Improving memory function, especially in people with fatigue, brain fog, or memory loss, starts with improving lifestyle and gut health.
Additional lifestyle changes include improving sleep and getting adequate exercise.
Supplements, brain training games, and nootropics can give your memory and cognition an extra boost.
Struggling with brain fog, having a hard time at work, or difficulty remembering people’s names? Or are you feeling pretty good and hoping to take your memory and cognitive performance to the next level? Maybe someone in your life has dementia and you want to know how to help them.
No matter what your starting point is, there’s a memory training strategy out there for you. You may have heard about memory training games, supplements to improve cognitive abilities, or memorization tricks to remember what you read and learn. This article will discuss what types of memory training actually work and when to use them.
What Is Memory Training?
There is actually no official definition of memory training. In general, it means anything that helps improve memory and cognition. Memory includes not just recollection of facts, but also our ability to do everyday things like tie our shoes, remember life events, know our emotional connection and relationship to others, and solve problems.
How Memory Works
A memory is a stored pattern, created by the neurons in the brain. Memory involves both manipulating and storing knowledge. In the brain, we receive information (from an event, learning a new hobby, reading, or from something we see, smell, or hear). Our brains work with that knowledge and either use it right away (short-term memory) or store it for later use.
Who Might Need or Want Memory Training?
Depending on your individual situation and goals, your memory training path may look a little different. In this article, we’ll cover these three categories of memory training:
You’re generally doing well but want to optimize your memory. You aren’t experiencing gaps in memory or struggling with cognition (ability to solve problems and make decisions.) You want to increase working memory capacity, strengthen your cognitive skills, improve academic performance, and process things faster.
You’re experiencing memory and cognition problems that impair your quality of life and do not know why. You may be experiencing brain fog, fatigue, struggling to complete tasks that were once easy for you, forgetting life events, or unable to keep up at work or school.
You want to help a loved one with diagnosed or suspected Alzheimer’s or another form of dementia. You want to know how to improve their daily functioning and possibly slow the rate of disease.
First let’s look at what is helpful for everyone when it comes to living a memory supportive life.
Living a Memory Supportive Life
Many factors can contribute to memory impairment and cognitive decline. However, a few key lifestyle factors can support brain health in most people:
Decreasing neuroinflammation and insulin resistance with a brain healthy diet.
Try to go to bed and wake up at the same time each day, even on weekends.
Get 15 minutes of sun within an hour of waking to support the circadian rhythm, which helps control the hormones of sleep (cortisol and melatonin.)
Wear blue-light blocking glasses two hours before bed to help start melatonin production.
Block all light in your room with blackout curtains and/or wearing a good sleep mask.
Now that you have a general base for memory support, let’s look at how you might optimize your memory.
How to Optimize for Better Memory and Performance
If your brain function is generally strong and you are just looking for cognition and memory improvement, there are a few types of brain games and supplements that might help.
Keep in mind that brain games and supplements are not a substitute for fixing any underlying causes of cognitive decline.
How Brain Games Work
Simply put, the brain learns things through repetition. When we do a task over and over again, synapses in the brain fire in a pattern that allows us to complete the task. When we do this enough, for example, when learning to play an instrument, the synaptic structure becomes so strong (and gets stored in long-term memory) that it becomes automated.
Memory games mainly work to improve working memory (information we can hold in our mind and work with in the present moment,) such as remembering a string of numbers or a grocery list. This is why some people keep repeating a list over and over again to remember it.
Memory games use techniques like mnemonic devices (brain exercises used by memory champions,) chunking, and method of loci to help improve working memory skills and remember things like names and lists of words more easily [33 Trusted SourcePubMedGo to source].
A few key points to understand when it comes to brain games:
If you’ve played a game for a long time, effectiveness goes down because the process becomes automated. Continually learning new things is important in improving cognition [34 Trusted SourcePubMedGo to source]. Try games that are completely new to you for better effectiveness [35 Trusted SourcePubMedGo to source].
Learn memory techniques such as how to create a memory palace or chunking. A memory palace is a mnemonic strategy used by memory athletes which involves using various auditory and visual memorization systems to recall information [33 Trusted SourcePubMedGo to source, 46]. One example of this is chunking, in which you take a whole bunch of small pieces of information and “chunk” them into larger groups, making the total number of things you need to remember smaller. For example, many people who remember phone numbers do not remember the 10 numbers in a string, but in chunks of 3, 3, 4.
Nootropic mixes (non-pharmacological and pharmacological substances/supplements) and supplements have been found to help with cognition and brain function, with the most positive effects being in people who are healthy.
