Biota-Dissolve
Biofilm support used in both months.
Protocol for Addressing Biofilm in SIBO
Biofilms can protect microbes from antimicrobial therapy. This protocol combines biofilm disruption with a structured herbal approach over eight weeks.
8 Weeks
Two-phase protocol structure.
5 Products
Herbal antimicrobials plus biofilm support.
PubMed
Published protocol chart review.
Study Overview
Dr. Ruscio and colleagues published a retrospective chart review examining the addition of biofilm support to an herbal antimicrobial protocol for SIBO.
- Biofilm disruption combined with herbals
- Associated reductions in hydrogen and methane gas levels
- Structured eight-week protocol
Why Biofilm Disruption Matters
Biofilms form protective structures around microbes. Breaking down these structures may allow antimicrobial therapies to reach bacteria more effectively.
Mechanism of Action
How BiotaDissolve Breaks Down Biofilm
A multi-enzyme approach targeting every layer of biofilm structure
Active Mechanisms
- Polysaccharide-Specific Enzymes Break down the polysaccharide scaffolding that forms the outer biofilm structure
- Protein / Peptide-Specific Enzymes Degrade structural proteins and quorum sensing peptides that coordinate bacterial behavior
- Lysozyme & Serratia Peptidase Erode bacterial wall integrity and break down the fibrin shield protecting bacterial colonies
- EDTA Chelates the calcium and magnesium minerals that hold the biofilm matrix together
Visual Outcome
Before — Stubborn Biofilm
Persistent bacteria shielded below
Dense polysaccharide scaffolding protects bacteria from antimicrobials
After — Disrupted Biofilm
Biofilm loosened, bacteria cleared
Structural matrix broken apart, allowing antimicrobials to reach bacteria
BiotaDissolve®
— Cureus. 2025 Dec 13;17(12):e99116. doi. PMID: 41394228
The Two-Month Protocol Structure
Biota-Dissolve
Biofilm support used throughout the protocol to help disrupt protective microbial structures.
Month One
Biota-Clear 1a + 1b form the first antimicrobial phase.
Month Two
Biota-Clear 2a + 2b continue the protocol with a second botanical phase.
Products Used in the Protocol
Dosing Structure
Weeks 1-4
Biota-Clear 1a — 4 caps twice daily
Biota-Clear 1b — 2 caps twice daily
Biota-Dissolve — 3 caps twice daily (away from meals)
Weeks 5-8
Biota-Clear 2a — 3 caps twice daily
Biota-Clear 2b — 3 caps twice daily
Biota-Dissolve — 3 caps twice daily (away from meals)
Optional Supports
FAQs
Why is Biota-Dissolve used throughout the protocol?
It supports biofilm disruption while the antimicrobial phases target microbial balance.
Why does the protocol change after month one?
The second phase introduces different botanicals rather than repeating the same approach.
Is this medical advice?
No. This page provides educational information. Protocols should align with practitioner guidance when appropriate.