Improving Your PCOS Symptoms: A User Guide
- What is PCOS?|
- Diets That Help|
- Microbiome-Hormone Connection|
- Probiotics|
- Other Supplements|
- Lifestyle Support|
- Managing PCOS|
Polycystic ovary syndrome, or PCOS, is a common hormonal condition affecting up to 10% of women worldwide 1.
If you’re one of these women, you’ll know the array of symptoms PCOS can cause and how much they can disrupt your life. Some of the symptoms, like acne and hair loss, are usually not of great medical consequence but can still be highly upsetting. Others, like infertility and pre-diabetes, can have serious or life-changing implications.
While I can’t offer a cookie-cutter solution for PCOS, many of my female patients have gotten a lot of relief from a range of self-help options that encompass diet, supplementation, and certain lifestyle changes.
In this article, we’ll look into how to balance hormones, with PCOS as the specific focus. I’ll walk you through what the research says can help the condition. And I’ll share what my clients say are the most useful natural treatments for improving their quality of life.
But first, let’s dive into what PCOS is and what it means when you have it.
What Is PCOS?
PCOS is a condition of imbalanced reproductive hormones. Usually in PCOS, the ovaries produce too much of the androgen (or “male” hormone), testosterone 1.
As the name suggests, some women with PCOS develop polycystic ovaries. In other words, their ovaries become enlarged and contain many fluid-filled sacs (follicles) that surround the eggs and interfere with ovulation 1. But despite the name, not everyone with PCOS has these follicles 1.
In fact, only two of the following three signs and symptoms must be present for a PCOS diagnosis 2:
- Polycystic ovaries, as described above (diagnosed by ultrasound)
- Chronic irregular periods, including infrequent periods (oligomenorrhea) or absent periods (amenorrhea)
- Elevated testosterone or excessive facial or body hair (aka hirsutism, the most diagnostically valid symptom of too much testosterone)
Among people with PCOS, 80% tend to gain weight and accumulate fat around the belly 3 4, while the remaining 20% have so-called “lean PCOS” and are a healthy weight 4.
Some other symptoms or health problems that women with PCOS commonly have include:
- Persistent acne or oily skin 5
- Darker or thicker patches of skin on the back of the neck or armpits, or under the breasts 5
- Infertility 5
- Metabolic syndrome (including insulin resistance and increased risk for heart disease) 3
- Nonalcoholic fatty liver disease 3
- Depression and anxiety 3 6
Additionally, more than half of women with PCOS develop type-2 diabetes by the time they turn 40 7.
While these statistics appear pretty worrying, a lot can be done to balance hormones and reduce PCOS symptoms 8.
PCOS Overlaps With Other Conditions
Below is a simplified flowchart showing the proposed relationships between inflammation, gut microbe imbalances (dysbiosis), insulin resistance, and PCOS 1 10.
If this chart appears complex, the key thing to notice is that unhealthy diet and lifestyle are central drivers of PCOS.
We’ll dig a bit more into the underlying role that gut health plays in PCOS later, but first, let’s get straight into what diets may work for the condition.
Diets That Help PCOS
Eating fewer highly processed and non-nutritious calories plays a major part in improving PCOS for most people with the condition, particularly when fat loss is a goal 6.
However, losing weight is easier said than done if hormones and metabolism are working against you, as they might be in PCOS. For success, people with PCOS need to find a dietary sweet spot that will help them eat fewer calories while still feeling full and satisfied, and getting balanced nutrition.
Below is a table of some of the diets studies have shown can help with weight loss and PCOS symptoms. These are listed in order of strongest to weakest evidence. But remember, what works in the real world for each person with PCOS might vary.
Diet | What’s Involved? | What the Research Says |
Reduced calorie diet* | This means cutting down on calorie-dense foods and portion sizes while emphasizing nutritious foods that help you feel full. Most of the lower-calorie diets that show a benefit for PCOS also advocate exercise to increase the calorie deficit 14, 15 | Low-calorie diets may be the most effective for weight management in PCOS 16. Reduced calorie diets can improve body composition 14 16 17 18, reproductive hormone levels 17 18 19 20, insulin resistance 15 18 19 21, and inflammation 14 18 19. |
DASH (Dietary Approaches to Stop Hypertension) diet | The DASH diet is a whole-food, lower-sodium diet that focuses on a variety of fruits, vegetables, low-fat dairy products, whole grains (like brown rice or quinoa), nuts, seeds, legumes (such as beans and lentils), lean meats, poultry, fish, herbs, spices, and olive oil 22. | The DASH diet appears to be best for reducing insulin resistance in PCOS, particularly for those who do not tolerate metformin well 16. *Metformin is a drug often prescribed to help PCOS patients manage insulin resistance and diabetes. |
Lower carb/higher protein | Lower-carb and higher-protein diets have fewer or smaller portions of carbs (like bread, potatoes, pasta, rice, and sugary foods). Instead, they focus more on lean protein (such as lean meats, fish, and poultry), plant proteins (like soy products and pea protein powder), and non- starchy veggies (like leafy greens and cauliflower) | In people with PCOS, low-carb, higher-protein diets (particularly those that are also lower in fat and total calories) may reduce body weight 23 24 25 and improve blood sugar regulation 23, insulin resistance 13 21 24, inflammation 19, and hormone balance 13 24. In contrast, a high-carb diet may increase androgens (e.g. testosterone) 13. |
Keto (ketogenic) diet | Ketogenic diets are extremely low in carbs and high in fat. The idea is that keto dieters stay in a state of ketosis (which is when the body’s main fuel is fat). | Some clinical trials have shown that PCOS patients with liver dysfunction and obesity can gain metabolic benefits (like weight loss and healthy blood sugar and cholesterol) and improve their liver health on a ketogenic diet 26 27. Menstrual cycles and hormone levels may also improve 26 27. |
*If you are pregnant, breastfeeding, or planning to conceive a low-calorie diet may not be the best option for you. It’s important to consult with your healthcare provider to ensure you are meeting your nutritional requirements.