Here are some supplements with the most supporting research for memory improvement:
Improvements in long-term memory, visual memory, and attention
This improvement could be due to decreased inflammation and a reduction in amyloid and tau protein concentrations in areas of the brain that modulate mood and memory [52 Trusted SourcePubMedGo to source]
Include the spice in cooking or take a daily supplement
Other supplements that have shown evidence of improving brain health and may be found in a nootropic mix:
If you are having serious memory and cognition deficits, the path to improving your memory lies in addressing some of the root causes of memory impairment. Barring stroke, traumatic brain injury, or other acute injury to the brain, some of the most common issues that lead to memory trouble are issues with the brain/gut axis and/or brain liver axis.
The Gut, Your Second Brain
The health of our gut directly influences the health of our brain:
I recommend starting with a Paleo diet, which removes inflammatory foods such as gluten, dairy, and legumes. However, a more restrictive diet may be needed if you do not see enough gut health improvement.
If you try a Paleo diet and are still having memory problems, you may want to try a low-FODMAP (fermentable oligo-, di-, mono-saccharides and polyols) diet which removes foods that can feed bacterial overgrowths. This diet is particularly helpful if you have SIBO or IBS [73 Trusted SourcePubMedGo to source].
For people who have more severe cognitive decline (Alzheimer’s and other dementias) or mental health issues, an anti-inflammatory ketogenic diet has been shown to increase cognition. Recent case studies connect the diet to improvement in mental health disorders like schizophrenia [14 Trusted SourcePubMedGo to source, 74 Trusted SourcePubMedGo to source]. (The research on mental illness is still preliminary and clinical trials are needed.)
With a ketogenic diet, the body gets into a metabolic state of ketosis, using ketones (and some glucose) to fuel the body and brain. It decreases insulin resistance and regulates blood sugar, which we discussed earlier as being a factor in poor brain function. A ketogenic diet is still anti-inflammatory, so the foods are similar to a Paleo diet, but carbohydrates stay low. The macronutrient ratio for a keto diet is generally 5% carbohydrates, 25% protein, and 70% healthy fats.
Probiotics can help support your gut reset by balancing the gut microbiome, thus improving the gut-brain axis.
Here is a simple chart to show you how you can add probiotics into your life:
Memory Training and Support for People with Dementia
While people with dementia have cognitive decline, studies where a mix of interventions were used, such as lifestyle changes, training working memory tasks, and executive function, show improvement in cognitive function and quality of life [80 Trusted SourcePubMedGo to source, 81 Trusted SourcePubMedGo to source].
Working memory is often impaired early on in dementia, which is why people struggle with completing a task, remembering the steps to button a shirt, or how to pay bills. All of this information is stored in their procedural memory, but they have a hard time bringing it into working memory to use the information in the present moment.
There are two key ways to improve memory for people with dementia:
Environmental cues. Environmental cues target poor working memory and procedural memory. These ask the brain to bring into working memory how to complete a task or a reminder to do a task.
These include step directions signage (how to button a shirt) leaving out an item you want a person to use (for example a pitcher of water and a cup or taking the cabinet doors off so they can see the cups), providing wayfinding signs (signs to find the bathroom in your home), and decreasing clutter so people can focus on improve quality of life and memory for people with dementia and help them function more independently [85 Trusted SourcePubMedGo to source, 86 Trusted SourcePubMedGo to source, 87].
Choosing the Right Memory Training For You
Depending on how your memory is currently working, you will want to choose what kind of interventions you want to implement. Even if you’re doing quite well, eat a low-inflammatory diet, get good sleep and proper exercise, and challenge your brain with new activities (we recommend this to all levels of cognitive health).
Here is a quick summary of ways to improve your memory:
If you have good cognition but want to optimize your brain even more, you can try adding some brain support supplements.
If you have significant memory impairment or other brain health issues, follow the rest-reset-remove steps to help resolve any root issues that may lead to a poor gut-brain and gut-brain-liver connection. Also get good sleep and proper exercise and challenge your brain.
If you are looking to help a loved one with dementia, big changes to diet may be difficult for someone with memory impairment, so consider those with your whole care team, especially your loved one’s doctor.
Whether or not you try dietary interventions, you can greatly increase their quality of life (and decrease caregiver stress) by using spaced retrieval and environmental cues.
If you want to take a closer look at your cognitive function or that of a loved one and want support with a more targeted and personalized approach, reach out to our clinic.
