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This article is based on scientific evidence, written by experts and fact checked by experts.

Our team of licensed nutritionists and dietitians strive to be objective, unbiased, honest and to present both sides of the argument.

This article contains scientific references. The numbers in the parentheses (1, 2, 3) are clickable links to peer-reviewed scientific papers.

8 Best Microbiome Supplements for a Happier, Healthier Gut

Written by Michael Ruscio on June 6, 2024

Our Favorite Microbiome Supplements Backed by Science and Clinical Experience

When you have gastrointestinal issues, it’s tempting to buy every new supplement you can get your hands on to try to fix the problem and get your microbiome back to a good place. But it’s much better to choose a combination of supplements based on your individual needs rather than what’s trendy in the wellness world right now. The resulting supplement “stack” might not be what’s popular, but it will be tailored to you.

This article is about eight supplements we’ve found to be useful in clinical practice for healing the gut and restoring a balanced microbiome, listed in order of importance at the Ruscio clinic. I’ll also talk about a couple popular supplements that could set back your healing unless you have the right approach.

1. Probiotic Supplements

Dozens of clinical trials and large-scale meta-analyses show that probiotics are consistently better than placebos at improving leaky gut, reducing inflammation, increasing beneficial bacteria, and correcting gut dysbiosis (imbalanced gut microbes) 1.

Probiotics can also be just as effective as antibiotics for treating small intestinal bacterial overgrowth (SIBO) 2 and Giardia infections 3. They may work by attacking the bacteria or parasites directly, or by making the gut environment less hospitable so the bad guys don’t stick around 4.

best microbiome supplements

In both research and my clinical experience, probiotics are an excellent treatment for common gut ailments, like irritable bowel syndrome (IBS) 5, inflammatory bowel disease (IBD) 6, and constipation 7 8. They’re also great for preventing the side effects of antibiotics 9.

This is why we use probiotics as foundational gut support at The Ruscio Institute for Functional Health. While many people believe they need antibiotics or antimicrobial herbs first to kill off pathogens in the gut, often all they need is to reintroduce some good bacteria.

From helping hundreds of people improve their gut health over the last decade, we’ve developed an evidence-based probiotic therapy protocol called Probiotic Triple Therapy. Triple Therapy combines the three main types of probiotics—a blend of Lactobacillus and Bifidobacterium species, soil-based probiotic strains, and a probiotic yeast called Saccharomyces boulardii—to provide a full spectrum of beneficial bacteria and encourage a happy, healthy gut microbiome. 

Our Triple Therapy Sticks offer a convenient way to get all three of these probiotic types in one effective supplement. As a powder, you can easily mix your probiotics in a beverage or food, and increase or decrease as needed.

best microbiome supplements

2. Herbal Antimicrobials

Our next microbiome recommendation is actually a category of supplements. Antimicrobial herbs can be effective against many underlying gut infections, including: 

In a small clinical trial our team conducted, herbal antimicrobials, with or without enzymes that dissolve biofilms, eradicated SIBO in about 40% of patients. That’s close to the 50–60% eradication rate of antibiotics 33 34. When combined with probiotics, herbal antimicrobials may be almost as effective (86%) as antibiotics plus probiotics 2.

One big caveat here: It’s important to always use herbal antimicrobials with the guidance of a knowledgeable healthcare professional. People with compromised immunity should take extra caution. Just because herbal antimicrobials are natural doesn’t mean they aren’t potent and can’t cause problems if used incorrectly 35. 

But in general, they tend to be gentler on the gut microbiome and don’t seem to contribute to bacterial resistance, such as methicillin-resistant Staphylococcus aureus, aka MRSA 36.

Want to learn more about herbal medicine and how it can support your health and well-being? Check out my conversation with herbalist Olivia Amitrano: 

3. Elemental Diet

Maybe an elemental diet counts as more than just a supplement (it’s more of a therapeutic meal replacement), but it can be an enormously helpful tool to reset your gut and recalibrate the microbes in it. (That said, if your gut is already healthy, it’s also a great high-protein option to keep it that way!)

The following are a few mechanisms behind why an elemental diet may help people with microbiome-disrupting conditions, such as SIBO, eosinophilic esophagitis, and Crohn’s disease.

  • It gives your digestive tract a break and a chance to rest, heal, and then repair itself 37 38.
  • It reduces inflammation 37 39.
  • It starves SIBO and other overgrowths 40.

In terms of how to use an elemental diet for gut microbiome health, here are a few options: 

  • As a gut-healing meal replacement, you can use it instead of one or more meals daily.
  • As a gut reset, you can use it for 1–4 days on your own (without clinical supervision).
  • As a remedy for potential overgrowths, you can use it for 1–3 weeks with clinical supervision.

We even have this Dosing Calculator for our elemental diet formula, Elemental Heal, to make it easy to find your best personal dose (especially if you want to use it for multiple days).