Although it’s not been specifically researched for PCOS, the Paleo diet is another diet that my clients with PCOS often find helpful. This diet cuts out refined carbohydrates and focuses on good-quality proteins, nuts, fresh vegetables, and berries, all of which helps reduce blood sugar levels 28 29 and might help balance hormones 30.
Healthy Fats
Incorporating healthy fats into the diet is important for people with PCOS. That’s because dietary fats are essential for healthy hormone production 31 32.
A good rule of thumb is to include a small portion of healthy fat with every meal. Extra virgin olive oil, avocados or avocado oil, flaxseeds or flaxseed oil, fatty fish, nuts, and chia seeds are all good options for healthy hormone production.
If you’re not getting enough healthy fat in your diet, a fish oil supplement may also be helpful.
The Microbiome-Hormone Connection
It’s interesting to note that a bunch of microbiome studies have found that PCOS patients have less diverse gut microbes than healthy people 33 34 35 36 37 38 39.
The microbiome-based theory of how PCOS develops (which you can see as Gut dysbiosis in the flowchart above) is that it stems from gut dysbiosis, or imbalances in gut microbes. These imbalances cause gut permeability (a leaky gut) and allow harmful substances into the bloodstream, which triggers the immune system and interferes with how insulin works. This may lead to high insulin resistance, more testosterone hormones being made in the ovaries, and the onset of PCOS symptoms 41.
Newer research has found that people with PCOS have lower levels of bacteria that break down bile acids (which help us digest fat). Without those bacteria, the levels of certain bile acids that influence fat storage and insulin levels go up, possibly harming gut bacteria and weakening intestinal walls 42.
Fiber Boost?
When good bacteria have plenty of healthy plant fibers to ferment, they can produce more short-chain fatty acids (SCFAs), which may have a positive effect on the metabolic and hormonal aspects of PCOS 42.
You’d imagine that women with PCOS would therefore benefit from eating a lot of fiber, and some randomized clinical research has found that they can 43 44.
However, it’s important to take any fiber supplementation slowly, especially if you have delicate gut health. For instance, some of my clients have had big improvements in their hormone balance and PCOS symptoms by bumping up their fiber, while for others, too much fiber irritates their gut and makes them feel worse.
In particular, when people have food intolerances and sensitivities or IBS-type symptoms, increasing fiber—especially quickly—may not be a good idea.
For anyone with gut sensitivities, starting with a gentler way to improve gut health, such as probiotics, could be better. Not only can probiotics help your gut, but I’ll explain how they can also be helpful for dealing with PCOS.
Probiotics Work for PCOS
Probiotics can offer valuable support for managing PCOS via their microbiome benefits. For this reason, they are usually the next step I recommend to my clients after they’ve made healthy diet changes.
Numerous meta-analyses show that probiotics can significantly improve various aspects of PCOS, including 45 46 47:
- Insulin sensitivity
- Triglyceride levels
- Inflammation
- Hirsutism (excessive hair growth in unwanted places)
- Testosterone levels
That said, some research has found probiotics might be less useful for helping with hormonal balance, body composition, and blood sugar control 45 48 49. However, there are no known downsides to taking probiotics, so it usually makes good sense to try them.
Triple Therapy
While any well-formulated probiotic is likely better than none, we’ve found at the clinic that our clients achieve the best results by using probiotics from these three main categories:
- A Lactobacillus and Bifidobacterium blend (for example, L. acidophilus, L. plantarum, B. infantis, and B. lactis).
- Saccharomyces boulardii (a beneficial yeast).
- Soil-based probiotics, typically Bacillus species.
Some clients find that a Lactobacillus and Bifidobacterium blend alone is sufficient, while others benefit more by adding Saccharomyces boulardii and soil-based probiotics.
For those who respond well to this triple-therapy approach, this convenient combination product is stable at room temperature and easy to travel with.
Lifestyle Support for PCOS: Exercise, Sleep, and More
Diet and lifestyle modifications—especially exercise—remain a cornerstone of PCOS management. Other lifestyle changes that reduce stress and insomnia can have a big impact, too. I’ll describe my favorite ways to help people change their lifestyle and form habits that will support hormone health.
Exercise You Can Stick To
Many types of exercise show promise for improving the symptoms of polycystic ovary syndrome. Benefits include improved body composition (more lean muscle, less fat) 50 51, lowered androgen levels 11 12, improved cardiovascular health 14, and improved measures of metabolic health 11 50 52.
However, because PCOS can negatively affect both body image and mood, people with the condition must find physical activities they enjoy and that boost their self-esteem.
Common options include walking, hiking, jogging, or bicycling. Other great options include dance classes, kettlebell training, high-intensity interval training (HIIT), weight lifting, pilates, rowing, rebounding (minitrampoline), body-weight exercises, fencing, or rock climbing.
But even more meditative types of exercise can be beneficial, too. For example, one randomized controlled trial found that yoga improved female hormone levels, testosterone levels, male-pattern hair growth, and menstrual cycle frequency in women with PCOS 54. Another one found that tai chi helped reduce BMI, testosterone, and cholesterol in a group of young women with PCOS 55.
And don’t discount everyday movements like pushing or pulling heavy loads (say, in a wheelbarrow), lifting and moving things around the house or office, watering plants, carrying groceries and kids, doing yard work, vacuuming, and other bits of labor that get the muscles moving. These can add up and help regulate your hormones.
In a nutshell, exercising regularly (which most of us will only do if we find movements that we enjoy) is more important for health, with or without PCOS, than the type of exercise performed.