Hommet C, Mondon K, Camus V, Ribeiro MJ, Beaufils E, Arlicot N, et al. Neuroinflammation and β amyloid deposition in Alzheimer’s disease: in vivo quantification with molecular imaging. Dement Geriatr Cogn Disord. 2014;37(1–2):1–18. DOI: 10.1159/000354363. PMID: 24107621. Trusted SourcePubMedGo to source
Bradburn S, Murgatroyd C, Ray N. Neuroinflammation in mild cognitive impairment and Alzheimer’s disease: A meta-analysis. Ageing Res Rev. 2019 Mar;50:1–8. DOI: 10.1016/j.arr.2019.01.002. PMID: 30610927. Trusted SourcePubMedGo to source
Marques TR, Ashok AH, Pillinger T, Veronese M, Turkheimer FE, Dazzan P, et al. Neuroinflammation in schizophrenia: meta-analysis of in vivo microglial imaging studies. Psychol Med. 2019 Oct;49(13):2186–96. DOI: 10.1017/S0033291718003057. PMID: 30355368. PMCID: PMC6366560. Trusted SourcePubMedGo to source
Bora E, Akdede BB, Alptekin K. The relationship between cognitive impairment in schizophrenia and metabolic syndrome: a systematic review and meta-analysis. Psychol Med. 2017 Apr;47(6):1030–40. DOI: 10.1017/S0033291716003366. PMID: 28032535. Trusted SourcePubMedGo to source
Cooper C, Sommerlad A, Lyketsos CG, Livingston G. Modifiable predictors of dementia in mild cognitive impairment: a systematic review and meta-analysis. Am J Psychiatry. 2015 Apr;172(4):323–34. DOI: 10.1176/appi.ajp.2014.14070878. PMID: 25698435. Trusted SourcePubMedGo to source
Greenwood EA, Pasch LA, Cedars MI, Legro RS, Eisenberg E, Huddleston HG, et al. Insulin resistance is associated with depression risk in polycystic ovary syndrome. Fertil Steril. 2018 Jul 1;110(1):27–34. DOI: 10.1016/j.fertnstert.2018.03.009. PMID: 29908775. PMCID: PMC6392023. Trusted SourcePubMedGo to source
Ye F, Luo Y-J, Xiao J, Yu N-W, Yi G. Impact of Insulin Sensitizers on the Incidence of Dementia: A Meta-Analysis. Dement Geriatr Cogn Disord. 2016 Jun 2;41(5–6):251–60. DOI: 10.1159/000445941. PMID: 27250528. Trusted SourcePubMedGo to source
Lutski M, Weinstein G, Goldbourt U, Tanne D. Insulin Resistance and Future Cognitive Performance and Cognitive Decline in Elderly Patients with Cardiovascular Disease. J Alzheimers Dis. 2017;57(2):633–43. DOI: 10.3233/JAD-161016. PMID: 28304291. Trusted SourcePubMedGo to source
Riccio P, Rossano R. Undigested food and gut microbiota may cooperate in the pathogenesis of neuroinflammatory diseases: A matter of barriers and a proposal on the origin of organ specificity. Nutrients. 2019 Nov 9;11(11). DOI: 10.3390/nu11112714. PMID: 31717475. PMCID: PMC6893834. Trusted SourcePubMedGo to source
Lichtwark IT, Newnham ED, Robinson SR, Shepherd SJ, Hosking P, Gibson PR, et al. Cognitive impairment in coeliac disease improves on a gluten-free diet and correlates with histological and serological indices of disease severity. Aliment Pharmacol Ther. 2014 Jul;40(2):160–70. DOI: 10.1111/apt.12809. PMID: 24889390. Trusted SourcePubMedGo to source
Chen X, Maguire B, Brodaty H, O’Leary F. Dietary patterns and cognitive health in older adults: A systematic review. J Alzheimers Dis. 2019;67(2):583–619. DOI: 10.3233/JAD-180468. PMID: 30689586. Trusted SourcePubMedGo to source
Grammatikopoulou MG, Goulis DG, Gkiouras K, Theodoridis X, Gkouskou KK, Evangeliou A, et al. To keto or not to keto? A systematic review of randomized controlled trials assessing the effects of ketogenic therapy on alzheimer disease. Adv Nutr. 2020 Nov 16;11(6):1583–602. DOI: 10.1093/advances/nmaa073. PMID: 32597927. PMCID: PMC7666893. Trusted SourcePubMedGo to source
