Revolutionary Treatment for Maintaining Your HCl

Did you know that autoimmunity is one cause of low stomach acid?  More importantly there may actually be a novel treatment for this.  Let’s discuss some very interesting research regarding how you may be able to preserve your stomach’s ability to release hydrochloric acid by combating the autoimmune process, using a natural treatment.

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Revolutionary Treatment for Maintaining Your HCl

Dr. Michael Ruscio: Very interesting research regarding how you may be able to preserve your stomach’s ability to release hydrochloric acid and to absorb vitamin B12.

There are many types of autoimmunity, one of which is autoimmunity against your stomach tissue. Now, when this occurs, you can have what’s called anti-parietal cell antibodies. And when you form these antibodies, you can destroy the parietal cells, which are needed to release hydrochloric acid and also needed to release intrinsic factor, allowing one to absorb vitamin B12.

Now, how common is this? Well, up to 40%—I used to think it was 25%. But recently, a paper was published showing up to 40% of people with Hashimoto’s thyroid autoimmunity will also have this condition. So it may be more prevalent than you think, especially when you consider that if someone has one form of autoimmunity, they’re at a heightened risk for other forms of autoimmunity.

And knowing how common autoimmunity is becoming, additionally when you factor in the fact that many people have chronic digestive issues and many people seem to respond well to hydrochloric acid supplementation, my thinking is this may be a far more prevalent issue than it has been given appreciation for.

So when one forms the anti-parietal cell antibodies, again you essentially destroy the parietal cells. And the parietal cells are needed to release hydrochloric acid and to release intrinsic factor.

Now, this can lead to a condition known as pernicious anemia where someone becomes B12 anemic. And even though they’re ingesting B12, they can’t absorb it. This is where vitamin B12 injections essentially come from because if you do an intramuscular injection, you bypass absorbing it through the digestive tract.

Now, a study was done. And I’ll put the cover slide of the study up here so you can see it and look up the reference if you’d like. A study was done on what’s called oral lichen planus, which is essentially a disease where people have sores in the mouth essentially, amongst other things. And they wanted to see how vitamin B12 or vitamin B12 plus a drug or just a drug helped in this condition.

And they weren’t necessarily trying to find this. But they found and what is very, very interesting is by administering about 100 mcg/mL of hydroxocobalamin via B12 injections, they were able to stop the anti-parietal cell antibodies and therefore arrest stomach autoimmunity.

Now, what they did in the study was they did these injections once a week for a period of several months until they saw the antibody levels become zero. And then they reverted to a once a month dose as a maintenance therapy. And they found that virtually all the patients that did this maintained and did not have any further antibodies against their stomach cells in the future, whereas people who came off the injections, they saw some people have a return of the antibodies.

So this is the first, to my knowledge, I have seen vitamin B12 injections as a useful aid in preventing loss of parietal cells in the stomach which, again, is significant because it can interfere with your body’s ability to absorb B12. And it can also interfere with your ability to release hydrochloric acid.

So for those of you out there who are struggling with a stomach condition, you may want to have the anti-parietal antibody test run which can be run at LabCorp or Quest or any major lab. And then consider going through this protocol to prevent any further damage or deterioration of your parietal cells.

So this is Dr. Ruscio. And I hope you found this helpful. Thanks!


If you need help with maintaining your HCl,
click here.

What do you think? I would like to hear your thoughts or experience with this.

Dr. Ruscio is your leading functional and integrative doctor specializing in gut related disorders such as SIBO, leaky gut, Celiac, IBS and in thyroid disorders such as hypothyroid and hyperthyroid. For more information on how to become a patient, please contact our office. Serving the San Francisco bay area and distance patients via phone and Skype.

Discussion

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72 thoughts on “Revolutionary Treatment for Maintaining Your HCl

  1. Great Post on this interesting observation. I hadn’t seen this paper and just read the abstract you linked to. Do you recall if they included a proposed mechanism to explain how B12 injections eliminated the anti-parietal cell antibodies? I recall reading about B12 stimulating cytotoxic / killer type T-cells, but not immune suppressive/tolerance-promoting T-cells.

    1. Hey Norm,
      Nothing definitive on mechanism….. but this group just published a follow up study (more to follow) and found only injections had this effect, oral B12 did not. Fascinating stuff!

  2. Thanks for this interesting gem. I have tried to get those injections in the past for dna support purposes. The drs in the area don’t do that type of injections because the compounded script of the b12 expires so quickly (like in 2 days?). Is that right? Thank you!