Sleep Solutions
Sleep disturbances are very common in people with PCOS 56, so any habits that improve sleep are worthwhile. Science-backed steps that have worked for my clients include 57:
- Maximizing outdoor light exposure in the morning and limiting light exposure in the evening
- Maintaining consistent sleep/wake times
- Maintaining consistent meal times each day, including eating breakfast shortly after waking and eating dinner by 7 pm
- Not napping after 4 pm
- Not drinking coffee or other caffeine sources in the afternoon 58
- Exercising regularly (see above) 59, but not close to bedtime
- Wearing blue light-blocking glasses before bed 60 61 62
- CBTi (a special sort of cognitive behavioral therapy for insomnia) 63
- Acupuncture 64
Mental Health Support
Unfortunately, PCOS often introduces depression, anxiety, and a lower quality of life. But the good news is that a couple of interventions can support mental health in people with PCOS. These are:
- Cognitive behavioral therapy (CBT), which can greatly reduce depression in women with PCOS 65; and
- Mindfulness-based stress reduction (MBSR), which, in one randomized controlled trial, cut the worries of PCOS patients to half the worries of those who didn’t do MBSR 66.
Other Potentially Useful Supplements
A gut-healthy diet with probiotics and healthy lifestyle changes are central to how we balance hormones with PCOS clients at the clinic. However, for clients who need extra help to get their hormonal balance back on track, the following supplements are also worth considering.
Inositol
Sometimes inaccurately classified as a B vitamin (it’s actually a type of natural sugar), inositol can greatly improve the chances of PCOS patients having regular periods again 67. Inositol is also as good as the diabetes medication metformin at improving body mass index, hormone levels, blood sugar, and insulin in people with PCOS 67 68.
DOSE: Studies used a range of 600–4,000 mg/day for 7–24 weeks, but always work with your doctor to get the right dose for you. Myo-inositol (or just “inositol”) is the type used in studies and what to look for in supplements.
Vitamin D
Of all the true vitamins that have been researched for PCOS, vitamin D has the most promising effects on menstrual cycle regularity. High doses of vitamin D for more than 8 weeks improved menstrual cycle regularity by 35% 69.
DOSE: When working with clients who might benefit from vitamin D supplementation, I recommend they start by testing their current vitamin D levels. Depending on their starting point, they’ll typically need to take between 400 and 2,000 IU vitamin D per day to achieve the 100–125 nmol/L (40–50 ng/mL) vitamin D level I think is optimal 70 71 72. It’s always ideal to work with a trusted clinician to get your levels right.
For better absorption and utilization, choose vitamin D3 rather than D2 73. Combining D3 with vitamin K can support bone mineral density, too 74.
Omega-3 Fatty Acids
A meta-analysis showed that omega 3s can help reduce waist size, blood sugar, insulin resistance, triglycerides, and LDL cholesterol in PCOS patients 75.
DOSE: The study found that any amount of omega 3s from fish oil or flaxseed oil was helpful. Work with your doctor to find the form and dosage best for you.
Vitamin E
A meta-analysis found that vitamin E helped reduce triglycerides, LDL, and total cholesterol, C-reactive protein, and unwanted hair growth in women with PCOS. Vitamin E also increased nitric oxide (an important chemical messenger that helps blood flow) 76.
DOSE: Most studies used 400 mg/day for 8–12 weeks, but ask your doctor what’s right for you.
Coenzyme Q10 (aka CoQ10 or Ubiquinol)
CoQ10 is a vitamin-like substance in the mitochondria of cells. It acts as an antioxidant and plays an important role in energy release.
Research suggests that CoQ10 supplements can also improve insulin resistance, blood sugar, sex hormone levels, testosterone, triglycerides, and cholesterol in women with PCOS 77.
DOSE: Doses of between 50 mg and 300 mg are typical. Ask your doctor what is likely to work best for you.
Chromium
This trace mineral plays a role in how insulin helps the body regulate blood sugar levels. A meta-analysis of randomized controlled trials found that chromium (as chromium picolinate) can help reduce BMI, free testosterone, and insulin levels in PCOS patients 78.
DOSE: Studies used 200–1,000 micrograms/day for 8–24 weeks, but please ask your doctor what dose is right for you.
Resveratrol
Resveratrol is a polyphenol (type of plant chemical) found naturally in grapes and other fruits and vegetables. It has antioxidant and anti-inflammatory effects and can help to reduce cholesterol and improve acne severity in women with PCOS. It also lowers excess prolactin 79.
DOSE: Studies found benefits when patients used 800–1,500 mg/day resveratrol, for 40–90 days, but check with your doctor.
Herbal Blends
Several herbs may help to balance hormones in general and for people with PCOS. When I’m using herbals in clients with PCOS, I’ll usually recommend a proprietary blend (Progest-Harmony or Estro-Harmony), depending on symptoms and whether they’re pre- or postmenopausal. Which herbs may be best for you is something to figure out with your healthcare provider and may take some trial and error.
Here are some potentially useful herbs to look out for:
- Berberine can improve insulin resistance in PCOS patients 80.
- Chasteberry (aka Vitex) may lower prolactin and improve menstrual regularity in PCOS, and it might help with infertility issues 81.
- Black cohosh may improve pregnancy rates when used alongside clomiphene citrate (a medication that can stimulate the ovaries to produce eggs) in women with PCOS 81.
- Licorice may reduce testosterone levels in women with PCOS 81.
- White peony (also known as Chinese peony): When combined with licorice, it may help reduce testosterone, and when combined with cinnamon, it may help improve ovulation in PCOS patients 81.
PCOS: Tricky but Solvable
Though managing PCOS is challenging, understanding the condition and making targeted diet and lifestyle changes can significantly improve your quality of life.
Research shows that inflammation and poor gut health often play a significant role in the insulin resistance and higher testosterone levels that occur in PCOS. Addressing these by eating a balanced diet with probiotics, making positive lifestyle changes, and possibly adding other targeted supplements can improve symptoms, fertility, and life in general.