Masharani U, Sherchan P, Schloetter M, Stratford S, Xiao A, Sebastian A, et al. Metabolic and physiologic effects from consuming a hunter-gatherer (Paleolithic)-type diet in type 2 diabetes. Eur J Clin Nutr. 2015 Aug;69(8):944–8. DOI: 10.1038/ejcn.2015.39. PMID: 25828624. Trusted SourcePubMedGo to source
Jönsson T, Granfeldt Y, Ahrén B, Branell U-C, Pålsson G, Hansson A, et al. Beneficial effects of a Paleolithic diet on cardiovascular risk factors in type 2 diabetes: a randomized cross-over pilot study. Cardiovasc Diabetol. 2009 Jul 16;8:35. DOI: 10.1186/1475-2840-8-35. PMID: 19604407. PMCID: PMC2724493. Trusted SourcePubMedGo to source
Ticinesi A, Lauretani F, Tana C, Nouvenne A, Ridolo E, Meschi T. Exercise and immune system as modulators of intestinal microbiome: implications for the gut-muscle axis hypothesis. Exerc Immunol Rev. 2019;25:84–95. PMID: 30753131. Trusted SourcePubMedGo to source
Biazus-Sehn LF, Schuch FB, Firth J, Stigger F de S. Effects of physical exercise on cognitive function of older adults with mild cognitive impairment: A systematic review and meta-analysis. Arch Gerontol Geriatr. 2020 May 12;89:104048. DOI: 10.1016/j.archger.2020.104048. PMID: 32460123. Trusted SourcePubMedGo to source
Baker LD, Frank LL, Foster-Schubert K, Green PS, Wilkinson CW, McTiernan A, et al. Aerobic exercise improves cognition for older adults with glucose intolerance, a risk factor for Alzheimer’s disease. J Alzheimers Dis. 2010;22(2):569–79. DOI: 10.3233/JAD-2010-100768. PMID: 20847403. PMCID: PMC3049111. Trusted SourcePubMedGo to source
Haverkamp BF, Wiersma R, Vertessen K, van Ewijk H, Oosterlaan J, Hartman E. Effects of physical activity interventions on cognitive outcomes and academic performance in adolescents and young adults: A meta-analysis. J Sports Sci. 2020 Dec;38(23):2637–60. DOI: 10.1080/02640414.2020.1794763. PMID: 32783695. Trusted SourcePubMedGo to source
Miranda M, Morici JF, Zanoni MB, Bekinschtein P. Brain-Derived Neurotrophic Factor: A Key Molecule for Memory in the Healthy and the Pathological Brain. Front Cell Neurosci. 2019 Aug 7;13:363. DOI: 10.3389/fncel.2019.00363. PMID: 31440144. PMCID: PMC6692714. Trusted SourcePubMedGo to source
Campbell KL, Zadravec K, Bland KA, Chesley E, Wolf F, Janelsins MC. The Effect of Exercise on Cancer-Related Cognitive Impairment and Applications for Physical Therapy: Systematic Review of Randomized Controlled Trials. Phys Ther. 2020 Mar 10;100(3):523–42. DOI: 10.1093/ptj/pzz090. PMID: 32065236. Trusted SourcePubMedGo to source
Jurado-Fasoli L, De-la-O A, Molina-Hidalgo C, Migueles JH, Castillo MJ, Amaro-Gahete FJ. Exercise training improves sleep quality: A randomized controlled trial. Eur J Clin Invest. 2020 Mar;50(3):e13202. DOI: 10.1111/eci.13202. PMID: 31989592. Trusted SourcePubMedGo to source
Hunt AP, Minett GM, Gibson OR, Kerr GK, Stewart IB. Could heat therapy be an effective treatment for alzheimer’s and parkinson’s diseases? A narrative review. Front Physiol. 2019;10:1556. DOI: 10.3389/fphys.2019.01556. PMID: 31998141. PMCID: PMC6965159. Trusted SourcePubMedGo to source
Goekint M, Roelands B, Heyman E, Njemini R, Meeusen R. Influence of citalopram and environmental temperature on exercise-induced changes in BDNF. Neurosci Lett. 2011 Apr 25;494(2):150–4. DOI: 10.1016/j.neulet.2011.03.001. PMID: 21385602. Trusted SourcePubMedGo to source
Tsai S-R, Hamblin MR. Biological effects and medical applications of infrared radiation. J Photochem Photobiol B, Biol. 2017 May;170:197–207. DOI: 10.1016/j.jphotobiol.2017.04.014. PMID: 28441605. PMCID: PMC5505738. Trusted SourcePubMedGo to source