4. Glutamine

Maybe you’ve heard of this microbiome supplement. Glutamine is the most abundant free amino acid in human blood and the main energy source for intestinal cells 41. Glutamine may reduce inflammation and leaky gut by supporting the integrity of the tight junctions that hold intestinal cells together 41 42 43 44. One study found that glutamine was better than a placebo for reducing leaky gut and improving IBS symptoms 42.

You’ll often see glutamine labeled as L-glutamine 45 46. L-glutamine is the molecular form found in foods and commonly used in supplements.

I talk more in this video about using a glutamine supplement (along with probiotics and bovine colostrum) as part of a gut healing protocol.

5. Zinc Carnosine

Let’s switch our focus now to an important nutrient for the gut and immune system: zinc. Zinc is an essential mineral in meat, eggs, shellfish, cheese, legumes, and tofu that enables enzyme activity and cell production, particularly in the gut lining and skin 47. 

Another nutrient in meat is L-carnosine, an antioxidant that may play a role in wound healing, immune function, diabetes, and vision 47.

As you’ve probably figured, the compound zinc carnosine is a combo of these two nutrients that’s more effective than zinc alone. This is because carnosine can enhance the body’s absorption of zinc and deliver it more efficiently to the tissues, especially in the stomach and intestines 47. 

Randomized controlled trials have shown that zinc carnosine can improve stomach ulcers and leaky gut 48 49 50 51. Adding this nutrient may therefore improve the gut terrain to support a healthy microbiome. 

At the risk of starting to sound salesy, this is another key supplement we include in Gut Rebuild Nutrients for intestinal support and leaky gut. We’ve seen great results with 75 mg in the clinic, but consult your provider for guidance on dosing.

6. Immunoglobulins

In the clinic, we have found immunoglobulins to be very effective for treating stubborn gut issues that don’t resolve completely with diet changes, probiotics, and other therapies. That makes them solid microbiome supplements in our book.

Serum-derived bovine immunoglobulins are a mix of protein and immunoglobulin G (IgG) that exist naturally in the gut lining. A randomized clinical trial and a later assessment of the same study showed that immunoglobulins may reduce bloating, loose stools, and urgency in people with diarrhea-predominant or mixed-type IBS 52 53. Similarly, other studies found that immunoglobulin therapy was associated with reductions in IBS symptoms 54 55 56 57.

We typically use our immunoglobulin supplement, Intestinal Support Formula, at the clinic. Adding an immunoglobulin formula can support a healthy immune response in the gut by binding to and fighting harmful bacteria, allowing for a healthier microbiome and gut overall. 

7. Curcumin

Curcumin is an anti-inflammatory compound that comes from the spice turmeric. People started using it medicinally in India at least 4,000 years ago 58. Human studies have found that curcumin can benefit people with IBS and IBD, and it has the potential to help eradicate H. pylori 59. In other clinical research, curcumin outperformed placebo at reducing gut pain, diarrhea, constipation, and indigestion 60. An in vitro study also suggests it has the potential to reduce leaky gut 61.

All of this points to curcumin’s ability to modulate the gut microbiome by reducing systemic inflammation, eradicating pathogenic organisms (like H. pylori) from the digestive tract, and improving digestive health. In the clinic, we use curcumin when someone seems to have a high inflammatory burden, especially in cases of IBD or severe IBS.

8. Vitamin D

Interestingly, we have early evidence suggesting that natural vitamin D (mainly from healthy sun exposure and some from foods, like oily fish) and supplemental vitamin D may regulate the gut bacteria 62 63 64 65 66 67. However, the jury is still out as far as how and to what degree 62 63 64 65 66 67. 

That said, a lack of vitamin D is often associated with gut disorders 68, so it stands to reason that improving your vitamin D status would contribute to gut health. Clinically, we’ve found that supplemental vitamin D can support a healthy gut and microbiome, especially in those with low vitamin D (less than 30 ng/mL). 

In any case, we need vitamin D for overall health: to regulate the immune system, metabolize calcium, grow and develop cells, and keep our bones strong 69 70 71. 

Bonus: Popular Gut Supplements That May Impede Your Progress (When Used Incorrectly)

Two popular supplements often end up causing further gut issues for people with gut dysbiosis, depending on whether their microbes are imbalanced in the small intestine, large intestine, or both. 

Fiber

The first supplement is fiber. Metamucil, Citrucel, psyllium, and acacia fiber are common examples of supplemental fiber, typically used to add bulk to the stool and improve bowel movements. Often, well-meaning gut doctors prescribe fiber supplements to patients with constipation or diarrhea, but fiber can easily become a double-edged sword. 

Although supplemental fiber can be especially great for constipation relief, it can also worsen gut troubles in some people 72 73 74. For people with a sensitive gut, starting with a lower dose (2.5 g, or ½ tsp, of psyllium or pectin) and slowly increasing over time often resolves the issue 72. Five to 10 grams, or about 1 to 2 teaspoons, a day is the ideal range for most people. 

For those whose symptoms get worse with even low doses of supplemental fiber, more complex gut issues, such as dysbiosis or leaky gut, may be at play. In such cases, other steps, like dietary and lifestyle changes, probiotics, and possibly antimicrobials should likely come in first to curb the underlying problem. Once the roots of chronic gut symptoms have been handled, then adding supplemental fiber should be less of an issue. 