However, if you are finding PCOS or other hormonal issues too tricky to resolve alone (or if you can’t find a practitioner to fit your needs and help you), we’d be delighted to help—just reach out to one of our experienced health practitioners. If digging deeper into gut-healing therapies interests you, you may also benefit from reading my book, Healthy Gut, Healthy You.
The Ruscio Institute has developed a range of high-quality formulations to help our clients and audience. If you’re interested in learning more about these products, please click here. Note that there are many other options available, and we encourage you to research which products may be right for you. The information on DrRuscio.com is for educational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment.
Dr. Michael Ruscio is a DC, natural health provider, researcher, and clinician. He serves as an Adjunct Professor at the University of Bridgeport and has published numerous papers in scientific journals as well as the book Healthy Gut, Healthy You. He also founded the Ruscio Institute of Functional Health, where he helps patients with a wide range of GI conditions and serves as the Head of Research.➕ References
- Singh S, Pal N, Shubham S, Sarma DK, Verma V, Marotta F, et al. Polycystic ovary syndrome: etiology, current management, and future therapeutics. J Clin Med. 2023 Feb 11;12(4). DOI: 10.3390/jcm12041454. PMID: 36835989. PMCID: PMC9964744.
- Christ JP, Cedars MI. Current guidelines for diagnosing PCOS. Diagnostics (Basel). 2023 Mar 15;13(6). DOI: 10.3390/diagnostics13061113. PMID: 36980421. PMCID: PMC10047373.
- Rasquin LI, Anastasopoulou C, Mayrin JV. Polycystic Ovarian Disease. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024. PMID: 29083730.
- Toosy S, Sodi R, Pappachan JM. Lean polycystic ovary syndrome (PCOS): an evidence-based practical approach. J Diabetes Metab Disord. 2018 Dec;17(2):277–85. DOI: 10.1007/s40200-018-0371-5. PMID: 30918863. PMCID: PMC6405408.
- What are the symptoms of PCOS? | NICHD – Eunice Kennedy Shriver National Institute of Child Health and Human Development [Internet]. [cited 2024 May 24]. Available from: https://www.nichd.nih.gov/health/topics/pcos/conditioninfo/symptoms
- Tay CT, Moran LJ, Wijeyaratne CN, Redman LM, Norman RJ, Teede HJ, et al. Integrated model of care for polycystic ovary syndrome. Semin Reprod Med. 2018 Jan;36(1):86–94. DOI: 10.1055/s-0038-1667310. PMID: 30189456.
- Diabetes and Polycystic Ovary Syndrome (PCOS) | Diabetes | CDC [Internet]. [cited 2024 Nov 23]. Available from: https://www.cdc.gov/diabetes/risk-factors/pcos-polycystic-ovary-syndrome.html?CDC_AAref_Val=https://www.cdc.gov/diabetes/basics/pcos.html
- Khadilkar SS. Can Polycystic Ovarian Syndrome be cured? Unfolding the Concept of Secondary Polycystic Ovarian Syndrome! J Obstet Gynaecol India. 2019 Aug;69(4):297–302. DOI: 10.1007/s13224-019-01253-z. PMID: 31391734. PMCID: PMC6661052.
- Brenjian S, Moini A, Yamini N, Kashani L, Faridmojtahedi M, Bahramrezaie M, et al. Resveratrol treatment in patients with polycystic ovary syndrome decreased pro-inflammatory and endoplasmic reticulum stress markers. Am J Reprod Immunol. 2020 Jan;83(1):e13186. DOI: 10.1111/aji.13186. PMID: 31483910.
- Barrea L, Marzullo P, Muscogiuri G, Di Somma C, Scacchi M, Orio F, et al. Source and amount of carbohydrate in the diet and inflammation in women with polycystic ovary syndrome. Nutr Res Rev. 2018 Dec;31(2):291–301. DOI: 10.1017/S0954422418000136. PMID: 30033891.
- Abdolahian S, Tehrani FR, Amiri M, Ghodsi D, Yarandi RB, Jafari M, et al. Effect of lifestyle modifications on anthropometric, clinical, and biochemical parameters in adolescent girls with polycystic ovary syndrome: a systematic review and meta-analysis. BMC Endocr Disord. 2020 May 19;20(1):71. DOI: 10.1186/s12902-020-00552-1. PMID: 32429890. PMCID: PMC7236342.
- Lim SS, Hutchison SK, Van Ryswyk E, Norman RJ, Teede HJ, Moran LJ. Lifestyle changes in women with polycystic ovary syndrome. Cochrane Database Syst Rev. 2019 Mar 28;3(3):CD007506. DOI: 10.1002/14651858.CD007506.pub4. PMID: 30921477. PMCID: PMC6438659.
- Moran LJ, Ko H, Misso M, Marsh K, Noakes M, Talbot M, et al. Dietary composition in the treatment of polycystic ovary syndrome: a systematic review to inform evidence-based guidelines. J Acad Nutr Diet. 2013 Apr;113(4):520–45. DOI: 10.1016/j.jand.2012.11.018. PMID: 23420000.
- Haqq L, McFarlane J, Dieberg G, Smart N. The Effect of Lifestyle Intervention on Body Composition, Glycemic Control, and Cardiorespiratory Fitness in Polycystic Ovarian Syndrome: A Systematic Review and Meta-Analysis. Int J Sport Nutr Exerc Metab. 2015 Dec;25(6):533–40. DOI: 10.1123/ijsnem.2013-0232. PMID: 24668721.
- Domecq JP, Prutsky G, Mullan RJ, Hazem A, Sundaresh V, Elamin MB, et al. Lifestyle modification programs in polycystic ovary syndrome: systematic review and meta-analysis. J Clin Endocrinol Metab. 2013 Dec;98(12):4655–63. DOI: 10.1210/jc.2013-2385. PMID: 24092832.
- Shang Y, Zhou H, Hu M, Feng H. Effect of diet on insulin resistance in polycystic ovary syndrome. J Clin Endocrinol Metab. 2020 Oct 1;105(10). DOI: 10.1210/clinem/dgaa425. PMID: 32621748.
