Dr. Michael Ruscio, DC is a clinician, Naturopathic Practitioner, clinical researcher, author, and adjunct professor at the University of Bridgeport. His work has been published in peer-reviewed medical journals and he speaks at conferences around the globe.
Autoimmune Symptoms to Watch Out for and Natural Strategies for Healing
The early warning signs of autoimmune disease may include fatigue, brain fog, joint pain, skin rashes, hair loss, and digestive distress.
However, not everyone with autoimmunity will present with these symptoms, and not everyone with these “warning signs” will have autoimmunity.
Warning signs can be highly variable in severity, location, and duration, with many people having periods of intense symptoms (flares) followed by periods of mild-to-no symptoms.
Some common autoimmune diseases include rheumatoid arthritis, type 1 diabetes, psoriasis, Crohn’s disease, multiple sclerosis, and celiac disease.
There are many different autoimmune conditions but they all share the same or similar root causes, like a genetic predisposition, stress, and an unhealthy gut.
Autoimmune conditions are often brought on by disruptions in the GI tract like dysbiosis and inflammation.
Natural therapies that target gut health like elemental and elimination diets, probiotics, nutritional supplements, and lifestyle changes may help to reverse the autoimmune process in the body.
Despite more than 24 million people in the U.S. having an autoimmune disease like psoriasis, inflammatory bowel disease, celiac disease, Hashimoto’s, or type 1 diabetes, they still don’t seem to get as much airplay as other chronic diseases. Part of this may be related to our poor understanding of autoimmune diseases on the whole, including what triggers them and how best to treat them.
But with 8 million Americans experiencing the early warning signs of autoimmune disease [1, 2, 3], which can include fatigue, digestive distress, brain fog, joint pain, and/or skin rashes, it’s important to know what can be done to help prevent someone from developing an autoimmune disease. We know there’s a genetic component, but not everyone with a gene that is predisposed to autoimmunity will develop it.
Everyone with autoimmunity is each impacted in a unique way and can have a highly variable onset. Symptoms can pop up rapidly or develop over a period of years, can be persistent or come and go across the course of the disease, and can exist on a spectrum from mild to debilitating.
Research suggests poor gut health is an important trigger for those with autoimmunity. This is great news because it means that even if you have a genetic predisposition, developing an autoimmune disease doesn’t have to be inevitable. We can have more control over our health when we correct gut imbalances like microbial dysbiosis and intestinal inflammation.
If you’re noticing the early warning signs of autoimmune disease, foundational strategies such as elemental diets, probiotics, nutritional supplements, and personalized lifestyle changes to heal your gut may actually interrupt and reverse the underlying autoimmune process. And if you’ve already been diagnosed with an autoimmune condition, these same strategies can be used to heal your symptoms. All this to say, there’s a lot of hope for anyone who’s at risk or has already developed an autoimmune condition.
In this article, I’ll share the role the gut plays in autoimmunity and the effective natural therapies I use in the clinic to help restore healthy immune system function. So, let’s get started by reviewing what you need to know about autoimmune diseases.
Normally, the immune system protects your body from infections and illnesses by identifying and neutralizing potentially harmful foreign invaders. When someone has an autoimmune disease though, their immune system isn’t working the way it should. So, in addition to attacking truly harmful microbes, the body’s immune system also attacks its own healthy cells and tissues, which can increase the risk of other diseases, like cancer, cardiovascular disease, type 2 diabetes, and even death [1, 2, 3].
It’s thought that the body begins attacking its own cells as a result of various root causes like [1, 2, 3]:
Viral or bacterial infections
Excessive and/or chronic stress
Poor gut health
It’s not likely that any one of the above root causes on its own is responsible for the development of an autoimmune disorder, rather research suggests autoimmune diseases are probably caused by a combination of genetic and environmental factors that are unique to an individual .
Epigenetics (the study of how environment affects genetic expression) suggests that in people with certain genetic factors, specific environmental exposures like too much sunlight, childhood poverty, agricultural chemicals, mercury, vitamin D deficiency, and cigarette smoke might increase the risk that they’ll develop an autoimmune condition [1, 2].
In other words, the environmental factors are probably influencing the genes, and the genes are enhancing or diminishing the effects of the environmental factors to set off the autoimmune cascade [1, 2, 3].
More than 24 million people in the United States have at least one of the 80 types of autoimmune diseases that have been identified, and at least 8 million more may be at risk of developing one [1, 2, 3]. Some of the most common types include:
While all autoimmune diseases tend to have a similar immunological mechanism of action, each one differs depending on which body parts the immune system is attacking. Autoimmune disease may impact the skin, kidneys, mouth, nervous system, lungs, eyes, heart, digestive system, and joints . As such, people with autoimmune diseases can also experience an impact on their hormones, metabolic health, digestion, and many other body systems .
