Symptoms of Leaky Gut

Support gut health to improve symptoms of leaky gut.

Leaky gut can cause a wide variety of symptoms, both in the digestive system and in the rest of the body. But to improve the symptoms of leaky gut, it’s not necessary to try to address all those symptoms individually. Because leaky gut syndrome is more of a side effect of a gut imbalance, working to improve your overall gut health will improve your leaky gut symptoms.

What is Leaky Gut?

Leaky gut, also called “intestinal permeability” or “gut hyperpermeability”, is when the tight junctions between the cells that line your small intestine loosen.

Most of your nutrition is absorbed through the cells of your small intestine. Natural digestive enzymes help prepare the food you eat to be absorbed in the digestive system. But inflammation of the gut lining and gastrointestinal tract from poor diet, [1 Trusted SourcePubMedGo to source] stress, [2 Trusted SourcePubMedGo to source] NSAIDs (nonsteroidal anti-inflammatory drugs) such as ibuprofen or aspirin, [3 Trusted SourcePubMedGo to source, 4 Trusted SourcePubMedGo to source, 5 Trusted SourcePubMedGo to source] alcohol, [6 Trusted SourcePubMedGo to source] or other causes can cause larger gaps to develop. These irritants increase a protein called zonulin, which causes gaps in the intestinal lining to open up.

Undigested food particles, bacteria, or other irritants can then “leak” through the gaps in your intestinal wall and into your bloodstream. This can cause an unwelcome immune response. These food particles and bacteria are thought to contribute to the wide variety of leaky gut symptoms.

Symptoms of Leaky Gut

The immune response that results from leaky gut can lead to a wide variety of digestive and non-digestive symptoms.

Because leaky gut is often caused by digestive issues, the most common are gut symptoms. These include:

  • Gas and bloating
  • Diarrhea or constipation
  • Heartburn or reflux
  • Symptoms from digestive disorders like celiac disease, inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), colitis, and Crohn’s disease.
Symptoms of Leaky Gut - auto

Many of these symptoms and digestive disorders are associated with an overgrowth of bacteria or other microorganisms, and the gut inflammation that they cause. This irritation of the gut lining can be a main cause of leaky gut symptoms.

However, because leaky gut allows unwelcome undigested food particles and bacterial fragments to enter your bloodstream, symptoms can also occur elsewhere in the body as your immune system tries to get rid of these intruders. As the immune system responds, it releases compounds called inflammatory cytokines, which create inflammation. Depending on where in your body this battle is happening, it can lead to a variety of inflammatory symptoms.

Here are some of the non-gut symptoms that are associated with leaky gut:

Body SystemLeaky Gut SymptomsResearch
Brain/Neurological Brain fog 7 Trusted SourcePubMedGo to source
Joints Joint pain 8 Trusted SourcePubMedGo to source,9 Trusted SourcePubMedGo to source,10 Trusted SourcePubMedGo to source
Energy Production Fatigue (especially after eating) or chronic fatigue 11 Trusted SourcePubMedGo to source,12 Trusted SourcePubMedGo to source,13 Trusted SourcePubMedGo to source
Immune System Food sensitivities or food allergies 14 Trusted SourcePubMedGo to source,15 Trusted SourcePubMedGo to source,16
Digestive Food cravings, especially for carbs 17 Trusted SourcePubMedGo to source
Brain/Neurological Mood symptoms like anxiety and depression 18 Trusted SourcePubMedGo to source,19 Trusted SourcePubMedGo to source,20 Trusted SourcePubMedGo to source
Skin Skin irritation or lesions, like acne or rashes 21 Trusted SourcePubMedGo to source,22 Trusted SourcePubMedGo to source,23 Trusted SourcePubMedGo to source,24 Trusted SourcePubMedGo to source
Blood Nutritional deficiencies, like anemia 25 Trusted SourcePubMedGo to source,26 Trusted SourcePubMedGo to source

The Link Between Leaky Gut and Diseases

Many digestive and autoimmune disorders are associated with a leaky gut, but it is not yet clear whether leaky gut causes all autoimmune disease, as some claim.

Symptoms of a general digestive disorder—like irritable bowel syndrome, for example—are also symptoms of leaky gut.

