Reducing Aging and Increasing Quality of Life with Senolytics - Dr. Michael Ruscio, DNM, DC

Reducing Aging and Increasing Quality of Life with Senolytics

Healthy dietary, supplemental, and lifestyle interventions for longevity with Dr. Greg Kelly

There are many research-backed ways to increase quality of life and slow or prevent age-related diseases. In this episode, Dr. Greg Kelly–naturopathic physician and author of Shape Shift–expands on senolytics, a class of drugs that show positive effects on aging, brain and skin health, and anabolic resistance. Hear how senolytics, along with strength and resistance training, walking, perfecting your circadian rhythm, and consuming protein, can help you age and feel well.

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➕ Dr. Ruscio’s Notes

The Main Reasons We Age

  • Damage progressively accumulates in cells 
  • Programmed aging (cells failing to repair) 


9 Hallmarks of Aging 

  • Genomic instability 
  • Telomere attrition
  • Epigenetic alterations
  • Loss of proteostasis
  • Deregulated nutrient-sensing
  • Mitochondrial dysfunction
  • Cellular senescence
  • Stem cell exhaustion
  • Altered intercellular communication


How to Improve Aging Outcomes and Quality of Life 

  • Consume enough protein and calories daily 
  • Maintain grip strength and muscle mass 
  • Measure heart rate variability (HRV)
  • Walk every day
  • Get into a healthy circadian rhythm 
  • Consider senolytics


Senolytics for Aging 

  • Senolytics are a class of drugs that target senescent cells to remove them.
  • The combination of Quercetin and Dasatinib has proven to be helpful, as well as Phycatin. 
  • Senolytics dosing is dependent on age.
    • For adults, take them two days once a month.
    • For someone younger, take them two days once a quarter.

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