Autoimmunity can take years to develop, which means in a lot of cases we have a significant amount of time to act beforehand. So, let’s take a look at the early warning signs of autoimmune disease you need to know about.
Early Warning Signs of Autoimmune Disease
Most people with an autoimmune disease experience the signs and symptoms for several years before the development of the disease, but for some people, they may come on suddenly. Common symptoms may include:
Heat, redness, pain, and swelling of at least one part of the body [2, 25]
Loss of balance
However, not everyone with autoimmunity will present with these specific symptoms, and not everyone with the above symptoms will have autoimmunity. Seeing a healthcare provider for a comprehensive work-up is important, as autoimmunity can’t be diagnosed from symptoms alone.
Where the warning signs occur can be largely dependent on what type of autoimmunity is present, though many people will experience similar symptoms of appetite loss, weight changes, low-grade fever, and/or fatigue at some point in time.
People with thyroid autoimmunity, like Hashimoto’s thyroiditis, might first see symptoms of difficulty swallowing and cold intolerance, while someone with Crohn’s or ulcerative colitis could notice abdominal pain, and loose or frequent stool. Lupus often presents with widespread joint pain and skin rashes, as does psoriatic arthritis.
However, even though an autoimmune condition is known to attack a specific area of the body, it can cause body-wide symptoms, due to the widespread inflammation discussed above. This is clearly evident in the case of IBD, where swollen, painful knees are fairly common, and RA where the rates of gastritis, stomach pain, and reflux occur more frequently than in the general population .
It’s important to understand that these symptoms often come and go – they worsen during flare-ups and then ease up for a while before the next flare . There can be long periods of time with minimal to no symptoms, and may be one reason people with the early warning signs of autoimmune disease have a difficult time getting effective treatment early on.
It’s important to document your symptoms and how frequently they occur in order to help your provider recognize what’s going on. If we catch this early enough, it may be possible to reverse this process and prevent an autoimmune disease from developing .
I’m a gut geek, so in the clinic, I generally always consider gut health and function first. And since gut dysbiosis and dysfunction can lead to autoimmunity, it’s especially important for people with the early warning signs of autoimmune disease to take a deeper look at their gut.
The Gut-Autoimmune Connection
Research suggests that in addition to environment and genetics, poor gut health may be a trigger for the development of autoimmune diseases . One large analysis of genetic data found altered levels of normal gut flora could possibly lead to the development of type 1 diabetes and celiac disease, both of which are autoimmune diseases . And several meta-analyses have found gut dysbiosis (altered gut microbiota) to be a common feature in autoimmune conditions .
While we can’t yet say gut dysbiosis causes autoimmunity, it likely contributes and gives us a great target for treating autoimmunity naturally. I’ve had many patients with autoimmune disease improve by healing their gut, so, let’s take a look at how leaky gut impacts autoimmunity.
How Leaky Gut Can Cause a Haywire Immune System
The gut environment includes a variety of microbes that live together harmoniously (symbiosis) until something (stress, toxins, drugs, food particles, and/or pathogens) disrupts the ecosystem . When the contents of the gut are imbalanced, the delicate small intestinal barrier is weakened .
Once this barrier is compromised — known as leaky gut— contents that should remain in the GI tract and/or exit the body through stool (like undigested food particles, bacteria, and toxins) can cross the gut wall and enter the systemic circulation. After these foreign antigens enter the bloodstream, inflammatory signaling molecules are released that tell the immune system to be on high alert.
The bacterial metabolites and other antigens that cross into the systemic circulation can have a molecular makeup similar to the body’s own cells (molecular mimicry), so in addition to attacking the invader, the immune system begins to attack its own tissues by mistake. Furthermore, healthy tissues of the body can be damaged just by being in the vicinity of the inflammatory/immune system response, similar to an innocent bystander.
Over time, this process may lead to common autoimmune diseases like celiac disease, type 1 diabetes, multiple sclerosis (MS), and RA .
Here’s a nice graphic detailing this leaky gut progression :
While we can’t yet say definitively that gut problems cause autoimmunity [31, 32, 33], we do know that gut dysbiosis has a significant impact on how the immune system functions and that there is a considerable link between the two [27, 29, 30]. The symptoms of poor gut health can be a sign that your immune system is overactive, making it one of the top early warning signs of autoimmune disease. Healing your gut is a great first place to start to get a hold on this process to prevent it from progressing .
As a reminder, just because poor gut health can be a common factor in people with autoimmunity, doesn’t mean that gas, bloating, or constipation are always indicative of an autoimmune process. It’s important to remember that autoimmunity is only diagnosed by a doctor through a comprehensive work-up.