Prebiotics

The second supplement is prebiotics. These commonly include inulin, fructo-oligosaccharides, and galacto-oligosaccharides. Prebiotics in foods and supplements are also a type of fiber, but their primary function is to feed the microbiome so that good bacteria will make byproducts like butyrate, a short-chain fatty acid with health benefits. 

Unfortunately, multiple meta-analyses with thousands of participants have found that prebiotics have no beneficial effect on people with IBS or similar symptoms, even if these supplements increase the numbers of beneficial species, like Bifidobacterium 74 75 76 77 78 79 80.

Typically, for clients with chronic gut symptoms, I recommend avoiding prebiotic supplements (or taking no more than 3–5 mg/day, which is commonly added to probiotics) in the early stages of their gut healing. After we’ve implemented changes to strengthen their gut health, they may tolerate prebiotics and benefit from them. In the clinic, we’ve found well-placed prebiotics especially good for helping some clients beat Candida. 

Choose Dietary Supplements Wisely

When looking for supplements to improve the gut microbiome, a variety of options can support different aspects of gut health. Whether we’re hoping to directly impact our microbes, support their living environment, improve our immune health, or put the brakes on systemic inflammation, a few choice supplements are worth a look. 

When considering the best microbiome supplements, working with an experienced clinician can streamline the process so you don’t waste time or money on supplements that aren’t right for you. If you’re so inclined, check out our clinic, the Ruscio Institute for Functional Health, and schedule a consultation today.

The Ruscio Institute has developed a range of high-quality formulations to help our clients and audience. If you’re interested in learning more about these products, please click here. Note that there are many other options available, and we encourage you to research which products may be right for you. The information on DrRuscio.com is for educational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment.

Dr. Michael Ruscio is a DC, natural health provider, researcher, and clinician. He serves as an Adjunct Professor at the University of Bridgeport and has published numerous papers in scientific journals as well as the book Healthy Gut, Healthy You. He also founded the Ruscio Institute of Functional Health, where he helps patients with a wide range of GI conditions and serves as the Head of Research.

