should I do a re-testing? Since is just slightly above could it be a false positive? How to prevent the progression to hypothyroidism? Sorry for all the questions, but I don’t know much about this.
        Thank you very much!

        1. Hi Claudia,
          I have spoken at length on the site in terms of therapies for hashimoto’s. If you need personalized guidance feel free to contact my office. The very low levels of antibodies you listed are associated with minimal risk so I wouldn’t be worried.
          Hope this helps.

  23. This was extremely helpful, especially on the ranges and supplements. I have a question: I am 34 have PCOS AND WAS JUST DISFNOSED WITH hashimottos based on my levels being at 100. I feel in my gut this can be addressed or improved with diet but my doc wants me on medication.
    I am also trying to conceive and he said that if I don’t take the medication I would be putting my baby at risk. Is this true?

    1. Hi Yuly,
      Thyroid Rx has been shown to help with fertility in those with hypothyroid, subclinical hypothyroid and may help in those with Hashimoto’s, so I agree with your doctors advise regarding fertility. If you are looking for another opinion here postpartum, feel free to contact my office.

  24. This was extremely helpful, especially on the ranges and supplements. I have a question: I am 34 have PCOS AND WAS JUST DISFNOSED WITH hashimottos based on my levels being at 100. I feel in my gut this can be addressed or improved with diet but my doc wants me on medication.
    I am also trying to conceive and he said that if I don’t take the medication I would be putting my baby at risk. Is this true?

    1. Hi Yuly,
      Thyroid Rx has been shown to help with fertility in those with hypothyroid, subclinical hypothyroid and may help in those with Hashimoto’s, so I agree with your doctors advise regarding fertility. If you are looking for another opinion here postpartum, feel free to contact my office.

  25. Hi Doctor.
    I had Helicobacter pylori and parasites in my intestines, plus fever was going with that. Got treatment for that, and because of faster heartbeat checked my thyroid hormones. Apparently I have Anti TPO 41 where normal is up to 36. The rest of the hormones were under normal. Should I worry about this or will it go back to normal after I fully recover my intestines and Helicobacter Pylori? Also my vitamin D was low.

      1. Sorry, I wasn’t clear enough. My concern is if I should worry and take preventive means with Anti TPO 41, or just wait and see what happens. I also lack vitamin D.

        1. Right now doctor I am taking anti acid pills for my gastritis. I had been taking it for over a month. My doctor prescribed it to take it for another month, but I feel there is no need any more. and as far as I know anti acids increase the level of Anti TPO hormone. I am really confused if I should stop the antiacid for normalizing my Anti TPO or should I continue anti acids to completely fix my gastritis which is a result of helicobacter pylori.

        2. Hi Liana,
          As I mentioned in this video a TPO below 500 has been associated with minimal risk. In my opinion at TPO between 100 and roughly 300 could be considered a good position clinically. But, ultimately you should check in with your doctor here.

  26. Hi Doctor.
    I had Helicobacter pylori and parasites in my intestines, plus fever was going with that. Got treatment for that, and because of faster heartbeat checked my thyroid hormones. Apparently I have Anti TPO 41 where normal is up to 36. The rest of the hormones were under normal. Should I worry about this or will it go back to normal after I fully recover my intestines and Helicobacter Pylori? Also my vitamin D was low.

      1. Sorry, I wasn’t clear enough. My concern is if I should worry and take preventive means with Anti TPO 41, or just wait and see what happens. I also lack vitamin D.

        1. Right now doctor I am taking anti acid pills for my gastritis. I had been taking it for over a month. My doctor prescribed it to take it for another month, but I feel there is no need any more. and as far as I know anti acids increase the level of Anti TPO hormone. I am really confused if I should stop the antiacid for normalizing my Anti TPO or should I continue anti acids to completely fix my gastritis which is a result of helicobacter pylori.

        2. Hi Liana,
          As I mentioned in this video a TPO below 500 has been associated with minimal risk. In my opinion at TPO between 100 and roughly 300 could be considered a good position clinically. But, ultimately you should check in with your doctor here.

  27. I got my results today and my Thyroglubulin Antibodies is <1 and the Thyroid Peroxidase Antibodies is <1 and my TSH is 1.37.

  28. I got my results today and my Thyroglubulin Antibodies is <1 and the Thyroid Peroxidase Antibodies is <1 and my TSH is 1.37.

  29. My thyroglobulin auto antibody is 3.0 and my TPO Iis 743. I understand the meaning of the high TPO but not the low thyroglobulin score. Can you explain.
    Thank you so much for your site!

  30. My thyroglobulin auto antibody is 3.0 and my TPO Iis 743. I understand the meaning of the high TPO but not the low thyroglobulin score. Can you explain.
    Thank you so much for your site!

  31. Hi Dr,

    20-21 months into these symptoms (biggest worry hair loss – all started 4 months after I had a very badly sore throat lost a stone of weight in a week, looked anorexic after it, couldn’t swallow or move my head, took about 3 months to put the weight back on and get appetite back completely. I think caused by h1n1 flu as it was rampant In Dublin in February 2016 the week I got it.)

    Most concerning symptom hair loss and thinning, lack of sweating and lighter periods.

    Didn’t get thyroid tested until hair loss was noticed 4 months later. GPs over here only test tsh and t4 no matter what symptoms:

    Test Date 03 June 2016 08:40 (GP)
    Serum free T4 level
    19.4 Pmol/l 12.0-22.0
    Serum TSH level 3.18 mU/l 0.3-4.5

    Test Date 21st October 2016 3.19pm (GP)
    Serum free T4 level
    14.9 Pmol/l 12.0-22.0
    Serum TSH level 5.24 mU/l 0.3-4.5

    Test Date 6th January 2017 3.33pm (GP)
    Serum free T4 level
    15.6 Pmol/l 12.0-22.0
    Serum TSH level 2.07 mU/l 0.3-4.5

    Test Date 11th May 2017 at 3pm (GP)
    Serum free T4 level
    16.3 Pmol/l 12.0-22.0
    Serum TSH level 2.13 mU/l 0.3-4.5

    I got the full panel done 3 months ago, which made me then check my stomach because I had pain in it for the same length of time as the hair loss. I had h pylori which was successfully treated clear of it now for 2 weeks,

    based on my current tsh value and antibodies (which are raised so indicate hashimiotos) do you think the h pylori eradication could lower it? how much do you think possibly it could lower it by? Would that then lower the tsh value?
    do you think I may have started out with sub acute thyroiditis with that throat infection and the stomach infection has lead to the raised antibodies and hashimotos?

    no dr,, derm or endocrinologist (have seen 9) over here believe there is a problem with my thyroid. I am imagining it all I think they believe I should leave them alone.

    please help I am desperate, America is leaps ahead of us an so much more advanced than the nhs

    Test Date 13th August 2017 @9-30am (private test)
    ¬¬¬¬Thyroid Stimulating Hormone
    3.32 miu/L 0.27 – 4.20
    Free Thyroxine 16.6 Pmol/l 12.00-22.00
    Total Thyroxine 106.5 Nmo/l 59.00-154.00
    Free T3 4.69 Pmol/l 3.10-6.80
    Reverse T3 16 Ng/dl 10.00-24.00
    Reverse T3 ratio 19.08 15.01-75.00
    Thyroid Antibodies
    Thyrogloubin Antibody 19.400 Iu/ml 0.00-115.00
    Thyroid peroxidise antibodies 43.6 Iu/ml 0.00-34.00

    1. Hi Jay,
      It’s never a bad idea to take steps to improve ones gut health. It appears you have a lot of questions, which are understandable. I am happy to help but I would ask you contact my office to schedule a consultation via Skype so I can give these questions the attention they deserve.
      Best

  32. Hi Dr,

    20-21 months into these symptoms (biggest worry hair loss – all started 4 months after I had a very badly sore throat lost a stone of weight in a week, looked anorexic after it, couldn’t swallow or move my head, took about 3 months to put the weight back on and get appetite back completely. I think caused by h1n1 flu as it was rampant In Dublin in February 2016 the week I got it.)

    Most concerning symptom hair loss and thinning, lack of sweating and lighter periods.

    Didn’t get thyroid tested until hair loss was noticed 4 months later. GPs over here only test tsh and t4 no matter what symptoms:

    Test Date 03 June 2016 08:40 (GP)
    Serum free T4 level
    19.4 Pmol/l 12.0-22.0
    Serum TSH level 3.18 mU/l 0.3-4.5

    Test Date 21st October 2016 3.19pm (GP)
    Serum free T4 level
    14.9 Pmol/l 12.0-22.0
    Serum TSH level 5.24 mU/l 0.3-4.5

    Test Date 6th January 2017 3.33pm (GP)
    Serum free T4 level
    15.6 Pmol/l 12.0-22.0
    Serum TSH level 2.07 mU/l 0.3-4.5

    Test Date 11th May 2017 at 3pm (GP)
    Serum free T4 level
    16.3 Pmol/l 12.0-22.0
    Serum TSH level 2.13 mU/l 0.3-4.5

    I got the full panel done 3 months ago, which made me then check my stomach because I had pain in it for the same length of time as the hair loss. I had h pylori which was successfully treated clear of it now for 2 weeks,

    based on my current tsh value and antibodies (which are raised so indicate hashimiotos) do you think the h pylori eradication could lower it? how much do you think possibly it could lower it by? Would that then lower the tsh value?
    do you think I may have started out with sub acute thyroiditis with that throat infection and the stomach infection has lead to the raised antibodies and hashimotos?

    no dr,, derm or endocrinologist (have seen 9) over here believe there is a problem with my thyroid. I am imagining it all I think they believe I should leave them alone.

    please help I am desperate, America is leaps ahead of us an so much more advanced than the nhs

    Test Date 13th August 2017 @9-30am (private test)
    ¬¬¬¬Thyroid Stimulating Hormone
    3.32 miu/L 0.27 – 4.20
    Free Thyroxine 16.6 Pmol/l 12.00-22.00
    Total Thyroxine 106.5 Nmo/l 59.00-154.00
    Free T3 4.69 Pmol/l 3.10-6.80
    Reverse T3 16 Ng/dl 10.00-24.00
    Reverse T3 ratio 19.08 15.01-75.00
    Thyroid Antibodies
    Thyrogloubin Antibody 19.400 Iu/ml 0.00-115.00
    Thyroid peroxidise antibodies 43.6 Iu/ml 0.00-34.00

    1. Hi Jay,
      It’s never a bad idea to take steps to improve ones gut health. It appears you have a lot of questions, which are understandable. I am happy to help but I would ask you contact my office to schedule a consultation via Skype so I can give these questions the attention they deserve.
      Best

  33. Can you please share the study that shows that a gluten-free diet lowers the autoimmunity? I see the gluten-free diet recommendation everywhere I look, but I can’t seem to find a study anywhere. I just recently tried a strict gluten-free diet for three months. My TPO antibodies before the diet were 176. Now after three months of eating no gluten they’re 802. How can this be?! I have no digestive symptoms with or without gluten. I really expected a positive result considering all the talk about gluten.