- Toscani MK, Mario FM, Radavelli-Bagatini S, Wiltgen D, Matos MC, Spritzer PM. Effect of high-protein or normal-protein diet on weight loss, body composition, hormone, and metabolic profile in southern Brazilian women with polycystic ovary syndrome: a randomized study. Gynecol Endocrinol. 2011 Nov;27(11):925–30. DOI: 10.3109/09513590.2011.564686. PMID: 21627406.
- Salama AA, Amine EK, Salem HAE, Abd El Fattah NK. Anti-Inflammatory Dietary Combo in Overweight and Obese Women with Polycystic Ovary Syndrome. N Am J Med Sci. 2015 Jul;7(7):310–6. DOI: 10.4103/1947-2714.161246. PMID: 26258078. PMCID: PMC4525389.
- Mehrabani HH, Salehpour S, Amiri Z, Farahani SJ, Meyer BJ, Tahbaz F. Beneficial effects of a high-protein, low-glycemic-load hypocaloric diet in overweight and obese women with polycystic ovary syndrome: a randomized controlled intervention study. J Am Coll Nutr. 2012 Apr;31(2):117–25. DOI: 10.1080/07315724.2012.10720017. PMID: 22855917.
- Stamets K, Taylor DS, Kunselman A, Demers LM, Pelkman CL, Legro RS. A randomized trial of the effects of two types of short-term hypocaloric diets on weight loss in women with polycystic ovary syndrome. Fertil Steril. 2004 Mar;81(3):630–7. DOI: 10.1016/j.fertnstert.2003.08.023. PMID: 15037413.
- Porchia LM, Hernandez-Garcia SC, Gonzalez-Mejia ME, López-Bayghen E. Diets with lower carbohydrate concentrations improve insulin sensitivity in women with polycystic ovary syndrome: A meta-analysis. Eur J Obstet Gynecol Reprod Biol. 2020 May;248:110–7. DOI: 10.1016/j.ejogrb.2020.03.010. PMID: 32200247.
- DASH diet: Tips for shopping and cooking – Mayo Clinic [Internet]. [cited 2021 Nov 11]. Available from: https://www.mayoclinic.org/healthy-lifestyle/nutrition-and-healthy-eating/in-depth/dash-diet/art-20045913
- Sørensen LB, Søe M, Halkier KH, Stigsby B, Astrup A. Effects of increased dietary protein-to-carbohydrate ratios in women with polycystic ovary syndrome. Am J Clin Nutr. 2012 Jan;95(1):39–48. DOI: 10.3945/ajcn.111.020693. PMID: 22158730.
- Zhang X, Zheng Y, Guo Y, Lai Z. The Effect of Low Carbohydrate Diet on Polycystic Ovary Syndrome: A Meta-Analysis of Randomized Controlled Trials. Int J Endocrinol. 2019 Nov 26;2019:4386401. DOI: 10.1155/2019/4386401. PMID: 31885557. PMCID: PMC6899277.
- Frary JMC, Bjerre KP, Glintborg D, Ravn P. The effect of dietary carbohydrates in women with polycystic ovary syndrome: a systematic review. Minerva Endocrinol. 2016 Mar;41(1):57–69. PMID: 24914605.
- Li J, Bai W-P, Jiang B, Bai L-R, Gu B, Yan S-X, et al. Ketogenic diet in women with polycystic ovary syndrome and liver dysfunction who are obese: A randomized, open-label, parallel-group, controlled pilot trial. J Obstet Gynaecol Res. 2021 Mar;47(3):1145–52. DOI: 10.1111/jog.14650. PMID: 33462940.
- Paoli A, Mancin L, Giacona MC, Bianco A, Caprio M. Effects of a ketogenic diet in overweight women with polycystic ovary syndrome. J Transl Med. 2020 Feb 27;18(1):104. DOI: 10.1186/s12967-020-02277-0. PMID: 32103756. PMCID: PMC7045520.
- Masharani U, Sherchan P, Schloetter M, Stratford S, Xiao A, Sebastian A, et al. Metabolic and physiologic effects from consuming a hunter-gatherer (Paleolithic)-type diet in type 2 diabetes. Eur J Clin Nutr. 2015 Aug;69(8):944–8. DOI: 10.1038/ejcn.2015.39. PMID: 25828624.
- Jönsson T, Granfeldt Y, Ahrén B, Branell U-C, Pålsson G, Hansson A, et al. Beneficial effects of a Paleolithic diet on cardiovascular risk factors in type 2 diabetes: a randomized cross-over pilot study. Cardiovasc Diabetol. 2009 Jul 16;8:35. DOI: 10.1186/1475-2840-8-35. PMID: 19604407. PMCID: PMC2724493.
- Shah S, Mahamat-Saleh Y, Hajji-Louati M, Correia E, Oulhote Y, Boutron-Ruault M-C, et al. Palaeolithic diet score and risk of breast cancer among postmenopausal women overall and by hormone receptor and histologic subtypes. Eur J Clin Nutr. 2023 May;77(5):596–602. DOI: 10.1038/s41430-023-01267-x. PMID: 36726032.
- Delgado BJ, Lopez-Ojeda W. Estrogen. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2023. PMID: 30855848.
- Nassar GN, Leslie SW. Physiology, Testosterone. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024. PMID: 30252384.
- Qi X, Yun C, Sun L, Xia J, Wu Q, Wang Y, et al. Gut microbiota-bile acid-interleukin-22 axis orchestrates polycystic ovary syndrome. Nat Med. 2019 Aug;25(8):1225–33. DOI: 10.1038/s41591-019-0509-0. PMID: 31332392. PMCID: PMC7376369.
