Iodine, Thyroid, Hashimoto’s, and Sleep Research Updates - Dr. Michael Ruscio, DC

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Iodine, Thyroid, Hashimoto’s, and Sleep Research Updates

The latest research findings in sleep apnea, subclinical hypothyroidism, mold toxicity, kidney disease, diabetes, and more

This podcast episode covers a wide range of research topics, inviting you to learn about the potential connections between: 

  • Iodine deficiency and hypothyroidism 
  • Vitamin D and erectile dysfunction 
  • Sleep apnea and anxiety and depression
  • Subclinical hypothyroidism and bone health
  • Low carb diets and kidney disease
  • Omega 3s and blood pressure
  • Mold exposure and fatigue

Tune in to hear what the research reveals.

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➕ Dr. Ruscio’s, DC Notes


  • Subclinical Hypothyroidism and Cognitive Impairment
    • 1,118 euthyroid patients, 283 subclinical hypothyroid (SCH) patients
      • All >60 years old 
    • After 3 years, there was NO difference in cognitive function between the euthyroid and SCH group, even when SCH patients had a TSH >10 mIU/L
    • Commentary: This study did NOT find an association between SCH and worse cognitive outcomes in an older patient population. 



  • Uterine Fibroid Patients Reveal Alterations in the Gut Microbiome
    • 42 uterine fibroid patients, 43 healthy controls
    • Compared to healthy controls, those with fibroids had:
      • Lower diversity of gut microbiome 
      • Increased pathogenic bacteria (Pseudomonas, Prevotella)
      • Reduced normal bacteria (Bifidobacteria, Lactobacillus, Lactococcus) 
    • Commentary: Uterine fibroids may be associated with dysbiosis in the gut.



  • Hashimoto Thyroiditis, Anti-Parietal Cell Antibodies: Associations With Autoimmune Diseases and Malignancies
    • 840 participants diagnosed with Hashimoto’s thyroiditis (HT) based on positive TPOabs and/or positive TgAbs
    • Of those with HT, the prevalence of other autoimmune diseases was: 
    • 21% anti-parietal cell antibodies (APCA)
    • 9.4% one or more organ-specific autoimmune disease
      • E.g. type 1 diabetes, vitiligo, etc
    • 7.3% systemic autoimmune disease
      • E.g. SLE, Rheumatoid arthritis, Sjogren’s syndrome, etc 
    • Commentary: About 1 in 5 individuals with HT will have APCA antibodies. 





  • Safety and efficacy of very low carbohydrate diet in patients with diabetic kidney disease-A randomized controlled trial
    • 30 type 2 diabetic patients w/ kidney disease randomized to:
      • Very low carb (<20g carbs/d)
      • Or low protein, low salt diet
    • After 12 weeks, the low carb group had:
      • No change in serum creatinine
      • More decrease in A1C (-1.3% vs -0.7%)
      • More reduction in insulin dose (-39 IU vs +0 IU)
      • Reduction in LDL-C 
      • Reduction in inflammatory markers (IL-6)
      • More weight loss (-4.0 kg vs +0.2 kg)
    • Commentary: This study demonstrated that a very low carb (e.g. ketogenic) and higher protein diet is both safe and can ameliorate glycemic abnormalities in those w/ kidney disease.


  • Mandibular advancement devices in patients with severe OSAHS
    • 271 severe sleep apnea patients treated with a mandibular advancement device (MAD)
    • Treatment with MAD led to: 
      • Complete response in 19.3% 
      • >50% reduction in sleep apnea severity in 71% 
      • Sleep apnea/hypopnea index <15/h in 59%
    • 9.6% patients discontinued therapy due to ineffectiveness and rarely intolerance
    • Commentary: MAD led to significant improvements in severe sleep apnea patients with a high tolerability. 




  • Quality of life in upper airway resistance syndrome
    • Retrospective study of 888 sleep PSG studies
      • 10.5% had upper airway resistance syndrome (UARS)
      • 90.5% had sleep apnea
    • Compared to 641 healthy controls
    • UARS had 5.5x and OSA patients had 6.2x greater probability of having a low quality of life score (compared to the healthy controls)
    • Commentary: Those w/ sleep disordered breathing are more likely to suffer from lower quality of life. 









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