  3. I have all my older clients take a sublingual methyl-B12 just in case stomach acid is reduced with aging. Same rationale as injection: bypassing possible impaired digestion. Don’t know the viability of this method compared to injection.

      1. Hi, I had parietal cell antibodies identified 2 years ago along with severe B12 deficiency and was diagnosed with autoimmune gastritis. I have been taking sublingual B12 for around 18 months now (initially had injections) and my latest blood results show NEGATIVE parietal cell antibodies, this was a complete surprise to me as I had been told that once I had these antibodies they would not go away! I will continue taking the sublingual B12. It’s not absorbed through the gut so isn’t the same as the usual oral B12 that you swallow, seems to be having the same effect as injections in my case.

        1. Thanks for sharing your experience, Wendy! Also glad to hear you’re healing!

  4. Shivan,

    My Doc wrote me a script for 10ml vial. My compound pharmacist called me and said it wasn’t doable because the vial would expire in 30 days. We compromised and he made me 4 syringes for me to inject once a week. After those were finished he made another 4 for the next 30 days… then 2 more to complete after that to complete the 10ml. He claimed the pre-made syringes would be good for 30 days if kept refrigerated.

  5. Hey Dr. Ruscio,

    Like always, I’m grateful that you reply to all of the comments on your website 🙂

    At what point would you recommend getting this test? What other symptoms besides low HCL are associated with anti-parietal cell antibodies?

    I’m exploring this right now actually, so you are right on point again with my n=1 experiments. Do you agree with this as a baseline for diagnosing low HCL? http://drjockers.com/5-ways-to-test-your-stomach-acid-levels/
    I’ve never seen a blood test associated with HCL, so I thought that was interesting.

    One more thing: say after trying the baking soda test, one consistently belches after 3 minutes, would one then move on to an HCL supplement, or would further testing be ideal?

    Thanks again for what you do!

    -Mike in NYC

    1. Thanks Mike. If you have thyroid autoimmunity or any other autoimmunity than this test may make sense. There are many symptoms of low HCl, I detail this my coming book http://www.drruscio.com/GutBook. Interesting article, but more than I can comment on here. I don’t recognize the baking soda test as being valid, sorry! Hope this helps!

  6. I suspected I had hypothroidsim and low B12. My doctor disagree but ran the tests. My b12 was quite low. She didn’t recommend anything…so I started taking B12 methylcobalamin sublingual. I felt I was deficient because I have acid reflux.
    Next blood test showed an improvement in b12 level into he normal range. Is this an acceptable treatment rather than injections?

    1. Hi. Dr. Ruscio stated above that oral did not work as well. However I too thought that sublingual would be different as it bypasses gut etc.

    2. Hi Nancy,
      It really depends on what you are trying to do. Oral or sublingual B12 will certainly increases one’s levels, but it has not been shown to help with the stomach autoimmunity. So, if stomach autoimmunity is present you may want to speak with a clinical about the injectable option.

    1. Hi Marie,

      gut bacteria are known to synthesize B vitamins which is why levels can be high in sibo. I’d suggest to get your other B vitamins checked, especially B6 and foltate as these can be toxic in large amounts.

  7. Hey Dr. Ruscio,

    Like always, I’m grateful that you reply to all of the comments on your website 🙂

    At what point would you recommend getting this test? What other symptoms besides low HCL are associated with anti-parietal cell antibodies?

    I’m exploring this right now actually, so you are right on point again with my n=1 experiments. Do you agree with this as a baseline for diagnosing low HCL? http://drjockers.com/5-ways-to-test-your-stomach-acid-levels/
    I’ve never seen a blood test associated with HCL, so I thought that was interesting.

    One more thing: say after trying the baking soda test, one consistently belches after 3 minutes, would one then move on to an HCL supplement, or would further testing be ideal?

    Thanks again for what you do!

    -Mike in NYC

    1. Thanks Mike. If you have thyroid autoimmunity or any other autoimmunity than this test may make sense. There are many symptoms of low HCl, I detail this my coming book http://www.drruscio.com/GutBook. Interesting article, but more than I can comment on here. I don’t recognize the baking soda test as being valid, sorry! Hope this helps!

  8. I suspected I had hypothroidsim and low B12. My doctor disagree but ran the tests. My b12 was quite low. She didn’t recommend anything…so I started taking B12 methylcobalamin sublingual. I felt I was deficient because I have acid reflux.
    Next blood test showed an improvement in b12 level into he normal range. Is this an acceptable treatment rather than injections?

    1. Hi. Dr. Ruscio stated above that oral did not work as well. However I too thought that sublingual would be different as it bypasses gut etc.