- Eyupoglu ND, Caliskan Guzelce E, Acikgoz A, Uyanik E, Bjørndal B, Berge RK, et al. Circulating gut microbiota metabolite trimethylamine N-oxide and oral contraceptive use in polycystic ovary syndrome. Clin Endocrinol (Oxf). 2019 Dec;91(6):810–5. DOI: 10.1111/cen.14101. PMID: 31556132.
- Insenser M, Murri M, Del Campo R, Martínez-García MÁ, Fernández-Durán E, Escobar-Morreale HF. Gut microbiota and the polycystic ovary syndrome: influence of sex, sex hormones, and obesity. J Clin Endocrinol Metab. 2018 Jul 1;103(7):2552–62. DOI: 10.1210/jc.2017-02799. PMID: 29897462.
- Torres PJ, Siakowska M, Banaszewska B, Pawelczyk L, Duleba AJ, Kelley ST, et al. Gut microbial diversity in women with polycystic ovary syndrome correlates with hyperandrogenism. J Clin Endocrinol Metab. 2018 Apr 1;103(4):1502–11. DOI: 10.1210/jc.2017-02153. PMID: 29370410. PMCID: PMC6276580.
- Lindheim L, Bashir M, Münzker J, Trummer C, Zachhuber V, Leber B, et al. Alterations in Gut Microbiome Composition and Barrier Function Are Associated with Reproductive and Metabolic Defects in Women with Polycystic Ovary Syndrome (PCOS): A Pilot Study. PLoS ONE. 2017 Jan 3;12(1):e0168390. DOI: 10.1371/journal.pone.0168390. PMID: 28045919. PMCID: PMC5207627.
- Zeng B, Lai Z, Sun L, Zhang Z, Yang J, Li Z, et al. Structural and functional profiles of the gut microbial community in polycystic ovary syndrome with insulin resistance (IR-PCOS): a pilot study. Res Microbiol. 2019;170(1):43–52. DOI: 10.1016/j.resmic.2018.09.002. PMID: 30292647.
- Thackray VG. Sex, microbes, and polycystic ovary syndrome. Trends Endocrinol Metab. 2019 Jan;30(1):54–65. DOI: 10.1016/j.tem.2018.11.001. PMID: 30503354. PMCID: PMC6309599.
- Ojo O, Feng Q-Q, Ojo OO, Wang X-H. The Role of Dietary Fibre in Modulating Gut Microbiota Dysbiosis in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomised Controlled Trials. Nutrients. 2020 Oct 23;12(11). DOI: 10.3390/nu12113239. PMID: 33113929. PMCID: PMC7690692.
- Sun J, Wang M, Kan Z. Causal relationship between gut microbiota and polycystic ovary syndrome: a literature review and Mendelian randomization study. Front Endocrinol (Lausanne). 2024 Feb 1;15:1280983. DOI: 10.3389/fendo.2024.1280983. PMID: 38362275. PMCID: PMC10867277.
- Li P, Shuai P, Shen S, Zheng H, Sun P, Zhang R, et al. Perturbations in gut microbiota composition in patients with polycystic ovary syndrome: a systematic review and meta-analysis. BMC Med. 2023 Aug 9;21(1):302. DOI: 10.1186/s12916-023-02975-8. PMID: 37559119. PMCID: PMC10413517.
- Nybacka Å, Hellström PM, Hirschberg AL. Increased fibre and reduced trans fatty acid intake are primary predictors of metabolic improvement in overweight polycystic ovary syndrome-Substudy of randomized trial between diet, exercise and diet plus exercise for weight control. Clin Endocrinol (Oxf). 2017 Dec;87(6):680–8. DOI: 10.1111/cen.13427. PMID: 28727165.
- Wang X, Xu T, Liu R, Wu G, Gu L, Zhang Y, et al. High-Fiber Diet or Combined With Acarbose Alleviates Heterogeneous Phenotypes of Polycystic Ovary Syndrome by Regulating Gut Microbiota. Front Endocrinol (Lausanne). 2021;12:806331. DOI: 10.3389/fendo.2021.806331. PMID: 35185786. PMCID: PMC8847200.
- Tabrizi R, Ostadmohammadi V, Akbari M, Lankarani KB, Vakili S, Peymani P, et al. The Effects of Probiotic Supplementation on Clinical Symptom, Weight Loss, Glycemic Control, Lipid and Hormonal Profiles, Biomarkers of Inflammation, and Oxidative Stress in Women with Polycystic Ovary Syndrome: a Systematic Review and Meta-analysis of Randomized Controlled Trials. Probiotics Antimicrob Proteins. 2022 Feb;14(1):1–14. DOI: 10.1007/s12602-019-09559-0. PMID: 31165401.
- Liao D, Zhong C, Li C, Mo L, Liu Y. Meta-analysis of the effects of probiotic supplementation on glycemia, lipidic profiles, weight loss and C-reactive protein in women with polycystic ovarian syndrome. Minerva Med. 2018 Dec;109(6):479–87. DOI: 10.23736/S0026-4806.18.05728-2. PMID: 30256077.
- Shamasbi SG, Ghanbari-Homayi S, Mirghafourvand M. The effect of probiotics, prebiotics, and synbiotics on hormonal and inflammatory indices in women with polycystic ovary syndrome: a systematic review and meta-analysis. Eur J Nutr. 2020 Mar;59(2):433–50. DOI: 10.1007/s00394-019-02033-1. PMID: 31256251.
- Miao C, Guo Q, Fang X, Chen Y, Zhao Y, Zhang Q. Effects of probiotic and synbiotic supplementation on insulin resistance in women with polycystic ovary syndrome: a meta-analysis. J Int Med Res. 2021 Jul;49(7):3000605211031758. DOI: 10.1177/03000605211031758. PMID: 34311599. PMCID: PMC8320576.
