The Link Between MCAS, POTS, and EDS with Dr. Leonard Weinstock

Exploring the Link Between These Three Syndromes—Referred to as the “Evil Triad”

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Mast cell activation (MCAS), Ehlers-Danlos syndrome (EDS), and postural orthostatic tachycardia syndrome (POTS) are three often debilitating conditions on their own, but it seems they’re likely connected to one another.

Join me and Dr. Weinstock as he explains the symptoms of these conditions, how they’re linked, and what the future looks like for treatment. Even if you’re only dealing with MCAS or POTS, this episode is worth a listen.

Featured Studies 

• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10352424/
• https://pubmed.ncbi.nlm.nih.gov/26976734/
• https://pubmed.ncbi.nlm.nih.gov/34618688/
• https://pubmed.ncbi.nlm.nih.gov/32824107/
• https://pubmed.ncbi.nlm.nih.gov/30022117/
• https://pubmed.ncbi.nlm.nih.gov/36337620/
• https://pubmed.ncbi.nlm.nih.gov/25640519/
• https://pubmed.ncbi.nlm.nih.gov/34496250/
• https://pubmed.ncbi.nlm.nih.gov/35636614/
• https://pubmed.ncbi.nlm.nih.gov/31421665/
• https://pubmed.ncbi.nlm.nih.gov/34441978/
• https://pubmed.ncbi.nlm.nih.gov/27741023/
• https://pubmed.ncbi.nlm.nih.gov/33629149/
• https://pubmed.ncbi.nlm.nih.gov/30118241/#:~:text=Conclusions%3A%20This%20study%20clearly%20confirms,controlled%20trial%20is%20thus%20warranted.
• https://pubmed.ncbi.nlm.nih.gov/35663980/
• https://pubmed.ncbi.nlm.nih.gov/27436071/
• https://pubmed.ncbi.nlm.nih.gov/23666445/
• https://pubmed.ncbi.nlm.nih.gov/29183244/
• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537261/

Related Resources

• What is POTS: https://drruscio.com/pots/
• Choosing an MCAS diet: https://drruscio.com/mcas-diet/ 
• To contribute to the MCAS documentary: https://ldnresearchtrust.org/documentary-fundraiser 
• More about LDN: https://ldnresearchtrust.org/what-is-low-dose-naltrexone-ldn 
• Courses, free guides, and more: https://drruscio.com/resources?utm_source=youtube&utm_medium=link&utm_campaign=drruscio.com_resources

Timestamps

00:00 Intro

01:06 What is the “triad”?

02:58 MCAS, POTS, & EDS defined

14:33 What are effective therapeutics for healing?

17:20 Approach to MCAS: Step 1

18:14 The importance of mental health

27:32 How these immune symptoms connect to gut health

33:18 Where Dr. Weinstock starts with stomach distension 

36:32 Immunoglobulins

38:50 Sodium butyrate 

39:42 The low FODMAP diet for dysbiosis

42:30 Effective therapies for POTS & EDS

47:39 Low-dose naltrexone

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DISCLAIMER: The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified healthcare provider before starting any new treatment or discontinuing an existing treatment.

Music featured in this video: “Modern Technology” by Andrew G, https://audiojungle.net/user/andrew_g 

*Full transcript available on YouTube by clicking the “Show transcript” button on the bottom right of the video.

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