    1. Hi,
      I don’t have the study off hand, most of them are in those with celiac but at least one other study has shown a decrease with gluten elimination in non-celiac subjects. That being said just because you cut out gluten does not guarantee your antibodies will drop. There are other therapies you might want to consider; vitamin D, Selenium, Magnesium, CoQ10 – all discussed on this site. Also, an evaluation for H. Pylori. All things to consider speaking with your doctor about.

  34. Hello –
    I got bloodwork done in July and then again in October. I did a gluten and dairy free diet for 3 months to see how my levels will change. According to these numbers do you see any correlation to my new diet and should I continue or is it unlinked (generally speaking)? Or any other advice on how to keep the levels getting better? I went to my General Physician and Naturopath and am having a hard time finding solid advice…

    JULY:
    TSH: 3.08
    FreeT4: 0.93
    FreeT3: 2.97
    TPO: 229.6
    TGAB: 185.5

    OCTOBER:
    TSH: 4.86 (increased randomly…)
    FreeT4: 0.92
    FreeT3: 3.44
    TPO: 76.7
    TGAB: 131.8

    Thank you!!

    1. Hi Maggie,
      Your antibodies look good, I wouldn’t fret over them any more. Keep an eye on the TSH though and fT4. Right now you look to be sub-clinical hypothyroid, but if you progress to overt hypothyroid you might need thyroid hormone replacement. Ultimately, check in with a doc so you can obtain the appropriate advise for your individual case.

  35. Hello –
    I got bloodwork done in July and then again in October. I did a gluten and dairy free diet for 3 months to see how my levels will change. According to these numbers do you see any correlation to my new diet and should I continue or is it unlinked (generally speaking)? Or any other advice on how to keep the levels getting better? I went to my General Physician and Naturopath and am having a hard time finding solid advice…

    JULY:
    TSH: 3.08
    FreeT4: 0.93
    FreeT3: 2.97
    TPO: 229.6
    TGAB: 185.5

    OCTOBER:
    TSH: 4.86 (increased randomly…)
    FreeT4: 0.92
    FreeT3: 3.44
    TPO: 76.7
    TGAB: 131.8

    Thank you!!

    1. Hi Maggie,
      Your antibodies look good, I wouldn’t fret over them any more. Keep an eye on the TSH though and fT4. Right now you look to be sub-clinical hypothyroid, but if you progress to overt hypothyroid you might need thyroid hormone replacement. Ultimately, check in with a doc so you can obtain the appropriate advise for your individual case.

  36. Hi,
    I got my test results
    TSH – 3.010
    T4 – 7.8
    T3 uptake – 28
    free T4 index – 2.2
    Triiodothyronine – 85
    T3 ,free,serum – 2.6
    T4,free – 1.36
    Thyroid peroxidase ab – 9 IU/ml
    Thyroglobulin antibody – 49.9 IU/ml

    Is this considered as hashimoto thyroiditis? Right now I am taking levothyroxine. When I am searching online or books those antibody numbers are in hundreds and thousands to consider them hashimoto. but I got these and my functional medicine practioner said that it’s Hashimoto. what to do??

    1. Hi Emma,
      Ultimately check in with your doctor on what to do. With antibodies this low, I am generally not concerned but wouldn’t be a bad idea to keep an eye on your levels periodically. Once per year could be reasonable, to monitor the antibodies. If they do increase there is a protocol listed on my site. Try to search box to find it.
      Hope this helps!

  37. Hi,
    I got my test results
    TSH – 3.010
    T4 – 7.8
    T3 uptake – 28
    free T4 index – 2.2
    Triiodothyronine – 85
    T3 ,free,serum – 2.6
    T4,free – 1.36
    Thyroid peroxidase ab – 9 IU/ml
    Thyroglobulin antibody – 49.9 IU/ml

    Is this considered as hashimoto thyroiditis? Right now I am taking levothyroxine. When I am searching online or books those antibody numbers are in hundreds and thousands to consider them hashimoto. but I got these and my functional medicine practioner said that it’s Hashimoto. what to do??

    1. Hi Emma,
      Ultimately check in with your doctor on what to do. With antibodies this low, I am generally not concerned but wouldn’t be a bad idea to keep an eye on your levels periodically. Once per year could be reasonable, to monitor the antibodies. If they do increase there is a protocol listed on my site. Try to search box to find it.
      Hope this helps!

  38. Hello
    My blood test result says “anti-tg <10.00 ml " and the normal range says "<115.0 ml" can you please tell me what does it mean. Is it normal or I need to get alarmed

    Thanks in advance

    1. Hi Solomon,
      We know much less about TG antibodies, however some papers have suggested have a 10x elevation above the normal range or higher is when there should be concern.
      Hope this helps.

  39. Hi Dr.
    I’m 8 week pregnant.
    My TSH result high 15.85 (.27-4.2)
    Dr gave me euthyox medicine for hypothyroidism. Now,
    I’m taking daily 125mg medicine euthyox in morning before breakfast.
    Again Dr suggested two test t4 and tpo.
    FT4 result 12.4 (12-22)
    Anti thyroid preoxidase antibody result (anti thyroid 9.2 (<34).
    What does it means ?

    1. Hi Qurat,
      It’s good you are on thyroid medication because even sub-clinical hypothyroid (high TSH and normal T4) can interfere with fertility. Your antibodies are normal, so that is good too. Continue to be monitored and work with you doctor here. Looks like you are on the right track.

  40. Hi Dr.
    I’m 8 week pregnant.
    My TSH result high 15.85 (.27-4.2)
    Dr gave me euthyox medicine for hypothyroidism. Now,
    I’m taking daily 125mg medicine euthyox in morning before breakfast.
    Again Dr suggested two test t4 and tpo.
    FT4 result 12.4 (12-22)
    Anti thyroid preoxidase antibody result (anti thyroid 9.2 (<34).
    What does it means ?

    1. Hi Qurat,
      It’s good you are on thyroid medication because even sub-clinical hypothyroid (high TSH and normal T4) can interfere with fertility. Your antibodies are normal, so that is good too. Continue to be monitored and work with you doctor here. Looks like you are on the right track.

  41. Hi! In October of this year, my TPO was 82 (lab range = less than 34) and my TG was 533 (lab range = less than 115). I implemented a paleo diet cutting out gluten, dairy, soy and other inflammatory foods, and also started taking vitamins (no thyroid medication).

    Recently my levels were retested using a different lab so I am confused as to whether I can compare my results with my October results apples to apples. Or do I have to account for the differing lab ranges? My TPO is now 50 (lab range = less than 9) and my TG is 4 (lab range = 4). From the looks of it, it looks a lot better, or are they not comparable because the lab ranges are so different?

    1. HI Madelyn,
      TPO and TG testing are fairly consistent across labs, so you should be able to make a comparison. Looks like you have improved nicely. Make sure to keep your doctor in the loop though.

  42. Hi! In October of this year, my TPO was 82 (lab range = less than 34) and my TG was 533 (lab range = less than 115). I implemented a paleo diet cutting out gluten, dairy, soy and other inflammatory foods, and also started taking vitamins (no thyroid medication).

    Recently my levels were retested using a different lab so I am confused as to whether I can compare my results with my October results apples to apples. Or do I have to account for the differing lab ranges? My TPO is now 50 (lab range = less than 9) and my TG is 4 (lab range = 4). From the looks of it, it looks a lot better, or are they not comparable because the lab ranges are so different?

    1. HI Madelyn,
      TPO and TG testing are fairly consistent across labs, so you should be able to make a comparison. Looks like you have improved nicely. Make sure to keep your doctor in the loop though.

  43. Hi Dr. Ruscio,

    I recently had blood tests and am unable to see my doctor until mid January. I see the following and don’t really know what it means:

    T3 1.4
    T4 1.1
    T-SHIRT 1.49
    Thyroperoxidase AB 0.7

    Does this mean that I have low functioning thyroid and can it be helped through diet supplements. Could you make any recommendations.? Thanks so much!

  44. Hi Dr. Ruscio,

    I recently had blood tests and am unable to see my doctor until mid January. I see the following and don’t really know what it means:

    T3 1.4
    T4 1.1
    T-SHIRT 1.49
    Thyroperoxidase AB 0.7

    Does this mean that I have low functioning thyroid and can it be helped through diet supplements. Could you make any recommendations.? Thanks so much!

  45. Hello Dr. Ruscio,

    I was told 4 years ago that I had Hashimoto’s Thyroid Disease, but never followed up or got on any medications. Now, 34 I just got my lab work back and my TSH is at 5.70 and my antibodies are at 563. Final reports state hypoechoic nodularity extends from the posterior margin and appears to be part of diffuse process rather than the separate discrete nodule. That’s all Chinese to me. I have set up an app with an endo, just would like a little knowledge about what you think from what I commented. Thanks in advance.

    1. Hope you were able to get some help from your doctor! There’s also a lot of great content on this site that could be helpful if you type “thyroid” or “hashimoto’s” into the search box.

  46. I am having hashimotto thyroiditis with ANTI TPO antibodies more than 1000 how to reduce antibodies is it problem with these antibodies to cause other disease?