If you’re high risk for or are suspicious of an autoimmune condition, you should continue to follow up with your doctor. But if you also have symptoms of an unhealthy gut, it can be a sign that you’re experiencing inflammation and altered immune system function, and there’s a lot we can do to heal these symptoms.
Let’s discuss some of the natural therapies I use in the clinic.
Natural Therapies for Autoimmune Symptoms
There are a lot of simple, natural therapies that can be used early on (or any time for that matter) to address autoimmunity and its root causes such as gut dysbiosis, nutrient deficiencies, pollutants, stress, and obesity.
One approach I’ve found especially effective in the clinic is to start by targeting gut dysbiosis and leaky gut with an elemental diet reset followed by an elimination diet protocol, probiotics, and other lifestyle measures. Let’s discuss why this 2-step approach seems to work and how you can implement it.
Step One: Elemental Diet Reset
As I discuss in Healthy Gut, Healthy You, elemental diets for autoimmunity haven’t been well-researched yet. But some studies have shown the elemental diet to be as effective as corticosteroids (anti-inflammatory medications) for IBD and RA, and it can improve symptoms in people with celiac disease.
Additional research has found:
Patients with Crohn’s disease relapse less often when they incorporate elemental dieting when compared to those who don’t 
An elemental diet improves inflammatory cells and symptoms in people with eosinophilic esophagitis (a condition with a strong link to existing autoimmunity) 
While there’s not much long-term research available on elemental diets and autoimmunity, your gut health has a very strong influence on your immune system, so it makes sense that anything you do to improve your gut health may also help with the early warning signs of autoimmune disease.
While the mechanisms by which an elemental diet helps will differ to some degree for every condition and person, we think this therapy works by [36, 37, 38]:
Giving your digestive tract a break and a chance to rest, heal, and repair
Starving small intestinal bacterial overgrowth (SIBO) and other overgrowths that may contribute to leaky gut 
The elemental diet is a meal replacement formula that’s hypoallergenic, anti-bacterial, and anti-inflammatory. It’s sold as a powder that you simply mix, blend, or shake up with water.
Elemental diets may be used as the sole source of nutrition for several weeks and then intermittently as needed. But for a reset to quell inflammation or a flare of autoimmune symptoms, you can use it for 2–4 days. If you’re responding well, go for the full four days, if you’re having a reaction that doesn’t abate after the second day, stop at day two.
At this point, you may be wondering, why not just start with the autoimmune protocol diet (AIP)? The AIP diet is definitely an option for anyone who has gone through this 2-step process and not found significant relief. It’s not a first option for most people though because it’s very restrictive, and in my experience, many patients with autoimmunity can find symptom relief without this level of restriction.
Once you’ve completed your elemental diet reset, it’s time to move on to step 2 with an elimination diet plus probiotics.
Step Two: Elimination Diet Plus Probiotics
You’ll want to transition slowly back to whole foods once you’re finished with the elemental diet. But you want to be selective with this process and consider eliminating common food allergens and inflammatory foods like gluten, lactose, corn, and soy.
These types of elimination diets have been found to help patients with Hashimoto’s thyroiditis (an autoimmune condition that impacts the thyroid gland, which can lead to hypothyroidism) reduce their thyroid autoantibodies and improve thyroid hormone levels . Similarly, anti-inflammatory diets like the Mediterranean diet and other elimination-type diets have been found to improve RA outcomes .
You have a few different options, but I would recommend starting with the Paleo diet, since it’s pretty easy to implement and it removes allergens and inflammatory foods. Here’s an overview of the Paleo meal plan:
If you feel great on the Paleo diet after 2–3 weeks, then stick with it. If you’re not happy with your results, then you can try other elimination diets one by one for 2–3 weeks each until you find one that works best for you.
If Paleo improved your symptoms but didn’t take care of your early warning signs of autoimmune disease completely, then move on to Paleo plus low FODMAP. If Paleo didn’t work at all, then you may want to just try the low FODMAP diet.
Once you find the right meal plan, stick with it for several weeks until your symptoms are gone or at least significantly improved. At this point, you can begin to reintroduce the eliminated foods one by one while monitoring your symptoms.
The ultimate goal is to have the least restrictive, most whole foods diet you possibly can while still maintaining relief from your symptoms.
Probiotics for Autoimmunity
While you’re on the elimination diet, you may want to consider adding probiotics, which have been shown in several meta-analyses to effectively help fight autoimmune diseases like RA, psoriasis, MS, and other types of autoimmune arthritis [42, 43, 44].
Trials assessing probiotics in autoimmunity have found they:
Reduce C-reactive protein and inflammatory markers in RA 
Improve symptoms in people with spondyloarthritis, juvenile idiopathic arthritis, and IBD arthritis 
Positively impact certain markers of inflammation and oxidative stress that contribute to autoimmunity 
Significantly improve disease progression, depression, and general health in MS patients .