➕ References

  1. Zheng Y, Zhang Z, Tang P, Wu Y, Zhang A, Li D, et al. Probiotics fortify intestinal barrier function: a systematic review and meta-analysis of randomized trials. Front Immunol. 2023 Apr 24;14:1143548. DOI: 10.3389/fimmu.2023.1143548. PMID: 37168869. PMCID: PMC10165082.
  2. Zhong C, Qu C, Wang B, Liang S, Zeng B. Probiotics for Preventing and Treating Small Intestinal Bacterial Overgrowth: A Meta-Analysis and Systematic Review of Current Evidence. J Clin Gastroenterol. 2017 Apr;51(4):300–11. DOI: 10.1097/MCG.0000000000000814. PMID: 28267052.
  3. Besirbellioglu BA, Ulcay A, Can M, Erdem H, Tanyuksel M, Avci IY, et al. Saccharomyces boulardii and infection due to Giardia lamblia. Scand J Infect Dis. 2006;38(6–7):479–81. DOI: 10.1080/00365540600561769. PMID: 16798698.
  4. Vazquez-Munoz R, Dongari-Bagtzoglou A. Anticandidal activities by lactobacillus species: an update on mechanisms of action. Front Oral Health. 2021 Jul 16;2:689382. DOI: 10.3389/froh.2021.689382. PMID: 35048033. PMCID: PMC8757823.
  5. Zhang T, Zhang C, Zhang J, Sun F, Duan L. Efficacy of Probiotics for Irritable Bowel Syndrome: A Systematic Review and Network Meta-Analysis. Front Cell Infect Microbiol. 2022 Apr 1;12:859967. DOI: 10.3389/fcimb.2022.859967. PMID: 35433498. PMCID: PMC9010660.
  6. Zhang X-F, Guan X-X, Tang Y-J, Sun J-F, Wang X-K, Wang W-D, et al. Clinical effects and gut microbiota changes of using probiotics, prebiotics or synbiotics in inflammatory bowel disease: a systematic review and meta-analysis. Eur J Nutr. 2021 Aug;60(5):2855–75. DOI: 10.1007/s00394-021-02503-5. PMID: 33555375.
  7. Zhang C, Jiang J, Tian F, Zhao J, Zhang H, Zhai Q, et al. Meta-analysis of randomized controlled trials of the effects of probiotics on functional constipation in adults. Clin Nutr. 2020 Oct;39(10):2960–9. DOI: 10.1016/j.clnu.2020.01.005. PMID: 32005532.
  8. Šola KF, Vladimir-Knežević S, Hrabač P, Mucalo I, Saso L, Verbanac D. The effect of multistrain probiotics on functional constipation in the elderly: a randomized controlled trial. Eur J Clin Nutr. 2022 Dec;76(12):1675–81. DOI: 10.1038/s41430-022-01189-0. PMID: 35927504. PMCID: PMC9708599.
  9. Fernández-Alonso M, Aguirre Camorlinga A, Messiah SE, Marroquin E. Effect of adding probiotics to an antibiotic intervention on the human gut microbial diversity and composition: a systematic review. J Med Microbiol. 2022 Nov;71(11). DOI: 10.1099/jmm.0.001625. PMID: 36382780.
  10. Hawrelak JA, Wohlmuth H, Pattinson M, Myers SP, Goldenberg JZ, Harnett J, et al. Western herbal medicines in the treatment of irritable bowel syndrome: A systematic review and meta-analysis. Complement Ther Med. 2020 Jan;48:102233. DOI: 10.1016/j.ctim.2019.102233. PMID: 31987249.
  11. Tan N, Gwee KA, Tack J, Zhang M, Li Y, Chen M, et al. Herbal medicine in the treatment of functional gastrointestinal disorders: A systematic review with meta-analysis. J Gastroenterol Hepatol. 2020 Apr;35(4):544–56. DOI: 10.1111/jgh.14905. PMID: 31674057.
  12. Khanna R, MacDonald JK, Levesque BG. Peppermint oil for the treatment of irritable bowel syndrome: a systematic review and meta-analysis. J Clin Gastroenterol. 2014 Jul;48(6):505–12. DOI: 10.1097/MCG.0b013e3182a88357. PMID: 24100754.
  13. Alammar N, Wang L, Saberi B, Nanavati J, Holtmann G, Shinohara RT, et al. The impact of peppermint oil on the irritable bowel syndrome: a meta-analysis of the pooled clinical data. BMC Complement Altern Med. 2019 Jan 17;19(1):21. DOI: 10.1186/s12906-018-2409-0. PMID: 30654773. PMCID: PMC6337770.
  14. Black CJ, Yuan Y, Selinger CP, Camilleri M, Quigley EMM, Moayyedi P, et al. Efficacy of soluble fibre, antispasmodic drugs, and gut-brain neuromodulators in irritable bowel syndrome: a systematic review and network meta-analysis. Lancet Gastroenterol Hepatol. 2020;5(2):117–31. DOI: 10.1016/S2468-1253(19)30324-3. PMID: 31859183.
  15. Mahboubi M. Therapeutic Potential of Zataria multiflora Boiss in Treatment of Irritable Bowel Syndrome (IBS). J Diet Suppl. 2019;16(1):119–28. DOI: 10.1080/19390211.2017.1409852. PMID: 29333891.
  16. Rahimi R, Nikfar S, Abdollahi M. Induction of clinical response and remission of inflammatory bowel disease by use of herbal medicines: a meta-analysis. World J Gastroenterol. 2013 Sep 14;19(34):5738–49. DOI: 10.3748/wjg.v19.i34.5738. PMID: 24039370. PMCID: PMC3769914.