  47. I am having hashimotto thyroiditis with ANTI TPO antibodies more than 1000 how to reduce antibodies is it problem with these antibodies to cause other disease?

  48. Why am I reading that normal anti tpo levels are less than 35 iu/ml but on my test it says normal range is less than 5.6 iu/ml? Is it because I am in Canada? My level came back as high at 11.1 but that doesn’t appear to be high according to what I am seeing online. I am confused. Tsh was normal at 1.1. Thanks

  49. Why am I reading that normal anti tpo levels are less than 35 iu/ml but on my test it says normal range is less than 5.6 iu/ml? Is it because I am in Canada? My level came back as high at 11.1 but that doesn’t appear to be high according to what I am seeing online. I am confused. Tsh was normal at 1.1. Thanks

  50. Hi
    My tpo level is 86 and my tgab is 6.8 , I’m planning to have ababy soon and afraid that these antibodies can effect my pregnancy or effect the baby health or nerve system.plz advise me.thx

    1. Hi Asma,
      You will want to check in with your doctor here. If you also have sub-clinical hypothyroid then he/she may want to start you on medication. Selenium has also been shown to be safe for pregnant mothers, and to lower antibody levels.

  51. Hi
    My tpo level is 86 and my tgab is 6.8 , I’m planning to have ababy soon and afraid that these antibodies can effect my pregnancy or effect the baby health or nerve system.plz advise me.thx

    1. Hi Asma,
      You will want to check in with your doctor here. If you also have sub-clinical hypothyroid then he/she may want to start you on medication. Selenium has also been shown to be safe for pregnant mothers, and to lower antibody levels.

  52. Hi

    My TPO level is -28(Negative) and T4 and T3 is normal level and TSH. 7.5. Can you please tell me what does it mean. Is it normal or I need to get alarmed

  53. Hi

    My TPO level is -28(Negative) and T4 and T3 is normal level and TSH. 7.5. Can you please tell me what does it mean. Is it normal or I need to get alarmed

  54. Hi Dr. Ruscio,

    My brother had papillary cancer and I was advised to get my thyroid checked. In a scan they found nodules. I then went on to do a fine needle biopsy; however, the person doing it kept making mistakes and had to keep repeating the exam. It seemed like he was new to the job. After agonizing pain, I was told to go home. A week later I was told I tested positive for Hashimoto’s. I was 29 years old.

    I am now 46 and I’ve had 2 kids. Every time I get my antibodies checked, it’s always negative. My thyroid levels are all normal (low end of normal in fact).

    I just had my antibodies tested and it came out at 13…negative again.

    Is it possible I had a misdiagnosis? The technician did a particularly terrible job of obtaining a sample.

    Thanks,
    Heloise

    1. It’s very difficult to say. However, if you have had repeat antibodies testing that was negative and your hormone levels are normal that is highly suggestive that your thyroid is just fine 🙂

  55. I was diagnosed with Hashimotos at a TPO level of 15 in Feb 2017 and it has only increased (33 as of 12/17), but it is still well below your ideal range of 35 or below. The more I read I’m starting to wonder if I really do have Hashimotos or some other issue causing similar problems. Is it possible to have a low TPO like mine and not have a thyroid autoimmune disease? My mother had Graves, so is it possible for that to give me antibodies but not the actual autoimmune disease?

    1. Hi Trish,
      Thyroid autoimmunity can eventually lead to hypothyroidism. Some research suggests that if your TPO antibodies are below 500 you are at minimal risk of your thyroid autoimmunity causing hypothyroidism. Hope this helps.

  56. I was diagnosed with Hashimotos at a TPO level of 15 in Feb 2017 and it has only increased (33 as of 12/17), but it is still well below your ideal range of 35 or below. The more I read I’m starting to wonder if I really do have Hashimotos or some other issue causing similar problems. Is it possible to have a low TPO like mine and not have a thyroid autoimmune disease? My mother had Graves, so is it possible for that to give me antibodies but not the actual autoimmune disease?

    1. Hi Trish,
      Thyroid autoimmunity can eventually lead to hypothyroidism. Some research suggests that if your TPO antibodies are below 500 you are at minimal risk of your thyroid autoimmunity causing hypothyroidism. Hope this helps.

  57. This is a basic question, but when you refer to 500 as a cutoff for TPO antibodies, are you referring to IU/ml or IU/L?

  58. I have been diagnosed with hypothyroidism in 2000, given the routine treatment and drank my Eltroxin for 15 years.

    Then I started with goiter in July 2015, went to see a homeopath and Hashimotos was diagnosed with TPO of 347. Guess it has been Hashimoto’s since before 2000….

    Anyways, the homeopath started me on treatment and I started the AIP and other selfhelp remedies (stress relief – I took a sabbatical year off everything). I most definitely saw symptoms drop, to the point where I actually feel good, even though my TPO rose to 436.

    I still want to explore heavy metal poisoning (mercury as I have amalgams, flouride as our borehole water has high levels and as a child we had several flouride treatments at dentists, gluphosate as we are commercial farmers) and chronic infections (root canal treatments especially they all show infections in the bone structure.)

  59. hello Dr, I am sana I am 27 years old and I am a diagnosed patient of hypothyrodism from the last 10 years and I am on euthyrox, recently I had an abortion because my fetus stopped growing his cardiac activitu was missing, Dr said that it is due to the elevated Tsh levels which was 11 at that time, Now I am worried for my antibodies , which is under 500 but in the range of 400, what should I do to have normal levels of tsh and antibodies, and prevent future pregnancy losses

    1. Hi Sana,
      Make sure to speak with your doctor here. Thyroid hormone can be used to normalize your TSH and T4, and selenium can be used safely while pregnant to lower thyroid antibodies. Vitamin D and healthy diet should also be used.

      1. Thankyou Dr, but here in beijing china where I am living right now is very difficult to find a good english speaking doctor , I am worried that if my TGab and TGPO levels rose up will further harm my thyroid, I am confused which blood test or scans are now important to do at this level to know if I have any serious problem

  60. Hello, I am writing because thyroid issues are new to me. My ENT thought he found a nodule, but the ultrasound showed nothing. Lab work showed FT4 = 0.8; TSH 3rd gen = 2.74; Anti-TPO = 133. Dr said only problem is TPO. It’s just so difficult to get an appt with an endocrinologist – several months of wait time. Given that TPO is only issue, and I have no symptoms, can I just let this go? I’m 72 yrs old. Thank you!

    1. Hi Sharon,
      If someone has normal levels of thyroid hormones + no symptom + TPO antibodies in the low hundreds, I am generally not concerned. I would however, follow through with any recommended follow up just to be safe.
      Hope this helps!

  61. I am confused with the numbers that you are using. My TPO is at 24……the lab states >9 is where it should be. And my doctor has diagnosed me with Hashimotos. I do not take anything for it but I don’t understand the numbers……..Could you help clarify?

    1. Thanks – I just don’t have any more info other than what’s on the lab report. In my looking around on the Internet, I saw where a TPO of under 500 is acceptable. I understand if you can’t offer any more info.

    2. Hi Amy,
      That sounds like a low level of TPO positivity and therefor associated with minimal risk. I would check in with a healthcare provider for personalized care though.

  62. Hello, I am writing because thyroid issues are new to me. My ENT thought he found a nodule, but the ultrasound showed nothing. Lab work showed FT4 = 0.8; TSH 3rd gen = 2.74; Anti-TPO = 133. Dr said only problem is TPO. It’s just so difficult to get an appt with an endocrinologist – several months of wait time. Given that TPO is only issue, and I have no symptoms, can I just let this go? I’m 72 yrs old. Thank you!

    1. Hi Sharon,
      If someone has normal levels of thyroid hormones + no symptom + TPO antibodies in the low hundreds, I am generally not concerned. I would however, follow through with any recommended follow up just to be safe.
      Hope this helps!

  63. I am confused with the numbers that you are using. My TPO is at 24……the lab states >9 is where it should be. And my doctor has diagnosed me with Hashimotos. I do not take anything for it but I don’t understand the numbers……..Could you help clarify?

    1. Thanks – I just don’t have any more info other than what’s on the lab report. In my looking around on the Internet, I saw where a TPO of under 500 is acceptable. I understand if you can’t offer any more info.

    2. Hi Amy,
      That sounds like a low level of TPO positivity and therefor associated with minimal risk. I would check in with a healthcare provider for personalized care though.

  64. Hi Doctor,

    I was diagnosed with post partum thyroiditis about 3 months after giving birth. Was put on medication and that dipped my condition from hyper to hypo. Wasn’t treated for hypo with any meds whatsoever. Ever since, now over a year after, I have not been feeling well, physically or mentally, just so off and not like myself. I am so so tired all the time, I have memory issues, my joints&muscles hurt, feelings of sadness, occasional skin issues, etc. List goes on and on.
    My recent blood results were as following;
    t4 16.8 (10.0-19.0)
    tsh 2.18 (0.5-4.00)
    t3 4.9 (3.5-6.5)
    Antithyroid peroxidase 118 (below 60)
    Anti-Thyroglobulin 409 (below 60)

    What would you say is the issue here? As my doctors think all my symptoms are just because I am experiencing motherhood.
    Is it normal to go from post partum thyroiditis to hashimoto? As I sure dont feel well even though my tsh levels are normal.
    Cheers

  65. Dear Doctor,

    Many thanks for a very informative article.

    I have a Grave’s disease for over a year. Antibodies went from 800 to 420.
    However I have an upper lid retraction and it gives very unpleasant look.
    Would it disappear with time or it will remain permanently?