Bossers WJR, van der Woude LHV, Boersma F, Hortobágyi T, Scherder EJA, van Heuvelen MJG. A 9-Week Aerobic and Strength Training Program Improves Cognitive and Motor Function in Patients with Dementia: A Randomized, Controlled Trial. Am J Geriatr Psychiatry. 2015 Nov;23(11):1106–16. DOI: 10.1016/j.jagp.2014.12.191. PMID: 25648055. Trusted SourcePubMedGo to source
Hiscock H, Sciberras E, Mensah F, Gerner B, Efron D, Khano S, et al. Impact of a behavioural sleep intervention on symptoms and sleep in children with attention deficit hyperactivity disorder, and parental mental health: randomised controlled trial. BMJ. 2015 Jan 20;350:h68. DOI: 10.1136/bmj.h68. PMID: 25646809. PMCID: PMC4299655. Trusted SourcePubMedGo to source
Segura-Jiménez V, Carbonell-Baeza A, Keating XD, Ruiz JR, Castro-Piñero J. Association of sleep patterns with psychological positive health and health complaints in children and adolescents. Qual Life Res. 2015 Apr;24(4):885–95. DOI: 10.1007/s11136-014-0827-0. PMID: 25319339. Trusted SourcePubMedGo to source
Hardy JL, Nelson RA, Thomason ME, Sternberg DA, Katovich K, Farzin F, et al. Enhancing Cognitive Abilities with Comprehensive Training: A Large, Online, Randomized, Active-Controlled Trial. PLoS ONE. 2015 Sep 2;10(9):e0134467. DOI: 10.1371/journal.pone.0134467. PMID: 26333022. PMCID: PMC4557999. Trusted SourcePubMedGo to source
Peijnenborgh JCAW, Hurks PM, Aldenkamp AP, Vles JSH, Hendriksen JGM. Efficacy of working memory training in children and adolescents with learning disabilities: A review study and meta-analysis. Neuropsychol Rehabil. 2016 Oct;26(5–6):645–72. DOI: 10.1080/09602011.2015.1026356. PMID: 25886202. Trusted SourcePubMedGo to source
Sala G, Tatlidil KS, Gobet F. Video game training does not enhance cognitive ability: A comprehensive meta-analytic investigation. Psychol Bull. 2018;144(2):111–39. DOI: 10.1037/bul0000139. PMID: 29239631. Trusted SourcePubMedGo to source
Melby-Lervåg M, Redick TS, Hulme C. Working Memory Training Does Not Improve Performance on Measures of Intelligence or Other Measures of “Far Transfer”: Evidence From a Meta-Analytic Review. Perspect Psychol Sci. 2016 Jul;11(4):512–34. DOI: 10.1177/1745691616635612. PMID: 27474138. PMCID: PMC4968033. Trusted SourcePubMedGo to source
Bonnechère B, Langley C, Sahakian BJ. The use of commercial computerised cognitive games in older adults: a meta-analysis. Sci Rep. 2020 Sep 17;10(1):15276. DOI: 10.1038/s41598-020-72281-3. PMID: 32943742. PMCID: PMC7498601. Trusted SourcePubMedGo to source
Powers KL, Brooks PJ, Aldrich NJ, Palladino MA, Alfieri L. Effects of video-game play on information processing: a meta-analytic investigation. Psychon Bull Rev. 2013 Dec;20(6):1055–79. DOI: 10.3758/s13423-013-0418-z. PMID: 23519430. Trusted SourcePubMedGo to source
Marr C, Vaportzis E, Dewar M, Gow AJ. Investigating associations between personality and the efficacy of interventions for cognitive ageing: A systematic review. Arch Gerontol Geriatr. 2020;87:103992. DOI: 10.1016/j.archger.2019.103992. PMID: 31835190. Trusted SourcePubMedGo to source
Al-Thaqib A, Al-Sultan F, Al-Zahrani A, Al-Kahtani F, Al-Regaiey K, Iqbal M, et al. Brain training games enhance cognitive function in healthy subjects. Med Sci Monit Basic Res. 2018 Apr 20;24:63–9. DOI: 10.12659/msmbr.909022. PMID: 29674605. PMCID: PMC5930973. Trusted SourcePubMedGo to source
Irazoki E, Contreras-Somoza LM, Toribio-Guzmán JM, Jenaro-Río C, van der Roest H, Franco-Martín MA. Technologies for cognitive training and cognitive rehabilitation for people with mild cognitive impairment and dementia. A systematic review. Front Psychol. 2020 Apr 9;11:648. DOI: 10.3389/fpsyg.2020.00648. PMID: 32373018. PMCID: PMC7179695. Trusted SourcePubMedGo to source