- Heshmati J, Farsi F, Yosaee S, Razavi M, Rezaeinejad M, Karimie E, et al. The Effects of Probiotics or Synbiotics Supplementation in Women with Polycystic Ovarian Syndrome: a Systematic Review and Meta-Analysis of Randomized Clinical Trials. Probiotics Antimicrob Proteins. 2019 Dec;11(4):1236–47. DOI: 10.1007/s12602-018-9493-9. PMID: 30547393.
- Kite C, Lahart IM, Afzal I, Broom DR, Randeva H, Kyrou I, et al. Exercise, or exercise and diet for the management of polycystic ovary syndrome: a systematic review and meta-analysis. Syst Rev. 2019 Feb 12;8(1):51. DOI: 10.1186/s13643-019-0962-3. PMID: 30755271. PMCID: PMC6371542.
- Dos Santos IK, Ashe MC, Cobucci RN, Soares GM, de Oliveira Maranhão TM, Dantas PMS. The effect of exercise as an intervention for women with polycystic ovary syndrome: A systematic review and meta-analysis. Medicine (Baltimore). 2020 Apr;99(16):e19644. DOI: 10.1097/MD.0000000000019644. PMID: 32311937. PMCID: PMC7220722.
- Benham JL, Yamamoto JM, Friedenreich CM, Rabi DM, Sigal RJ. Role of exercise training in polycystic ovary syndrome: a systematic review and meta-analysis. Clin Obes. 2018 Aug;8(4):275–84. DOI: 10.1111/cob.12258. PMID: 29896935.
- Santos IKD, Nunes FAS de S, Queiros VS, Cobucci RN, Dantas PB, Soares GM, et al. Effect of high-intensity interval training on metabolic parameters in women with polycystic ovary syndrome: A systematic review and meta-analysis of randomized controlled trials. PLoS ONE. 2021 Jan 19;16(1):e0245023. DOI: 10.1371/journal.pone.0245023. PMID: 33465123. PMCID: PMC7815156.
- Nidhi R, Padmalatha V, Nagarathna R, Amritanshu R. Effects of a holistic yoga program on endocrine parameters in adolescents with polycystic ovarian syndrome: a randomized controlled trial. J Altern Complement Med. 2013 Feb;19(2):153–60. DOI: 10.1089/acm.2011.0868. PMID: 22808940.
- Li Y, Peng C, Zhang M, Xie L, Gao J, Wang Y, et al. Tai Chi for Overweight/Obese Adolescents and Young Women with Polycystic Ovary Syndrome: A Randomized Controlled Pilot Trial. Evid Based Complement Alternat Med. 2022 Jun 17;2022:4291477. DOI: 10.1155/2022/4291477. PMID: 35754690. PMCID: PMC9232331.
- Zhang J, Ye J, Tao X, Lu W, Chen X, Liu C. Sleep disturbances, sleep quality, and cardiovascular risk factors in women with polycystic ovary syndrome: Systematic review and meta-analysis. Front Endocrinol (Lausanne). 2022 Sep 13;13:971604. DOI: 10.3389/fendo.2022.971604. PMID: 36176474. PMCID: PMC9513052.
- Facer-Childs ER, Middleton B, Skene DJ, Bagshaw AP. Resetting the late timing of “night owls” has a positive impact on mental health and performance. Sleep Med. 2019 Aug;60:236–47. DOI: 10.1016/j.sleep.2019.05.001. PMID: 31202686.
- Gardiner C, Weakley J, Burke LM, Roach GD, Sargent C, Maniar N, et al. The effect of caffeine on subsequent sleep: A systematic review and meta-analysis. Sleep Med Rev. 2023 Jun;69:101764. DOI: 10.1016/j.smrv.2023.101764. PMID: 36870101.
- Liang YY, Feng H, Chen Y, Jin X, Xue H, Zhou M, et al. Joint association of physical activity and sleep duration with risk of all-cause and cause-specific mortality: a population-based cohort study using accelerometry. Eur J Prev Cardiol. 2023 Jul 12;30(9):832–43. DOI: 10.1093/eurjpc/zwad060. PMID: 36990109.
- Singh S, Keller PR, Busija L, McMillan P, Makrai E, Lawrenson JG, et al. Blue-light filtering spectacle lenses for visual performance, sleep, and macular health in adults. Cochrane Database Syst Rev. 2023 Aug 18;8(8):CD013244. DOI: 10.1002/14651858.CD013244.pub2. PMID: 37593770. PMCID: PMC10436683.
- Knufinke M, Fittkau-Koch L, Møst EIS, Kompier MAJ, Nieuwenhuys A. Restricting short-wavelength light in the evening to improve sleep in recreational athletes – A pilot study. Eur J Sport Sci. 2019 Jul;19(6):728–35. DOI: 10.1080/17461391.2018.1544278. PMID: 30427265.
- Choi K, Shin C, Kim T, Chung HJ, Suk H-J. Awakening effects of blue-enriched morning light exposure on university students’ physiological and subjective responses. Sci Rep. 2019 Jan 23;9(1):345. DOI: 10.1038/s41598-018-36791-5. PMID: 30674951. PMCID: PMC6344573.
- Lu M, Zhang Y, Zhang J, Huang S, Huang F, Wang T, et al. Comparative effectiveness of digital cognitive behavioral therapy vs medication therapy among patients with insomnia. JAMA Netw Open. 2023 Apr 3;6(4):e237597. DOI: 10.1001/jamanetworkopen.2023.7597. PMID: 37040111. PMCID: PMC10091171.
- Cao H, Pan X, Li H, Liu J. Acupuncture for treatment of insomnia: a systematic review of randomized controlled trials. J Altern Complement Med. 2009 Nov;15(11):1171–86. DOI: 10.1089/acm.2009.0041. PMID: 19922248. PMCID: PMC3156618.
- Jiskoot G, van der Kooi A-L, Busschbach J, Laven J, Beerthuizen A. Cognitive behavioural therapy for depression in women with PCOS: systematic review and meta-analysis. Reprod Biomed Online. 2022 Sep;45(3):599–607. DOI: 10.1016/j.rbmo.2022.05.001. PMID: 35810080.