    Thank you,
    Yana

  66. Hi Doctor,

    I was diagnosed with post partum thyroiditis about 3 months after giving birth. Was put on medication and that dipped my condition from hyper to hypo. Wasn’t treated for hypo with any meds whatsoever. Ever since, now over a year after, I have not been feeling well, physically or mentally, just so off and not like myself. I am so so tired all the time, I have memory issues, my joints&muscles hurt, feelings of sadness, occasional skin issues, etc. List goes on and on.
    My recent blood results were as following;
    t4 16.8 (10.0-19.0)
    tsh 2.18 (0.5-4.00)
    t3 4.9 (3.5-6.5)
    Antithyroid peroxidase 118 (below 60)
    Anti-Thyroglobulin 409 (below 60)

    What would you say is the issue here? As my doctors think all my symptoms are just because I am experiencing motherhood.
    Is it normal to go from post partum thyroiditis to hashimoto? As I sure dont feel well even though my tsh levels are normal.
    Cheers

  67. Hi.
    I have Celiacs and have been on a Gluten Free diet for the past 6 years. Despite diet, exercise, and generally healthy eating, it has become increasingly difficult for me to lose weight since my last pregnancy (almost 3 years ago). I “settled” 10 lbs above my pre-pregnancy weight, and I gained 15 lbs between the end of August, and New Years. I just lost 7 by going on a restrictive diet the past month. I do exercise and am active.

    Post-partum, my periods were so awful that I had an ablation procedure to stop them. My feet are always cold. Thyroid disease runs in my family (maternal grandmother, and paternal Uncle).

    My most recent labwork was from 2016 (heading in for new lab work next week). It showed the following:

    Thyroglobulim Antibody: 2.3 (above normal)
    Thyroid Peroxidase: 16
    Thyroglobulin by RIA : 12
    Triiodothyronine (T3) : 123
    TSH: 1.27
    T4,Free(Direct): 1.15
    LDL cholesterol: 104

    I was told that this did not indicate much of anything. I know there HAS to be a reason why A. I can’t lose the weight I gained no matter what I do, and B. I gained so much weight so quickly. I really hope the answer is not just “you are 36 and have had 3 kids… embrace your new body”. Do these numbers indicate anything? As I said, I am heading in for new blood work next week.

    1. Hi Amanda,
      You might want to look at the Alt Shift diet for weight loss. Consider some herbal meds for female hormone balancing and have a thorough gut eval. My book will help with the last two points, and we have a podcast out on the first point.

  68. Hi.
    I have Celiacs and have been on a Gluten Free diet for the past 6 years. Despite diet, exercise, and generally healthy eating, it has become increasingly difficult for me to lose weight since my last pregnancy (almost 3 years ago). I “settled” 10 lbs above my pre-pregnancy weight, and I gained 15 lbs between the end of August, and New Years. I just lost 7 by going on a restrictive diet the past month. I do exercise and am active.

    Post-partum, my periods were so awful that I had an ablation procedure to stop them. My feet are always cold. Thyroid disease runs in my family (maternal grandmother, and paternal Uncle).

    My most recent labwork was from 2016 (heading in for new lab work next week). It showed the following:

    Thyroglobulim Antibody: 2.3 (above normal)
    Thyroid Peroxidase: 16
    Thyroglobulin by RIA : 12
    Triiodothyronine (T3) : 123
    TSH: 1.27
    T4,Free(Direct): 1.15
    LDL cholesterol: 104

    I was told that this did not indicate much of anything. I know there HAS to be a reason why A. I can’t lose the weight I gained no matter what I do, and B. I gained so much weight so quickly. I really hope the answer is not just “you are 36 and have had 3 kids… embrace your new body”. Do these numbers indicate anything? As I said, I am heading in for new blood work next week.

    1. Hi Amanda,
      You might want to look at the Alt Shift diet for weight loss. Consider some herbal meds for female hormone balancing and have a thorough gut eval. My book will help with the last two points, and we have a podcast out on the first point.

  69. Hi Doc,
    Thanks for helping us try to make sense of all the info. I have felt like I’ve been in a mental fog for a few years, dry brittle hair and nails, can’t lose weight and have zero energy. So I had some blood work done and came back at:

    Free T3 was 2.0
    Free T4 was 0.6
    TPO antibiotics were 574
    TSH was 3.8

    I’ve been taking probiotics daily. Should I try to continue helping with diet and vitamins, maybe go gluten free? Or do these numbers indicate I need to see about medications?

    1. The hormone levels here are in the normal range, other than TPO, which does not typically indicate need for meds. Something other than your thyroid might be the culprit. If you have any digestive symptoms, I would try the protocol in my book. Hope this helps!

  70. Hi Doc,
    Thanks for helping us try to make sense of all the info. I have felt like I’ve been in a mental fog for a few years, dry brittle hair and nails, can’t lose weight and have zero energy. So I had some blood work done and came back at:

    Free T3 was 2.0
    Free T4 was 0.6
    TPO antibiotics were 574
    TSH was 3.8

    I’ve been taking probiotics daily. Should I try to continue helping with diet and vitamins, maybe go gluten free? Or do these numbers indicate I need to see about medications?

    1. The hormone levels here are in the normal range, other than TPO, which does not typically indicate need for meds. Something other than your thyroid might be the culprit. If you have any digestive symptoms, I would try the protocol in my book. Hope this helps!

  71. Feeling a little stuck. Just had bloodwork done.
    FT4 = .9. (.7_1.6)
    TSH = 1.62. (.358-3.74)
    FT3= 2.4 (1.7-5.2)
    THYROGLOBULIN = 84.8 HIGH (1.6 – 59.9)
    Anti-thyroglobulin <20. (<40)

    I have all of the symptoms of hypothyroidism but tests appear normal.

    What should I do next?

      1. I had a thyroid ultrasound with some nodules. I just had a scan with uptake done. Something isn’t right. I do take probuotics daily.

  72. Sir my daughter who is 9 years old has normal value of T3 and T4 Tsh is 7.11 and TPO 345 sir should she go for medicines or not?

  73. Sir my daughter who is 9 years old has normal value of T3 and T4 Tsh is 7.11 and TPO 345 sir should she go for medicines or not?

  74. I was diagnosed with Hashimoto’s thyroiditis back in 2004 after a needle biopsy. I was on Synthroid for about a year then it was discontinued. Since then, my TSH and other thyroid function levels have come back normal. I suffer from severe fatigue, weight gain, double vision and vitamin D deficiency. The last year, I have suffered from high heart rate (ranging 130-152), palpitations, and shaking. I had a Holter Monitor test which showed a high heart rate and a few PVC’s. More notably, my Dr stated that my thyroid antibodies were increasing at an alarming rate. She did not give me a number. I was referred to an endocrinologist and see him in a week for possible removable of my thyroid. Are there any suggestions as to what questions I need to ask the endocrinologist, or how should I be better prepared for my visit. are there other treatment solutions Besides removal? Any help is greatly appreciated!

    1. Yes, sounds like you might now have Graves’. Search Graves’ in our search box and you will see a number of articles including one that lays out treatment options. There is help!

  75. Okay super confused. My TPO is at 293 every doctor I have seen said it needs to be below 9!? I stopped taking my meds 2 years ago. A week after stopping my TSH was 29.86 I have been gluten free for 2 years still no meds and my TSH as of last week was 8.6. now I am adding essential oils for inflammation and hope to stay off meds. But would you say I am good then because I am confused with what I just read vs. what I have always been told. Thank you.

    1. Hi Tammy,
      I don’t know enough about what happening to be able to comment, sorry. If you need help please feel free to contact my office and we can dig into the details.

  76. Okay super confused. My TPO is at 293 every doctor I have seen said it needs to be below 9!? I stopped taking my meds 2 years ago. A week after stopping my TSH was 29.86 I have been gluten free for 2 years still no meds and my TSH as of last week was 8.6. now I am adding essential oils for inflammation and hope to stay off meds. But would you say I am good then because I am confused with what I just read vs. what I have always been told. Thank you.

    1. Hi Tammy,
      I don’t know enough about what happening to be able to comment, sorry. If you need help please feel free to contact my office and we can dig into the details.

  77. Hello, I have 0.03 TSH and 43 ANTI TPO. My brothers used to suffer from Hashimoto’s, developed nodular gland and had is thyroid removed. My other brother had hid Thyroid removed as well because of follicular cancer. What could my test results indicate?

  78. Just got my test results back
    THYROID PEROXIDASE ANTIBODIES: >900
    TSH, Thyrotropin: 8.48
    T3, TOTAL: 90
    T4, Free Thyroxine: 0.8

    I really have no idea what any of this means.

        1. Hi Nancy,
          Yes there is. I have published a few posts on this. Paleo diet, vitamin D, selenium, CoQ10 and magnesium. Test for and treat H. Pylori if present. There are protocols on the website for this, you might have to search. Also, working on creating a master page with all protocols soon.

  79. Hello Doctor, due to low vit d which was at 14 i went to see my endo and had some tests done. This was in Dec, TSH 1.6, ANTI TG 475 and ANTI TPO 96.3. 2 months later after taking selenium my TSH came back at 4.1. I do not understand why it has gone up so fast. The past 5 years my TSH was always 1.6. I also do not understand after 2 months of taking vit d 1000 it has risen from 14 to only 17. My doctor is putting me on tirosint 13mg. Is this necessary?

  80. Hello,

    My TPO is 35. The rest of my Tsh panel is low, to low normal. I feel a wide range of hypothyroid symptoms. I have changed diet, tested sleep. I still don’t feel good. Any ideas?

  81. My TPO is 15.6 (range 0-34 IU/ml). I have Fibro and ME. My TSH and T3 are low normal. I’m assuming I couldn’t have Hashimotos although I’ve heard some don’t normal antibodies or they fluctuate wildly. When I was very young teens and 20s I was underweight and jittery. Now sluggish and overweight in my 50s. Any advice welcome. Thanks

    1. Hi Jaki,
      It’s tough to say based on this. The plan in my book works well for thyroid health and is good for overall health and symptoms, so you might want to start there.

  82. I was a FOOL & took high iodine for several months. My TSH jumped to 6.8 (w/nodules & terrible reflux/digestive issues out of the blue).

    Since stopping iodine 3 months ago, TSH went from 5.1 and is now 3.84 w/ labs below:

    Free T3 = 2.53
    Free T4 = 0.98
    TgAb = 5
    TpAB = <1
    Parathyroid hormone = 18.2

    Might this signify autoimmune Hashimoto&#039s & would thyroid meds help? (Iodine hurt me.)