There are three major categories of probiotics that benefit human health, and I’ve seen the best results with my patients when we use a combination of the three, which I call the Triple Therapy Probiotic approach:
Saccharomyces boulardii (a healthy fungus)
Soil-based (Bacillus species)
If you’d like to try probiotics, here’s a simple step-by-step guide:
Try a quality formula probiotic from category 1, category 2, and category 3, and take all three together.
Monitor your symptoms for 3–4 weeks. If you’re improving, stay on this triple therapy protocol until your improvements have plateaued.
Once you’ve seen your maximum improvement, stick with the triple therapy probiotics for about a month to allow your system to calibrate to these new improvements. Then reduce your dose to find the minimal effective dose, and stick with that for the long run.
If you haven’t noticed any change in your symptoms after 3–4 weeks, you can stop taking probiotics and feel confident that you’ve fully explored probiotic therapy. If you notice improvements, continue to take as long as needed, as probiotics are safe for long-term use.
Nutritional Supplements for Autoimmunity
In addition to dietary changes, some nutritional and herbal supplements may significantly impact autoimmune symptoms.
Several studies have shown an association with vitamin D deficiency and autoimmunity [45, 46, 47, 48, 49, 50, 51], so it’s worth it to talk to your healthcare provider about getting a vitamin D blood test and supplement if needed. Patients with RA who took vitamin D supplements had reduced disease activity and inflammation , and those with Hashimoto’s had improved thyroid antibody levels .
One 2021 meta-analysis found people with RA and ulcerative colitis who took 250–1,500 milligrams of curcumin per day for 8–12 weeks had lower markers of inflammation (younger patients who took this supplement for longer than 8 weeks seemed to have the most improvement) .
In addition to diet and supplements, there are several lifestyle factors to consider when you’re experiencing the early signs of autoimmunity. You don’t need to wait to complete the above 2-step process to begin these additional strategies, they can be incorporated at any time.
Lifestyle Considerations for Autoimmune Symptoms
While dietary-related changes and probiotics will likely significantly improve your symptoms, additional lifestyle strategies that address stress and weight are important for autoimmune disease prevention and treatment.
Stress and Autoimmunity
Unmanaged stress, whether physical (lack of sleep or movement) or mental, can have negative consequences on gut health via leaky gut, increased inflammation, and altered immune system function .
Indeed, negative stressful life events are associated with a higher risk of primary Sjogren’s syndrome , and people with RA tend to have more work-related and interpersonal stress than the general population . For those who already have autoimmunity, stress is a well-known trigger of flares.
Creating a healthy foundation for managing stress can go a long way to improving gut health and immune system function, and may help you avoid an autoimmune diagnosis and/or heal current autoimmunity. Here are a few ways to decrease stress levels and improve the early warning signs of autoimmune disease:
Unwanted weight gain/obesity is a known risk factor for developing autoimmune disease, but it also worsens outcomes for people who have already been diagnosed [61, 62, 63, 64]. If you’re overweight, losing excess weight may help to prevent the onset and progression of an autoimmune disease.
Improving your gut health with a whole-foods diet and probiotics will also likely help with healthy weight loss. But focusing on getting restful sleep and appropriate amounts and types of exercise can also support weight loss.
Target Gut Health to Heal the Early Warning Signs of Autoimmune Disease
Autoimmune diseases like psoriasis, IBD, and RA develop when the immune system begins to recognize its own tissues as foreign. The misguided immune system attack damages tissues and organs putting you at greater risk for other health problems and poor quality of life.
Autoimmunity develops from the interplay of genetics and environmental factors, like poor gut health and stress. This is great news because it means that even if you have a family history, developing an autoimmune disease doesn’t have to be your fate. You absolutely have a ton of control over your autoimmune disease risk.
If you’re experiencing the early symptoms of autoimmune disease like digestive distress, skin rashes, fatigue, brain fog, and joint pain, targeting gut health with natural therapies like elemental and elimination diets, probiotics, nutritional supplements, and lifestyle-related changes can interrupt and even reverse the underlying autoimmune process.
The Ruscio Institute has developed a range of high-quality formulations to help our patients and audience. If you’re interested in learning more about these products, please click here. Note that there are many other options available, and we encourage you to research which products may be right for you.
Vojdani A, Pollard KM, Campbell AW. Environmental triggers and autoimmunity. Autoimmune Dis. 2014 Dec 24;2014:798029. DOI: 10.1155/2014/798029. PMID: 25610638. PMCID: PMC4290643.
Paraschou V, Partalidou S, Siolos P, Papadopoulou Z, Chaitidis N. Prevalence of hearing loss in patients with Sjögren syndrome: a systematic review and meta-analysis. Rheumatol Int. 2023 Feb;43(2):233–44. DOI: 10.1007/s00296-022-05235-9. PMID: 36305918.