- Salajegheh Z, Ahmadi A, Shahrahmani H, Jahani Y, Alidousti K, Nasiri Amiri F, et al. Mindfulness-based stress reduction (MBSR) effects on the worries of women with poly cystic ovary syndrome (PCOS). BMC Psychiatry. 2023 Mar 21;23(1):185. DOI: 10.1186/s12888-023-04671-6. PMID: 36944940. PMCID: PMC10032018.
- Greff D, Juhász AE, Váncsa S, Váradi A, Sipos Z, Szinte J, et al. Inositol is an effective and safe treatment in polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials. Reprod Biol Endocrinol. 2023 Jan 26;21(1):10. DOI: 10.1186/s12958-023-01055-z. PMID: 36703143. PMCID: PMC9878965.
- Fatima K, Jamil Z, Faheem S, Adnan A, Javaid SS, Naeem H, et al. Effects of myo-inositol vs. metformin on hormonal and metabolic parameters in women with PCOS: a meta-analysis. Ir J Med Sci. 2023 Dec;192(6):2801–8. DOI: 10.1007/s11845-023-03388-5. PMID: 37148410.
- Han Y, Cao Q, Qiao X, Huang W. Effect of vitamin D supplementation on hormones and menstrual cycle regularization in polycystic ovary syndrome women: A systemic review and meta-analysis. J Obstet Gynaecol Res. 2023 Sep;49(9):2232–44. DOI: 10.1111/jog.15727. PMID: 37364886.
- Zajac IT, Barnes M, Cavuoto P, Wittert G, Noakes M. The Effects of Vitamin D-Enriched Mushrooms and Vitamin D3 on Cognitive Performance and Mood in Healthy Elderly Adults: A Randomised, Double-Blinded, Placebo-Controlled Trial. Nutrients. 2020 Dec 16;12(12). DOI: 10.3390/nu12123847. PMID: 33339304. PMCID: PMC7766163.
- Morris AL, Mohiuddin SS. Biochemistry, Nutrients. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2022. PMID: 32119432.
- Cashman KD, Ritz C, Kiely M, Odin Collaborators. Improved Dietary Guidelines for Vitamin D: Application of Individual Participant Data (IPD)-Level Meta-Regression Analyses. Nutrients. 2017 May 8;9(5). DOI: 10.3390/nu9050469. PMID: 28481259. PMCID: PMC5452199.
- Balachandar R, Pullakhandam R, Kulkarni B, Sachdev HS. Relative Efficacy of Vitamin D2 and Vitamin D3 in Improving Vitamin D Status: Systematic Review and Meta-Analysis. Nutrients. 2021 Sep 23;13(10). DOI: 10.3390/nu13103328. PMID: 34684328. PMCID: PMC8538717.
- Kuang X, Liu C, Guo X, Li K, Deng Q, Li D. The combination effect of vitamin K and vitamin D on human bone quality: a meta-analysis of randomized controlled trials. Food Funct. 2020 Apr 30;11(4):3280–97. DOI: 10.1039/c9fo03063h. PMID: 32219282.
- Zhou J, Zuo W, Tan Y, Wang X, Zhu M, Zhang H. Effects of n-3 polyunsaturated fatty acid on metabolic status in women with polycystic ovary syndrome: a meta-analysis of randomized controlled trials. J Ovarian Res. 2023 Mar 17;16(1):54. DOI: 10.1186/s13048-023-01130-4. PMID: 36932420. PMCID: PMC10022207.
- Heidari H, Hajhashemy Z, Saneei P. A meta-analysis of effects of vitamin E supplementation alone and in combination with omega-3 or magnesium on polycystic ovary syndrome. Sci Rep. 2022 Nov 19;12(1):19927. DOI: 10.1038/s41598-022-24467-0. PMID: 36402830. PMCID: PMC9675810.
- Zhang T, He Q, Xiu H, Zhang Z, Liu Y, Chen Z, et al. Efficacy and Safety of Coenzyme Q10 Supplementation in the Treatment of Polycystic Ovary Syndrome: a Systematic Review and Meta-analysis. Reprod Sci. 2023 Apr;30(4):1033–48. DOI: 10.1007/s43032-022-01038-2. PMID: 35941510.
- Fazelian S, Rouhani MH, Bank SS, Amani R. Chromium supplementation and polycystic ovary syndrome: A systematic review and meta-analysis. J Trace Elem Med Biol. 2017 Jul;42:92–6. DOI: 10.1016/j.jtemb.2017.04.008. PMID: 28595797.
- Larik MO, Ahmed A, Khan L, Iftekhar MA. Effects of resveratrol on polycystic ovarian syndrome: a systematic review and meta-analysis of randomized controlled trials. Endocrine. 2024 Jan;83(1):51–9. DOI: 10.1007/s12020-023-03479-4. PMID: 37568063.
- Li M-F, Zhou X-M, Li X-L. The Effect of Berberine on Polycystic Ovary Syndrome Patients with Insulin Resistance (PCOS-IR): A Meta-Analysis and Systematic Review. Evid Based Complement Alternat Med. 2018 Nov 14;2018:2532935. DOI: 10.1155/2018/2532935. PMID: 30538756. PMCID: PMC6261244.
- Arentz S, Abbott JA, Smith CA, Bensoussan A. Herbal medicine for the management of polycystic ovary syndrome (PCOS) and associated oligo/amenorrhoea and hyperandrogenism; a review of the laboratory evidence for effects with corroborative clinical findings. BMC Complement Altern Med. 2014 Dec 18;14:511. DOI: 10.1186/1472-6882-14-511. PMID: 25524718. PMCID: PMC4528347.
Discussion
I care about answering your questions and sharing my knowledge with you. Leave a comment or connect with me on social media asking any health question you may have and I just might incorporate it into our next listener questions podcast episode just for you!