    I already follow your vitamin protocol…

  83. I was a FOOL & took high iodine for several months. My TSH jumped to 6.8 (w/nodules & terrible reflux/digestive issues out of the blue).

    Since stopping iodine 3 months ago, TSH went from 5.1 and is now 3.84 w/ labs below:

    Free T3 = 2.53
    Free T4 = 0.98
    TgAb = 5
    TpAB = <1
    Parathyroid hormone = 18.2

    Might this signify autoimmune Hashimoto's & would thyroid meds help? (Iodine hurt me.)

    I already follow your vitamin protocol…

  84. Is having multiple nodules (at least 1 is “warm” and is greater than 2.5 cm) a concern?

  85. goodmorning.
    i have 2 questions in one.
    first, what are the prices of measurements of TSH, T3, T4, anti-TG, anti-TPO, for anybody, to be diagnosed as Hashimoto?
    in many articles i rear, that high levels of anti-TG and anti-TPO means Hashimoto.
    but what are those high levels? with numebers! over 100? 200? 1000?
    second, is a measuse anti-GT 138, with level <115 can be diagnosed as hasihmoto?
    is it something to worry about?
    thank you

    1. Cost varies from lab to lab. The most relevant marker is TPO. Over 35 is usually considered positive and suggests Hashimoto’s. I feel being below 500 is a good goal clinically.

      1. If over 35 is positive for hashimoto s, how can having antibodies up to 500 be ok? I’m confused. That is over 10 times higher then 35.

        1. I’m confused also. These two numbers make no sense. To quote Judy, “If over 35 is positive for hashimoto’s, how can having antibodies up to 500 be OK?”

          1. This is one of the main points of the post. Please give it another read. 35 is lab cut off, 500 is clinical cut off (as described in detail in post).

  86. goodmorning.
    i have 2 questions in one.
    first, what are the prices of measurements of TSH, T3, T4, anti-TG, anti-TPO, for anybody, to be diagnosed as Hashimoto?
    in many articles i rear, that high levels of anti-TG and anti-TPO means Hashimoto.
    but what are those high levels? with numebers! over 100? 200? 1000?
    second, is a measuse anti-GT 138, with level <115 can be diagnosed as hasihmoto?
    is it something to worry about?
    thank you

    1. Cost varies from lab to lab. The most relevant marker is TPO. Over 35 is usually considered positive and suggests Hashimoto’s. I feel being below 500 is a good goal clinically.

      1. If over 35 is positive for hashimoto s, how can having antibodies up to 500 be ok? I’m confused. That is over 10 times higher then 35.

        1. I’m confused also. These two numbers make no sense. To quote Judy, “If over 35 is positive for hashimoto’s, how can having antibodies up to 500 be OK?”

          1. This is one of the main points of the post. Please give it another read. 35 is lab cut off, 500 is clinical cut off (as described in detail in post).

  87. Total T3 = 1.4
    Total T4 = 8.0
    Free T4 = 1.2
    TSH = 2.33
    TPO Antimicrosomal Ab = 19

    What does this all mean?

  88. Dear doctor .I did my blood test few days ago and it showed that I have thyroglobulin antibodies which’s is 232.2 and the reference range supposed to be <60 . I am very scare I have read a lot of stuff about it and I have my appointment next week .I am very scare that every single day it can be hi .I would be appreciated if you can tell me what should I do ? Is it dangerous any help any advice would be really appreciated.Thank you so much in advance .

  89. Dear doctor .I did my blood test few days ago and it showed that I have thyroglobulin antibodies which’s is 232.2 and the reference range supposed to be <60 . I am very scare I have read a lot of stuff about it and I have my appointment next week .I am very scare that every single day it can be hi .I would be appreciated if you can tell me what should I do ? Is it dangerous any help any advice would be really appreciated.Thank you so much in advance .

  90. MY TPO IS 20 AND Thyroglobulin IS 806, DOES THIS MEAN I HAVE HASHIMOTOS, I AM CONFUSED, PLEASE CLARIFY, AND TIA

  91. MY TPO IS 20 AND Thyroglobulin IS 806, DOES THIS MEAN I HAVE HASHIMOTOS, I AM CONFUSED, PLEASE CLARIFY, AND TIA

        1. Sorry.. TSH was less than 0.01 last month and is 0.1 after stopping thyroxine for 15 days
          TPO anitbodies is more than 600
          Free T3 (FT3) 3.32,Free T4 (FT4) 1.44

  92. Hi Doctor,
    My TSH was 600
    Free T3 (FT3) 3.32,Free T4 (FT4) 1.44
    What does this indicate? Kindly suggest. Thanks

    1. Is your TSH is flagged high and fT4 is flagged low, this indicates hypothyroid. A TSH is considered very high and I would follow up with your doctor promptly.

        1. Sorry.. TSH was less than 0.01 last month and is 0.1 after stopping thyroxine for 15 days
          TPO anitbodies is more than 600
          Free T3 (FT3) 3.32,Free T4 (FT4) 1.44

  93. Hi Doctor Ruscio,
    I had metastatic pappillary thyroid cancer, post RAI and its shows that my cancers was heal, but my antibodies raises from 989 to 2266.0 within this 2 years. What does this indicates?

    Thank you

    Poline Kong
    .

  94. Hi Doctor Ruscio,
    I had metastatic pappillary thyroid cancer, post RAI and its shows that my cancers was heal, but my antibodies raises from 989 to 2266.0 within this 2 years. What does this indicates?

    Thank you

    Poline Kong
    .

      1. Hi Doctor Ruscio,
        Thank you very much for your help. Your response gave me hope. God bless you.

        Thank you

        Poline

  95. Thanks for all of this great information, and thanks in advance if you’re able to answer my question. Is it the case that numerically small results (~40 IU/mL) for TPO antibody lab tests could be serological false positives caused by cross-reactivity or other imperfections of the measurement process? I understand that this is different than a false positive in the sense of the diagnostic interpretation of the results.

    1. Hi Michael,

      Thanks for taking the time to comment. I’ve passed your comment on to Dr. Ruscio and hopefully he will answer it in an upcoming podcast.

  96. Thanks for all of this great information, and thanks in advance if you’re able to answer my question. Is it the case that numerically small results (~40 IU/mL) for TPO antibody lab tests could be serological false positives caused by cross-reactivity or other imperfections of the measurement process? I understand that this is different than a false positive in the sense of the diagnostic interpretation of the results.

    1. Hi Michael,

      Thanks for taking the time to comment. I’ve passed your comment on to Dr. Ruscio and hopefully he will answer it in an upcoming podcast.

  97. My T3 & T4 is normal… TSH is 7…and anti TPO is 1300 which shouldb below 60 …. Should I b treated or it goes normal with diet & exercises…plz suggest me sir

  98. My T3 & T4 is normal… TSH is 7…and anti TPO is 1300 which shouldb below 60 …. Should I b treated or it goes normal with diet & exercises…plz suggest me sir

    1. Hi Mary,

      You’ll want to check in with your doctor about this. Thanks and good luck!

  99. Hello,

    I have had Thyroid issues in the past. Every time we have been able to get things under wraps. I am starting to lose weight, my hair is falling out clumps at a time, my skin is super dry and I am very sluggish all the time. I was young the last few times that I had a flare up.

    I just went and saw my family doctor and when he called back he said all of my levels were normal expect my antibodies which is at a 70. I am just confused and cant get in to see a specialist for a month. I was wondering if you could point me in the right direction if there is anything I can be doing to help myself feel better.

    Thank you for your time

  100. Hello,

    I have had Thyroid issues in the past. Every time we have been able to get things under wraps. I am starting to lose weight, my hair is falling out clumps at a time, my skin is super dry and I am very sluggish all the time. I was young the last few times that I had a flare up.

    I just went and saw my family doctor and when he called back he said all of my levels were normal expect my antibodies which is at a 70. I am just confused and cant get in to see a specialist for a month. I was wondering if you could point me in the right direction if there is anything I can be doing to help myself feel better.

    Thank you for your time

  101. Hi doc,
    I have TSH =16 and TPO as 109, and i not taking any meds . I have consulted a doc and he gave me 25mg Thyronorm. meds What will you suggest me to do?

  102. Hi doc,
    I have TSH =16 and TPO as 109, and i not taking any meds . I have consulted a doc and he gave me 25mg Thyronorm. meds What will you suggest me to do?

  103. All levels point toward hashimotos… TSH from 9.9, 3.7 then 5.6 in a 4 month span, low normal T4, TPO over 2,000 ,thyroglobulin antibody 1.1, low normal testosterone, low DHEAS levels, cortisol anomalies, vitamin d deficiency (19), suspect Candida overgrowth, luckily Crp levels were normal and didn’t indicate inflammation with hypothyroid symptoms have ultrasound scheduled for suspected nodule/enlargement and scheduled appointment at duke integrative med … now on gut supplement and vitamin d supplement and high end probiotic already a super clean eating vegan, brain fog gone and luckily able to exercise vigorously 4-5 days a week but eyes get fatigued at computer, it’s getting better but a few weeks ago it was so severe it was impairing my ability to work and caused me to feel the need to lay down and close my eyes after only being up for an hour or two… saw a neuro but he didn’t see neuro problem… have you ever had a patient present with eye fatigue and light sensitivity with some floaty/dizzy with such poor lab numbers? Hoping not thyroid cancer… also any resources for remaining vegan but going after the autoimmune component! Any suggestions appreciated . Would schedule Skype visit but u are booked until November and But I’m too acute to wait.

    1. Hi Ellen,
      My book is the most comprehensive offering I can point you to. It’s focus is gut health, but this has carryover to thyroid. Wish I could offer more but I can’t do much in a comments section.