Park IS, Lee KJ, Han JW, Lee NJ, Lee WT, Park KA, et al. Experience-dependent plasticity of cerebellar vermis in basketball players. Cerebellum. 2009 Sep;8(3):334–9. DOI: 10.1007/s12311-009-0100-1. PMID: 19259755. Trusted SourcePubMedGo to source
Niemann C, Godde B, Staudinger UM, Voelcker-Rehage C. Exercise-induced changes in basal ganglia volume and cognition in older adults. Neuroscience. 2014 Dec 5;281:147–63. DOI: 10.1016/j.neuroscience.2014.09.033. PMID: 25255932. Trusted SourcePubMedGo to source
McGrattan AM, McEvoy CT, McGuinness B, McKinley MC, Woodside JV. Effect of dietary interventions in mild cognitive impairment: a systematic review. Br J Nutr. 2018 Nov 9;120(12):1388–405. DOI: 10.1017/S0007114518002945. PMID: 30409231. PMCID: PMC6679717. Trusted SourcePubMedGo to source
Suh SW, Kim HS, Han JH, Bae JB, Oh DJ, Han JW, et al. Efficacy of Vitamins on Cognitive Function of Non-Demented People: A Systematic Review and Meta-Analysis. Nutrients. 2020 Apr 22;12(4). DOI: 10.3390/nu12041168. PMID: 32331312. PMCID: PMC7231132. Trusted SourcePubMedGo to source
Ford TC, Downey LA, Simpson T, McPhee G, Oliver C, Stough C. The Effect of a High-Dose Vitamin B Multivitamin Supplement on the Relationship between Brain Metabolism and Blood Biomarkers of Oxidative Stress: A Randomized Control Trial. Nutrients. 2018 Dec 1;10(12). DOI: 10.3390/nu10121860. PMID: 30513795. PMCID: PMC6316433. Trusted SourcePubMedGo to source
Grima NA, Pase MP, Macpherson H, Pipingas A. The effects of multivitamins on cognitive performance: a systematic review and meta-analysis. J Alzheimers Dis. 2012;29(3):561–9. DOI: 10.3233/JAD-2011-111751. PMID: 22330823. Trusted SourcePubMedGo to source
Small GW, Siddarth P, Li Z, Miller KJ, Ercoli L, Emerson ND, et al. Memory and Brain Amyloid and Tau Effects of a Bioavailable Form of Curcumin in Non-Demented Adults: A Double-Blind, Placebo-Controlled 18-Month Trial. Am J Geriatr Psychiatry. 2018 Mar;26(3):266–77. DOI: 10.1016/j.jagp.2017.10.010. PMID: 29246725. Trusted SourcePubMedGo to source
Ng QX, Loke W, Foo NX, Tan WJ, Chan HW, Lim DY, et al. A systematic review of the clinical use of Withania somnifera (Ashwagandha) to ameliorate cognitive dysfunction. Phytother Res. 2020 Mar;34(3):583–90. DOI: 10.1002/ptr.6552. PMID: 31742775. Trusted SourcePubMedGo to source
Chengappa KNR, Bowie CR, Schlicht PJ, Fleet D, Brar JS, Jindal R. Randomized placebo-controlled adjunctive study of an extract of withania somnifera for cognitive dysfunction in bipolar disorder. J Clin Psychiatry. 2013 Nov;74(11):1076–83. DOI: 10.4088/JCP.13m08413. PMID: 24330893. Trusted SourcePubMedGo to source
Li M, Yang HM, Luo DX, Chen JZ, Shi HJ. Multi-dimensional analysis on Parkinson’s disease questionnaire-39 in Parkinson’s patients treated with Bushen Huoxue Granule: A multicenter, randomized, double-blinded and placebo controlled trial. Complement Ther Med. 2016 Dec;29:116–20. DOI: 10.1016/j.ctim.2016.09.008. PMID: 27912935. Trusted SourcePubMedGo to source
Fioravanti M, Buckley AE. Citicoline (Cognizin) in the treatment of cognitive impairment. Clin Interv Aging. 2006;1(3):247–51. DOI: 10.2147/ciia.2006.1.3.247. PMID: 18046877. PMCID: PMC2695184. Trusted SourcePubMedGo to source
Jasielski P, Piędel F, Piwek M, Rocka A, Petit V, Rejdak K. Application of citicoline in neurological disorders: A systematic review. Nutrients. 2020 Oct 12;12(10). DOI: 10.3390/nu12103113. PMID: 33053828. PMCID: PMC7601330. Trusted SourcePubMedGo to source
Piamonte BLC, Espiritu AI, Anlacan VMM. Effects of citicoline as an adjunct treatment for alzheimer’s disease: A systematic review. J Alzheimers Dis. 2020;76(2):725–32. DOI: 10.3233/JAD-200378. PMID: 32538854. Trusted SourcePubMedGo to source