Zhang T, Yan H-X, An Y, Yin L, Sun P-P, Zhao J-N, et al. The Efficacy and Safety of Manual Therapy for Symptoms Associated with Multiple Sclerosis: A Systematic Review and Meta-Analysis. J Integr Complement Med. 2022 Oct 7;28(10):780–90. DOI: 10.1089/jicm.2021.0382. PMID: 36206232. PMCID: PMC9595630.
Yuan J, Qi S, Zhang X, Lai H, Li X, Xiaoheng C, et al. Local symptoms of Hashimoto’s thyroiditis: A systematic review. Front Endocrinol (Lausanne). 2022;13:1076793. DOI: 10.3389/fendo.2022.1076793. PMID: 36743914. PMCID: PMC9892448.
Lynall M. Neuropsychiatric symptoms in lupus. Lupus. 2018 Oct;27(1_suppl):18–20. DOI: 10.1177/0961203318801672. PMID: 30452327.
Mackay M. Lupus brain fog: a biologic perspective on cognitive impairment, depression, and fatigue in systemic lupus erythematosus. Immunol Res. 2015 Dec;63(1–3):26–37. DOI: 10.1007/s12026-015-8716-3. PMID: 26481913.
Oláh C, Schwartz N, Denton C, Kardos Z, Putterman C, Szekanecz Z. Cognitive dysfunction in autoimmune rheumatic diseases. Arthritis Res Ther. 2020 Apr 15;22(1):78. DOI: 10.1186/s13075-020-02180-5. PMID: 32293528. PMCID: PMC7158026.
Cojocaru M, Cojocaru IM, Silosi I, Vrabie CD. Pulmonary manifestations of systemic autoimmune diseases. Maedica (Buchar). 2011 Jul;6(3):224–9. PMID: 22368703. PMCID: PMC3282547.
Medlin JL, Hansen KE, Fitz SR, Bartels CM. A systematic review and meta-analysis of cutaneous manifestations in late- versus early-onset systemic lupus erythematosus. Semin Arthritis Rheum. 2016 Jun;45(6):691–7. DOI: 10.1016/j.semarthrit.2016.01.004. PMID: 26972993. PMCID: PMC4879060.
Kallinich T, Gattorno M, Grattan CE, de Koning HD, Traidl-Hoffmann C, Feist E, et al. Unexplained recurrent fever: when is autoinflammation the explanation? Allergy. 2013 Mar;68(3):285–96. DOI: 10.1111/all.12084. PMID: 23330689.
Cojocaru M, Cojocaru IM, Silosi I, Vrabie CD. Gastrointestinal manifestations in systemic autoimmune diseases. Maedica (Buchar). 2011 Jan;6(1):45–51. PMID: 21977190. PMCID: PMC3150032.
Kunovsky L, Dite P, Jabandziev P, Kala Z, Vaculova J, Andrasina T, et al. Autoimmune Diseases of Digestive Organs-A Multidisciplinary Challenge: A Focus on Hepatopancreatobiliary Manifestation. J Clin Med. 2021 Dec 11;10(24). DOI: 10.3390/jcm10245796. PMID: 34945093. PMCID: PMC8705412.
Zerwas S, Larsen JT, Petersen L, Thornton LM, Quaranta M, Koch SV, et al. Eating disorders, autoimmune, and autoinflammatory disease. Pediatrics. 2017 Dec;140(6). DOI: 10.1542/peds.2016-2089. PMID: 29122972. PMCID: PMC5703777.
Hommer RE, Swedo SE. Anorexia and autoimmunity: challenging the etiologic constructs of disordered eating. Pediatrics. 2017 Dec;140(6). DOI: 10.1542/peds.2017-3060. PMID: 29122974. PMCID: PMC5703770.
Chareh N, Kiesswetter E, Kob R, Hannink A, Brandl B, Skurk T, et al. Association Between Inflammation and Appetite in Healthy Community-Dwelling Older Adults-An enable Study. Front Aging. 2022 Mar 18;3:826816. DOI: 10.3389/fragi.2022.826816. PMID: 35821805. PMCID: PMC9261305.
Giri PS, Dwivedi M. Meta-analysis for Association of Interleukin 4 VNTR Polymorphism with Rheumatoid Arthritis Risk and Severity. Biochem Genet. 2023 Jun;61(3):823–46. DOI: 10.1007/s10528-022-10288-3. PMID: 36258103.
Cui J, Jin L, Ding M, He J, Yang L, Cui S, et al. Efficacy and safety of mesenchymal stem cells in the treatment of systemic sclerosis: a systematic review and meta-analysis. Stem Cell Res Ther. 2022 Mar 21;13(1):118. DOI: 10.1186/s13287-022-02786-3. PMID: 35313985. PMCID: PMC8935249.