  104. All levels point toward hashimotos… TSH from 9.9, 3.7 then 5.6 in a 4 month span, low normal T4, TPO over 2,000 ,thyroglobulin antibody 1.1, low normal testosterone, low DHEAS levels, cortisol anomalies, vitamin d deficiency (19), suspect Candida overgrowth, luckily Crp levels were normal and didn’t indicate inflammation with hypothyroid symptoms have ultrasound scheduled for suspected nodule/enlargement and scheduled appointment at duke integrative med … now on gut supplement and vitamin d supplement and high end probiotic already a super clean eating vegan, brain fog gone and luckily able to exercise vigorously 4-5 days a week but eyes get fatigued at computer, it’s getting better but a few weeks ago it was so severe it was impairing my ability to work and caused me to feel the need to lay down and close my eyes after only being up for an hour or two… saw a neuro but he didn’t see neuro problem… have you ever had a patient present with eye fatigue and light sensitivity with some floaty/dizzy with such poor lab numbers? Hoping not thyroid cancer… also any resources for remaining vegan but going after the autoimmune component! Any suggestions appreciated . Would schedule Skype visit but u are booked until November and But I’m too acute to wait.

    1. Hi Ellen,
      My book is the most comprehensive offering I can point you to. It’s focus is gut health, but this has carryover to thyroid. Wish I could offer more but I can’t do much in a comments section.

  105. Do you treat children? My 4 yr old son has hypothyroidism and gut issues. His TSH is 10 but it’s not improving on 50 mcg of thyroxine.
    Thank you,
    Amanda

  106. Do you treat children? My 4 yr old son has hypothyroidism and gut issues. His TSH is 10 but it’s not improving on 50 mcg of thyroxine.
    Thank you,
    Amanda

  107. Hi Dr. Ruscio! I was wondering what it means if thyroid peroxidase antibodies stays almost the exact same of 74 over a period of 2 years? When I was originally diagnosed, I went on a hardcore gluten free diet and they dropped from 97 down to the 70ish range and surprisingly have stayed there, despite eating tons of gluten!

  108. Hi Dr. Ruscio! I was wondering what it means if thyroid peroxidase antibodies stays almost the exact same of 74 over a period of 2 years? When I was originally diagnosed, I went on a hardcore gluten free diet and they dropped from 97 down to the 70ish range and surprisingly have stayed there, despite eating tons of gluten!

  109. MY TPOAb test was ran 2 days go and my TPO is 0.50 IU/mL 0.00-9.00
    My TSH (H) 5.55 mcIU/mL and .44-4.21
    and my ERSA SED Rate Auto 13 mm/hr 0-26
    My doctor is not really giving me much to go off of here and says take Levothyroxine 1, 25mg tablet for 2 weeks and then increase it to 50 mg in week 3 to week 6. I don’t want to take it due to crazy side effects and long term effects/ can I take Silenium, B-12, and Detoxadine in place of it to regulate the same natural results? if so what mg’s should I be taking? I am hoping you can help.

    1. Hi Kristen,
      I can’t provide personalized treatment advice here. I would recommend taking steps to optimize your gut health as this can very beneficially effect thyroid-symptoms and overall health. My book provides the best gut protocol I can offer. Hope this helps!

  110. MY TPOAb test was ran 2 days go and my TPO is 0.50 IU/mL 0.00-9.00
    My TSH (H) 5.55 mcIU/mL and .44-4.21
    and my ERSA SED Rate Auto 13 mm/hr 0-26
    My doctor is not really giving me much to go off of here and says take Levothyroxine 1, 25mg tablet for 2 weeks and then increase it to 50 mg in week 3 to week 6. I don’t want to take it due to crazy side effects and long term effects/ can I take Silenium, B-12, and Detoxadine in place of it to regulate the same natural results? if so what mg’s should I be taking? I am hoping you can help.

    1. Hi Kristen,
      I can’t provide personalized treatment advice here. I would recommend taking steps to optimize your gut health as this can very beneficially effect thyroid-symptoms and overall health. My book provides the best gut protocol I can offer. Hope this helps!

  111. I looked at my thyroid test that was done and it says Triiodothyronine T3 which was 123, Thyroid Peroxidase TPO the number was <6 , is that good?

  112. I looked at my thyroid test that was done and it says Triiodothyronine T3 which was 123, Thyroid Peroxidase TPO the number was <6 , is that good?

  113. I had my thyroid tested and was told everything was ok but I did have TPO of <3 and range was <6 IU/ml. Is it normal to have antibodies???

  114. I had my thyroid tested and was told everything was ok but I did have TPO of <3 and range was <6 IU/ml. Is it normal to have antibodies???

  115. Hi
    My TSH :7.38
    T3 and T4 are in normal range

    My Tpo anitbody:406
    should i start thyroid replacement harmone or go on a diet for healing by tpo antibodies

  116. Hi
    My TSH :7.38
    T3 and T4 are in normal range

    My Tpo anitbody:406
    should i start thyroid replacement harmone or go on a diet for healing by tpo antibodies

  117. Hi Dr. Ruscio,

    Firstly, I’d just like to say that I think it’s great that you take the time to feed back to people in need of support and advice on your website!

    I was wondering if you might be able to share any suggestions with me regarding my TPO level.

    I am a 32 year old male, who was diagnosed with Hashimoto’s 1 month ago. Back then, my readings showed normal T3 and T4 levels, but a TSH level of 6.03. My TPO level was above 1300.

    I was prescribed 25 mg of levothyroxine daily. I have been following an aip diet – cutting out dairy but having the odd cheat day a couple of times in the month (my wife loves chocolate). I have also been taking selenium and probiotics daily.

    I had another test yesterday, and my results have shown normal T3 and T4 levels, as well as an improvement in my TSH, which is now 2.1. However, my tpo level is still over 1300. I also have a slight goiter appearing over where the left thyroid is located.

    I realise that only being on the levothyroxine for 1 month, and testing out these supplements and new diets might not be long enough yet to see a drop in my TPO level. I am just wondering what your opinion is on me being on such a low dosage of thyroxine, and how long would you normally expect it to take to see improvements in the TPO level?

    I move to China in 2 weeks, and I know it will be very challenging to avoid soy and gluten, hence why I am wondering if being strictly gluten free is a denial of enjoyment rather than a sure-way route to better results.

    Any advice or opinion from you would be greatly appreciated.

    Kind regards,

    Matt

  118. Hi again, just to also add on, I have been take vitamin D supplements for the last 4 weeks. I have also had an ultrasound which showed me having multi nodules on the goiter, but no signs of anything sinister.

  119. Hi Dr. Ruscio,

    Firstly, I’d just like to say that I think it’s great that you take the time to feed back to people in need of support and advice on your website!

    I was wondering if you might be able to share any suggestions with me regarding my TPO level.

    I am a 32 year old male, who was diagnosed with Hashimoto’s 1 month ago. Back then, my readings showed normal T3 and T4 levels, but a TSH level of 6.03. My TPO level was above 1300.

    I was prescribed 25 mg of levothyroxine daily. I have been following an aip diet – cutting out dairy but having the odd cheat day a couple of times in the month (my wife loves chocolate). I have also been taking selenium and probiotics daily.

    I had another test yesterday, and my results have shown normal T3 and T4 levels, as well as an improvement in my TSH, which is now 2.1. However, my tpo level is still over 1300. I also have a slight goiter appearing over where the left thyroid is located.

    I realise that only being on the levothyroxine for 1 month, and testing out these supplements and new diets might not be long enough yet to see a drop in my TPO level. I am just wondering what your opinion is on me being on such a low dosage of thyroxine, and how long would you normally expect it to take to see improvements in the TPO level?

    I move to China in 2 weeks, and I know it will be very challenging to avoid soy and gluten, hence why I am wondering if being strictly gluten free is a denial of enjoyment rather than a sure-way route to better results.

    Any advice or opinion from you would be greatly appreciated.

    Kind regards,

    Matt

  120. 2 months before my TSH was 7.17, now its 4.52 (which is normal) and now I just got tested for Anti Thyroid Peroxidase Antibodies range, comes out that it’s 111.8 IU/mL so I don’t know if that’s good or bad. Can you please tell about it and am I healthy?
    Thanks in advance.

  121. Hi again, just to also add on, I have been take vitamin D supplements for the last 4 weeks. I have also had an ultrasound which showed me having multi nodules on the goiter, but no signs of anything sinister.

  122. 2 months before my TSH was 7.17, now its 4.52 (which is normal) and now I just got tested for Anti Thyroid Peroxidase Antibodies range, comes out that it’s 111.8 IU/mL so I don’t know if that’s good or bad. Can you please tell about it and am I healthy?
    Thanks in advance.

  123. My TPO Antibodies went from 208 in 2014 (after giving birth to first son) to 118 in 2018. I have been gluten free for 9 months. I take 88mcg levothyroxine to feel normal and maintain good TSH levels. Doesn’t this mean I have hypothyroidism even though my levels were below the 500 you spoke about? thank you for any clarification.

  124. My TPO Antibodies went from 208 in 2014 (after giving birth to first son) to 118 in 2018. I have been gluten free for 9 months. I take 88mcg levothyroxine to feel normal and maintain good TSH levels. Doesn’t this mean I have hypothyroidism even though my levels were below the 500 you spoke about? thank you for any clarification.

  125. I am 28yrs old undergone from IVF treatment having one child 6month after this I have stopped thayronom 100 medicines for one month suddenly after one month my TSH bounced to 95.14 (reference range 0.45 to 4.5,max 4to 15) with 600Tpo and thyroid USG normal ,kindly suggest me can it be totally CURED.??

    1. I’m sorry Crystal but the question here is unclear. I also can’t provide person health advise here. Feel free to contact my office if you are in need of personalize help.

  126. I am 28yrs old undergone from IVF treatment having one child 6month after this I have stopped thayronom 100 medicines for one month suddenly after one month my TSH bounced to 95.14 (reference range 0.45 to 4.5,max 4to 15) with 600Tpo and thyroid USG normal ,kindly suggest me can it be totally CURED.??

    1. I’m sorry Crystal but the question here is unclear. I also can’t provide person health advise here. Feel free to contact my office if you are in need of personalize help.

  127. with above question reference…sorry my USG shows ” ?hashimoto thyroiditis “.
    Kindly suggest me treatment for thyroid with antitpo is different or same.my doctor suggested life long medicines :((( kindly give me right suggestion.