    2. Hi Nancy,
      It really depends on what you are trying to do. Oral or sublingual B12 will certainly increases one’s levels, but it has not been shown to help with the stomach autoimmunity. So, if stomach autoimmunity is present you may want to speak with a clinical about the injectable option.

  9. I have SIBO, candida, hormonal imbalances, leaky gut, high cholesterol, MTHFR, and reactived EBV. My B12 is sky high. I have lost my muscle mass and it is hard to gain weight. I have had thyroid antibodies tested and they are within normal range. I have nodules on my thyroid and the endo said they are real small so I just have an ultrasound annually to watch them. I really would love to find a physician that would get to the root causes. I live in Florida. Do you see patients remotely? Thank you for all that you do.

  10. I have SIBO, candida, hormonal imbalances, leaky gut, high cholesterol, MTHFR, and reactived EBV. My B12 is sky high. I have lost my muscle mass and it is hard to gain weight. I have had thyroid antibodies tested and they are within normal range. I have nodules on my thyroid and the endo said they are real small so I just have an ultrasound annually to watch them. I really would love to find a physician that would get to the root causes. I live in Florida. Do you see patients remotely? Thank you for all that you do.

  11. Hi Dr. Ruscio:
    Is there another name for the test “anti-parietal antibody” as I am trying to find it on Health Testing Centers and it comes back with no result?
    Thank you for all your great posts.
    Best regards for a successful 2017.

    1. My anti-parietal antibodies were found in the Cyrex Labs test. I do not remember which array but I think I got the one that tests for most of the autoimmune antibodies. With all I have, it was very good to know what I am dealing with. I also got my genetics test.(some recommend 23 and me) That also helps with how to approach my future in healing

        1. I believe it was the Genova test that my Dr. noted that hydroxylcobalamin was my preffered type of B12., so yes this type was recommended. I have to say that I have not noticed any effect with the sublingual. I have very low stomach acid and have had bleeding problems in all 9 of my pregrancies. The B12(methyl) injections helped w the heavy mensus’s i’ve had but that was 15 yrs ago (before the autoimmunity of parietal cells was diagnosed). I do so very much want to try the hydroxylcobalamin injections and my provider is open to it, but she said that hydroxylcobalamin injections are not available. How can I find where to get my prescription filled? BTW, the elemental diet was fantastic for my SIBO! However, the stomach just does not want to make HCL and being sad and still not as energetic as i’d like without my ‘B’ happy nutrition is still a problem.

  12. Hi Dr. Ruscio:
    Is there another name for the test “anti-parietal antibody” as I am trying to find it on Health Testing Centers and it comes back with no result?
    Thank you for all your great posts.
    Best regards for a successful 2017.

    1. My anti-parietal antibodies were found in the Cyrex Labs test. I do not remember which array but I think I got the one that tests for most of the autoimmune antibodies. With all I have, it was very good to know what I am dealing with. I also got my genetics test.(some recommend 23 and me) That also helps with how to approach my future in healing

        1. I believe it was the Genova test that my Dr. noted that hydroxylcobalamin was my preffered type of B12., so yes this type was recommended. I have to say that I have not noticed any effect with the sublingual. I have very low stomach acid and have had bleeding problems in all 9 of my pregrancies. The B12(methyl) injections helped w the heavy mensus’s i’ve had but that was 15 yrs ago (before the autoimmunity of parietal cells was diagnosed). I do so very much want to try the hydroxylcobalamin injections and my provider is open to it, but she said that hydroxylcobalamin injections are not available. How can I find where to get my prescription filled? BTW, the elemental diet was fantastic for my SIBO! However, the stomach just does not want to make HCL and being sad and still not as energetic as i’d like without my ‘B’ happy nutrition is still a problem.

  13. My Antiparietal cell antibody 68, I have been taking B12 shots since June, so far no help at all. Very colicky and lots of stomach pain.

  14. My Antiparietal cell antibody 68, I have been taking B12 shots since June, so far no help at all. Very colicky and lots of stomach pain.

  15. Is it OK to supplement with HCL if you have partiel cell antibodies?

    If they are getting destroyed does that make the chances higher of hCl “burning” a hole where the parietal cell was?

    1. Hi Micki,
      I don’t know of any reason not to use HCl if you have APC antibodies. In fact you may have increased chance of benefit form using HCl. However, it’s also important not to use HCl if you have any reaction. If you want a specific HCl and enzyme protocol, in addition to a full program for healing your gut, I would grab a copy of Healthy Gut, Health You https://drruscio.com/getgutbook/
      Hope this helps!