Fellas A, Coda A, Hawke F. Physical and Mechanical Therapies for Lower-Limb Problems in Juvenile Idiopathic ArthritisA Systematic Review with Meta-Analysis. J Am Podiatr Med Assoc. 2017 Sep;107(5):399–412. DOI: 10.7547/15-213. PMID: 28738165.
Bartsch P, Schossee A, Sitte J, Mertens PR. Joint pain, digital necrosis and acute kidney failure in small-vessel autoimmune disease. Clin Kidney J. 2013 Apr;6(2):240–2. DOI: 10.1093/ckj/sft015. PMID: 26019859. PMCID: PMC4432452.
Paray BA, Albeshr MF, Jan AT, Rather IA. Leaky gut and autoimmunity: an intricate balance in individuals health and the diseased state. Int J Mol Sci. 2020 Dec 21;21(24). DOI: 10.3390/ijms21249770. PMID: 33371435. PMCID: PMC7767453.
Xu Q, Ni J-J, Han B-X, Yan S-S, Wei X-T, Feng G-J, et al. Causal Relationship Between Gut Microbiota and Autoimmune Diseases: A Two-Sample Mendelian Randomization Study. Front Immunol. 2021;12:746998. DOI: 10.3389/fimmu.2021.746998. PMID: 35140703. PMCID: PMC8819003.
Christovich A, Luo XM. Gut microbiota, leaky gut, and autoimmune diseases. Front Immunol. 2022 Jun 27;13:946248. DOI: 10.3389/fimmu.2022.946248. PMID: 35833129. PMCID: PMC9271567.
Kinashi Y, Hase K. Partners in leaky gut syndrome: intestinal dysbiosis and autoimmunity. Front Immunol. 2021 Apr 22;12:673708. DOI: 10.3389/fimmu.2021.673708. PMID: 33968085. PMCID: PMC8100306.
Islam MZ, Tran M, Xu T, Tierney BT, Patel C, Kostic AD. Reproducible and opposing gut microbiome signatures distinguish autoimmune diseases and cancers: a systematic review and meta-analysis. Microbiome. 2022 Dec 9;10(1):218. DOI: 10.1186/s40168-022-01373-1. PMID: 36482486. PMCID: PMC9733034.
Xiang S, Qu Y, Qian S, Wang R, Wang Y, Jin Y, et al. Association between systemic lupus erythematosus and disruption of gut microbiota: a meta-analysis. Lupus Sci Med. 2022 Mar;9(1). DOI: 10.1136/lupus-2021-000599. PMID: 35346981. PMCID: PMC8961174.
Gong B, Wang C, Meng F, Wang H, Song B, Yang Y, et al. Association Between Gut Microbiota and Autoimmune Thyroid Disease: A Systematic Review and Meta-Analysis. Front Endocrinol (Lausanne). 2021 Nov 17;12:774362. DOI: 10.3389/fendo.2021.774362. PMID: 34867823. PMCID: PMC8635774.
Takagi S, Utsunomiya K, Kuriyama S, Yokoyama H, Takahashi S, Iwabuchi M, et al. Effectiveness of an “half elemental diet” as maintenance therapy for Crohn’s disease: A randomized-controlled trial. Aliment Pharmacol Ther. 2006 Nov 1;24(9):1333–40. DOI: 10.1111/j.1365-2036.2006.03120.x. PMID: 17059514.
Warners MJ, Vlieg-Boerstra BJ, Verheij J, van Rhijn BD, Van Ampting MTJ, Harthoorn LF, et al. Elemental diet decreases inflammation and improves symptoms in adult eosinophilic oesophagitis patients. Aliment Pharmacol Ther. 2017 Mar;45(6):777–87. DOI: 10.1111/apt.13953. PMID: 28112427. PMCID: PMC5324627.
Xue Z, Miller TL, Abramson L, Thakkar KP, Ketchem CJ, Reddy S, et al. Association of eosinophilic esophagitis with autoimmune and connective tissue disorders, and the impact on treatment response. Dis Esophagus. 2022 Dec 31;36(1). DOI: 10.1093/dote/doac043. PMID: 35829628. PMCID: PMC9817824.
Xu H, Liu M, Cao J, Li X, Fan D, Xia Y, et al. The Dynamic Interplay between the Gut Microbiota and Autoimmune Diseases. J Immunol Res. 2019 Oct 27;2019:7546047. DOI: 10.1155/2019/7546047. PMID: 31772949. PMCID: PMC6854958.
Wechsler JB, Schwartz S, Amsden K, Kagalwalla AF. Elimination diets in the management of eosinophilic esophagitis. J Asthma Allergy. 2014 May 24;7:85–94. DOI: 10.2147/JAA.S47243. PMID: 24920928. PMCID: PMC4043711.