    1. Hi Crystal,

      I’m sorry to hear about your diagnosis.

      If you’d like to apply to become a patient of Dr. Ruscio’s, you can do so here: https://drruscio.com/consult-dr-ruscio/

      If you’d like to look through some of the resources we have for hashimoto’s, you may want to check out this podcast: https://drruscio.com/tips-for-hashimotos-thyroiditis-hypothyroid-symptoms/

      Or you may be interested in Dr. Ruscio’s book “Healthy Gut, Healthy You” because we know the gut and the thyroid have a very strong link and working to improve gut health often improves thyroid conditions. The book can be found here: https://drruscio.com/getgutbook/

      Good luck!

  128. with above question reference…sorry my USG shows ” ?hashimoto thyroiditis “.
    Kindly suggest me treatment for thyroid with antitpo is different or same.my doctor suggested life long medicines :((( kindly give me right suggestion.

    1. Hi Crystal,

      I’m sorry to hear about your diagnosis.

      If you’d like to apply to become a patient of Dr. Ruscio’s, you can do so here: https://drruscio.com/consult-dr-ruscio/

      If you’d like to look through some of the resources we have for hashimoto’s, you may want to check out this podcast: https://drruscio.com/tips-for-hashimotos-thyroiditis-hypothyroid-symptoms/

      Or you may be interested in Dr. Ruscio’s book “Healthy Gut, Healthy You” because we know the gut and the thyroid have a very strong link and working to improve gut health often improves thyroid conditions. The book can be found here: https://drruscio.com/getgutbook/

      Good luck!

  129. Hi. I have just received blood test results with a Thyroid Peroxidase Antibody Level of 1646 iu/mL !
    I am already taking 150mg of levothyroxin per day.
    Should I be alarmed at this high reading ?
    Many thanks,
    Russell

  130. Hi. I have just received blood test results with a Thyroid Peroxidase Antibody Level of 1646 iu/mL !
    I am already taking 150mg of levothyroxin per day.
    Should I be alarmed at this high reading ?
    Many thanks,
    Russell

      1. Sir, My question has been skipped mistakenly I do check every day waiting for your reply..kindly reply.thank you.

  131. Hi there, if all my thyroid levels are normal besides the thyroglobulin antibodies which is 5.00 iu/ml, do i need to be on medication.

  132. Hi there, if all my thyroid levels are normal besides the thyroglobulin antibodies which is 5.00 iu/ml, do i need to be on medication.

  133. Sir, my TSH is 99.55(Normal=0.70-6.40), T3=0.74(normal=0.80-2.10),T4=3.40(normal=5.01-12.45)
    Anti tpo levels = 75(Normal<60)
    Am i having hashimoto&#039s thyroiditis

  134. Sir, my TSH is 99.55(Normal=0.70-6.40), T3=0.74(normal=0.80-2.10),T4=3.40(normal=5.01-12.45)
    Anti tpo levels = 75(Normal<60)
    Am i having hashimoto's thyroiditis

  135. My THYROID PEROXIDASE ANTIBODIES test results are 595 but my TESTOSTERONE, TOTAL, LC/MS/MS is very high at 54. I cant find anything on the testosterone. I dont have any symptoms of thyroid or high testosterone. I only have very dry skin and scalp. I am a juvenile diabetic and in menopause. My hormones are a nightmare 🙁 no one seems to know why the testosterone is so high and it concerns me that something is being overlooked. Has anyone else had elevated testosterone with thyroid?

  136. My THYROID PEROXIDASE ANTIBODIES test results are 595 but my TESTOSTERONE, TOTAL, LC/MS/MS is very high at 54. I cant find anything on the testosterone. I dont have any symptoms of thyroid or high testosterone. I only have very dry skin and scalp. I am a juvenile diabetic and in menopause. My hormones are a nightmare 🙁 no one seems to know why the testosterone is so high and it concerns me that something is being overlooked. Has anyone else had elevated testosterone with thyroid?

  137. Hello Dr. Ruscio. I was just tested for thyroid problems and my Thyroid Perioxidase (TPO) Ab is over 4000. I had it retested, and it is still the same. You write that 500 is still ok, but what shall I do with myself?

  138. Hello Dr. Ruscio. I was just tested for thyroid problems and my Thyroid Perioxidase (TPO) Ab is over 4000. I had it retested, and it is still the same. You write that 500 is still ok, but what shall I do with myself?

  139. My tpo antibodies are 1926. My doctor doesn’t seem concerned but I am. What can I do? I have been diagnosed with hashimotos and take armour for hypothyroidism.

  140. My tpo antibodies are 1926. My doctor doesn’t seem concerned but I am. What can I do? I have been diagnosed with hashimotos and take armour for hypothyroidism.

  141. Hello. I have been experiencing pretty severe fatigue, body pain, and memory issues/ brain fog. Was told to get thyroid checked. How likely is it that thyroid is causing symptoms with these results…
    TSH- 2.8
    Tg ab- 75
    Total T4- 6.6
    Total t3- 84
    Tp ab- 8

    1. Hi Chuck,

      I’m sorry to hear you’re not feeling well. Those results need to be interpreted by a clinician. I’d suggest chatting with your doctor, or if you’d like to become a patient of Dr. Ruscio’s, you can do so here: drruscio.com/gethelp

      Fatigue and brain fog can also be related to the gut, so working to improve gut health may be helpful as well (see more info here: drruscio.com/getgutbook)

      Good luck!

  142. Hello. I have been experiencing pretty severe fatigue, body pain, and memory issues/ brain fog. Was told to get thyroid checked. How likely is it that thyroid is causing symptoms with these results…
    TSH- 2.8
    Tg ab- 75
    Total T4- 6.6
    Total t3- 84
    Tp ab- 8

    1. Hi Chuck,

      I’m sorry to hear you’re not feeling well. Those results need to be interpreted by a clinician. I’d suggest chatting with your doctor, or if you’d like to become a patient of Dr. Ruscio’s, you can do so here: drruscio.com/gethelp

      Fatigue and brain fog can also be related to the gut, so working to improve gut health may be helpful as well (see more info here: drruscio.com/getgutbook)

      Good luck!

  143. Abnormal
    Tsh 12.83
    Tpo 163

    Normal
    T3 uptake 34
    T4 total 5.4
    Free t4 index (t7) 1.8
    T4 Free 1.0
    T3 Free 2.3
    Thyroglobulin <1

    46 years old, female
    I am asymptomatic except get cold a lot which seems to have been lifelong and low HR, b/p but Very athletic. My doctor wanted to put me on meds but I want a natural approach if any.
    Do I need to seek help?

    1. I can’t advise you on personal health decisions here. I have addressed subclinical hypothyroid, which is what this appears to be, many times on this site. You can also contact office.

  144. Abnormal
    Tsh 12.83
    Tpo 163

    Normal
    T3 uptake 34
    T4 total 5.4
    Free t4 index (t7) 1.8
    T4 Free 1.0
    T3 Free 2.3
    Thyroglobulin <1

    46 years old, female
    I am asymptomatic except get cold a lot which seems to have been lifelong and low HR, b/p but Very athletic. My doctor wanted to put me on meds but I want a natural approach if any.
    Do I need to seek help?

    1. I can’t advise you on personal health decisions here. I have addressed subclinical hypothyroid, which is what this appears to be, many times on this site. You can also contact office.

  145. Hello

    My wife is 36 years old

    Recently when we have gome through a routine check we got the TSH level 7.2

    And when we done TPO (Anti Microsomal Antibodies) test result is 248 U/ml

    Can you suggest is this serious.

    Regards

    1. I’m sorry, I can’t provide diagnoses here. I have spoken about subclinical hypothyroid on this site many times. You can also reach out to my office if you would like a second opinion.

  146. Hello

    My wife is 36 years old

    Recently when we have gome through a routine check we got the TSH level 7.2

    And when we done TPO (Anti Microsomal Antibodies) test result is 248 U/ml

    Can you suggest is this serious.

    Regards

    1. I’m sorry, I can’t provide diagnoses here. I have spoken about subclinical hypothyroid on this site many times. You can also reach out to my office if you would like a second opinion.

  147. Hi I had my TPO levels tested and they were >1000 TSH T4 were normal. I have symptoms of hypothyroidism. I have a positive ANA with anti nuclear antibody titre 1/160 homogeneous. Any suggestions what this could be?

  148. Hi I had my TPO levels tested and they were >1000 TSH T4 were normal. I have symptoms of hypothyroidism. I have a positive ANA with anti nuclear antibody titre 1/160 homogeneous. Any suggestions what this could be?

  149. My TPO was 91 in 2015. My TSH just taken was 7.0 and T4free was 9.0. Is has been 9.00 3 times. I want to redo TPO .

    I do not want to start medicine.

    Mayo clinic had on their site (awhile ago) that your result may be affected if you have been exposed to animal antigens. I get allergy shots for horses, dogs, cats and don’t know if other animals are in shots. I can’t find anything else that says this but I would like to get TPO test done again. Have you heard of this?
    Dr. just wanted to put me on medicine and did not even know about TPO done in 2015
    Am I a strong candidate for medicine at this point. (age 72 female)

  150. My TPO was 91 in 2015. My TSH just taken was 7.0 and T4free was 9.0. Is has been 9.00 3 times. I want to redo TPO .

    I do not want to start medicine.

    Mayo clinic had on their site (awhile ago) that your result may be affected if you have been exposed to animal antigens. I get allergy shots for horses, dogs, cats and don’t know if other animals are in shots. I can’t find anything else that says this but I would like to get TPO test done again. Have you heard of this?
    Dr. just wanted to put me on medicine and did not even know about TPO done in 2015
    Am I a strong candidate for medicine at this point. (age 72 female)

  151. Thank you very much. I couldn’t reach my doctor after getting my test results and I was going south. This video made me feel better.

  152. Thank you very much. I couldn’t reach my doctor after getting my test results and I was going south. This video made me feel better.