  17. Ng SC, Lam YT, Tsoi KKF, Chan FKL, Sung JJY, Wu JCY. Systematic review: the efficacy of herbal therapy in inflammatory bowel disease. Aliment Pharmacol Ther. 2013 Oct;38(8):854–63. DOI: 10.1111/apt.12464. PMID: 23981095.
  18. Omer B, Krebs S, Omer H, Noor TO. Steroid-sparing effect of wormwood (Artemisia absinthium) in Crohn’s disease: a double-blind placebo-controlled study. Phytomedicine. 2007 Feb;14(2–3):87–95. DOI: 10.1016/j.phymed.2007.01.001. PMID: 17240130.
  19. Krebs S, Omer TN, Omer B. Wormwood (Artemisia absinthium) suppresses tumour necrosis factor alpha and accelerates healing in patients with Crohn’s disease – A controlled clinical trial. Phytomedicine. 2010 Apr;17(5):305–9. DOI: 10.1016/j.phymed.2009.10.013. PMID: 19962291.
  20. Langhorst J, Wulfert H, Lauche R, Klose P, Cramer H, Dobos GJ, et al. Systematic review of complementary and alternative medicine treatments in inflammatory bowel diseases. J Crohns Colitis. 2015 Jan;9(1):86–106. DOI: 10.1093/ecco-jcc/jju007. PMID: 25518050.
  21. Mueller MS, Runyambo N, Wagner I, Borrmann S, Dietz K, Heide L. Randomized controlled trial of a traditional preparation of Artemisia annua L. (Annual Wormwood) in the treatment of malaria. Trans R Soc Trop Med Hyg. 2004 May;98(5):318–21. DOI: 10.1016/j.trstmh.2003.09.001. PMID: 15109558.
  22. Priotto G, Kabakyenga J, Pinoges L, Ruiz A, Eriksson T, Coussement F, et al. Artesunate and sulfadoxine-pyrimethamine combinations for the treatment of uncomplicated Plasmodium falciparum malaria in Uganda: a randomized, double-blind, placebo-controlled trial. Trans R Soc Trop Med Hyg. 2003 Jun;97(3):325–30. PMID: 15228253.
  23. Force M, Sparks WS, Ronzio RA. Inhibition of enteric parasites by emulsified oil of oregano in vivo. Phytother Res. 2000 May;14(3):213–4. DOI: 10.1002/(sici)1099-1573(200005)14:3<213::aid-ptr583>3.0.co;2-u. PMID: 10815019.
  24. Ghitea TC, El-Kharoubi A, Ganea M, Bimbo-Szuhai E, Nemeth TS, Ciavoi G, et al. The Antimicrobial Activity of Origanum vulgare L. Correlated with the Gastrointestinal Perturbation in Patients with Metabolic Syndrome. Molecules. 2021 Jan 8;26(2). DOI: 10.3390/molecules26020283. PMID: 33429991. PMCID: PMC7827761.
  25. Shayegh S, Rasooli I, Taghizadeh M, Astaneh SDA. Phytotherapeutic inhibition of supragingival dental plaque. Nat Prod Res. 2008 Mar 20;22(5):428–39. DOI: 10.1080/14786410701591739. PMID: 18404563.
  26. Hu Q, Peng Z, Li L, Zou X, Xu L, Gong J, et al. The Efficacy of Berberine-Containing Quadruple Therapy on Helicobacter Pylori Eradication in China: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Front Pharmacol. 2019;10:1694. DOI: 10.3389/fphar.2019.01694. PMID: 32116685. PMCID: PMC7010642.
  27. Wang F, Feng J, Chen P, Liu X, Ma M, Zhou R, et al. Probiotics in Helicobacter pylori eradication therapy: Systematic review and network meta-analysis. Clin Res Hepatol Gastroenterol. 2017 Sep;41(4):466–75. DOI: 10.1016/j.clinre.2017.04.004. PMID: 28552432.
  28. Singh A, Daing A, Dixit J. The effect of herbal, essential oil and chlorhexidine mouthrinse on de novo plaque formation. Int J Dent Hyg. 2013 Feb;11(1):48–52. DOI: 10.1111/j.1601-5037.2012.00556.x. PMID: 22583681.
  29. Yu M, Jin X, Liang C, Bu F, Pan D, He Q, et al. Berberine for diarrhea in children and adults: a systematic review and meta-analysis. Therap Adv Gastroenterol. 2020 Oct 23;13:1756284820961299. DOI: 10.1177/1756284820961299. PMID: 33149763. PMCID: PMC7586028.
  30. Di Pierro F, Bertuccioli A, Giuberti R, Saponara M, Ivaldi L. Role of a berberine-based nutritional supplement in reducing diarrhea in subjects with functional gastrointestinal disorders. Minerva Gastroenterol Dietol. 2020 Mar;66(1):29–34. DOI: 10.23736/S1121-421X.19.02649-7. PMID: 32283882.
  31. Beba M, Djafarian K, Shab-Bidar S. Effect of Berberine on C-reactive protein: A systematic review and meta-analysis of randomized controlled trials. Complement Ther Med. 2019 Oct;46:81–6. DOI: 10.1016/j.ctim.2019.08.002. PMID: 31519292.
  32. Lockyer S, Corona G, Yaqoob P, Spencer JPE, Rowland I. Secoiridoids delivered as olive leaf extract induce acute improvements in human vascular function and reduction of an inflammatory cytokine: a randomised, double-blind, placebo-controlled, cross-over trial. Br J Nutr. 2015 Jul 14;114(1):75–83. DOI: 10.1017/S0007114515001269. PMID: 26051429.