  16. Is it OK to supplement with HCL if you have partiel cell antibodies?

    If they are getting destroyed does that make the chances higher of hCl “burning” a hole where the parietal cell was?

    1. Hi Micki,
      I don’t know of any reason not to use HCl if you have APC antibodies. In fact you may have increased chance of benefit form using HCl. However, it’s also important not to use HCl if you have any reaction. If you want a specific HCl and enzyme protocol, in addition to a full program for healing your gut, I would grab a copy of Healthy Gut, Health You https://drruscio.com/getgutbook/
      Hope this helps!

    1. Hi Rob,

      When you click that link, there’s a button at the top of the page that says “Download PDF” that will enable you to see the whole article. It looks like they used 1000mcg. Hope this helps!

    1. Hi Rob,

      When you click that link, there’s a button at the top of the page that says “Download PDF” that will enable you to see the whole article. It looks like they used 1000mcg. Hope this helps!

  17. Hi I was diagnosed with autoimmune attopic gastric and I get b12injection once a week for the past 4 months but the blood test showed no changes with partial cell bodily level ? Do you think I still should continue with injection once a week ? Also I want to know since the stomach wall has tinned out due to atropic gastric, is it ok to use hcl suplements ?would not damages the stomach walls more due to its acidity? Thanks

    1. Hi Yekta,

      I would consult with your doctor on what you should do moving forward.

      I don’t know of any reason not to use HCl if you have APC antibodies. In fact you may have increased chance of benefit from using HCl. However, it’s also important not to use HCl if you have any reaction. If you want a specific HCl and enzyme protocol, in addition to a full program for healing your gut, I would grab a copy of “Healthy Gut, Healthy You”: https://drruscio.com/getgutbook/

  18. Hi I was diagnosed with autoimmune attopic gastric and I get b12injection once a week for the past 4 months but the blood test showed no changes with partial cell bodily level ? Do you think I still should continue with injection once a week ? Also I want to know since the stomach wall has tinned out due to atropic gastric, is it ok to use hcl suplements ?would not damages the stomach walls more due to its acidity? Thanks

    1. Hi Yekta,

      I would consult with your doctor on what you should do moving forward.

      I don’t know of any reason not to use HCl if you have APC antibodies. In fact you may have increased chance of benefit from using HCl. However, it’s also important not to use HCl if you have any reaction. If you want a specific HCl and enzyme protocol, in addition to a full program for healing your gut, I would grab a copy of “Healthy Gut, Healthy You”: https://drruscio.com/getgutbook/

  19. I have all my older clients take a sublingual methyl-B12 just in case stomach acid is reduced with aging. Same rationale as injection: bypassing possible impaired digestion. Don’t know the viability of this method compared to injection.

      1. Hi, I had parietal cell antibodies identified 2 years ago along with severe B12 deficiency and was diagnosed with autoimmune gastritis. I have been taking sublingual B12 for around 18 months now (initially had injections) and my latest blood results show NEGATIVE parietal cell antibodies, this was a complete surprise to me as I had been told that once I had these antibodies they would not go away! I will continue taking the sublingual B12. It’s not absorbed through the gut so isn’t the same as the usual oral B12 that you swallow, seems to be having the same effect as injections in my case.

  20. Shivan,

    My Doc wrote me a script for 10ml vial. My compound pharmacist called me and said it wasn’t doable because the vial would expire in 30 days. We compromised and he made me 4 syringes for me to inject once a week. After those were finished he made another 4 for the next 30 days… then 2 more to complete after that to complete the 10ml. He claimed the pre-made syringes would be good for 30 days if kept refrigerated.

  21. Thanks for this interesting gem. I have tried to get those injections in the past for dna support purposes. The drs in the area don’t do that type of injections because the compounded script of the b12 expires so quickly (like in 2 days?). Is that right? Thank you!

  22. Great Post on this interesting observation. I hadn’t seen this paper and just read the abstract you linked to. Do you recall if they included a proposed mechanism to explain how B12 injections eliminated the anti-parietal cell antibodies? I recall reading about B12 stimulating cytotoxic / killer type T-cells, but not immune suppressive/tolerance-promoting T-cells.

    1. Hey Norm,
      Nothing definitive on mechanism….. but this group just published a follow up study (more to follow) and found only injections had this effect, oral B12 did not. Fascinating stuff!

    1. Hi Marie,

      gut bacteria are known to synthesize B vitamins which is why levels can be high in sibo. I’d suggest to get your other B vitamins checked, especially B6 and foltate as these can be toxic in large amounts.

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