  153. Hello Dr. Ruscio,

    I have been hypothyroid now for about 20 years. I have never been referred to an endocrinologist and just last week I had blood work done. Now to be fair I did run out of meds at the end of July beginning of August so have not been on medication for about 6-8 weeks. I finally got tested to see if I have Hashimoto’s Disease. So, My TSH came back at 264+ and my TPO came back at 31. To complicate things further I don’t have a family doctor as there are none accepting new patients in my area so I have been relying on walk-in clinics to get my prescriptions renewed. I live in Canada. My last two doctors left family practice to go into specialties. The doctor I saw today was emphatic that I do not have Hashimoto’s though I have all of the symptoms associated with it. I’m at my wits end and have no clue what to do next? Hoping you can possibly steer me in the right direction for managing my systems….My thanks in advance.

    1. Hi Wendy,

      I’m sorry to hear this – I know trying to sort it all out can feel overwhelming at time.

      It sounds like getting a doctor experienced in treating thyroid issues would be helpful for you. If you’d like to become a patient of Dr. Ruscio’s (he sees people virtually), you can apply here: drruscio.com/gethelp

      You may also want to check out some of the other thyroid resources on our website, like this podcast: https://drruscio.com/tips-for-hashimotos-thyroiditis-hypothyroid-symptoms/

      Good luck!

  154. Hello Dr. Ruscio,

    I have been hypothyroid now for about 20 years. I have never been referred to an endocrinologist and just last week I had blood work done. Now to be fair I did run out of meds at the end of July beginning of August so have not been on medication for about 6-8 weeks. I finally got tested to see if I have Hashimoto’s Disease. So, My TSH came back at 264+ and my TPO came back at 31. To complicate things further I don’t have a family doctor as there are none accepting new patients in my area so I have been relying on walk-in clinics to get my prescriptions renewed. I live in Canada. My last two doctors left family practice to go into specialties. The doctor I saw today was emphatic that I do not have Hashimoto’s though I have all of the symptoms associated with it. I’m at my wits end and have no clue what to do next? Hoping you can possibly steer me in the right direction for managing my systems….My thanks in advance.

    1. Hi Wendy,

      I’m sorry to hear this – I know trying to sort it all out can feel overwhelming at time.

      It sounds like getting a doctor experienced in treating thyroid issues would be helpful for you. If you’d like to become a patient of Dr. Ruscio’s (he sees people virtually), you can apply here: drruscio.com/gethelp

      You may also want to check out some of the other thyroid resources on our website, like this podcast: https://drruscio.com/tips-for-hashimotos-thyroiditis-hypothyroid-symptoms/

      Good luck!

  155. I had a thyroidectomy early June and although the biopsy wasn’t positive for cancer the doctor requested a follow up. So, I had analysis for tumor markers and the results are:
    LDH 236.0
    Anti-TPO 15.4
    Thyroglobulin abs 22.9
    Thyroglobulin Test (TG) undetectable

    Do I have to worry about anything?
    Thank you

    1. Hi Anna,

      I hope you’re recovering well from the surgery.

      We’re unable to interpret labs or offer personalized advice on the website, but he does talk about levels of several of these markers in the video, so it’s worth going back and watching again.

      Good luck!

  156. I had a thyroidectomy early June and although the biopsy wasn’t positive for cancer the doctor requested a follow up. So, I had analysis for tumor markers and the results are:
    LDH 236.0
    Anti-TPO 15.4
    Thyroglobulin abs 22.9
    Thyroglobulin Test (TG) undetectable

    Do I have to worry about anything?
    Thank you

    1. Hi Anna,

      I hope you’re recovering well from the surgery.

      We’re unable to interpret labs or offer personalized advice on the website, but he does talk about levels of several of these markers in the video, so it’s worth going back and watching again.

      Good luck!

  157. Hi ,
    I was diagnosed with ths 4.110H range is (0.3-3) in 2010 with free t4 serum 13.40 (11-18pmol/L) took no medication as nobody told me anything.

    In 2013 it was in range. Then in

    01/04/ 2017 tsh 3.271 H
    Free t4 12.69

    09/11/2017 tsh 5.848 H
    Free t4 11.74

    15/03/2018 tsh 5.232 H
    Free t4 12.48

    17/07/2018 tsh 4.699 H
    Free t4 14.06

    16/10/2018 Tsh 5.336 H
    Free t4 15.35
    Anti thyroid peroxidase antibody 500 (range 0.0-50.0 IU/ml

    I am not on thyroxine as it made me very anxious.
    I am having zinc, selenium, fish oils, l-tyrosine, vitamin D3 , ashwaganda, spirulina, chlorella, rhodiola, iodine not everyday but a few tablets a month. The rest everyday.
    Vitamin d they found it low . My iodine levels are in range.

    Please can you tell me how I am going to get my TSH and anti thyroid peroxidase antibody in range? I am being depressed and stress out at times.
    Please help. Thanks

  158. Hi ,
    I was diagnosed with ths 4.110H range is (0.3-3) in 2010 with free t4 serum 13.40 (11-18pmol/L) took no medication as nobody told me anything.

    In 2013 it was in range. Then in

    01/04/ 2017 tsh 3.271 H
    Free t4 12.69

    09/11/2017 tsh 5.848 H
    Free t4 11.74

    15/03/2018 tsh 5.232 H
    Free t4 12.48

    17/07/2018 tsh 4.699 H
    Free t4 14.06

    16/10/2018 Tsh 5.336 H
    Free t4 15.35
    Anti thyroid peroxidase antibody 500 (range 0.0-50.0 IU/ml

    I am not on thyroxine as it made me very anxious.
    I am having zinc, selenium, fish oils, l-tyrosine, vitamin D3 , ashwaganda, spirulina, chlorella, rhodiola, iodine not everyday but a few tablets a month. The rest everyday.
    Vitamin d they found it low . My iodine levels are in range.

    Please can you tell me how I am going to get my TSH and anti thyroid peroxidase antibody in range? I am being depressed and stress out at times.
    Please help. Thanks

  159. Since my hemithyroidectomy in 2014, I have been symptomatic, however all levels according to blood draws are ‘within normal ranges”. I have chill blaines, digestive issues, abdo distention, chronic constipation, general muscle fatigue (no muscular endurance however I have maintained muscle strength), and emotional ups and downs. I have chronic alopecia however i still have a full head of hair. I have chronic dry skin, anorexia. Less than 6 mths post sx an US revealed two new nodules in the bed of the thyroid that was removed, and there was residual thyroid tissue there as well. Also, a new nodule on the Rt side was noted. My cognitive flexibility is extremely high, although I do have a slight memory loss.I experience vasovagal events periodically. I recently had my TPO, T4/3 and TSH done and the TPO was 22 (i am in canada). Since the sx I have not been medicated. I have a chronic abdominal pressure, look like I’m 6 mths pregnant, I am tired all the time and have no one that will listen to or bother medicating me or looking past the normal findings. I would love some advice, as to what is normal, what isn’t and what recourse there is when you are symptomatic and all your labs come back as within normal limits.

    1. Hi Louise,

      I’m so sorry to hear you’re dealing with all of that, I know how frustrating it can be.

      I would definitely recommend working with a professional to try and get the disordered eating ironed out, because many of the symptoms you’re describing can also be attributed to anorexia.

      As far as still having thyroid symptoms, check out this post as it may have some helpful info: https://drruscio.com/still-have-hypothyroid-symptoms-despite-normal-lab-results/

      And if you’d like to become a patient of Dr Ruscio’s for personalized advice, feel free to apply here: https://www.drruscio.com/gethelp

      Good luck!

  160. Since my hemithyroidectomy in 2014, I have been symptomatic, however all levels according to blood draws are ‘within normal ranges”. I have chill blaines, digestive issues, abdo distention, chronic constipation, general muscle fatigue (no muscular endurance however I have maintained muscle strength), and emotional ups and downs. I have chronic alopecia however i still have a full head of hair. I have chronic dry skin, anorexia. Less than 6 mths post sx an US revealed two new nodules in the bed of the thyroid that was removed, and there was residual thyroid tissue there as well. Also, a new nodule on the Rt side was noted. My cognitive flexibility is extremely high, although I do have a slight memory loss.I experience vasovagal events periodically. I recently had my TPO, T4/3 and TSH done and the TPO was 22 (i am in canada). Since the sx I have not been medicated. I have a chronic abdominal pressure, look like I’m 6 mths pregnant, I am tired all the time and have no one that will listen to or bother medicating me or looking past the normal findings. I would love some advice, as to what is normal, what isn’t and what recourse there is when you are symptomatic and all your labs come back as within normal limits.

    1. Hi Louise,

      I’m so sorry to hear you’re dealing with all of that, I know how frustrating it can be.

      I would definitely recommend working with a professional to try and get the disordered eating ironed out, because many of the symptoms you’re describing can also be attributed to anorexia.

      As far as still having thyroid symptoms, check out this post as it may have some helpful info: https://drruscio.com/still-have-hypothyroid-symptoms-despite-normal-lab-results/

      And if you’d like to become a patient of Dr Ruscio’s for personalized advice, feel free to apply here: https://www.drruscio.com/gethelp

      Good luck!

  161. Hi!

    My anti-TPO have always been between 400 and 800 for the last ten years. In 2015, they were at almost 5,000 and my endocrinologist wasn’t worried about it. Now, I went through a major depression at the same time. They went down around 1,000 after that. I had my levels checked last week again and now they are at 3,900. Should I consider a thyroid removal? I feel like crap even though I take .88 of Levo and my TSH is within normal range. Thank you for your advise.

  162. Hi!

    My anti-TPO have always been between 400 and 800 for the last ten years. In 2015, they were at almost 5,000 and my endocrinologist wasn’t worried about it. Now, I went through a major depression at the same time. They went down around 1,000 after that. I had my levels checked last week again and now they are at 3,900. Should I consider a thyroid removal? I feel like crap even though I take .88 of Levo and my TSH is within normal range. Thank you for your advise.

    1. Hi Maite,

      We can’t give direct medical advice on this site, but I would suggest looking through the thyroid resources on the site (https://drruscio.com/thyroid-disorders/) because there’s some really useful content on healing the thyroid that may help you. If you’d like to apply to become a patient o