Gul A, Bakht J, Mehmood F. Huperzine-A response to cognitive impairment and task switching deficits in patients with Alzheimer’s disease. J Chin Med Assoc. 2019 Jan;82(1):40–3. DOI: 10.1016/j.jcma.2018.07.004. PMID: 30839402. Trusted SourcePubMedGo to source
Saitsu Y, Nishide A, Kikushima K, Shimizu K, Ohnuki K. Improvement of cognitive functions by oral intake of Hericium erinaceus. Biomed Res. 2019;40(4):125–31. DOI: 10.2220/biomedres.40.125. PMID: 31413233. Trusted SourcePubMedGo to source
Arneth BM. Gut-brain axis biochemical signalling from the gastrointestinal tract to the central nervous system: gut dysbiosis and altered brain function. Postgrad Med J. 2018 Aug;94(1114):446–52. DOI: 10.1136/postgradmedj-2017-135424. PMID: 30026389. Trusted SourcePubMedGo to source
Tran N, Zhebrak M, Yacoub C, Pelletier J, Hawley D. The gut-brain relationship: Investigating the effect of multispecies probiotics on anxiety in a randomized placebo-controlled trial of healthy young adults. J Affect Disord. 2019 Jun 1;252:271–7. DOI: 10.1016/j.jad.2019.04.043. PMID: 30991255. Trusted SourcePubMedGo to source
Kennedy PJ, Cryan JF, Dinan TG, Clarke G. Irritable bowel syndrome: a microbiome-gut-brain axis disorder? World J Gastroenterol. 2014 Oct 21;20(39):14105–25. DOI: 10.3748/wjg.v20.i39.14105. PMID: 25339800. PMCID: PMC4202342. Trusted SourcePubMedGo to source
Bravo JA, Julio-Pieper M, Forsythe P, Kunze W, Dinan TG, Bienenstock J, et al. Communication between gastrointestinal bacteria and the nervous system. Curr Opin Pharmacol. 2012 Dec;12(6):667–72. DOI: 10.1016/j.coph.2012.09.010. PMID: 23041079. Trusted SourcePubMedGo to source
Zhang Y, Feng Y, Cao B, Tian Q. The effect of small intestinal bacterial overgrowth on minimal hepatic encephalopathy in patients with cirrhosis. Arch Med Sci. 2016 Jun 1;12(3):592–6. DOI: 10.5114/aoms.2015.55675. PMID: 27279853. PMCID: PMC4889679. Trusted SourcePubMedGo to source
Caraceni P, Vargas V, Solà E, Alessandria C, de Wit K, Trebicka J, et al. The use of rifaximin in patients with cirrhosis. Hepatology. 2021 Jan 9; DOI: 10.1002/hep.31708. PMID: 33421158. Trusted SourcePubMedGo to source
Flamm SL, Mullen KD, Heimanson Z, Sanyal AJ. Rifaximin has the potential to prevent complications of cirrhosis. Therap Adv Gastroenterol. 2018 Sep 28;11:1756284818800307. DOI: 10.1177/1756284818800307. PMID: 30283499. PMCID: PMC6166307. Trusted SourcePubMedGo to source
Abid S, Kamran M, Abid A, Butt N, Awan S, Abbas Z. Minimal Hepatic Encephalopathy: Effect of H. pylori infection and small intestinal bacterial overgrowth treatment on clinical outcomes. Sci Rep. 2020 Jun 22;10(1):10079. DOI: 10.1038/s41598-020-67171-7. PMID: 32572109. PMCID: PMC7308324. Trusted SourcePubMedGo to source
Lehert P, Villaseca P, Hogervorst E, Maki PM, Henderson VW. Individually modifiable risk factors to ameliorate cognitive aging: a systematic review and meta-analysis. Climacteric. 2015 Oct;18(5):678–89. DOI: 10.3109/13697137.2015.1078106. PMID: 26361790. PMCID: PMC5199766. Trusted SourcePubMedGo to source
Orchard TS, Gaudier-Diaz MM, Weinhold KR, Courtney DeVries A. Clearing the fog: a review of the effects of dietary omega-3 fatty acids and added sugars on chemotherapy-induced cognitive deficits. Breast Cancer Res Treat. 2017;161(3):391–8. DOI: 10.1007/s10549-016-4073-8. PMID: 27933449. PMCID: PMC5526680. Trusted SourcePubMedGo to source