  33. Shah SC, Day LW, Somsouk M, Sewell JL. Meta-analysis: antibiotic therapy for small intestinal bacterial overgrowth. Aliment Pharmacol Ther. 2013 Oct;38(8):925–34. DOI: 10.1111/apt.12479. PMID: 24004101. PMCID: PMC3819138.
  34. Wang J, Zhang L, Hou X. Efficacy of rifaximin in treating with small intestine bacterial overgrowth: a systematic review and meta-analysis. Expert Rev Gastroenterol Hepatol. 2021 Dec;15(12):1385–99. DOI: 10.1080/17474124.2021.2005579. PMID: 34767484.
  35. Purssell E. Antimicrobials. In: Hood P, Khan E, editors. Understanding pharmacology in nursing practice. Cham: Springer International Publishing; 2020. p. 147–65. DOI: 10.1007/978-3-030-32004-1_6.
  36. Anand U, Jacobo-Herrera N, Altemimi A, Lakhssassi N. A comprehensive review on medicinal plants as antimicrobial therapeutics: potential avenues of biocompatible drug discovery. Metabolites. 2019 Nov 1;9(11). DOI: 10.3390/metabo9110258. PMID: 31683833. PMCID: PMC6918160.
  37. Warners MJ, Vlieg-Boerstra BJ, Verheij J, van Rhijn BD, Van Ampting MTJ, Harthoorn LF, et al. Elemental diet decreases inflammation and improves symptoms in adult eosinophilic oesophagitis patients. Aliment Pharmacol Ther. 2017 Mar;45(6):777–87. DOI: 10.1111/apt.13953. PMID: 28112427. PMCID: PMC5324627.
  38. Takagi S, Utsunomiya K, Kuriyama S, Yokoyama H, Takahashi S, Iwabuchi M, et al. Effectiveness of an “half elemental diet” as maintenance therapy for Crohn’s disease: A randomized-controlled trial. Aliment Pharmacol Ther. 2006 Nov 1;24(9):1333–40. DOI: 10.1111/j.1365-2036.2006.03120.x. PMID: 17059514.
  39. Wechsler JB, Schwartz S, Amsden K, Kagalwalla AF. Elimination diets in the management of eosinophilic esophagitis. J Asthma Allergy. 2014 May 24;7:85–94. DOI: 10.2147/JAA.S47243. PMID: 24920928. PMCID: PMC4043711.
  40. Pimentel M, Constantino T, Kong Y, Bajwa M, Rezaei A, Park S. A 14-day elemental diet is highly effective in normalizing the lactulose breath test. Dig Dis Sci. 2004 Jan;49(1):73–7. DOI: 10.1023/b:ddas.0000011605.43979.e1. PMID: 14992438.
  41. Camilleri M, Vella A. What to do about the leaky gut. Gut. 2022 Feb;71(2):424–35. DOI: 10.1136/gutjnl-2021-325428. PMID: 34509978. PMCID: PMC9028931.
  42. Zhou Q, Verne ML, Fields JZ, Lefante JJ, Basra S, Salameh H, et al. Randomised placebo-controlled trial of dietary glutamine supplements for postinfectious irritable bowel syndrome. Gut. 2019 Jun;68(6):996–1002. DOI: 10.1136/gutjnl-2017-315136. PMID: 30108163. PMCID: PMC9549483.
  43. Mottaghi A, Yeganeh MZ, Golzarand M, Jambarsang S, Mirmiran P. Efficacy of glutamine-enriched enteral feeding formulae in critically ill patients: a systematic review and meta-analysis of randomized controlled trials. Asia Pac J Clin Nutr. 2016;25(3):504–12. DOI: 10.6133/apjcn.092015.24. PMID: 27440684.
  44. Wang H, Zhang C, Wu G, Sun Y, Wang B, He B, et al. Glutamine enhances tight junction protein expression and modulates corticotropin-releasing factor signaling in the jejunum of weanling piglets. J Nutr. 2015 Jan;145(1):25–31. DOI: 10.3945/jn.114.202515. PMID: 25527658.
  45. Newsholme P, Procopio J, Lima MMR, Pithon-Curi TC, Curi R. Glutamine and glutamate–their central role in cell metabolism and function. Cell Biochem Funct. 2003 Mar;21(1):1–9. DOI: 10.1002/cbf.1003. PMID: 12579515.
  46. Breslow R, Cheng Z-L. On the origin of terrestrial homochirality for nucleosides and amino acids. Proc Natl Acad Sci USA. 2009 Jun 9;106(23):9144–6. DOI: 10.1073/pnas.0904350106. PMID: 19478058. PMCID: PMC2695116.
  47. Hewlings S, Kalman D. A Review of Zinc-L-Carnosine and Its Positive Effects on Oral Mucositis, Taste Disorders, and Gastrointestinal Disorders. Nutrients. 2020 Feb 29;12(3). DOI: 10.3390/nu12030665. PMID: 32121367. PMCID: PMC7146259.
  48. Shen W, Zhao X, Han Z, Miao Y, Huang H, Zhang Z, et al. Efficacy and safety of polaprezinc in the treatment of gastric ulcer: A multicenter, randomized, double-blind, double-dummy, positive-controlled clinical trial. Med Eng Phys. 2022 Dec;110:103860. DOI: 10.1016/j.medengphy.2022.103860. PMID: 35999163.