There is clear evidence linking celiac disease and Crohn’s disease with increased intestinal permeability. When a person with celiac disease consumes gluten, there is a very immediate and clear increase in leaky gut along with digestive symptoms. [27] Likewise, when a Crohn’s disease patient is having a flare, their intestinal permeability clearly increases, and appears to decrease as their symptom flare resolves. [28 Trusted SourcePubMedGo to source]

There is suggestive evidence linking other forms of inflammatory bowel disease, like ulcerative colitis, autoimmune disorders like rheumatoid arthritis and Hashimoto’s thyroiditis, ankylosing spondylitis, and chronic fatigue syndrome with intestinal permeability. [29 Trusted SourcePubMedGo to source,30,31 Trusted SourcePubMedGo to source,32 Trusted SourcePubMedGo to source,33 Trusted SourcePubMedGo to source,34 Trusted SourcePubMedGo to source,35 Trusted SourcePubMedGo to source,36 Trusted SourcePubMedGo to source]

Symptoms of Leaky Gut - auto

In fact, it’s been suggested that intestinal permeability may be associated with the onset of Type 1 diabetes [37 Trusted SourcePubMedGo to source], and that even the arterial inflammation of cardiovascular disease may be caused by leaky gut. [38 Trusted SourcePubMedGo to source] Research is still in the early phases, and it is difficult at this stage to make generalizations.

Some in the alternative medical community claim that all autoimmune disease is caused by leaky gut. The research data do not yet support this claim. At this time, it’s not clear whether autoimmune disease is preceded by leaky gut, or if leaky gut is a consequence of the disease. There is an association, but not clear causation.

In any event, if you have a digestive or autoimmune health condition, improving your gut health will likely improve your intestinal permeability and symptoms of leaky gut as well.

Leaky Gut Causes and Risk Factors

A few key risk factors increase your likelihood of having a leaky gut. Research does indicate that the following factors increase your risk of having a leaky gut.

Risk FactorResearch
Poor diet high in sugar, carbs, or processed foods. A diet with gluten may increase your risk, especially if you are celiac or have Crohn’s disease39 Trusted SourcePubMedGo to source,40 Trusted SourcePubMedGo to source
Chronic stress 41 Trusted SourcePubMedGo to source,42 Trusted SourcePubMedGo to source
Frequent use of NSAIDs or alcohol 43 Trusted SourcePubMedGo to source,44 Trusted SourcePubMedGo to source,45 Trusted SourcePubMedGo to source
Lack of quality sleep46 Trusted SourcePubMedGo to source
Over-exercising or overtraining47 Trusted SourcePubMedGo to source
Gut infections, like SIBO or dysbiosis48 Trusted SourcePubMedGo to source,49,50 Trusted SourcePubMedGo to source,51 Trusted SourcePubMedGo to source

How to Improve Symptoms of Leaky Gut

Even though leaky gut isn’t a recognized diagnosis, anything you do to improve digestive symptoms will indirectly improve symptoms of leaky gut.

There are three main categories of supports:

  1. Diet Changes
  2. Habit Changes
  3. Key Supplements

Diet Changes

With any gut health problem, improving your diet is one of the most important steps. This is because if you continue to eat things you have a food intolerance to, you continue to create gut inflammation and irritation. I like to use this example: If your skin reacts to a deodorant you’re using, you wouldn’t go get a prescription for cortisone cream. You would find a different brand that didn’t cause a reaction!

Symptoms of Leaky Gut - auto

Three diets that show promise for helping heal a leaky gut are the low FODMAP diet, the Paleo diet, and a gluten-free diet, but no single diet is right for everyone. It’s important to find an anti-inflammatory diet template that works for your body.

Working with a nutritionist or health coach may help you find the right diet plan faster.

Habit Changes

Many people get wooed with fancy supplement protocols and special diets, but some simple changes to your behavior can significantly improve leaky gut. You don’t need to necessarily do ALL these things to experience a benefit. Chances are there are one or two of these options that you know are most out of balance.

  • Reduce stress, however best works for you
  • Get regular, moderate exercise
  • Get enough sleep, ideally 7-9 hours per night
  • Reduce alcohol consumption
  • Use alternatives to NSAIDs (nonsteroidal anti-inflammatory drugs)

Supplements to Heal Leaky Gut

There are lots of leaky gut supplements that benefit the intestinal barrier function and gut health. The top three I encourage you to start with are probiotics, l-glutamine, and vitamin D.

Probiotics Good gut flora that encourages a healthy gut microbiome, which helps maintain a healthy intestinal barrier. [52 Trusted SourcePubMedGo to source, 53 Trusted SourcePubMedGo to source, 54 Trusted SourcePubMedGo to source, 55 Trusted SourcePubMedGo to source]
L-Glutamine Amino acid that has a significant body of research showing its restorative properties for the gut lining, especially during stress. [56 Trusted SourcePubMedGo to source, 57]
Vitamin DHelps maintain immune system balance in the gut and prevent gut health problems. I recommend safe sun exposure for increasing your vitamin D levels.


Leaky gut can cause symptoms both in the digestive tract and beyond. But this doesn’t mean that improving symptoms of leaky gut is difficult.

It’s not necessary to try to work separately on all the symptoms of leaky gut. Rather, a general approach to improve overall gut health, by focusing on eating an anti-inflammatory diet, adopting good self-care habits, and using a few key support supplements should improve your leaky gut symptoms.

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