McIntosh K, Reed DE, Schneider T, Dang F, Keshteli AH, De Palma G, et al. FODMAPs alter symptoms and the metabolome of patients with IBS: a randomised controlled trial. Gut. 2017 Jul;66(7):1241–51. DOI: 10.1136/gutjnl-2015-311339. PMID: 26976734. Trusted SourcePubMedGo to source
Sarnyai Z, Kraeuter A-K, Palmer CM. Ketogenic diet for schizophrenia: clinical implication. Curr Opin Psychiatry. 2019 Sep;32(5):394–401. DOI: 10.1097/YCO.0000000000000535. PMID: 31192814. Trusted SourcePubMedGo to source
Ng QX, Soh AYS, Loke W, Venkatanarayanan N, Lim DY, Yeo W-S. Systematic review with meta-analysis: The association between post-traumatic stress disorder and irritable bowel syndrome. J Gastroenterol Hepatol. 2019 Jan;34(1):68–73. DOI: 10.1111/jgh.14446. PMID: 30144372. Trusted SourcePubMedGo to source
Dalal R, McGee RG, Riordan SM, Webster AC. Probiotics for people with hepatic encephalopathy. Cochrane Database Syst Rev. 2017 Feb 23;2:CD008716. DOI: 10.1002/14651858.CD008716.pub3. PMID: 28230908. PMCID: PMC6464663. Trusted SourcePubMedGo to source
Flamm SL. Rifaximin treatment for reduction of risk of overt hepatic encephalopathy recurrence. Therap Adv Gastroenterol. 2011 May;4(3):199–206. DOI: 10.1177/1756283X11401774. PMID: 21694804. PMCID: PMC3105611. Trusted SourcePubMedGo to source
Lv T, Ye M, Luo F, Hu B, Wang A, Chen J, et al. Probiotics treatment improves cognitive impairment in patients and animals: A systematic review and meta-analysis. Neurosci Biobehav Rev. 2021 Jan;120:159–72. DOI: 10.1016/j.neubiorev.2020.10.027. PMID: 33157148. Trusted SourcePubMedGo to source
Lew L-C, Hor Y-Y, Yusoff NAA, Choi S-B, Yusoff MSB, Roslan NS, et al. Probiotic Lactobacillus plantarum P8 alleviated stress and anxiety while enhancing memory and cognition in stressed adults: A randomised, double-blind, placebo-controlled study. Clin Nutr. 2019;38(5):2053–64. DOI: 10.1016/j.clnu.2018.09.010. PMID: 30266270. Trusted SourcePubMedGo to source
Sherman DS, Mauser J, Nuno M, Sherzai D. The Efficacy of Cognitive Intervention in Mild Cognitive Impairment (MCI): a Meta-Analysis of Outcomes on Neuropsychological Measures. Neuropsychol Rev. 2017 Dec 27;27(4):440–84. DOI: 10.1007/s11065-017-9363-3. PMID: 29282641. PMCID: PMC5754430. Trusted SourcePubMedGo to source
Han JW, Son KL, Byun HJ, Ko JW, Kim K, Hong JW, et al. Efficacy of the Ubiquitous Spaced Retrieval-based Memory Advancement and Rehabilitation Training (USMART) program among patients with mild cognitive impairment: a randomized controlled crossover trial. Alzheimers Res Ther. 2017 Jun 6;9(1):39. DOI: 10.1186/s13195-017-0264-8. PMID: 28587629. PMCID: PMC5461696. Trusted SourcePubMedGo to source
Lin L-C, Huang Y-J, Su S-G, Watson R, Tsai BW-J, Wu S-C. Using spaced retrieval and Montessori-based activities in improving eating ability for residents with dementia. Int J Geriatr Psychiatry. 2010 Oct;25(10):953–9. DOI: 10.1002/gps.2433. PMID: 20054841. Trusted SourcePubMedGo to source
Oren S, Willerton C, Small J. Effects of spaced retrieval training on semantic memory in alzheimer’s disease: A systematic review. J Speech Lang Hear Res. 2014 Feb;57(1):247–70. DOI: 10.1044/1092-4388(2013/12-0352). PMID: 24023380. Trusted SourcePubMedGo to source
Davis R, Weisbeck C. Creating a supportive environment using cues for wayfinding in dementia. J Gerontol Nurs. 2016 Mar;42(3):36–44. DOI: 10.3928/00989134-20160212-07. PMID: 26934972. PMCID: PMC5358323. Trusted SourcePubMedGo to source
Motzek T, Bueter K, Marquardt G. Environmental Cues in Double-Occupancy Rooms to Support Patients With Dementia. HERD. 2016 Apr;9(3):106–15. DOI: 10.1177/1937586715619740. PMID: 26683622. Trusted SourcePubMedGo to source
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