  49. Jung DH, Park JC, Lee YC, Lee SK, Shin SK, Chung H, et al. Comparison of the Efficacy of Polaprezinc Plus Proton Pump Inhibitor and Rebamipide Plus Proton Pump Inhibitor Treatments for Endoscopic Submucosal Dissection-induced Ulcers. J Clin Gastroenterol. 2021 Mar 1;55(3):233–8. DOI: 10.1097/MCG.0000000000001357. PMID: 32341237. PMCID: PMC7960146.
  50. Roy SK, Behrens RH, Haider R, Akramuzzaman SM, Mahalanabis D, Wahed MA, et al. Impact of zinc supplementation on intestinal permeability in Bangladeshi children with acute diarrhoea and persistent diarrhoea syndrome. J Pediatr Gastroenterol Nutr. 1992 Oct;15(3):289–96. DOI: 10.1097/00005176-199210000-00010. PMID: 1432467.
  51. Davison G, Marchbank T, March DS, Thatcher R, Playford RJ. Zinc carnosine works with bovine colostrum in truncating heavy exercise-induced increase in gut permeability in healthy volunteers. Am J Clin Nutr. 2016 Aug;104(2):526–36. DOI: 10.3945/ajcn.116.134403. PMID: 27357095.
  52. Wilson D, Evans M, Weaver E, Shaw AL, Klein GL. Evaluation of serum-derived bovine immunoglobulin protein isolate in subjects with diarrhea-predominant irritable bowel syndrome. Clin Med Insights Gastroenterol. 2013 Dec 5;6:49–60. DOI: 10.4137/CGast.S13200. PMID: 24833942. PMCID: PMC4020402.
  53. Weinstock LB, Jasion VS. Serum-Derived Bovine Immunoglobulin/Protein Isolate Therapy for Patients with Refractory Irritable Bowel Syndrome. OJGas. 2014;04(10):329–34. DOI: 10.4236/ojgas.2014.410047.
  54. Valentin N, Camilleri M, Carlson P, Harrington SC, Eckert D, O’Neill J, et al. Potential mechanisms of effects of serum-derived bovine immunoglobulin/protein isolate therapy in patients with diarrhea-predominant irritable bowel syndrome. Physiol Rep. 2017 Mar;5(5). DOI: 10.14814/phy2.13170. PMID: 28275113. PMCID: PMC5350178.
  55. Panas RM. Post-Infectious Irritable Bowel Syndrome with Functional Diarrhea Following C. difficile Infections: Case Studies of Responses Using Serum-Derived Bovine Immunoglobulin. Journal of Gastroenterology and Hepatology Research. 2015 Apr 10;4(4). http://www.ghrnet.org/index.php/joghr/article/view/900?_gl=1*458ich*_gcl_aw*R0NMLjE3MDgwMjcyMzYuQ2p3S0NBaUFpYmV1QmhBQUVpd0FpWEJvSkhYTGs4LVN2aFEteTZSMDV4U0Z2THUtMXpxZkk1MlhKSHJuZzhMdHB0TnFwY2p1cC1zRzR4b0NoTVVRQXZEX0J3RQ..*_gcl_au*NDg3NTMzNzguMTcwNTUxOTE2OA.
  56. Good L, Rosario R, Panas R. New therapeutic option for irritable bowel syndrome: serum-derived bovine immunoglobulin. World J Gastroenterol. 2015 Mar 21;21(11):3361–6. DOI: 10.3748/wjg.v21.i11.3361. PMID: 25805945. PMCID: PMC4363768.
  57. Hilal R, Mitchell P, Guerra Jr. E, Burnett BP. Case Series of 10 Drug-Refractory IBS Patients Who Respond to Oral Serum-Derived Bovine Immunoglobulin/Protein Isolate (SBI). OJGas. 2014;04(10):321–8. DOI: 10.4236/ojgas.2014.410046.
  58. Hatcher H, Planalp R, Cho J, Torti FM, Torti SV. Curcumin: from ancient medicine to current clinical trials. Cell Mol Life Sci. 2008 Jun;65(11):1631–52. DOI: 10.1007/s00018-008-7452-4. PMID: 18324353. PMCID: PMC4686230.
  59. Atefi M, Darand M, Entezari MH, Jamialahmadi T, Bagherniya M, Sahebkar A. A systematic review of the clinical use of curcumin for the management of gastrointestinal diseases. Adv Exp Med Biol. 2021;1291:295–326. DOI: 10.1007/978-3-030-56153-6_18. PMID: 34331698.
  60. Lopresti AL, Smith SJ, Rea A, Michel S. Efficacy of a curcumin extract (CurcugenTM) on gastrointestinal symptoms and intestinal microbiota in adults with self-reported digestive complaints: a randomised, double-blind, placebo-controlled study. BMC Complement Med Ther. 2021 Jan 21;21(1):40. DOI: 10.1186/s12906-021-03220-6. PMID: 33478482. PMCID: PMC7818735.
  61. Wang J, Ghosh SS, Ghosh S. Curcumin improves intestinal barrier function: modulation of intracellular signaling, and organization of tight junctions. Am J Physiol, Cell Physiol. 2017 Apr 1;312(4):C438–45. DOI: 10.1152/ajpcell.00235.2016. PMID: 28249988. PMCID: PMC5407015.
  62. Bosman ES, Albert AY, Lui H, Dutz JP, Vallance BA. Skin exposure to narrow band ultraviolet (UVB) light modulates the human intestinal microbiome. Front Microbiol. 2019 Oct 24;10:2410. DOI: 10.3389/fmicb.2019.02410. PMID: 31708890. PMCID: PMC6821880.
  63. Conteville LC, Vicente ACP. Skin exposure to sunlight: a factor modulating the human gut microbiome composition. Gut Microbes. 2020 Sep 2;11(5):1135–8. DOI: 10.1080/19490976.2020.1745044. PMID: 32339065. PMCID: PMC7524261.