Pimentel M, Constantino T, Kong Y, Bajwa M, Rezaei A, Park S. A 14-day elemental diet is highly effective in normalizing the lactulose breath test. Dig Dis Sci. 2004 Jan;49(1):73–7. DOI: 10.1023/b:ddas.0000011605.43979.e1. PMID: 14992438.
Osowiecka K, Myszkowska-Ryciak J. The Influence of Nutritional Intervention in the Treatment of Hashimoto’s Thyroiditis-A Systematic Review. Nutrients. 2023 Feb 20;15(4). DOI: 10.3390/nu15041041. PMID: 36839399. PMCID: PMC9962371.
Philippou E, Petersson SD, Rodomar C, Nikiphorou E. Rheumatoid arthritis and dietary interventions: systematic review of clinical trials. Nutr Rev. 2021 Mar 9;79(4):410–28. DOI: 10.1093/nutrit/nuaa033. PMID: 32585000.
Askari G, Ghavami A, Shahdadian F, Moravejolahkami AR. Effect of synbiotics and probiotics supplementation on autoimmune diseases: A systematic review and meta-analysis of clinical trials. Clin Nutr. 2021 May;40(5):3221–34. DOI: 10.1016/j.clnu.2021.02.015. PMID: 33642142.
Zeng L, Deng Y, He Q, Yang K, Li J, Xiang W, et al. Safety and efficacy of probiotic supplementation in 8 types of inflammatory arthritis: A systematic review and meta-analysis of 34 randomized controlled trials. Front Immunol. 2022 Sep 23;13:961325. DOI: 10.3389/fimmu.2022.961325. PMID: 36217542. PMCID: PMC9547048.
Mirashrafi S, Hejazi Taghanaki SZ, Sarlak F, Moravejolahkami AR, Hojjati Kermani MA, Haratian M. Effect of probiotics supplementation on disease progression, depression, general health, and anthropometric measurements in relapsing-remitting multiple sclerosis patients: A systematic review and meta-analysis of clinical trials. Int J Clin Pract. 2021 Nov;75(11):e14724. DOI: 10.1111/ijcp.14724. PMID: 34379879.
Jiang H, Chen X, Qian X, Shao S. Effects of vitamin D treatment on thyroid function and autoimmunity markers in patients with Hashimoto’s thyroiditis-A meta-analysis of randomized controlled trials. J Clin Pharm Ther. 2022 Jan 3; DOI: 10.1111/jcpt.13605. PMID: 34981556. PMCID: PMC9302126.
Diaconu A-D, Ostafie I, Ceasovschih A, Șorodoc V, Lionte C, Ancuța C, et al. Role of vitamin D in systemic sclerosis: A systematic literature review. J Immunol Res. 2021 Nov 29;2021:9782994. DOI: 10.1155/2021/9782994. PMID: 34881335. PMCID: PMC8648450.
Taheriniya S, Arab A, Hadi A, Fadel A, Askari G. Vitamin D and thyroid disorders: a systematic review and Meta-analysis of observational studies. BMC Endocr Disord. 2021 Aug 21;21(1):171. DOI: 10.1186/s12902-021-00831-5. PMID: 34425794. PMCID: PMC8381493.
Guan S-Y, Cai H-Y, Wang P, Lv T-T, Liu L-N, Mao Y-M, et al. Association between circulating 25-hydroxyvitamin D and systemic lupus erythematosus: A systematic review and meta-analysis. Int J Rheum Dis. 2019 Oct;22(10):1803–13. DOI: 10.1111/1756-185X.13676. PMID: 31468723.
Lee S, Kim BJ, Lee CH, Lee WS. Increased prevalence of vitamin D deficiency in patients with alopecia areata: a systematic review and meta-analysis. J Eur Acad Dermatol Venereol. 2018 Jul;32(7):1214–21. DOI: 10.1111/jdv.14987. PMID: 29633370.
Yang M, Wu H, Zhao M, Long H, Lu Q. Vitamin D status in patients with autoimmune bullous dermatoses: a meta-analysis. J Dermatolog Treat. 2022 May;33(3):1356–67. DOI: 10.1080/09546634.2020.1810606. PMID: 32799714.
Upala S, Sanguankeo A. Low 25-hydroxyvitamin D levels are associated with vitiligo: a systematic review and meta-analysis. Photodermatol Photoimmunol Photomed. 2016 Jul;32(4):181–90. DOI: 10.1111/phpp.12241. PMID: 27005676.
Guan Y, Hao Y, Guan Y, Bu H, Wang H. The Effect of Vitamin D Supplementation on Rheumatoid Arthritis Patients: A Systematic Review and Meta-Analysis. Front Med (Lausanne). 2020 Oct 30;7:596007. DOI: 10.3389/fmed.2020.596007. PMID: 33195358. PMCID: PMC7661491.