  64. De Pessemier B, Grine L, Debaere M, Maes A, Paetzold B, Callewaert C. Gut-Skin Axis: Current Knowledge of the Interrelationship between Microbial Dysbiosis and Skin Conditions. Microorganisms. 2021 Feb 11;9(2). DOI: 10.3390/microorganisms9020353. PMID: 33670115. PMCID: PMC7916842.
  65. Bellerba F, Muzio V, Gnagnarella P, Facciotti F, Chiocca S, Bossi P, et al. The Association between Vitamin D and Gut Microbiota: A Systematic Review of Human Studies. Nutrients. 2021 Sep 26;13(10). DOI: 10.3390/nu13103378. PMID: 34684379. PMCID: PMC8540279.
  66. Waterhouse M, Hope B, Krause L, Morrison M, Protani MM, Zakrzewski M, et al. Vitamin D and the gut microbiome: a systematic review of in vivo studies. Eur J Nutr. 2019 Oct;58(7):2895–910. DOI: 10.1007/s00394-018-1842-7. PMID: 30324342.
  67. Pham VT, Fehlbaum S, Seifert N, Richard N, Bruins MJ, Sybesma W, et al. Effects of colon-targeted vitamins on the composition and metabolic activity of the human gut microbiome- a pilot study. Gut Microbes. 2021;13(1):1–20. DOI: 10.1080/19490976.2021.1875774. PMID: 33615992. PMCID: PMC7899684.
  68. Rasheed H, Mahgoub D, Hegazy R, El-Komy M, Abdel Hay R, Hamid MA, et al. Serum ferritin and vitamin d in female hair loss: do they play a role? Skin Pharmacol Physiol. 2013 Feb 20;26(2):101–7. DOI: 10.1159/000346698. PMID: 23428658.
  69. Morris AL, Mohiuddin SS. Biochemistry, Nutrients. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2022. PMID: 32119432.
  70. Sizar O, Givler A. Vitamin D Deficiency. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2018. PMID: 30335299.
  71. Papadimitriou DT. The big vitamin D mistake. J Prev Med Public Health. 2017 Jul;50(4):278–81. DOI: 10.3961/jpmph.16.111. PMID: 28768407. PMCID: PMC5541280.
  72. van der Schoot A, Drysdale C, Whelan K, Dimidi E. The Effect of Fiber Supplementation on Chronic Constipation in Adults: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials. Am J Clin Nutr. 2022 Oct 6;116(4):953–69. DOI: 10.1093/ajcn/nqac184. PMID: 35816465. PMCID: PMC9535527.
  73. Nagarajan N, Morden A, Bischof D, King EA, Kosztowski M, Wick EC, et al. The role of fiber supplementation in the treatment of irritable bowel syndrome: a systematic review and meta-analysis. Eur J Gastroenterol Hepatol. 2015 Sep;27(9):1002–10. DOI: 10.1097/MEG.0000000000000425. PMID: 26148247.
  74. Christodoulides S, Dimidi E, Fragkos KC, Farmer AD, Whelan K, Scott SM. Systematic review with meta-analysis: effect of fibre supplementation on chronic idiopathic constipation in adults. Aliment Pharmacol Ther. 2016 Jul;44(2):103–16. DOI: 10.1111/apt.13662. PMID: 27170558.
  75. Wilson B, Rossi M, Dimidi E, Whelan K. Prebiotics in irritable bowel syndrome and other functional bowel disorders in adults: a systematic review and meta-analysis of randomized controlled trials. Am J Clin Nutr. 2019 Apr 1;109(4):1098–111. DOI: 10.1093/ajcn/nqy376. PMID: 30949662.
  76. Zhang WX, Shi LB, Zhou MS, Wu J, Shi HY. Efficacy of probiotics, prebiotics and synbiotics in irritable bowel syndrome: a systematic review and meta-analysis of randomized, double-blind, placebo-controlled trials. J Med Microbiol. 2023 Sep;72(9). DOI: 10.1099/jmm.0.001758. PMID: 37772692.
  77. Ford AC, Harris LA, Lacy BE, Quigley EMM, Moayyedi P. Systematic review with meta-analysis: the efficacy of prebiotics, probiotics, synbiotics and antibiotics in irritable bowel syndrome. Aliment Pharmacol Ther. 2018 Nov;48(10):1044–60. DOI: 10.1111/apt.15001. PMID: 30294792.
  78. Ooi SL, Correa D, Pak SC. Probiotics, prebiotics, and low FODMAP diet for irritable bowel syndrome – What is the current evidence? Complement Ther Med. 2019 Apr;43:73–80. DOI: 10.1016/j.ctim.2019.01.010. PMID: 30935559.
  79. Asha MZ, Khalil SFH. Efficacy and Safety of Probiotics, Prebiotics and Synbiotics in the Treatment of Irritable Bowel Syndrome: A systematic review and meta-analysis. Sultan Qaboos Univ Med J. 2020 Feb;20(1):e13–24. DOI: 10.18295/squmj.2020.20.01.003. PMID: 32190365. PMCID: PMC7065695.
  80. Kamarul Zaman M, Chin K-F, Rai V, Majid HA. Fiber and prebiotic supplementation in enteral nutrition: A systematic review and meta-analysis. World J Gastroenterol. 2015 May 7;21(17):5372–81. DOI: 10.3748/wjg.v21.i17.5372. PMID: 25954112. PMCID: PMC4419079.

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