Ebrahimzadeh A, Abbasi F, Ebrahimzadeh A, Jibril AT, Milajerdi A. Effects of curcumin supplementation on inflammatory biomarkers in patients with Rheumatoid Arthritis and Ulcerative colitis: A systematic review and meta-analysis. Complement Ther Med. 2021 Sep;61:102773. DOI: 10.1016/j.ctim.2021.102773. PMID: 34478838.
Irwin MR, Olmstead R, Carroll JE. Sleep Disturbance, Sleep Duration, and Inflammation: A Systematic Review and Meta-Analysis of Cohort Studies and Experimental Sleep Deprivation. Biol Psychiatry. 2016 Jul 1;80(1):40–52. DOI: 10.1016/j.biopsych.2015.05.014. PMID: 26140821. PMCID: PMC4666828.
Jin L, Dai M, Li C, Wang J, Wu B. Risk factors for primary Sjögren’s Syndrome: a systematic review and meta-analysis. Clin Rheumatol. 2023 Feb;42(2):327–38. DOI: 10.1007/s10067-022-06474-8. PMID: 36534351. PMCID: PMC9873717.
De Cock D, Doumen M, Vervloesem C, Van Breda A, Bertrand D, Pazmino S, et al. Psychological stress in rheumatoid arthritis: a systematic scoping review. Semin Arthritis Rheum. 2022 Aug;55:152014. DOI: 10.1016/j.semarthrit.2022.152014. PMID: 35489168.
Kneebone II, Van Zanden BE, Dorstyn DS, Roberts RM, Lord SR, Querstret D, et al. Relaxation and related therapies for people with multiple sclerosis (MS): A systematic review. Clin Rehabil. 2022 Jul;36(7):883–99. DOI: 10.1177/02692155221091509. PMID: 35410503.
Gautam S, Tolahunase M, Kumar U, Dada R. Impact of yoga based mind-body intervention on systemic inflammatory markers and co-morbid depression in active Rheumatoid arthritis patients: A randomized controlled trial. Restor Neurol Neurosci. 2019;37(1):41–59. DOI: 10.3233/RNN-180875. PMID: 30714983.
Byrnes KL, Whillier S. Effects of Nonpharmaceutical Treatments on Symptom Management in Adults With Mild or Moderate Multiple Sclerosis: A Meta-analysis. J Manipulative Physiol Ther. 2019 Sep;42(7):514–31. DOI: 10.1016/j.jmpt.2018.12.010. PMID: 31771836.
Taul-Madsen L, Connolly L, Dennett R, Freeman J, Dalgas U, Hvid LG. Is Aerobic or Resistance Training the Most Effective Exercise Modality for Improving Lower Extremity Physical Function and Perceived Fatigue in People With Multiple Sclerosis? A Systematic Review and Meta-analysis. Arch Phys Med Rehabil. 2021 Oct;102(10):2032–48. DOI: 10.1016/j.apmr.2021.03.026. PMID: 33901439.
Ye D, Mao Y, Xu Y, Xu X, Xie Z, Wen C. Lifestyle factors associated with incidence of rheumatoid arthritis in US adults: analysis of National Health and Nutrition Examination Survey database and meta-analysis. BMJ Open. 2021 Jan 26;11(1):e038137. DOI: 10.1136/bmjopen-2020-038137. PMID: 33500279. PMCID: PMC7843328.
Ohno T, Aune D, Heath AK. Adiposity and the risk of rheumatoid arthritis: a systematic review and meta-analysis of cohort studies. Sci Rep. 2020 Sep 29;10(1):16006. DOI: 10.1038/s41598-020-71676-6. PMID: 32994434. PMCID: PMC7524740.
Richardson TG, Crouch DJM, Power GM, Morales-Berstein F, Hazelwood E, Fang S, et al. Childhood body size directly increases type 1 diabetes risk based on a lifecourse Mendelian randomization approach. Nat Commun. 2022 Apr 28;13(1):2337. DOI: 10.1038/s41467-022-29932-y. PMID: 35484151. PMCID: PMC9051135.
Gomez A, Hani Butrus F, Johansson P, Åkerström E, Soukka S, Emamikia S, et al. Impact of overweight and obesity on patient-reported health-related quality of life in systemic lupus erythematosus. Rheumatology (Oxford). 2021 Mar 2;60(3):1260–72. DOI: 10.1093/rheumatology/keaa453. PMID: 32918459. PMCID: PMC7937019.
I care about answering your questions and sharing my knowledge with you. Leave a comment or connect with me on social media asking any health question you may have and I just might incorporate it into our next listener questions podcast episode just for you!
Transform your health
Every product is science-based, validated by real-world use, and personally vetted by Dr. Ruscio, DC.